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Vibramycin (Doxycycline Monohydrate) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Due to oral doxycycline's virtually complete absorption, side effects of the lower bowel, particularly diarrhea, have been infrequent. The following adverse reactions have been observed in patients receiving tetracyclines:

Gastrointestinal: anorexia, nausea, vomiting, diarrhea, glossitis, dysphagia, enterocolitis, and inflammatory lesions (with monilial overgrowth) in the anogenital region. Hepatotoxicity has been reported rarely. These reactions have been caused by both the oral and parenteral administration of tetracyclines. Rare instances of esophagitis and esophageal ulcerations have been reported in patients receiving capsule and tablet forms of the drugs in the tetracycline class. Most of these patients took medications immediately before going to bed. (See DOSAGE AND ADMINISTRATION.)

Skin: toxic epidermal necrolysis, Stevens-Johnson syndrome, erythema multiforme, maculopapular and erythematous rashes. Exfoliative dermatitis has been reported but is uncommon. Photosensitivity is discussed above. (See WARNINGS.)

Renal toxicity: Rise in BUN has been reported and is apparently dose related. (See WARNINGS.)

Immune: Hypersensitivity reactions including urticaria, angioneurotic edema, anaphylaxis, anaphylactoid purpura, serum sickness, pericarditis, exacerbation of systemic lupus erythematosus, and drug rash with eosinophilia and systemic symptoms (DRESS).

Blood: Hemolytic anemia, thrombocytopenia, neutropenia, and eosinophilia have been reported.

Other: bulging fontanels in infants and intracranial hypertension in adults. (See PRECAUTIONS – General.)

When given over prolonged periods, tetracyclines have been reported to produce brown-black microscopic discoloration of the thyroid gland. No abnormalities of thyroid function studies are known to occur.



REPORTS OF SUSPECTED VIBRAMYCIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Vibramycin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Vibramycin side effects / adverse reactions in 78 year old male

Reported by a physician from Switzerland on 2011-10-18

Patient: 78 year old male

Reactions: Cholestatic Liver Injury

Adverse event resulted in: hospitalization

Suspect drug(s):
Plaquenil
    Dosage: 100 mg, 3x/day
    Administration route: Oral
    Indication: Aortitis
    Start date: 2011-05-30
    End date: 2011-07-08

Vibramycin
    Dosage: 100 mg, 3x/day
    Administration route: Oral
    Indication: Aortitis
    Start date: 2011-05-30
    End date: 2011-07-08

Other drugs received by patient: Marcumar; Crestor; Concor; Pantoprazole Sodium



Possible Vibramycin side effects / adverse reactions in 74 year old male

Reported by a physician from Japan on 2011-12-05

Patient: 74 year old male

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Suspect drug(s):
Vibramycin



Possible Vibramycin side effects / adverse reactions in 74 year old male

Reported by a physician from Japan on 2012-01-03

Patient: 74 year old male

Reactions: Drug Rash With Eosinophilia and Systemic Symptoms

Adverse event resulted in: hospitalization

Suspect drug(s):
Rulid

Vibramycin
    Dosage: 100 mg, daily
    Administration route: Oral
    Indication: Furuncle
    Start date: 2011-09-05
    End date: 2011-09-12



See index of all Vibramycin side effect reports >>

Drug label data at the top of this Page last updated: 2014-09-25

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