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Viagra (Sildenafil Citrate) - Summary

 
 



VIAGRA SUMMARY

VIAGRA®, an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate (cGMP)-specific phosphodiesterase type 5 (PDE5).

VIAGRA is indicated for the treatment of erectile dysfunction.


See all Viagra indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Viagra (Sildenafil)

'Female Viagra' approved by FDA
Source: Clinical Trials / Drug Trials News From Medical News Today [2015.08.19]
The FDA have approved the first ever drug to treat low sexual desire in premenopausal women. Flibanserin - brand name Addyi - will be available from mid-October.

Detecting Viagra's active ingredient, other dietary supplements' hidden ingredients
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2015.08.06]
To lose weight, boost energy or soothe nerves, many consumers turn to dietary supplements. But some of these products contain undeclared substances.

Viagra linked with higher risk of skin cancer
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2015.06.24]
Skin cancer had a higher incidence among men taking PDE5 inhibitors but the link may not be causal. Instead, it may be linked to other factors.

New study reveals mixed picture on the effectiveness of Viagra and related drugs
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2015.04.10]
Viagra and other related drugs are not a universal 'cure-all' for impotence, according to a new study from The University of Manchester and NatCen Social Research.

Study reveals mixed picture on the effectiveness of Viagra and related drugs
Source: Erectile Dysfunction / Premature Ejaculation News From Medical News Today [2015.04.08]
Viagra and other related drugs are not a universal 'cure-all' for impotence, according to a new study from The University of Manchester and NatCen Social Research.

more news >>

Published Studies Related to Viagra (Sildenafil)

Treatment of palmar-plantar erythrodysesthesia (PPE) with topical sildenafil: a pilot study. [2015]
treatment of PPE... CONCLUSIONS: In this limited, single-center study, topical cream containing 1 %

Efficacy of daily low-dose sildenafil for treating interstitial cystitis: results of a randomized, double-blind, placebo-controlled trial--treatment of interstitial cystitis/painful bladder syndrome with low-dose sildenafil. [2014]
treatment of nonulcer interstitial cystitis (IC) in women... CONCLUSION: Daily low-dose sildenafil is an easy, well-tolerated, and effective

Randomized controlled trial of sildenafil for preventing recurrent ischemic priapism in sickle cell disease. [2014]
recurrent ischemic priapism associated with sickle cell disease... CONCLUSIONS: Sildenafil use by systematic dosing may offer a strategy to prevent

Effect of sildenafil on skeletal and cardiac muscle in Becker muscular dystrophy. [2014]
heart function in patients with BMD... INTERPRETATION: Despite positive evidence from animal models of dystrophinopathy

Sildenafil citrate in the treatment of pain in primary dysmenorrhea: a randomized controlled trial. [2013]
STUDY QUESTION: Is a vaginal preparation of sildenafil citrate capable of alleviating acute menstrual pain in patients with primary dysmenorrhea (PD)? SUMMARY ANSWER: A vaginal preparation of sildenafil citrate is capable of alleviating acute menstrual pain in patients with PD with no observed adverse effects.

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Clinical Trials Related to Viagra (Sildenafil)

Does Oral Sildenafil (Viagra) Decrease Mean Pulmonary Artery Pressure After Cardiac Surgery? [Completed]
Post-operative pulmonary hypertension is a risk factor for right ventricular failure and an increasing cause of morbidity and mortality in patients undergoing high-risk cardiac surgery. Several treatments have been used to treat and reduce post operative pulmonary hypertension. Unfortunately none of these treatments are approved for use in this condition and only one (inhaled nitric oxide) is specific enough to pulmonary hypertension to not cause dangerous low blood pressure in the rest of the body. Sadly, inhaled nitric oxide is difficult and expensive to use, and can cause lung damage. Sildenafil citrate is quite specific to the lung vessels, is easy to administer and does not easily cause low blood pressure in other areas of the body. We hypothesize that oral sildenafil 12. 5mg will decrease the baseline (pre-dose) mPAP by at least 20% compared with a placebo.

Effects of Viagra on Heart Function in Patients With Heart Failure [Completed]
Sildenafil (Viagra) is known to reduce pulmonary hypertension. Heart failure patients also have pulmonary hypertension and several recent reports have shown that sildenafil leads to an improvement in their exercise capacity. In these studies sildenafil caused a reduction in the pulmonary and systemic vascular resistances, improved pulmonary gas diffusion and perhaps increased cardiac output. It is uncertain if left ventricular filling pressures are reduced and whether there is improvement in left ventricular relaxation. The investigators hypothesize that in heart failure patients the improvement in exercise capacity associated with sildenafil is related to a significant reduction in left ventricular filling pressures. The investigators propose to study 20 patients with stable but moderately symptomatic heart failure. The study design is a randomized cross-over trial of the administration of a single dose of sildenafil 50 mg or a matching placebo. Exercise capacity will be determined before and after the oral administration of sildenafil 50 mg or placebo. Left ventricular filling pressures will be assessed by Doppler echocardiography and the serum level of B-type natriuretic peptide (BNP is known to increase with higher left ventricular filling pressures). After an initial echocardiogram and performing a 6 minute walk test, the patient will then be given either sildenafil or a matching placebo in a randomized double-blind fashion. One hr later a blood sample for serum BNP, the echocardiogram and the 6 minute walk test will be repeated.

Sildenafil for Prevention of Cerebral Vasospasm [Withdrawn]
A Randomized Clinical Trial with security and dose testing of Sildenafil Citrate in patients with subarachnoid hemorrhage due to a rupture of a cerebral aneurism for prevention of cerebral vasospasm. The cerebral vasospasm is a decrease in blood flow that occurs when the intracranial vessels lose their capability of self-control of dilations and contractions. Patients with subarachnoid hemorrhage without neurological deficits who underwent endovascular or surgical correction of the aneurysm can participate in this trial. They will be randomized to a daily doses of 75 mg of Sildenafil, 150 mg of Sildenafil or Placebo from the third to the 14th day post bleeding. Today there is no proven clinical treatment for prevention of cerebral vasospasm.

Pharmacokinetics of Sildenafil in Premature Infants [Recruiting]

Bioequivalence Study For Orally-Disintegrating Tablet Of Sildenafil [Completed]
The purpose of this study is to assess the bioequivalence of Sildenafil ODT 50 mg without water to Japanese commercial oral tablet of sildenafil citrate (Viagra tablet) 50 mg under fasted conditions.

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Reports of Suspected Viagra (Sildenafil) Side Effects

Drug Ineffective (734)Erection Increased (165)Headache (117)Erectile Dysfunction (96)Penis Disorder (85)Drug Effect Decreased (63)Drug Interaction (55)Incorrect Dose Administered (48)Penile Pain (47)Nausea (43)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 4 ratings/reviews, Viagra has an overall score of 6.25. The effectiveness score is 8 and the side effect score is 5.50. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Viagra review by 70 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   ED
Dosage & duration:   100mg taken 3 x month for the period of 1 year
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   Strong erections
Side effects:   Headache/ mild
Comments:   Strong erections

 

Viagra review by 29 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Erectile Dysfunction
Dosage & duration:   100mg taken 1 for the period of 1
Other conditions:   High Blood Pressure
Other drugs taken:   Enalapril Maleate (not at the same time though)
  
Reported Results
Benefits:   Very effective.
Side effects:   VIAGRA WORKED BUT WITH HORRIBLE SIDE EFFECTS! I only took it once. Around 1040PM, I took a VERY small minute amount of a 100 mg dose. Seven minutes later, the side effects kicked in. I had VERY FAST RAPID HEARTBEAT FOR AN HOUR AND A HALF! I'm 29, with "slightly" high blood pressure (140/90), and I had to call 911 (around 12:00AM) because I SERIOUSLY THOUGHT I WAS GOING TO HAVE A HEART ATTACK! Around 1215AM, the EMS checked my blood pressure and it was at 188 (systolic). I also had facial flushing where my face seemed warmer/hotter than usual. Also, it was so uncomfortable that I had to "walk slower" around my apt and I could barely talk as I had to breathe in more carefully so that I could calm my heart down as much as I could. I didn't go to bed until 4/5am because I was so worried that I might have a heart attack! VIAGRA IS REALLY STRONG AND IT'S NOT SOMETHING TO TAKE LIGHTLY! TAKE A VERY VERY SMALL DOSE IF IT'S YOUR FIRST TIME TAKING IT! I'LL NEVER TAKE IT AGAIN!
Comments:   N/A

 

Viagra review by 29 year old male patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Extremely Severe Side Effects
  
Treatment Info
Condition / reason:   Erectile Dysfunction
Dosage & duration:   100mg taken 1 for the period of 1
Other conditions:   High Blood Pressure
Other drugs taken:   Enalapril Maleate (not at the same time though)
  
Reported Results
Benefits:   Very effective.
Side effects:   VIAGRA WORKED BUT WITH HORRIBLE SIDE EFFECTS! I only took it once. Around 1040PM, I took a VERY small minute amount of a 100 mg dose. Seven minutes later, the side effects kicked in. I had VERY FAST RAPID HEARTBEAT FOR AN HOUR AND A HALF! I'm 29, with "slightly" high blood pressure (140/90), and I had to call 911 (around 12:00AM) because I SERIOUSLY THOUGHT I WAS GOING TO HAVE A HEART ATTACK! Around 1215AM, the EMS checked my blood pressure and it was at 188 (systolic). I also had facial flushing where my face seemed warmer/hotter than usual. Also, it was so uncomfortable that I had to "walk slower" around my apt and I could barely talk as I had to breathe in more carefully so that I could calm my heart down as much as I could. I didn't go to bed until 4/5am because I was so worried that I might have a heart attack! VIAGRA IS REALLY STRONG AND IT'S NOT SOMETHING TO TAKE LIGHTLY! TAKE A VERY VERY SMALL DOSE IF IT'S YOUR FIRST TIME TAKING IT! I'LL NEVER TAKE IT AGAIN!
Comments:   N/A

See all Viagra reviews / ratings >>

Page last updated: 2015-08-19

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