Vesicare (Solifenacin Succinate) - Drug Interactions, Contraindications, Overdosage, etc

DRUG INTERACTIONS

Drug-Drug Interactions

Do not exceed a 5 mg daily dose of VESIcare when administered with therapeutic doses of ketoconazole or other potent CYP3A4 inhibitors. (See CLINICAL PHARMACOLOGY, DOSAGE AND ADMINISTRATION)

OVERDOSAGE

Acute

Overdosage with VESIcare can potentially result in severe anticholinergic effects and should be treated accordingly. The highest case of accidental overdose of solifenacin succinate was 280mg in a 5 hour period, resulting in mental status changes but not requiring hospitalization.

Chronic

Intolerable anticholinergic side effects (fixed and dilated pupils, blurred vision, failure of heel-to-toe exam, tremors and dry skin) occurred on day 3 in normal volunteers taking 50 mg daily (5 times the maximum recommended therapeutic dose) and resolved within 7 days following discontinuation of drug.

Treatment of Overdosage

In the event of overdose with VESIcare, treat with gastric lavage and appropriate supportive measures. ECG monitoring is also recommended.

CONTRAINDICATIONS

VESIcare is contraindicated in patients with urinary retention, gastric retention, uncontrolled narrow-angle glaucoma, and in patients who have demonstrated hypersensitivity to the drug substance or other components of the product.