Overdosage with VESIcare can potentially result in severe anticholinergic effects and should be treated accordingly. The highest case of accidental overdose of solifenacin succinate was 280mg in a 5 hour period, resulting in mental status changes but not requiring hospitalization.
Intolerable anticholinergic side effects (fixed and dilated pupils, blurred vision, failure of heel-to-toe exam, tremors and dry skin) occurred on day 3 in normal volunteers taking 50 mg daily (5 times the maximum recommended therapeutic dose) and resolved within 7 days following discontinuation of drug.
Treatment of Overdosage
In the event of overdose with VESIcare, treat with gastric lavage and appropriate supportive measures. ECG monitoring is also recommended.