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Vesicare (Solifenacin Succinate) - Summary

 
 



VESICARE SUMMARY

VESIcare®  (solifenacin succinate) is a muscarinic receptor antagonist.

VESIcare is indicated for the treatment of overactive bladder with symptoms of urge urinary incontinence, urgency, and urinary frequency.


See all Vesicare indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Vesicare (Solifenacin)

Solifenacin as add-on therapy for overactive bladder symptoms in men treated for lower urinary tract symptoms--ASSIST, randomized controlled study. [2011.07]
OBJECTIVES: To assess the efficacy and safety of solifenacin add-on therapy to tamsulosin in lower urinary tract symptoms (LUTS) men with residual overactive bladder (OAB) symptoms despite tamsulosin monotherapy... CONCLUSIONS: In male LUTS patients with residual OAB symptoms despite tamsulosin monotherapy, TAM+SOL showed efficacy on urgency, which represents OAB symptoms and was well tolerated. Copyright (c) 2011 Elsevier Inc. All rights reserved.

Tadalafil versus solifenacin for persistent storage symptoms after prostate surgery in patients with erectile dysfunction: a prospective randomized study. [2011.07]
OBJECTIVES: The occurrence of residual storage symptoms after surgical relief of bladder outlet obstruction as a result of benign prostatic enlargement (BPE) underlines the intricate mechanism involved in lower urinary tract symptoms (LUTS). The aim of the present study was to compare tadalafil with solifenacin in modifying symptoms and uroflowmetric parameters in patients with erectile dysfunction (ED) and residual storage symptoms after prostate surgery... CONCLUSIONS: In patients suffering from ED and storage symptoms after surgical treatment for LUTS-BPE, tadalafil 5mg given once daily for 12weeks provided a comparable improvement in IPSS to solifenacin 5mg given for the same period of time. (c) 2011 The Japanese Urological Association.

Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary. [2011.07]
PURPOSE: We compared changes in nocturia and sleep related parameters between the anticholinergic solifenacin and placebo in patients with overactive bladder associated with nocturia... CONCLUSIONS: Solifenacin 10 mg decreases nocturia episodes. Solifenacin 5 and 10 mg increases nighttime volume voided per micturition and may improve quality of sleep and sleep related quality of life in patients with overactive bladder. Copyright (c) 2011 American Urological Association Education and Research, Inc. Published by Elsevier Inc. All rights reserved.

Tolerability of solifenacin and oxybutynin immediate release in older (> 65 years) and younger (</= 65 years) patients with overactive bladder: sub-analysis from a Canadian, randomized, double-blind study. [2011.02]
CONCLUSIONS: Solifenacin 5 mg/day was better tolerated than oxybutynin IR 15 mg/day in younger (</= 65 years) and older (> 65 years) subgroups. Solifenacin was equally well tolerated in both age subgroups. Limitations of the analysis were that the study was not preplanned to perform post-hoc subgroup analysis, patients knew that dry mouth was a primary outcome, and the study used fixed doses of each drug.

Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary. [2011]
associated with nocturia... CONCLUSIONS: Solifenacin 10 mg decreases nocturia episodes. Solifenacin 5 and 10

more studies >>

Clinical Trials Related to Vesicare (Solifenacin)

Open-Label Study of the Efficacy and Safety of VESIcare® in Patients With Overactive Bladder Symptoms [Completed]
To evaluate the safety and efficacy of solifenacin succinate in subjects with overactive bladder symptoms (urgency, with or without urge incontinence, usually with frequency and nocturia).

Efficacy & Safety Study of VESIcare® (Solifenacin Succinate) in Patients Wishing to Switch From Detrol LA® for Treatment of Overactive Bladder [Completed]
To evaluate the efficacy of 5 and10mg solifenacin succinate in patients with urgency who have OAB syndrome (urgency, with or without urge incontinence, usually with frequency and nocturia) and wish to switch from tolterodine tartrate extended release to solifenacin succinate due to lack of sufficient improvement in urgency episodes

A Study of Solifenacin With Bladder Training Versus Solifenacin Alone in Patients With Overactive Bladder (SOLAR) [Active, not recruiting]
This study will look at a drug for OAB (solifenacin) in combination with a non drug treatment (bladder training) compared to the drug on its own. The study will compare the symptoms of OAB by assessing patient diaries and other patient reported outcomes.

A Multicenter VESIcare® Efficacy and Safety Study for the Treatment of Urgency Associated With Overactive Bladder (OAB) [Completed]
The purpose is to evaluate the efficacy of 5 and 10mg VESIcare® (solifenacin succinate) in patients with urgency who have overactive bladder syndrome.

Study to Compare the Safety and Efficacy of Solifenacin With Oxybutynin for the Treatment of Overactive Bladder (VECTOR) [Active, not recruiting]
The purpose of this study is to compare the safety and efficacy of solifenacin with oxybutynin immediate-release (IR) for the treatment of overactive bladder (OAB).

more trials >>

Reports of Suspected Vesicare (Solifenacin) Side Effects

DRY Mouth (42)Drug Ineffective (37)Vision Blurred (33)Fall (32)Constipation (28)Death (28)Confusional State (23)Urinary Retention (20)Drug Interaction (17)OFF Label USE (16)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Vesicare has an overall score of 8.67. The effectiveness score is 9.33 and the side effect score is 9.33. The scores are on ten point scale: 10 - best, 1 - worst.
 

Vesicare review by 62 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   overactive bladder
Dosage & duration:   5 mgm. by mouth, once a day taken daily for the period of 1 year and ongoing
Other conditions:   pelvic prolapse;mild asthma; allergic rhinitis; hypothyroidism
Other drugs taken:   Allegra; Nasacort; Premarin; Levoxyl; Advair Diskus
  
Reported Results
Benefits:   Urinary frequency and urgency have been substantially reduced; I have a vastly improved lifestyle because these problems no longer inhibit my activities.
Side effects:   I experienced mild constipation in the beginning but because I eat a vegetarian diet I have been able to manage this side effect easily by increasing dietary fiber. No other measures have been necessary.
Comments:   My gynecologist changed me to Vesicare when I complained about side effects from the previous Rx I was on for overactive bladder. (These were dry mouth and constipation.) After beginning to take Vesicare daily, I noticed an immediate improvement, i.e., sharp decrease in the negative side effects. I plan to continue the use of Vesicare because there seem to be no prohibitions to its long term use. It may also possibly postpone surgical repair of the pelvic prolapse.

 

Vesicare review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   frequent urination
Dosage & duration:   10mg taken 1/day for the period of continue
Other conditions:   lack of sleep
Other drugs taken:   n/a
  
Reported Results
Benefits:   I was able to hold and wait to use restroom and urges were less frequent.
Side effects:   dry mouth constipation
Comments:   I've been taking 5 mg per day for a month and I felt it was losing effectiveness so incresed to 10 mg and been taking 3 month so far. I still have some what of problem before period and have more frequent urge to goto restroom than other people but I am able to hole and wait. It is much more controlable than I wasn't taking anything.

 

Vesicare review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   frequent urination
Dosage & duration:   10mg taken 1/day for the period of continue
Other conditions:   lack of sleep
Other drugs taken:   n/a
  
Reported Results
Benefits:   I was able to hold and wait to use restroom and urges were less frequent.
Side effects:   dry mouth constipation
Comments:   I've been taking 5 mg per day for a month and I felt it was losing effectiveness so incresed to 10 mg and been taking 3 month so far. I still have some what of problem before period and have more frequent urge to goto restroom than other people but I am able to hole and wait. It is much more controlable than I wasn't taking anything.

See all Vesicare reviews / ratings >>

Page last updated: 2013-02-10

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