VERMOX SUMMARY
VERMOX® (mebendazole) is a (synthetic) broad-spectrum anthelmintic available as chewable tablets, each containing 100 mg of mebendazole.
VERMOX® (mebendazole) is indicated for the treatment of
Enterobius vermicularis
(pinworm),
Trichuris trichiura
(whipworm),
Ascaris lumbricoides
(common roundworm),
Ancylostoma duodenale
(common hookworm),
Necator americanus
(American hookworm) in single or mixed infections.
Efficacy varies as a function of such factors as pre-existing diarrhea and gastrointestinal transit time, degree of infection, and helminth strains.
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NEWS HIGHLIGHTS
Published Studies Related to Vermox (Mebendazole)
Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. [2011]
BACKGROUND: The control of soil-transmitted helminth (STH) infections currently relies on the large-scale administration of single-dose oral albendazole or mebendazole. However, these treatment regimens have limited efficacy against hookworm and Trichuris trichiura in terms of cure rates (CR), whereas fecal egg reduction rates (ERR) are generally high for all common STH species...
Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial. [2010.12.15]
BACKGROUND: Single-dose albendazole and mebendazole show limited efficacy in the treatment of trichuriasis. The combination of albendazole with ivermectin improves efficacy, but a mebendazole-ivermectin combination has not been previously investigated... CONCLUSIONS: Addition of ivermectin improves the therapeutic outcomes of both albendazole and mebendazole against T. trichiura and may be considered for use in soil-transmitted helminth control programs and individual patient management. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN08336605.
Activities of biotransformation enzymes in pheasant (Phasianus colchicus) and their modulation by in vivo administration of mebendazole and flubendazole. [2007.08]
Basal activities of certain pheasant hepatic and intestinal biotransformation enzymes and modulation of their activities by anthelmintics flubendazole (FLBZ) and mebendazole (MBZ) were investigated in subcellular fractions that were prepared from liver and small intestine of control and FLBZ or MBZ treated birds...
LOW EFFICACY OF MEBENDAZOLE AGAINST HOOKWORM IN VIETNAM: TWO RANDOMIZED CONTROLLED TRIALS. [2007.04]
Vietnam is participating in a global de-worming effort that aims to treat 650 million school children regularly by 2010... We recommend that efficacy of anti-helminth therapies is pilot tested before implementation of national gut worm control programs.
A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children. [2006.11]
CONCLUSIONS: Three doses of mebendazole, in a single day, are inferior to a single dose tinidazole in the treatment of giardiasis.
Clinical Trials Related to Vermox (Mebendazole)
Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide [Recruiting]
The purpose of this study is to find the highest dose of mebendazole (MBZ) that can be
safely given to people with malignant brain tumors in combination with the current standard
of care (temozolomide) without causing severe side effects. We also want to find out if MBZ
can slow the growth of the brain tumor. The study doctors have found that MBZ is effective
against malignant brain tumors in the laboratory and animal models of brain tumors.
Monitoring the Efficacy of Anthelmintics for the Treatment of Soil Transmitted Helminths P2 [Recruiting]
Severe Anemia Treatment Trials, Pakistan [Completed]
The purpose of this study is to test the efficacy of two enhanced regimens (deworming and
multivitamins) in the treatment of severe anemia in pregnant women and children 6-24 months
of age in Karachi, Pakistan.
The Effect of a Deworming Intervention to Improve Early Childhood Growth and Development in Resource-poor Areas [Recruiting]
Worldwide, over 2 billion people suffer from worm infections in developing countries. These
infections are especially damaging to the health of children, resulting in both short-term
and lifelong disability. Older children with worm infections are more likely to be stunted,
underweight, vulnerable to other illnesses and perform poorly in school compared to
non-infected children. Large-scale deworming programs in school-age children are therefore
recommended by the World Health Organization (WHO). WHO also recommends deworming of
preschool-age children (as of 12 months of age) in these areas; however, the benefits of
deworming, especially in the 12-24 month age group, have been inadequately studied. This
knowledge is urgently needed as studies show that all children have a similar potential for
healthy growth and development, provided that appropriate nutrition and health interventions
are given in the critical window of opportunity before the age of two.
Therefore, the investigators are proposing to undertake a randomized controlled trial to
determine the effect of deworming program for improving growth and development in children
between 12 and 24 months of age. Our results will provide solid rigorous evidence on if,
when, and how often, deworming should be integrated into routine child health care packages
provided by Ministries of Health in the 130 countries in the world where worm infections are
endemic.
Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women [Active, not recruiting]
The purpose of this research is to compare the efficacy of two low-cost low intervention
packages to prevent and treat severe anemia in pregnant women in Zanzibar, Tanzania. The two
packages are Standard of Care as described by the WHO (presumptive treatment for malaria and
helminths plus daily iron + folic acid supplements) and Enhanced Care (Standard of Care plus
daily multivitamins and a 2nd dose of anthelminthic.)
Reports of Suspected Vermox (Mebendazole) Side Effects
Conjunctivitis (5),
Headache (5),
Pyrexia (5),
Pruritus Generalised (5),
Dizziness (5),
Angioedema (5),
Gastrointestinal Disorder (5),
Pain (3),
Somnolence (3),
Dyspnoea (3), more >>
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