VERMOX® (mebendazole) is a (synthetic) broad-spectrum anthelmintic available as chewable tablets, each containing 100 mg of mebendazole.
VERMOX® (mebendazole) is indicated for the treatment of
(American hookworm) in single or mixed infections.
Efficacy varies as a function of such factors as pre-existing diarrhea and gastrointestinal transit time, degree of infection, and helminth strains.
Published Studies Related to Vermox (Mebendazole)
Efficacy of single-dose and triple-dose albendazole and mebendazole against soil-transmitted helminths and Taenia spp.: a randomized controlled trial. 
BACKGROUND: The control of soil-transmitted helminth (STH) infections currently relies on the large-scale administration of single-dose oral albendazole or mebendazole. However, these treatment regimens have limited efficacy against hookworm and Trichuris trichiura in terms of cure rates (CR), whereas fecal egg reduction rates (ERR) are generally high for all common STH species...
Albendazole and mebendazole administered alone or in combination with ivermectin against Trichuris trichiura: a randomized controlled trial. [2010.12.15]
BACKGROUND: Single-dose albendazole and mebendazole show limited efficacy in the treatment of trichuriasis. The combination of albendazole with ivermectin improves efficacy, but a mebendazole-ivermectin combination has not been previously investigated... CONCLUSIONS: Addition of ivermectin improves the therapeutic outcomes of both albendazole and mebendazole against T. trichiura and may be considered for use in soil-transmitted helminth control programs and individual patient management. TRIAL REGISTRATION: isrctn.org Identifier: ISRCTN08336605.
Activities of biotransformation enzymes in pheasant (Phasianus colchicus) and their modulation by in vivo administration of mebendazole and flubendazole. [2007.08]
Basal activities of certain pheasant hepatic and intestinal biotransformation enzymes and modulation of their activities by anthelmintics flubendazole (FLBZ) and mebendazole (MBZ) were investigated in subcellular fractions that were prepared from liver and small intestine of control and FLBZ or MBZ treated birds...
LOW EFFICACY OF MEBENDAZOLE AGAINST HOOKWORM IN VIETNAM: TWO RANDOMIZED CONTROLLED TRIALS. [2007.04]
Vietnam is participating in a global de-worming effort that aims to treat 650 million school children regularly by 2010... We recommend that efficacy of anti-helminth therapies is pilot tested before implementation of national gut worm control programs.
A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children. [2006.11]
CONCLUSIONS: Three doses of mebendazole, in a single day, are inferior to a single dose tinidazole in the treatment of giardiasis.
Clinical Trials Related to Vermox (Mebendazole)
A Study to Assess the Effect of Food on the Bioavailability of Mebendazole From a Fast-Disintegrating Chewable Formulation of Mebendazole in Healthy Participants [Completed]
The purpose of the study is to evaluate the effect of food on the bioavailability (how much
medication is in your blood) of mebendazole from a single 500 mg oral dose of a
fast-disintegrating chewable tablet formulation of mebendazole in healthy adult
Mebendazole in Newly Diagnosed High-Grade Glioma Patients Receiving Temozolomide [Recruiting]
The purpose of this study is to find the highest dose of mebendazole (MBZ) that can be
safely given to people with malignant brain tumors in combination with the current standard
of care (temozolomide) without causing severe side effects. We also want to find out if MBZ
can slow the growth of the brain tumor. The study doctors have found that MBZ is effective
against malignant brain tumors in the laboratory and animal models of brain tumors.
A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas [Recruiting]
This is a study to determine the safety and efficacy of the drug, mebendazole, when used in
combination with standard chemotherapy drugs for the treatment of pediatric brain tumors.
Mebendazole is a drug used to treat infections with intestinal parasites and has a long
track record of safety in humans. Recently, it was discovered that mebendazole may be
effective in treating cancer as well, in particular brain tumors. Studies using both cell
cultures and mouse models demonstrated that mebendazole was effective in decreasing the
growth of brain tumor cells.
This study focuses on the treatment of a category of brain tumors called gliomas. Low-grade
gliomas are tumors arising from the glial cells of the central nervous system and are
characterized by slower, less aggressive growth than that of high-grade gliomas. Some
low-grade gliomas have a more aggressive biology and an increased likelihood of resistance
Low-grade gliomas are often able to be treated by observation alone if they receive a total
surgical resection. However, tumors which are only partially resected and continue to grow
or cause symptoms, or those which recur following total resection require additional
treatment, such as chemotherapy. Due to their more aggressive nature, pilomyxoid
astrocytomas, even when totally resected, will often be treated with chemotherapy. The
current first-line treatment at our institution for these low-grade gliomas involves a
three-drug chemotherapy regimen of vincristine, carboplatin, and temozolomide. However,
based on our data from our own historical controls, over 50% of patients with pilomyxoid
astrocytomas will continue to have disease progression while on this treatment. We believe
that mebendazole in combination with vincristine, carboplatin, and temozolomide may provide
an additional therapeutic benefit with increased progression-free and overall survival for
low-grade glioma patients, particularly for those with pilomyxoid astrocytomas.
High grade gliomas are more aggressive tumors with poor prognoses. The standard therapy is
radiation therapy. A variety of adjuvant chemotherapeutic combinations have been used, but
with disappointing results. For high-grade gliomas this study will add mebendazole to the
established combination of bevacizumab and irinotecan to determine this combinations safety
Comparative Efficacy of Different Mebendazole Polymorphs in the Treatment of Soil-transmitted Helminth Infections [Completed]
Mebendazole tablets which are produced by most pharmaceutical manufacturers, including the
State Pharmaceutical Manufacturing Corporation (SPMC) of Sri Lanka, contain a mixture of
polymorphs A and C. However, there is some evidence to show that mebendazole polymorph C is
the only form effective against the soil-transmitted helminths. This protocol describes a
stratified, randomized, placebo-controlled trial that examined the efficacy of different
mebendazole polymorphs produced by the SPMC in the treatment of hookworm infections.
A Study to Assess the Efficacy and Safety of Mebendazole for the Treatment of Helminth Infections in Pediatric Participants [Recruiting]
The purpose of this study is to evaluate the efficacy and safety of mebendazole compared
with placebo in pediatric participants with Helminth infections.
Reports of Suspected Vermox (Mebendazole) Side Effects
Pruritus Generalised (5),
Gastrointestinal Disorder (5),
Dyspnoea (3), more >>
Page last updated: 2011-12-09