VERMOX SUMMARY
VERMOX® (mebendazole) is a (synthetic) broad-spectrum anthelmintic available as chewable tablets, each containing 100 mg of mebendazole.
VERMOX® (mebendazole) is indicated for the treatment of
Enterobius vermicularis
(pinworm),
Trichuris trichiura
(whipworm),
Ascaris lumbricoides
(common roundworm),
Ancylostoma duodenale
(common hookworm),
Necator americanus
(American hookworm) in single or mixed infections.
Efficacy varies as a function of such factors as pre-existing diarrhea and gastrointestinal transit time, degree of infection, and helminth strains.
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NEWS HIGHLIGHTSMedia Articles Related to Vermox (Mebendazole)
mebendazole chewable-oral, Vermox
Source: MedicineNet Pinworm Infection Specialty [2005.03.02]
Title: mebendazole chewable-oral, Vermox
Category: Medications
Created: 3/2/2005
Last Editorial Review: 3/2/2005
Published Studies Related to Vermox (Mebendazole)
Activities of biotransformation enzymes in pheasant (Phasianus colchicus) and their modulation by in vivo administration of mebendazole and flubendazole. [2007.08]
Basal activities of certain pheasant hepatic and intestinal biotransformation enzymes and modulation of their activities by anthelmintics flubendazole (FLBZ) and mebendazole (MBZ) were investigated in subcellular fractions that were prepared from liver and small intestine of control and FLBZ or MBZ treated birds...
LOW EFFICACY OF MEBENDAZOLE AGAINST HOOKWORM IN VIETNAM: TWO RANDOMIZED CONTROLLED TRIALS. [2007.04]
Vietnam is participating in a global de-worming effort that aims to treat 650 million school children regularly by 2010... We recommend that efficacy of anti-helminth therapies is pilot tested before implementation of national gut worm control programs.
A randomized, controlled, open-label trial of a single day of mebendazole versus a single dose of tinidazole in the treatment of giardiasis in children. [2006.11]
CONCLUSIONS: Three doses of mebendazole, in a single day, are inferior to a single dose tinidazole in the treatment of giardiasis.
A double-blind randomized controlled trial of antenatal mebendazole to reduce low birthweight in a hookworm-endemic area of Peru. [2006.10]
OBJECTIVE: To assess the effect on birthweight of antenatal mebendazole plus iron vs. placebo plus iron in a highly hookworm-endemic area... CONCLUSIONS: This trial provides additional evidence for the use of anthelmintics, over and above iron supplementation, within antenatal care programmes in hookworm-endemic areas. Benefits of de-worming may be higher in countries not having an antenatal iron supplementation programme or where intensity of hookworm infections is higher.
Comparative efficacy of albendazole and three brands of mebendazole in the treatment of ascariasis and trichuriasis. [2004.03]
OBJECTIVE: To evaluate the comparative efficacy of 400 mg albendazole (Smith Kline Beecham) as a single dose and three brands of mebendazole (Janssen, Unibios and East African Pharmaceuticals) at doses of 100 mg twice a day for three consecutive days in the treatment of single or mixed infections with Ascaris lumbricoides and or Trichuris trichiura in four treatment groups of school children... CONCLUSION: The results of this study suggest that in areas of single or mixed infections with Trichuris trichiura and/or Ascaris lumbricoides are common public health problems and where laboratory facilities are not available to make parasite identification, mebendazole (particularly vermox, a product of Janssen laboratory) would be the drug of choice to treat trichuriasis and ascariasis. However, either mebendazole from the different brands or albendazole is effective in the treatment of ascariasis in areas where trichuriasis is not prevalent.
Clinical Trials Related to Vermox (Mebendazole)
Severe Anemia Treatment Trials, Pakistan [Completed]
The purpose of this study is to test the efficacy of two enhanced regimens (deworming and
multivitamins) in the treatment of severe anemia in pregnant women and children 6-24 months
of age in Karachi, Pakistan.
Treatment and Prevention of Severe Anemia in Pregnant Zanzibari Women [Active, not recruiting]
The purpose of this research is to compare the efficacy of two low-cost low intervention
packages to prevent and treat severe anemia in pregnant women in Zanzibar, Tanzania. The two
packages are Standard of Care as described by the WHO (presumptive treatment for malaria and
helminths plus daily iron + folic acid supplements) and Enhanced Care (Standard of Care plus
daily multivitamins and a 2nd dose of anthelminthic.)
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