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Vepesid (Etoposide) - Indications and Dosage

 
 



INDICATIONS AND USAGE

VePesid (etoposide) is indicated in the management of:

Small Cell Lung Cancer— VePesid Capsules in combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer.

DOSAGE AND ADMINISTRATION

For recommended dosing adjustments in patients with renal impairment see PRECAUTIONS section.

Chemotherapy courses are repeated at 3- to 4-week intervals after adequate recovery from any toxicity.

VePesid Capsules

In small cell lung cancer, the recommended dose of VePesid Capsules is two times the IV dose rounded to the nearest 50 mg (i.e., two times 35 mg/m2/day for 4 days to 50 mg/m2/day for 5 days).

The dosage should be modified to take into account the myelosuppressive effects of other drugs in the combination or the effects of prior x-ray therapy or chemotherapy which may have compromised bone marrow reserve.

Administration Precautions

To minimize the risk of dermal exposure, always wear impervious gloves when handling blisterpacks of individually labeled blisters containing VePesid capsules. This includes all handling activities in clinical settings, pharmacies, storerooms, and home healthcare settings, including during unpacking and inspection, transport within a facility, and dose preparation and administration.

Stability

VePesid Capsules must be stored under refrigeration 2°– 8° C (36°– 46° F). The capsules are stable for 24 months under such refrigeration conditions.

Procedures for proper handling and disposal of anticancer drugs should be considered. Several guidelines on this subject have been published.1-8 There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.

HOW SUPPLIED

VePesid® (etoposide) Capsules

  •   NDC 0015-3091-45—50 mg pink capsules with “BRISTOL 3091” printed in black in blisterpacks of 20 individually labeled blisters, each containing one capsule.

Capsules are to be stored under refrigeration 2°– 8° C (36°– 46° F).

DO NOT FREEZE.

Dispense in child-resistant containers.

For information on package sizes available, refer to the current price schedule.

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