Vepesid (Etoposide) - Summary

VEPESID SUMMARY

VePesid^®
(etoposide)
Capsules

VePesid^® (etoposide) (also commonly known as VP-16) is a semisynthetic derivative of podophyllotoxin used in the treatment of certain neoplastic diseases. It is 4'-demethylepipodophyllotoxin 9-[4,6-O-(R)-ethylidene-β-D-glucopyranoside]. It is very soluble in methanol and chloroform, slightly soluble in ethanol, and sparingly soluble in water and ether. It is made more miscible with water by means of organic solvents.

VePesid (etoposide) is indicated in the management of the following neoplasms:

Refractory Testicular Tumors— VePesid For Injection in combination therapy with other approved chemotherapeutic agents in patients with refractory testicular tumors who have already received appropriate surgical, chemotherapeutic, and radiotherapeutic therapy.

Adequate data on the use of VePesid Capsules in the treatment of testicular cancer are not available.

Small Cell Lung Cancer— VePesid For Injection and/or Capsules in combination with other approved chemotherapeutic agents as first line treatment in patients with small cell lung cancer.

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VEPESID NEWS HIGHLIGHTS

Published Studies Related to Vepesid (Etoposide)

Results of the EICESS-92 Study: two randomized trials of Ewing's sarcoma treatment--cyclophosphamide compared with ifosfamide in standard-risk patients and assessment of benefit of etoposide added to standard treatment in high-risk patients. [2008.09.20]

Irinotecan plus carboplatin versus oral etoposide plus carboplatin in extensive small-cell lung cancer: a randomized phase III trial. [2008.09.10]

7-Year survival results of perioperative chemotherapy with epidoxorubicin, etoposide, and cisplatin (EEP) in locally advanced resectable gastric cancer: up-to-date analysis of a phase-II study. [2008.08]

Safety and efficacy of darbepoetin alpha in previously untreated extensive-stage small-cell lung cancer treated with platinum plus etoposide. [2008.05.10]

A threefold dose intensity treatment with ifosfamide, carboplatin, and etoposide for patients with small cell lung cancer: a randomized trial. [2008.04.16]

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Clinical Trials Related to Vepesid (Etoposide)

Ph II Bev + Either Temo/Etoposide for GBM Pts Who Have Failed Bev + Irinotecan [Active, not recruiting]

A Trial of Thalidomide, Celecoxib, Etoposide and Cyclophosphamide in Patients With Relapsed or Progressive Cancer [Completed]

Etoposide and G-CSF With or Without Rituximab in Treating Patients Who Are Undergoing an Autologous Peripheral Stem Cell Transplant For Non-Hodgkin's Lymphoma [Active, not recruiting]

Ph I Dose Escalation Trial of Vandetanib in Combo w Etoposide for Malignant Gliomas [Recruiting]

Cisplatin/Etoposide/Radiotherapy +/- Consolidation Docetaxel in Advanced Stage III Non-Small Cell Lung Cancer [Completed]

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