Venofer ®(iron sucrose injection, USP)
Venofer® (iron sucrose injection, USP) is a brown, sterile, aqueous, complex of polynuclear iron (III)-hydroxide in sucrose for intravenous use.
Venofer® is indicated in the treatment of iron deficiency anemia in the following patients:
- non-dialysis dependent-chronic kidney disease (NDD-CKD) patients receiving an erythropoietin
- non-dialysis dependent-chronic kidney disease (NDD-CKD) patients not receiving an erythropoietin
- hemodialysis dependent-chronic kidney disease (HDD-CKD) patients receiving an erythropoietin
- peritoneal dialysis dependent-chronic kidney disease (PDD-CKD) patients receiving an erythropoietin.
Published Studies Related to Venofer (Iron Sucrose)
Ferumoxytol: a new era of iron deficiency anemia treatment for patients with chronic kidney disease. [2011.11]
Ferumoxytol is a new product approved for intravenous use by the US Food and Drug Administration (FDA) in the treatment of iron deficiency anemia in adults with chronic kidney disease. This approval was based on data from 3 open-label, randomized, controlled clinical trials... This is a multicenter randomized trial of ferumoxytol compared with iron sucrose for the treatment of iron deficiency anemia in adult subjects with chronic kidney disease, where intravenous ferumoxytol is being compared with other intravenous agents to evaluate the safety of ferumoxytol and assess changes in hemoglobin level.
FERGIcor, a randomized controlled trial on ferric carboxymaltose for iron deficiency anemia in inflammatory bowel disease. [2011.09]
BACKGROUND & AIMS: Iron deficiency anemia (IDA) is common in chronic diseases and intravenous iron is an effective and recommended treatment. However, dose calculations and inconvenient administration may affect compliance and efficacy. We compared the efficacy and safety of a novel fixed-dose ferric carboxymaltose regimen (FCM) with individually calculated iron sucrose (IS) doses in patients with inflammatory bowel disease (IBD) and IDA... CONCLUSIONS: The simpler FCM-based dosing regimen showed better efficacy and compliance, as well as a good safety profile, compared with the Ganzoni-calculated IS dose regimen. Copyright (c) 2011 AGA Institute. Published by Elsevier Inc. All rights reserved.
Impact of iron treatment on immune effector function and cellular iron status of circulating monocytes in dialysis patients. [2011.03]
BACKGROUND: Iron is used as an adjunct therapy to treat anaemia in dialysis patients. However, iron may harbour detrimental effects in being a nutrient for invading pathogens or by modulating immune pathways. Thus, we prospectively studied the effects of iron treatment towards monocyte immune function... CONCLUSIONS: Intravenously administered iron is taken up by monocytes and leads to short-term activation of the nuclear factor kappa-B pathway. However, increased circulating ferritin levels are associated with an impaired immune response of monocytes. In addition, circulating hepcidin concentrations may determine the erythropoietic response to iron injection by modifying iron retention within monocytes.
Iron sucrose with and without recombinant erythropoietin for the treatment of severe postpartum anemia: a prospective, randomized, open-label study. [2011.02]
AIM: Postpartum anemia is a common problem in obstetrics. Depending on the severity of anemia, it can cause a wide range of symptoms. Obstetrical management should be focused on avoiding blood transfusion in young and otherwise healthy women. The aim of this study was to examine the effectiveness of recombinant human erythropoietin (rhEPO) combined with iron sucrose compared to iron sucrose alone in patients with severe postpartum anemia... CONCLUSION: In general, iron sucrose alone is a sufficient anemia therapy agent. A subgroup of patients (i.e. with a more pronounced inflammatory response after cesarean section) may benefit from additional rhEPO therapy. Despite being severely anemic, none of our patients required transfusion. Iron sucrose as well as rhEPO was very well tolerated. The benefit of the therapy lies in the avoidance of allogenic blood transfusions with their potential side effects. In cases of severe anemia after operative delivery, additional rhEPO therapy can result in a faster Hb increase and, therefore, faster recovery. (c) 2010 The Authors. Journal of Obstetrics and Gynaecology Research (c) 2010 Japan Society of Obstetrics and Gynecology.
Proteinuria induced by parenteral iron in chronic kidney disease--a comparative randomized controlled trial. [2011.01]
BACKGROUND AND OBJECTIVES: Among patients with chronic kidney disease (CKD), differences in proteinuria are seen between intravenous iron preparations after a single dose exposure. This study examined differences in proteinuria between two intravenous iron preparations after multiple doses... CONCLUSIONS: Although multiple doses of either intravenous iron did not increase basal levels of proteinuria, postdose proteinuria was greater with iron sucrose than with ferric gluconate. These data suggest that nephrotoxicity of iron may depend on type of intravenous iron and on ACEI/ARB use. The long-term effects on kidney function need to be further evaluated.
Clinical Trials Related to Venofer (Iron Sucrose)
Safety Assessment of Iron Sucrose (Venofer) in Patients With Chronic Kidney Disease Who Cannot Tolerate Ferumoxytol (Feraheme) or Iron Dextran (INFed or Dexferrum) [Recruiting]
The objective of this study is to assess the safety and tolerability of Venofer in patients
with chronic kidney disease who cannot tolerate Ferumoxytol (Feraheme) or intravenous iron
containing a dextran (INFed or Dexferrum).
Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Adult Subjects With Chronic Kidney Disease [Recruiting]
The purpose of the study is to evaluate the safety and efficacy of intravenous (IV)
ferumoxytol compared to IV iron sucrose for the treatment of iron deficiency anemia (IDA) in
subjects with chronic kidney disease (CKD).
IV Iron Sucrose vs Oral FeSO4 in Treating IDA in Pediatric IBD [Not yet recruiting]
The purpose of this study is to assess the safety and efficacy of intravenous iron sucrose
in comparison to oral ferrous sulfate in improving iron deficiency anemia in children with
inflammatory bowel disease.
A Trial Comparing Ferumoxytol With Iron Sucrose for the Treatment of Iron Deficiency Anemia [Recruiting]
A Phase IV Trial of Repeated Doses of Ferumoxytol Compared to Iron Sucrose for the Treatment of Iron Deficiency Anemia in Patients With Chronic Kidney Disease on Hemodialysis [Not yet recruiting]
The objectives of this study are to compare the efficacy and safety of repeat doses of
intravenous (IV) ferumoxytol with IV iron sucrose for the treatment of IDA in subjects with
Reports of Suspected Venofer (Iron Sucrose) Side Effects
Maternal Exposure During Pregnancy (9),
Oedema Peripheral (8),
Abdominal Pain (7),
Blood Glucose Increased (6), more >>