VECURONIUM SUMMARY
Vecuronium Bromide for Injection is a nondepolarizing neuromuscular blocking agent ofintermediate duration, chemically designated as 1-(3α,17β-Dihydroxy-2β-piperidino-5α-androstan-16β,5α-yl)-1-methylpiperidinium bromide, diacetate.
Vecuronium bromide is indicated as an adjunct to general anesthesia, to facilitate endotrachealintubation and to provide skeletal muscle relaxation during surgery or mechanical ventilation.
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NEWS HIGHLIGHTSMedia Articles Related to Vecuronium
Abdominal Surgery Without General Anesthesia
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
Need For Emergency Airway Surgery For Hard-to-Intubate Patients Reduced
Source: Respiratory / Asthma News From Medical News Today [2009.11.18]
Be prepared, that old Boy Scout motto, is being applied with great success to operating room patients whose anatomy may make it difficult for physicians to help them breathe during surgery, Johns Hopkins researchers report in a new study. When patients undergo general anesthesia, they stop breathing on their own and anesthesiologists must quickly insert a tube into the airway as a first step in machine-assisted breathing.
New Technique For Injectable Facial Fillers Improves Comfort, Recovery
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.10.29]
Less pain during injections for wrinkle-fighting facial fillers. Less swelling afterward. Less time in the office waiting for anesthesia to take effect. These and other benefits of a new injection technique that UT Southwestern Medical Center plastic surgeons are helping pioneer are outlined in the October issue of Plastic and Reconstructive Surgery.
Published Studies Related to Vecuronium
Sugammadex Provides Faster Reversal of Vecuronium-Induced Neuromuscular Blockade Compared with Neostigmine: A Multicenter, Randomized, Controlled Trial. [2009.08.27]
Background: Sugammadex, a specifically designed gamma-cyclodextrin, is a selective relaxant binding drug that rapidly reverses rocuronium-induced and, to a lesser extent, vecuronium-induced neuromuscular blockade. In this study, we compared the efficacy of sugammadex and neostigmine for the reversal of vecuronium-induced neuromuscular blockade in patients scheduled for elective surgery...
The post-tetanic count during vecuronium-induced neuromuscular blockade in halothane-anaesthetized dogs. [2009.05]
OBJECTIVE: To evaluate the post-tetanic count (PTC) for predicting the return of reversible neuromuscular blockade at the n.
Effects of olprinone on neuromuscular blockade caused by vecuronium. [2007.12]
We studied the effect of olprinone on neuromuscular blockade caused by vecuronium. Thirty women undergoing nitrous oxide-oxygen-isoflurane anesthesia were randomly divided into olprinone (n=15) or control group (n=15).
Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block. [2007.11]
BACKGROUND: /st> The aim of this study was to examine the efficacy of epidurally administered mepivacaine on recovery from vecuronium-induced neuromuscular block... CONCLUSIONS: /st> In clinical anaesthesia, it should be recognized that epidurally administered mepivacaine delays considerably the TOF recovery from neuromuscular block.
Comparisons of the dose-response and recovery time course of vecuronium and atracurium in anesthetized chinese adult patients. [2007.03]
BACKGROUND: The authors found no study comparing potency and duration of action of vecuronium and atracurium in healthy Chinese, so they compared the dose-response relations of vecuronium and atracurium in anesthetized Chinese adult patients and evaluated the time-course of action of two drugs following administration of equipotent doses... CONCLUSIONS: The neuromuscular blocking potency of atracurium is approximately 17% that of vecuronium in anesthetized Chinese adult patients. Following equipotent doses, the time course of action of atracurium is similar to that of vecuronium.
Clinical Trials Related to Vecuronium
Comparison of Sugammadex With Neostigmine Administered at 1-2 PTCs After Administration of Rocuronium or Vecuronium [Completed]
The purpose of the trial is to demonstrate a faster recovery from neuromuscular block with
rocuronium or vecuronium after reversal by 4. 0 mg/kg of Org 25969 compared with reversal by
70 ug/kg of neostigmine
Comparison of Org 25969 With Neostigmine as Reversal Agents for Rocuronium or Vecuronium at Reappearance of T2 [Completed]
The purpose of this study was to demonstrate in adult patients faster recovery from a
neuromuscular block induced by either rocuronium or vecuronium after reversal at reappearance
of T2 by 2. 0 mg/kg Org 25969 (sugammadex) compared to 50 ug/kg neostigmine.
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