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Vasotec I.V. (Enalaprilat) - Summary

 

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USE IN PREGNANCY

When used in pregnancy during the second and third trimesters, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, VASOTEC I.V. should be discontinued as soon as possible. See WARNINGS, Fetal/Neonatal Morbidity and Mortality.

 

VASOTEC I.V. SUMMARY

VASOTEC I.V. (Enalaprilat) is a sterile aqueous solution for intravenous administration. Enalaprilat is an angiotensin converting enzyme inhibitor.

VASOTEC I.V. is indicated for the treatment of hypertension when oral therapy is not practical.

VASOTEC I.V. has been studied with only one other antihypertensive agent, furosemide, which showed approximately additive effects on blood pressure. Enalapril, the pro-drug of enalaprilat, has been used extensively with a variety of other antihypertensive agents, without apparent difficulty except for occasional hypotension.

In using VASOTEC I.V., consideration should be given to the fact that another angiotensin converting enzyme inhibitor, captopril, has caused agranulocytosis, particularly in patients with renal impairment or collagen vascular disease, and that available data are insufficient to show that VASOTEC I.V. does not have a similar risk. (See WARNINGS.)

In considering use of VASOTEC I.V., it should be noted that in controlled clinical trials ACE inhibitors have an effect on blood pressure that is less in black patients than in non-blacks. In addition, it should be noted that black patients receiving ACE inhibitors have been reported to have a higher incidence of angioedema compared to non-blacks. (See WARNINGS, Angioedema.)

VASOTEC I.V. NEWS HIGHLIGHTS

Media Articles Related to Vasotec I.V. (Enalaprilat)

Treatment Of Lung Hypertension Does Not Help Patients With Chronic Bronchitis
Source: Respiratory / Asthma News From Medical News Today [2008.08.29]

Possible Association Between High Levels Of Uric Acid And Hypertension
Source: Hypertension News From Medical News Today [2008.08.28]

Allopurinol May Lower Blood Pressure In Teens With Hypertension
Source: Hypertension News From Medical News Today [2008.08.28]

Drug Designed To Lower Uric Acid Levels May Be Useful For Hypertension
Source: Blood / Hematology News From Medical News Today [2008.08.27]

Reducing Uric Acid Shows Promise for Hypertension in Children
Source: MedPage Today Nephrology [2008.08.26]

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Published Studies Related to Vasotec I.V. (Enalaprilat)

Pretreatment with intracoronary enalaprilat protects human myocardium during percutaneous coronary angioplasty. [2007.04.17]

Effects of enalaprilat infusion on hemodynamics and renal function in patients undergoing cardiac surgery. [2004.12]

Effects of enalaprilat on venoconstriction to norepinephrine: role of prostaglandins. [2003.07.01]

Effect of enalaprilat on postoperative hypertension after surgical repair of coarctation of the aorta. [2003.07]

Beneficial hemodynamic and renal effects of intravenous enalaprilat following coronary artery bypass surgery complicated by left ventricular dysfunction. [2003.05]

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Clinical Trials Related to Vasotec I.V. (Enalaprilat)

Comparison of the Antihypertensive Efficacy of Valsartan and Enalapril After Missing One Dose [Completed]

Effect of Enalapril Plus Folic Acid on Blood Pressure and Glycometabolism [Completed]

Long Term Safety, Tolerability and Efficacy of Valsartan and Enalapril Combined and Alone in Children With Hypertension [Recruiting]

Effect of Valsartan Compared to Enalapril on Sitting Systolic Blood Pressure in Children With High Blood Pressure [Recruiting]

Antihypertensive Effectiveness of the Associations of Hydrochlorothiazide and Amiloride and Hydrochlorothiazide and Enalapril [Completed]

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Page last updated: 2008-08-29

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