VASCEPA, a lipid-regulating agent, is supplied as a 1-gram amber-colored, liquid-filled soft gelatin capsule for oral administration.
Each VASCEPA capsule contains 1 gram of icosapent ethyl. Icosapent ethyl is an ethyl ester of the omega-3 fatty acid eicosapentaenoic acid (EPA).
VASCEPA™ (icosapent ethyl) is indicated as an adjunct to diet to reduce triglyceride (TG) levels in adult patients with severe (≥500 mg/dL) hypertriglyceridemia.
Usage Considerations: Patients should be placed on an appropriate lipid-lowering diet and exercise regimen before receiving VASCEPA and should continue this diet and exercise regimen with VASCEPA.
Attempts should be made to control any medical problems such as diabetes mellitus, hypothyroidism, and alcohol intake that may contribute to lipid abnormalities. Medications known to exacerbate hypertriglyceridemia (such as beta blockers, thiazides, estrogens) should be discontinued or changed, if possible, prior to consideration of TG-lowering drug therapy.
Limitations of Use:
The effect of VASCEPA on the risk for pancreatitis in patients with severe hypertriglyceridemia has not been determined.
The effect of VASCEPA on cardiovascular mortality and morbidity in patients with severe hypertriglyceridemia has not been determined.
Published Studies Related to Vascepa (Icosapent)
Icosapent ethyl, a pure EPA omega-3 fatty acid: effects on plasma and red blood
cell fatty acids in patients with very high triglyceride levels (results from the
MARINE study). 
lowering... CONCLUSIONS: IPE significantly increased plasma and RBC FAs, which correlated to
Eicosapentaenoic acid improves insulin sensitivity and blood sugar in overweight
type 2 diabetes mellitus patients: a double-blind randomised clinical trial. 
overweight patients with type 2 diabetes mellitus (T2DM)... CONCLUSION: The results of our study indicate that EPA supplementation could
Efficacy of omega-3 fatty acid supplements (eicosapentaenoic acid and
docosahexaenoic acid) in the secondary prevention of cardiovascular disease: a
meta-analysis of randomized, double-blind, placebo-controlled trials. 
docosahexaenoic acid in the secondary prevention of CVD... CONCLUSION: Our meta-analysis showed insufficient evidence of a secondary
Eicosapentaenoic acid interventions in schizophrenia: meta-analysis of
randomized, placebo-controlled studies. 
efficacy of such augmentation strategies is not well established... CONCLUSIONS: Meta-analysis of randomized controlled trials on symptomatic outcome
Neuroprotective effects of ethyl-eicosapentaenoic acid in first episode
psychosis: a longitudinal T2 relaxometry pilot study. 
We used magnetic resonance imaging to examine the effect of
ethyl-eicosapentaenoic acid (E-EPA) on hippocampal T(2) relaxation time in first
episode psychosis patients at baseline and after 12 weeks of follow-up. There was
an increase in T(2) in the placebo group but not in the E-EPA group, suggesting a
neuroprotective effect of E-EPA treatment.
Clinical Trials Related to Vascepa (Icosapent)
Effects of Eicosapentaenoic Acid on Endothelial Function in Diabetic Subjects [Not yet recruiting]
This pilot trial seeks to obtain preliminary data on the effects of eicosapentaenoic acid
(EPA) (4g/d) on endothelial function measured via endopat2000 after 12 weeks of intervention
among adults with elevated triglycerides and type 2 diabetes.
Eicosapentaenoic Acid Cerebral Vasospasm Therapy Study [Completed]
Cerebral vasospasm following subarachnoid hemorrhage (SAH) is the most common cause of
morbidity and mortality. Recent studies indicate that Rho-kinase play an important role in
the occurrence of such cerebral vasospasm. Eicosapentaenoic acid (EPA) inhibits
sphingosylphosphorylcholine (SPC)-induced Rho-kinase activation in vitro. So this study
examines whether EPA prevents cerebral vasospasm occurrence after SAH in patients.
Eicosapentaenoic Acid (EPA) for Treatment of Colorectal Cancer Liver Metastases [Completed]
Eicosapentaenoic acid (EPA) is a naturally occuring omega-3 polyunsaturated fatty acid found
in oily fish. EPA has anti-colorectal (bowel) cancer activity in experimental models. This
trial will test whether EPA reduces markers of tumour growth, and is safe and well
tolerated,in patients with colorectal cancer liver metastases awaiting surgery.
Effects of Eicosapentaenoic Acid on Subjects at High Risk for Colorectal Cancer [Recruiting]
The aim of this study is to test Eicosapentaenoic acid's effects on markers relevant to
colorectal carcinogenesis, RNA and DNA profiles, and the possibility that Eicosapentaenoic
Acid treatment might be associated with changes of the gut microbiota and metabolomic
profiles in patients with long-standing ulcerative colitis.
Ethyl Eicosapentanoic Acid (Ethyl-EPA) for Treating Major Depression [Completed]