Vaprisol (Conivaptan Hydrochloride Conjunctival) - Summary

VAPRISOL SUMMARY

Vaprisol^®
(conivaptan hydrochloride injection)

VAPRISOL^® (conivaptan hydrochloride injection) is a nonpeptide, dual antagonist of arginine vasopressin (AVP) V_1A and V₂ receptors.

VAPRISOL is indicated for the treatment of euvolemic hyponatremia (e.g., the syndrome of inappropriate secretion of antidiuretic hormone, or in the setting of hypothyroidism, adrenal insufficiency, pulmonary disorders, etc.) in hospitalized patients.

VAPRISOL is not indicated for the treatment of patients with congestive heart failure. (See PRECAUTIONS)

VAPRISOL NEWS HIGHLIGHTS

Media Articles Related to Vaprisol (Conivaptan Conjunctival)

Hypothyroidism
Source: MedicineNet Carpal Tunnel Syndrome Specialty [2008.07.22]

Hypothyroidism During Pregnancy
Source: MedicineNet Hypothyroidism Specialty [2008.01.31]

Synthroid, Hypothyroidism, and Cholesterol
Source: MedicineNet levothyroxine sodium Specialty [2007.02.13]

Hypothyroidism and Heart Palpitations
Source: MedicineNet levothyroxine sodium Specialty [2006.12.12]

Hypothyroidism: Specific References
Source: MedicineNet Thyroiditis Specialty [2006.05.05]

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Published Studies Related to Vaprisol (Conivaptan Conjunctival)

Intravenous conivaptan: effects on the QTc interval and other electrocardiographic parameters in healthy volunteers. [2007.03]

Assessment of the efficacy and safety of intravenous conivaptan in euvolemic and hypervolemic hyponatremia. [2007]

Efficacy and safety of oral conivaptan: a V1A/V2 vasopressin receptor antagonist, assessed in a randomized, placebo-controlled trial in patients with euvolemic or hypervolemic hyponatremia. [2006.06]

Acute hemodynamic effects of conivaptan, a dual V(1A) and V(2) vasopressin receptor antagonist, in patients with advanced heart failure. [2001.11.13]

Assessment of the efficacy and safety of intravenous conivaptan in patients with euvolaemic hyponatraemia: subgroup analysis of a randomized, controlled study. [2008.07]

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Clinical Trials Related to Vaprisol (Conivaptan Conjunctival)

An Open-Label Study of YM087 (Conivaptan) in Patients With Euvolemic or Hypervolemic Hyponatremia [Completed]

Safety and Efficacy Study of YM087 (Conivaptan) in Patients With Acute Decompensated Heart Failure [Completed]

Use of Conivaptan (Vaprisol) for Hyponatremic Neuro-ICU Patients [Not yet recruiting]

Study of Efficacy & Safety for 3 Infusion Regimens of IV YM087 in Subjects With Euvolemic or Hypervolemic Hyponatremia [Recruiting]

A Study of Multiple Dosing Regimens of IV Conivaptan in Subjects With Euvolemic or Hypervolemic Hyponatremia [Recruiting]

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