Supportive care is advised, with maintenance of glomerular filtration. Vancomycin is poorly removed by dialysis. Hemofiltration and hemoperfusion with polysulfone resin have been reported to result in increased vancomycin clearance.
To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. Telephone numbers of certified poison control centers are listed in the
Physicians’ Desk Reference (PDR)
. In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics.