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Vancomycin (Vancomycin Hydrochloride) - Drug Interactions, Contraindications, Overdosage, etc



Drug Interactions

Concomitant administration of vancomycin and anesthetic agents has been associated with erythema and histamine-like flushing (see PRECAUTIONS, Pediatrics Use) and anaphylactoid reactions (see ADVERSE REACTIONS).

Concurrent and/or sequential systemic or topical use of other potentially neurotoxic and/or nephrotoxic drugs, such as amphotericin B, aminoglycosides, bacitracin, polymyxin B, colistin, viomycin, or cisplatin, when indicated, requires careful monitoring.


Supportive care is advised, with maintenance of glomerular filtration. Vancomycin is poorly removed by dialysis.

Hemofiltration and hemoperfusion with polysulfone resin have been reported to result in increased vancomycin clearance. The median lethal intravenous dose is 319 mg/kg in rats and 400 mg/kg in mice.

To obtain up-to-date information about the treatment of overdose, a good resource is your certified Regional Poison Control Center. Telephone numbers of certified poison control centers are listed in the Physicians’ Desk Reference (PDR). In managing overdosage, consider the possibility of multiple drug overdoses, interaction among drugs, and unusual drug kinetics in your patient.


Vancomycin is contraindicated in patients with known hypersensitivity to this antibiotic. Diluents containing dextrose may be contraindicated in patients with known allergy to corn or corn products.


  1. Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically; Approved Standard – 7th ed., CLSI document M7-A7. Clinical and Laboratory Standards Institute. Wayne, PA. January, 2006.
  2. Performance Standards for Antimicrobial Susceptibility Testing; 18th Informational Supplement, CLSI document M100-S18. Clinical and Laboratory Standards Institute. Wayne, PA. January, 2008.
  3. Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard – 9th ed., CLSI document M2-A9. Clinical and Laboratory Standards Institute. Wayne, PA. January, 2006.
  4. Moellering RC, Krogstad DJ, Greenblatt DJ: Vancomycin therapy in patients with impaired renal function: A nomogram for dosage. Ann Inter Med 1981;94:343.

Manufactured for:

GeneraMedix Inc.

150 Allen Road

Liberty Corner, NJ 07938

Manufactured by:

Mustafa Nevzat İlaç Sanayii A.Ş.

Saatçi Bayırı, Prof.Dr. Bülent Tarcan Sokak, # 5/1

34349 Gayrettepe / İstanbul -Turkey

June 2008

PI 50000.02

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