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Ursodiol (Ursodiol) - Summary

 

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URSODIOL SUMMARY

Ursodiol is a bile acid available as 300-mg capsules suitable for oral administration. Ursodiol USP (ursodeoxycholic acid) is a naturally occurring bile acid found in small quantities in normal human bile and in the biles of certain other mammals. It is a bitter-tasting, white powder freely soluble in ethanol, methanol, and glacial acetic acid; sparingly soluble in chloroform; slightly soluble in ether; and insoluble in water.

  1. Ursodiol is indicated for patients with radiolucent, noncalcified gallbladder stones < 20 mm in greatest diameter in whom elective cholecystectomy would be undertaken except for the presence of increased surgical risk due to systemic disease, advanced age, idiosyncratic reaction to general anesthesia, or for those patients who refuse surgery. Safety of use of ursodiol beyond 24 months is not established.

  2. Ursodiol is indicated for the prevention of gallstone formation in obese patients experiencing rapid weight loss.

URSODIOL NEWS HIGHLIGHTS

Media Articles Related to Ursodiol

Primary Biliary Cirrhosis
Source: MedicineNet ursodiol Specialty [2005.09.17]

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Published Studies Related to Ursodiol

Clinical Trial: Randomized controlled trial of zidovudine and lamivudine for patients with primary biliary cirrhosis stabilized on ursodiol. [2008.07.09]

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Clinical Trials Related to Ursodiol

Ursodiol in Huntington's Disease [Recruiting]

Phase II Pilot Study to Compare the Bioavailability of Buffered, Enteric-Coated Ursodiol With Unmodified Ursodiol for Chronic Cholestatic Liver Disease and Cystic Fibrosis-Associated Liver Disease [Active, not recruiting]

Trial of High-Dose Urso in Primary Sclerosing Cholangitis [Completed]

Ursodeoxycholic Acid in the Treatment of Duodenal Adenomas in Familial Adenomatous Polyposis (FAP) Patients [Completed]

Efficacy and Safety Study of Ursodeoxycholic Acid to Treat Chronic Hepatitis C [Completed]

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Page last updated: 2008-08-10

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