NEWS HIGHLIGHTS
Published Studies Related to Urocit-K (Potassium Citrate)
Effect of potassium citrate supplementation or increased fruit and vegetable intake on bone metabolism in healthy postmenopausal women: a randomized controlled trial. [2008.08]
BACKGROUND: Alkali provision may explain why fruit and vegetables benefit bone health. OBJECTIVE: We aimed to determine the effects of alkali-providing potassium citrate (double-blind) and fruit and vegetable intake (single-blind) on bone turnover over 2 y... CONCLUSIONS: Two-year potassium citrate supplementation does not reduce bone turnover or increase BMD in healthy postmenopausal women, which suggests that alkali provision does not explain any long-term benefit of fruit and vegetable intake on bone.
The effect of a dietary supplement of potassium chloride or potassium citrate on blood pressure in predominantly normotensive volunteers. [2008.06]
Blood pressure (BP) shows a continuous relationship with the risk of CVD...
The effect of a dietary supplement of potassium chloride or potassium citrate on blood pressure in predominantly normotensive volunteers. [2007.12.06]
Blood pressure (BP) shows a continuous relationship with the risk of CVD...
Desensitizing efficacy of a new toothpaste containing 5.5% potassium citrate: a 4-week clinical study. [2007.08]
PURPOSE: To evaluate the desensitizing capabilities of a new toothpaste containing 5.5% potassium citrate (Colgate Sensitive Multi Protection Toothpaste) to another toothpaste containing 3.75% potassium chloride (Sensodyne Total Care F Toothpaste). METHODS: A 4-week clinical study was conducted in 75 subjects at the University of Rome, at Tor Vergata, in Rome, Italy, using a double blind, stratified, two treatment design...
Reduction of renal stone risk by potassium-magnesium citrate during 5 weeks of bed rest. [2007.06]
PURPOSE: Exposure to the microgravity environment of space increases the risk of kidney stone formation, particularly for calcium oxalate and uric acid stones. This study was performed to evaluate the efficacy of potassium alkali as potassium-magnesium citrate in reducing renal stone risk and bone turnover... CONCLUSIONS: Provision of alkali as potassium-magnesium citrate is an effective countermeasure for the increased risk of renal stone disease associated with immobilization. Despite an increase in urine calcium concentration, the relative saturation of calcium oxalate decreased due to citrate chelation of calcium and the concentration of undissociated uric acid decreased due to the significant increase in urine pH.
Clinical Trials Related to Urocit-K (Potassium Citrate)
Effects of Potassium Citrate in Urine of Children With Elevated Calcium in Urine and Kidney Stones [Completed]
High amounts of calcium in the urine (hypercalciuria) can cause development of kidney stones
in children. Treatment for these children includes plenty of fluids, a low-salt diet and
medications such as potassium citrate. A major advantage of potassium citrate, as compared to
hydrochlorothiazide, is its lack of side effects. One problem the researchers and others
have observed is that some children continue to form kidney stones despite correction of
hypercalciuria with potassium citrate. One possible explanation is that in some individuals
potassium citrate therapy results in an excessive elevation of urine pH, a situation that may
predispose to calcium phosphate stone formation. In this study, the researchers will study
the effects of potassium citrate on urine chemistries and acid-base balance in three groups
of children aged 5-17 years:
- children who are hypercalciuric stone formers;
- healthy children without a history of hypercalciuria or kidney stones.
Particular attention will be paid to try to identify those who develop a very high urine pH
(>8) and the factors leading to this metabolic reaction.
The researchers will try to learn whether it is the child’s characteristics, the disease
manifestations, the dose of the drug, or a combination of the above which may be the cause of
the development of very alkaline urine. Based on the results, the researchers hope to be able
to better “tailor” the individual treatment for each child with kidney stones.
The Effects of Potassium Citrate on Bone Metabolism [Recruiting]
Skeletal buffering of chronic acid loads may contribute to a significant amount of bone loss
over time. Evidence from a few small short-term studies suggests that basic compounds,
namely potassium citrate and potassium bicarbonate may reduce bone loss and improve bone
density.
The purpose of this study is to evaluate the effects of potassium citrate on bone
metabolism. We hypothesize that administration of potassium citrate to postmenopausal women
with osteopenia will reduce bone resorption and improve bone mineral density.
Postmenopausal women with osteopenia (T score between - 1. 0 and -2. 5) and no history of
fracture will be randomized to either daily potassium citrate or placebo for one year.
Primary outcomes will be markers of bone turnover, which will be measured over 12 months.
Secondary outcomes will be bone mineral density, compliance, and adverse events.
Potassium Citrate to Prevent Age Related Bone Loss [Recruiting]
Osteoporosis, a disease in which the bones become weak and are more likely to break, is a
major health problem in the United States. Too much acid in the body appears to be linked to
loss of calcium via urine, bone loss, and muscle breakdown. The purpose of this study is to
determine the effect of various doses of potassium citrate, a supplement that can neutralize
acid, on bone density and muscle mass in older, healthy adults.
Phase III Randomized, Double-Blind Study of Potassium Phosphate Vs Potassium Citrate for Absorptive Hypercalciuria [Completed]
OBJECTIVES: I. Evaluate the ability of a slow-releasing formulation of neutral potassium
phosphate to correct hypercalciuria and prevent recurrent stone formation in patients with
absorptive hypercalciuria.
II. Evaluate the safety of this treatment. III. Compare the efficacy of potassium phosphate
to that of potassium citrate.
Effect of Neutralization of Endogenous Acid Production on Bone Mineral Density and Microarchitectural Composition of Bone [Recruiting]
Hypothesis: Neutralization of acid production induced by the Western diet with oral
administration of potassium citrate increases bone mineral density and bone mass as well as
skeletal muscle mass and strength in elderly people (> 65y).
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