DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Ultram (Tramadol Hydrochloride) - Summary

 


Nutrilib.com
A comprihensive source of nutritional information

ULTRAM SUMMARY

ULTRAM® (tramadol hydrochloride tablets) is a centrally acting analgesic.

ULTRAM is indicated for the management of moderate to moderately severe pain in adults.


See all Ultram indications & dosage >>

ULTRAM NEWS HIGHLIGHTS

Media Articles Related to Ultram (Tramadol)

New Treatment For Receding Gums: No Pain, Lots Of Gain
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.07.02]
Tufts dental researchers conducted a three-year follow-up study that examined the stability of a treatment option for receding gums and found that complete root coverage the goal of the surgery had been maintained. This specific tissue regeneration application, developed at Tufts, reduces the considerable pain and recovery time of gum grafting surgery. The case study of six patients is published in the July 2009 issue of the Journal of Periodontology.

Increasing Age Of Mothers In Spain Leads To Rise In Mortality Rates
Source: Seniors / Aging News From Medical News Today [2009.07.02]
A new study examining the evolution of maternal mortality rates in Spain since 1996 shows a 17% increase in deaths. This trend is linked to the widespread increase in maternal age. The highest death rates are among foreign women and those who live in the province of Malaga. Medicine has taken giant strides during the 20th Century. However, European studies show a clear and constant increase in maternal mortality rates over recent years.

Health Tip: What's Causing My Neck Pain?
Source: MedicineNet Arthritis Specialty [2009.07.02]
Title: Health Tip: What's Causing My Neck Pain?
Category: Health News
Created: 7/2/2009 7:00:00 AM
Last Editorial Review: 7/2/2009

Laughter - The Best Medicine? Spain Hosts The Most Renowned International Symposium On Sense Of Humor And Its Applications
Source: Conferences News From Medical News Today [2009.07.01]
Spain hosts this week, for the first time in history, this event, the most renowned international symposium on humour and laughter, where scientists and experts from four continents will discuss the latest advances and research of this field of study.

Lower Empathic Responses To Outsiders' Pain Shown By Imaging Study
Source: Neurology / Neuroscience News From Medical News Today [2009.07.01]
An observer feels more empathy for someone in pain when that person is in the same social group, according to new research in the July 1 issue of The Journal of Neuroscience. The study shows that perceiving others in pain activates a part of the brain associated with empathy and emotion more if the observer and the observed are the same race. The findings may show that unconscious prejudices against outside groups exist at a basic level.

more news >>

Published Studies Related to Ultram (Tramadol)

Tramadol for prevention of postanaesthetic shivering: a randomised double-blind comparison with pethidine. [2009.02]
The present study was conducted with the aims of comparing intravenous tramadol [generic for Ultram] 1, 2 and 3 mg.kg(-1) with pethidine 0.5 mg.kg(-1) for prophylaxis of postanaesthetic shivering and to find a dose of tramadol that could provide the dual advantage of antishivering and analgesic effect in the postoperative period... Tramadol 2 mg.kg(-1) had the best combination of antishivering and analgesic efficacy without excessive sedation and thus appeared to be a good choice to be administered at the time of wound closure to provide antishivering effect and analgesia without significant side effects in the postoperative period.

Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs. [2009.01]
OBJECTIVE: To compare the effects of morphine, parecoxib, tramadol [generic for Ultram] and a combination of parecoxib, tramadol and pindolol on nociceptive thresholds in awake animals and their effect on glomerular filtration rate (GFR) in dogs subjected to 30 minutes of anesthesia. ANIMALS: Eight adult mixed breed experimental dogs. STUDY DESIGN: Randomized, controlled trial... CONCLUSION: Tramadol and parecoxib (either alone or in combination) can increase nociceptive thresholds in awake dogs and have minimal effects on renal perfusion in normotensive dogs subjected to anaesthesia.

Tramadol as an adjuvant to lidocaine for axillary brachial plexus block. [2009.01]
BACKGROUND: In this prospective randomized study, we evaluated the effect of tramadol [generic for Ultram] as an adjuvant to axillary block... CONCLUSIONS: The benefit of block prolongation associated with the addition of 200 mg tramadol to lidocaine during axillary block is limited by the slow onset of the block.

Addition of remifentanil to patient-controlled tramadol for postoperative analgesia: a double-blind, controlled, randomized trial after major abdominal surgery. [2008.12]
BACKGROUND AND OBJECTIVE: We have investigated whether, after major abdominal surgery, the addition of remifentanil to tramadol [generic for Ultram] for intravenous patient-controlled analgesia improved analgesia and lowered pain scores, compared to a patient-controlled analgesia containing only tramadol... CONCLUSIONS: After major abdominal surgery, adding remifentanil (0.2 microg kg(-1)) to tramadol (0.2 mg kg(-1)), with 10-min lockout times, for patient-controlled analgesia offered better postoperative pain relief and patient comfort, without causing any sedation or respiratory depression.

Comparison of caudal bupivacaine and bupivacaine-tramadol for postoperative analgesia in children with hypospadias repair. [2008.10]
Objective: To compare the effects after caudal bupivacaine alone and bupivacaine-tramadol [generic for Ultram] in young children with hypospadias repair... The risk of toxicity from bupivacaine decreased when combined with tramadol in low doses.

more studies >>

Clinical Trials Related to Ultram (Tramadol)

A Comparison of the Effectiveness and Safety of ULTRACETŪ (Tramadol Hydrochloride/Acetaminophen) Versus ULTRAMŪ (Tramadol Hydrochloride) Versus Placebo in Patients With Pain After Oral Surgery [Completed]
The purpose of this study is to explore the pain-relieving effects and safety of two analgesic treatment regimens as compared to placebo in patients experiencing pain after oral surgery. Tramadol hydrochloride/acetaminophen is approved to treat acute pain. This study will evaluate the effectiveness and safety of tramadol hydrochloride/acetaminophen compared with tramadol hydrochloride alone compared with placebo as a pain medication in the treatment of pain following oral surgery.

Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain. [Completed]
This study investigates if Celebrex is as effective as tramadol hydrochloride (Ultram) for patients with chronic low back pain, when administered over a 6-week period.

The Effect of Escitalopram on the Pharmacokinetics and Pharmacodynamics of Tramadol in Healthy Subjects [Recruiting]
Escitalopram will be given to a panel of 16 healthy subject for 9 days. On the ninth day a single dose of tramadol is administered to the subjects and pharmacokinetic(PK) and pharmacodynamic(PD) measurements are done for the next 24 hours.

It is stated that escitalopram is only a weak inhibitor of CYP2D6 and therefore no effect is seen in Pk or PK of tramadol

Comparison of Tramadol Orally Versus an Optimized Dose of Intravenous Tramadol for Postoperative Pain Relief in Ambulatory Surgery [Recruiting]
The purpose of this study is to compare the administration of 1 unit dose of 50 mg tramadol perorally given in 3 unit dosages versus tramadol IV given in 3 unit dosage of 35 mg during the first 6 hours postoperatively and to investigate the time course and accuracy of pain relief versus the onset and duration of side effects. The first unit dose will be administered at arrival at the PACU when a Visual Analogue Pain (VAS) score of more than 3 is reached. The second and third unit dose will be administered after 1 and 2 hours, respectively, when a VAS of more than 3 is observed.

Tramadol and Pain Sensitization [Recruiting]
Tramadol is a largely used analgesic drug. Its role however on sensitization as occurs for example in neuropathic pain is not very well known. This protocol aims therefore at studying the effect of tramadol in a human pain model with sensitization induced by a cold stimulus, using evoked potentials to elucidate how pain is modified when tramadol is administered.

more trials >>

ULTRAM PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 3 ratings/reviews, Ultram has an overall score of 6.67. The effectiveness score is 7.33 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
 

Ultram review by 55 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   arthritis pain
Dosage & duration:   100 mg taken twice a day for the period of 2 years now
Other conditions:   menopause
Other drugs taken:   hormone replacement therapy
  
Reported Results
Benefits:   I stayed loose and limber throughout the day. Didn't end up limping at the end of the day or after a 30 min car ride. It made me feel like I was in my 30's again instead of my 50's. It enables me to do yoga moves which I could not do because of the pain. It's changed my life. None of the side effects that narcotic pain relievers give. No tiredness or spaciness
Side effects:   At first, it caused itching, but now I don't have that. If I take it close to bedtime, I can't sleep.
Comments:   two 50 mg tabs twice a day. Usually at 0900 and 1700

 

Ultram review by 60 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Arthritis
Dosage & duration:   50 MG taken 2 times a day for the period of 2 years
Other conditions:   Diabetes
Other drugs taken:   Metformin & Glyberide
  
Reported Results
Benefits:   Arthritis Med/Tramadol HLC Only helps a little with Arthritis Pain. Keeps it down to a dull roar! Diabetes Meds,Helped lower Blood Levels. Kept A1c under 7%. Made it safe to live a normal life by keeping Blood Sugar under control. Helped keep Disease & Diabetes out of Eyes. Help Kidneys function normal.
Side effects:   Arthritis Med/Tramadol HLC causes slight dizziness! I also have to take 500 MG of Tylenol 3 times a day. to help with the pain. As the Tramadol HLC is not enough. Vioxx worked better! I can't take Nsaids as i am Allergic to Aspirin. Diabetes Meds make Blood Sugar level drop Between Breakfast & Lunch. Fast! Because I/Patient am almost in the Pre/Boaderline Diabetes Stage.
Comments:   50 MG Tramadol 2 times a day.Tylenol 500 MG 3 times a day for the Arthritis pain. Neither really help much to get rid of the pain. 500 MG Metformin 3 times a day.Glyberide 1.25 MG 1 time a day for the Diabetes.I have done well on the Meds as far as keeping Diabetes under control.

 

Ultram review by 60 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Arthritis
Dosage & duration:   50 MG taken 2 times a day for the period of 2 years
Other conditions:   Diabetes
Other drugs taken:   Metformin & Glyberide
  
Reported Results
Benefits:   Arthritis Med/Tramadol HLC Only helps a little with Arthritis Pain. Keeps it down to a dull roar! Diabetes Meds,Helped lower Blood Levels. Kept A1c under 7%. Made it safe to live a normal life by keeping Blood Sugar under control. Helped keep Disease & Diabetes out of Eyes. Help Kidneys function normal.
Side effects:   Arthritis Med/Tramadol HLC causes slight dizziness! I also have to take 500 MG of Tylenol 3 times a day. to help with the pain. As the Tramadol HLC is not enough. Vioxx worked better! I can't take Nsaids as i am Allergic to Aspirin. Diabetes Meds make Blood Sugar level drop Between Breakfast & Lunch. Fast! Because I/Patient am almost in the Pre/Boaderline Diabetes Stage.
Comments:   50 MG Tramadol 2 times a day.Tylenol 500 MG 3 times a day for the Arthritis pain. Neither really help much to get rid of the pain. 500 MG Metformin 3 times a day.Glyberide 1.25 MG 1 time a day for the Diabetes.I have done well on the Meds as far as keeping Diabetes under control.

See all Ultram reviews / ratings >>

Page last updated: 2009-07-02

-- advertisement -- The American Red Cross
We comply with
HONcode standard.
Verify here.
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2009