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Ultram (Tramadol Hydrochloride) - Summary

 
 



ULTRAM SUMMARY

ULTRAM® (tramadol hydrochloride) tablets is a centrally acting analgesic.

ULTRAM® is indicated for the management of moderate to moderately severe pain in adults.


See all Ultram indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Ultram (Tramadol)

DPP-4 Inhibitors Can Cause Severe Joint Pain, FDA Says
Source: Medscape Diabetes & Endocrinology Headlines [2015.08.28]
However, the pain associated with dipeptidyl peptidase-4 inhibitors for type 2 diabetes goes away once patients stop taking the medicine, according to the agency.
News Alerts

Group Offers Guidelines to Lessen Vaccination Pain
Source: Medscape Pediatrics Headlines [2015.08.28]
Clinicians can shuffle the order of vaccine injections, leverage the calming influence of parents and breast-feeding, and routinely apply topical anesthetic to ease vaccination pain for patients.
Medscape Medical News

DPP-4 Inhibitors Linked to Severe Joint Pain, FDA Warns
Source: MedPageToday.com - medical news plus CME for physicians [2015.08.28]
(MedPage Today) -- The agency has identified 33 cases since 2006

Low Back Pain and GI Symptoms on the Swiss Alps
Source: Medscape Gastroenterology Headlines [2015.08.26]
Dr Paget discusses a recent patient of his who presented with a 5-year history of recurrent severe low back pain and gastrointestinal symptoms.
Medscape Rheumatology

Is There Sex After Low Back Pain?
Source: Medscape Orthopaedics Headlines [2015.08.26]
For many people with low back pain, sex is excruciating. But the recommended position for the past 25 years--'side-lying' (ie, 'spooning')--is contraindicated by two new biomechanical studies.
Medscape Orthopedics

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Published Studies Related to Ultram (Tramadol)

Does the addition of tramadol and ketamine to ropivacaine prolong the axillary brachial plexus block? [2014]
ropivacaine in brachial plexus anesthesia... CONCLUSION: We conclude that when added to brachial plexus analgesia at a dose of

Efficacy of extended-release tramadol for treatment of prescription opioid withdrawal: a two-phase randomized controlled trial. [2013]
whether cessation of ER tramadol produces opioid withdrawal... CONCLUSIONS: ER tramadol 200mg modestly attenuated opioid withdrawal. Mild opioid

Comparison of the analgesic effects of oral tramadol and naproxen sodium on pain relief during IUD insertion. [2012]
on pain during insertion of an intrauterine device (IUD)... CONCLUSION: Prophylactic analgesia using 50 mg tramadol and 550 mg naproxen,

Tramadol versus methadone for treatment of opiate withdrawal: a double-blind, randomized, clinical trial. [2012]
The aim of this study was to compare the efficacy and safety of tramadol versus methadone for treatment of opiate withdrawal. Seventy patients randomly were assigned in two groups to receive either prescribed methadone (60 mg/day) or tramadol (600 mg/day)... Tramadol may be as effective as methadone in the control of withdrawal and could be considered as a potential substitute for methadone to manage opioids withdrawal.

Comparison of peritonsillar infiltration effects of ketamine and tramadol on post tonsillectomy pain: a double-blinded randomized placebo-controlled clinical trial. [2012]
on post tonsillectomy pain and compare the side effects... CONCLUSION: Preoperative peritonsillar infiltration of tramadol can decrease

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Clinical Trials Related to Ultram (Tramadol)

Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US, with over 530,000 procedures performed annually in children under 15 years (Baugh et al., 2011). The postoperative period can be particularly painful. A recent clinical consensus acknowledges there is no standard analgesic protocol, and calls for further research comparing postoperative pain medications (Baugh et al., 2011). Tramadol was found to be as effective as codeine with few reported side effects in a recent double-blinded, controlled trial conducted by the investigators at Children's Hospitals and Clinics (CHC), and it is currently being prescribed in the postoperative setting. However, despite its effectiveness for pain control, there were some children that continued to report pain during the 10-day follow-up period. In response, the investigators will conduct a randomized, double-blinded controlled trial to determine whether or not adding scheduled gabapentin to a scheduled tramadol + "as needed" (PRN) ibuprofen regimen provides better pain control than tramadol + ibuprofen PRN alone during the post-tonsillectomy period. Using a 10-day take-home diary, caregivers will be asked to record daily information about their child's postoperative pain and other core outcomes and domains as recommended in the recent consensus statement put forth by the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the efficacy and side effects associated with adding scheduled gabapentin to a postoperative pain management protocol in a pediatric population.

A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Completed]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The postoperative period can be particularly painful. Codeine (usually in mixed formulation with acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data questions its ability to provide optimal pain relief, while avoiding side effects, especially in the postoperative setting. Tramadol may be a better option for children in the postoperative setting due to its well-documented analgesic properties, low potential for side effects, and excellent safety profile. Seventy-two children scheduled to undergo tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers will be asked to record daily information about their child's postoperative pain and other core outcomes and domains as recommended in the recent consensus statement put forth by the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the efficacy and side effects associated with tramadol as compared with codeine/acetaminophen (the current practice standard) in a pediatric population. Hypotheses H1: Children who receive scheduled tramadol following tonsillectomy will report better pain control than children who receive scheduled codeine/acetaminophen. H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side effects than children who receive scheduled codeine/acetaminophen.

The Effect of Escitalopram on the Pharmacokinetics and Pharmacodynamics of Tramadol in Healthy Subjects [Completed]
Escitalopram will be given to a panel of 16 healthy subject for 9 days. On the ninth day a single dose of tramadol is administered to the subjects and pharmacokinetic(PK) and pharmacodynamic(PD) measurements are done for the next 24 hours. It is stated that escitalopram is only a weak inhibitor of CYP2D6 and therefore no effect is seen in Pk or PK of tramadol

A Pharmacokinetic Study to Evaluate the Dose-Proportionality of Tramadol (ULTRAM) Extended-Release (ER) in Healthy Participants [Completed]
The purpose of this study is to evaluate the dose proportionality of the pharmacokinetics (explores what the body does to the drug) of tramadol in healthy adult participants.

A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers [Completed]
The purpose of this study is to determine the safety and tolerability profile of tramadol hydrochloride (HCl) given as oral doses every 6 hours, within the range of dosages supported by currently available toxicology and clinical data (200 mg to 600 mg per day).

more trials >>

Reports of Suspected Ultram (Tramadol) Side Effects

Drug Ineffective (24)Multiple Drug Overdose (21)Toxicity TO Various Agents (20)Convulsion (19)Drug Hypersensitivity (18)Nausea (17)Vomiting (15)Pain (12)Loss of Consciousness (11)Malaise (11)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 17 ratings/reviews, Ultram has an overall score of 6.94. The effectiveness score is 7.88 and the side effect score is 7.53. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Ultram review by 55 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   arthritis pain
Dosage & duration:   100 mg taken twice a day for the period of 2 years now
Other conditions:   menopause
Other drugs taken:   hormone replacement therapy
  
Reported Results
Benefits:   I stayed loose and limber throughout the day. Didn't end up limping at the end of the day or after a 30 min car ride. It made me feel like I was in my 30's again instead of my 50's. It enables me to do yoga moves which I could not do because of the pain. It's changed my life. None of the side effects that narcotic pain relievers give. No tiredness or spaciness
Side effects:   At first, it caused itching, but now I don't have that. If I take it close to bedtime, I can't sleep.
Comments:   two 50 mg tabs twice a day. Usually at 0900 and 1700

 

Ultram review by 38 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   budging disk in neck
Dosage & duration:   50 mg 1-2 taken 1 time for the period of 3 weeks
Other conditions:   Fibro
Other drugs taken:   Cymbalta, Thyroid meds,Lamictal
  
Reported Results
Benefits:   For the most part the pain was taken away just enough that I could function. I like that it's not a narcotic, yet gives some of the benefits of one.
Side effects:   Because it only took away part of the pain I thought it would be OK to take 2 more tablets. That was a really bad idea. I started to feel pressure in my head, I felt like I was going to faint, my lips started to tingle. The worst effect though was that about 3 min after my heart started going extremely fast then started skipping over and over. It was very scary. I then read that a person can die from and overdose. I feel like I dodged death. Very important! take this as prescribed.
Comments:   This med was the drug of choice for me since I am in recovery for alcohol.

 

Ultram review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   headaches
Dosage & duration:   1 50mg 4 to 6 hrs taken daily for the period of ON AND OFF FOR THREE YEARS
Other conditions:   THYROID DISEASE
Other drugs taken:   zoloft and sinthroid
  
Reported Results
Benefits:   My pain would subside for several hours. The drug gave me a sense of Euphora which allowed me to deal with the pain better. It gave me a comforting sensation and allowed me to sleep good. My mood changed for the better, almost as if I were high.It actually motivated me to do the things i would normally be too lazy to do. This medication put me in a good mood and a carefree mood.
Side effects:   I would have mild itching
Comments:   I began taking this medication as prescribed but it put me in such a good mood I began taking more...and needing more. It works great for anxiety also but when I stopped taking it I had the most horrible withdrawls. I could not sleep. My insides felt like they were jumping. I was awfully tired and depressed. I could not keep my arms and legs still when i sat down. It was horrible. I WAS ADDICTED TO THIS MEDICATION AND I STILL AM. I am still trying to wean off of it. I DO NOT RECOMMEND THIS MEDICINE TO ANYONE. Especially if you've had an addiction problem with any other pain meds. BEWARE!!!!!!!!

See all Ultram reviews / ratings >>

Page last updated: 2015-08-28

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