Media Articles Related to Ultiva (Remifentanil)
General Anesthesia May Negate Endovascular Benefit in Stroke
Source: Medscape Critical Care Headlines [2015.02.17]
Subgroup analysis of the MR CLEAN trial has shown that patients who underwent endovascular clot retrieval under general anesthesia did not show the benefit seen overall in the trial.
Medscape Medical News
The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Source: MedicineNet Heart Attack Pathology: Photo Essay Specialty [2014.12.09]
Title: The Death of Joan Rivers: Endoscopy and Anesthesia Risks
Category: Doctor's Views
Created: 9/8/2014 12:00:00 AM
Last Editorial Review: 12/9/2014 12:00:00 AM
Parsing Out Best Practices for Endovascular Thrombectomy (CME/CE)
Source: MedPage Today Emergency Medicine [2015.02.16]
(MedPage Today) -- "Time is brain" in endovascular thrombectomy, more evidence against general anesthesia.
Published Studies Related to Ultiva (Remifentanil)
Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr
after sternotomy. 
patient and perioperative characteristics... CONCLUSIONS: In this follow-up study in cardiac surgery patients, intraoperative
An intraoperative small dose of ketamine prevents remifentanil-induced postanesthetic shivering. [2011.09]
Patients undergoing gynecological laparotomy were randomized to receive either 0.5 mg/kg ketamine at induction of anesthesia followed by an infusion of 0.3 mg/kg/h until the end of surgery (ketamine group, n = 32), or an equivalent volume of normal saline (control group, n = 32)...
A double-blind randomised comparison of intravenous patient-controlled remifentanil with intramuscular pethidine for labour analgesia. [2011.09]
In a prospective, double-blind, randomised controlled trial, we compared the efficacy of patient-controlled analgesia using remifentanil (25-30 mug per bolus) with intramuscular pethidine (50-75 mg) for labour analgesia in 69 parturients. Parturients receiving patient-controlled analgesia reported less pain than those receiving intramuscular pethidine throughout the study period (p < 0.001), with maximal reduction in visual analogue pain score at 2 h after commencement of analgesia (mean (SD) 20 (17) in the patient-controlled analgesia group and 36 (22) in the intramuscular pethidine group...
An exploration of remifentanil-propofol combinations that lead to a loss of response to esophageal instrumentation, a loss of responsiveness, and/or onset of intolerable ventilatory depression. [2011.09]
BACKGROUND: Remifentanil and propofol are increasingly used for short-duration procedures in spontaneously breathing patients. In this setting, it is preferable to block the response to moderate stimuli while avoiding loss of responsiveness (LOR) and intolerable ventilatory depression (IVD). In this study, we explored selected effects of combinations of remifentanil-propofol effect-site concentrations (Ces) that lead to a loss of response to esophageal instrumentation (EI), LOR, and/or onset of IVD. A secondary aim was to use these observations to create response surface models for each effect measure. We hypothesized that (1) in a large percentage of volunteers, selected remifentanil and propofol Ces would allow EI but avoid LOR and IVD, and (2) the drug interaction for these effects would be synergistic... CONCLUSION: Selected remifentanil-propofol concentration pairs, especially higher propofol-lower remifentanil concentration pairs, can block the response to EI while avoiding IVD in spontaneously breathing volunteers. It is, however, difficult to block the response to EI and avoid both LOR and IVD. It may be necessary to accept some discomfort and blunt rather than block the response to EI to consistently avoid LOR and IVD.
Magnesium sulfate prevents remifentanil-induced postoperative hyperalgesia in patients undergoing thyroidectomy. [2011.08]
BACKGROUND: In a randomized, double-blind, prospective study, we investigated whether an intraoperative high versus low dose of remifentanil increased postoperative hyperalgesia and whether magnesium can prevent remifentanil-induced hyperalgesia... CONCLUSIONS: A relatively high dose of intraoperative remifentanil enhances periincisional hyperalgesia. Intraoperative MgSO(4) prevents remifentanil-induced hyperalgesia. However, hyperalgesia did not reach clinical relevance in terms of postoperative pain or analgesic consumption in patients undergoing thyroidectomy.
Clinical Trials Related to Ultiva (Remifentanil)
Co-Administration of Propofol and Remifentanil for Lumbar Puncture in Children [Completed]
The objective of this study is to compare intraoperative and recovery parameters in patients
who receive two different dose combinations of propofol and remifentanil in patients
undergoing a lumbar puncture.
Safety of Remifentanil Infusion [Recruiting]
The effect of maintenance remifentanil infusion with target controlled infusion during
laryngeal mask airway removal on hemodynamic parameters and emergence quality is going to be
Sevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid Tolerance [Recruiting]
During this study, the pharmacodynamic interactions between sevoflurane and remifentanil
will be studied.
Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Recruiting]
The aim of the present study is to compare patients discharge time from the recovery unit
between remifentanil only group and combination group (midazolam + meperidine) during
Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia [Not yet recruiting]
This study is designed to compare the effects of two bolus doses of intravenous remifentanil
given prior to the emergence of anesthesia:
- on the incidence of perioperative coughing
- on the time needed for the emergence of a desflurane-based anesthesia
- on the incidence of sore throat after extubation.
The investigators hypothesis is that the use of a higher remifentanil bolus dose (0. 5
mcg/kg) given prior to emergence of a desflurane-based anesthesia will reduce the incidence
of perioperative coughing when compared to a lower dose of remifentanil (0. 25 mcg/kg).
Reports of Suspected Ultiva (Remifentanil) Side Effects
Drug Rash With Eosinophilia and Systemic Symptoms (21),
Premature Baby (11),
Drug Withdrawal Syndrome Neonatal (8),
Transient Tachypnoea of THE Newborn (8),
Feeding Disorder (8),
Anaphylactic Shock (7),
OFF Label USE (7), more >>