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Ultiva (Remifentanil Hydrochloride) - Summary



ULTIVA (remifentanil hydrochloride) for Injection is a µ-opioid agonist chemically designated as a 3-[4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino]-1-piperidine]propanoic acid methyl ester, hydrochloride salt, C20H28N2O5•HCl, with a molecular weight of 412.

ULTIVA is indicated for IV administration:

  1. As an analgesic agent for use during the induction and maintenance of general anesthesia for inpatient and outpatient procedures.
  2. For continuation as an analgesic into the immediate postoperative period in adult patients under the direct supervision of an anesthesia practitioner in a postoperative anesthesia care unit or intensive care setting.
  3. As an analgesic component of monitored anesthesia care in adult patients.

See all Ultiva indications & dosage >>


Media Articles Related to Ultiva (Remifentanil)

Feeling anxious? Check your orbitofrontal cortex and cultivate your optimism
Source: Anxiety / Stress News From Medical News Today [2015.09.23]
A new study links anxiety, a brain structure called the orbitofrontal cortex, and optimism, finding that healthy adults who have larger OFCs tend to be more optimistic and less anxious.

Study in mice suggests how anesthesia may fight lung infections
Source: Flu / Cold / SARS News From Medical News Today [2015.09.02]
In use for more than a century, inhaled anesthetics like nitrous oxide and halothane have made modern surgery possible.

more news >>

Published Studies Related to Ultiva (Remifentanil)

The effect of sufentanil administration on remifentanil-based anaesthesia during laparoscopic gynaecological surgery: a double-blind randomized controlled trial. [2014]
This study assessed the effect of sufentanil administered before conclusion of remifentanil-based anaesthesia on postoperative hyperalgesia and haemodynamic stability in patients undergoing laparoscopic gynaecological surgery. The patients were randomly allocated to a sufentanil administration group (S group) or a normal saline administration group (C group)...

Total intravenous anesthesia using remifentanil in extracorporeal shock wave lithotripsy (ESWL). Comparison of two dosages: a randomized clinical trial. [2014]
to assess which is the most appropriate infusion rate... CONCLUSION: According with previous results remifentanil at the infusion rate of

Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy. [2012]
patient and perioperative characteristics... CONCLUSIONS: In this follow-up study in cardiac surgery patients, intraoperative

An intraoperative small dose of ketamine prevents remifentanil-induced postanesthetic shivering. [2011.09]
Patients undergoing gynecological laparotomy were randomized to receive either 0.5 mg/kg ketamine at induction of anesthesia followed by an infusion of 0.3 mg/kg/h until the end of surgery (ketamine group, n = 32), or an equivalent volume of normal saline (control group, n = 32)...

A double-blind randomised comparison of intravenous patient-controlled remifentanil with intramuscular pethidine for labour analgesia. [2011.09]
In a prospective, double-blind, randomised controlled trial, we compared the efficacy of patient-controlled analgesia using remifentanil (25-30 mug per bolus) with intramuscular pethidine (50-75 mg) for labour analgesia in 69 parturients. Parturients receiving patient-controlled analgesia reported less pain than those receiving intramuscular pethidine throughout the study period (p < 0.001), with maximal reduction in visual analogue pain score at 2 h after commencement of analgesia (mean (SD) 20 (17) in the patient-controlled analgesia group and 36 (22) in the intramuscular pethidine group...

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Clinical Trials Related to Ultiva (Remifentanil)

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Completed]

Modulation of Remifentanil-induced Postinfusion Hyperalgesia [Completed]
In addition to alleviate pain there is growing evidence that -opioids enhance pain. This problem is known as opioid induced hyperalgesia(OIH).The NMDA receptor is involved in opioid induced hyperalgesia it may be possible to block OIH by cyclooxygenase inhibitors. This has been demonstrated with parecoxib, a COX-II inhibitor, in a experimental pain model. Both COX-1 and COX-2 are expressed in the spinal cord. It would be of interest to investigate whether a COX-1 preferring inhibitor like ketorolac also can reduce opioid induced hyperalgesic in this experimental pain model.

Pharmacogenetics of Remifentanil in Patients With Hypertension Undergoing Cesarean Delivery Under General Anesthesia [Completed]
Caesarean delivery under general anaesthesia (GA) carries nowadays still 25% risk of insufficient depth of anaesthesia in a time before the fetus delivery. The reason is the lack of opioid administration. Opioids easily cross placental barrier and negatively influence newborn postpartum adaptation by respiratory depression. Introduction to GA is thus accompanied by exaggerated autonomic stress reaction with hypertension and tachycardia. The use of ultra-short acting opioid remifentanil should suppress stress response in mother without increasing the risk for newborn. There are only a few clinical data available. This study will be the first one systematically studying the influence of remifentanil in pregnant women with hypertension on hemodynamic stability and newborns safety. This study will also identify potential pharmacogenetic factors of individual variability in remifentanil response with respect of drug efficacy and safety in mother and newborn.

Effect of Remifentanil on Postoperative Vomiting in Pediatric Strabismus Surgery [Recruiting]

Optimal Sevoflurane Concentration for Intubation in Combination of Clincal Remifentanil Doses [Recruiting]
Intubation is a procedure that requires well relaxed muscles while general anesthesia is performed. In order to get adequate muscle relaxation, remifentanil, sevoflurane or both agents in combination have been reported as they can provide adequate conditions for laryngoscopy and tracheal intubation without using muscle relaxants. However, there were no previous studies to find the effective dose of sevoflurane in combination with different bolus doses of remifentanil to obtain adequate endotracheal intubation conditions without using muscle relaxants. The aim of this study is to investigate the change in the minimum sevoflurane alveolar concentration which produces an adequate endotracheal intubation condition when sevoflurane is combined with different bolus doses of remifentanil used in clinical practice.

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Reports of Suspected Ultiva (Remifentanil) Side Effects

Drug Rash With Eosinophilia and Systemic Symptoms (21)Premature Baby (11)Drug Withdrawal Syndrome Neonatal (8)Transient Tachypnoea of THE Newborn (8)Vomiting (8)Hyperreflexia (8)Irritability (8)Feeding Disorder (8)Anaphylactic Shock (7)OFF Label USE (7)more >>

Page last updated: 2015-09-23

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