NEWS HIGHLIGHTSMedia Articles Related to Ultiva (Remifentanil)
Cholesterol Important For Brain Development, Study
Source: Cholesterol News From Medical News Today [2009.10.05]
A new study by an international team of researchers found that cholesterol is important for the formation of brain cells, and they hope the findings will help scientists cultivate dopamine-producing cells outside the body.
Cholesterol Necessary For Brain Development
Source: Cholesterol News From Medical News Today [2009.10.03]
A derivative of cholesterol is necessary for the formation of brain cells, according to a study from the Swedish medical university Karolinska Institutet. The results, which are published in the journal Cell Stem Cell, can help scientists to cultivate dopamine-producing cells outside the body.
Abdominal Surgery Without General Anesthesia
Source: GastroIntestinal / Gastroenterology News From Medical News Today [2009.11.04]
A recent review in Faculty of 1000 Medicine Reports, a publication in which clinicians highlight advances in medical practice, suggests regional pain relief could be used during abdominal surgery. In this review, Michael Schaefer recommends a new approach that can be performed without the need for general anaesthetics.
Anesthesia, Exertional Heat Deaths May Be Linked
Source: MedicineNet Hyperthermia Specialty [2009.10.26]
Title: Anesthesia, Exertional Heat Deaths May Be Linked
Category: Health News
Created: 10/23/2009 4:10:00 PM
Last Editorial Review: 10/26/2009
Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Source: MedicineNet Hernia Specialty [2009.03.25]
Title: Anesthesia in Youngest Kids May be Linked to Learning Disabilities
Category: Health News
Created: 3/25/2009 2:00:00 AM
Last Editorial Review: 3/25/2009
Published Studies Related to Ultiva (Remifentanil)
Effects of remifentanil on convulsion duration and hemodynamic responses during electroconvulsive therapy: a double-blind, randomized clinical trial. [2009.09]
BACKGROUND: Among the drugs used for the induction of anesthesia for electroconvulsive therapy (ECT), thiopental induces a greater degree of cardiovascular alteration than other agents. Remifentanil has been found to reduce blood pressure and heart rate when administered as an adjuvant during general anesthesia, with unknown effects on the duration of motor or electroencephalographic seizure activity during ECT. The purpose of this prospective, randomized, double-blind, placebo-controlled, crossover study was to evaluate the effects of supplementing thiopental anesthesia with remifentanil on convulsion duration and cardiovascular response during ECT... CONCLUSIONS: Remifentanil (1 microg/kg) administered before thiopental (1 mg/kg) has no adverse effect on the duration of ECT-induced convulsion and recovery time, but it can attenuate the increase in heart rate and arterial blood pressure.
Analgesia during abdominal aortic aneurysm endovascular repair: remifentanil vs. fentanyl-midazolam--a randomized controlled trial. [2009.09]
BACKGROUND AND OBJECTIVE: Endovascular repair offers a less surgically invasive procedure for abdominal aortic aneurysms but nevertheless, still requires analgesic sedative cover to ensure an acceptable level of patient comfort and cardiorespiratory stability. The peculiarity of this kind of operation is that painful stimuli are concentrated in specific moments separated by intervals devoid of pain, so the insurgence of pain can be predicted and prevented with a bolus of analgesic, making a continuous infusion not essential, but potentially useful in achieving a better analgesic stability. The primary objective of the study was pain control measured by Visual Analogue Scale; secondary endpoints were cardiorespiratory stability and an acceptable level of sedation... CONCLUSION: Both techniques were shown to be safe and most importantly effective in offering cardiovascular stability and analgesia for American Society of Anaesthesiologists III-IV patients undergoing endovascular abdominal aortic aneurysm repair. However, remifentanil continuous infusion proved to offer significantly more stable pain control compared with the currently used combination fentanyl-midazolam.
Effects of different doses of remifentanil on the end-tidal concentration of sevoflurane required for tracheal intubation in children. [2009.08]
We investigated the effects of different doses of remifentanil on the end-tidal concentration of sevoflurane required for tracheal intubation in children without the use of neuromuscular blocking drugs. One hundred and thirty paediatric patients, aged 3-8 years, were randomly allocated to receive no remifentanil (group control) or remifentanil 0.1 microg kg(-1) min(-1) (group remi(0.1)), 0.2 microg kg(-1) min(-1) (group remi(0.2)), 0.3 microg kg(-1) min(-1) (group remi(0.3))...
Effect of remifentanil on tracheal intubation conditions and haemodynamics in children anaesthetised with sevoflurane and nitrous oxide. [2009.07]
This study examined the effect of remifentanil added to inhalation agents on intubating conditions in children (aged one to seven years). As is our routine, all patients were premedicated with 0.004 mg/kg glycopyrrolate intramuscularly 30 minutes before anaesthesia to prevent bradycardia and salivary secretion, and received intravenous 1 mg/kg ketamine prior to transfer into the operating room to facilitate separation of the child from the parents...
Optimal remifentanil dosage for providing excellent intubating conditions when co-administered with a single standard dose of propofol. [2009.07]
This dose-response study aimed to determine the dose of remifentanil combined with propofol 2.5 mg.kg(-1) which provided excellent intubation conditions in 95% of patients. Ninety premedicated female ASA 1 and 2 patients were randomly allocated to five remifentanil dose groups (1, 2, 3, 4 or 5 microg.kg(-1))...
Clinical Trials Related to Ultiva (Remifentanil)
Co-Administration of Propofol and Remifentanil for Lumbar Puncture in Children [Completed]
The objective of this study is to compare intraoperative and recovery parameters in patients
who receive two different dose combinations of propofol and remifentanil in patients
undergoing a lumbar puncture.
A Dose Finding Study of Remifentanil and Propofol for Lumbar Punctures in Children [Completed]
This study will examine whether the combination of two anaesthetic medications, propofol and
remifentanil, is suitable for short duration surgical procedures, providing a shorter
recovery time and fewer side effects than either drug used alone.
Remifentanil and Propofol Versus Fentanyl and Midazolam for Sedation During Therapeutic Hypothermia. A Randomised, Controlled Trial [Enrolling by invitation]
The aim of this study is to increase knowledge about drug properties and effects during
therapeutic hypothermia. The primary end point of this study is the time from termination of
sedation to extubation in patients treated with therapeutic hypothermia, after treatment with
the combination remifentanil and propofol versus that of fentanyl and midazolam.
Modulation of Remifentanil-Induced Postinfusion Hyperalgesia [Not yet recruiting]
In addition to alleviate pain there is growing evidence that µ-opioids enhance pain. This
problem is known as opioid induced hyperalgesia(OIH).The NMDA receptor is involved in opioid
induced hyperalgesia it may be possible to block OIH by cyclooxygenase inhibitors. This has
been demonstrated with parecoxib, a COX-II inhibitor, in a experimental pain model. Both COX-1
and COX-2 are expressed in the spinal cord. It would be of interest to investigate whether a
COX-1 preferring inhibitor like ketorolac also can reduce opioid induced hyperalgesic in this
experimental pain model.
Sevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid Tolerance [Recruiting]
During this study, the pharmacodynamic interactions between sevoflurane and remifentanil
will be studied.
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