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Ultiva (Remifentanil Hydrochloride) - Summary



ULTIVA (remifentanil hydrochloride) for Injection is a -opioid agonist chemically designated as a 3-[4-methoxycarbonyl-4-[(1-oxopropyl)phenylamino]-1-piperidine]propanoic acid methyl ester, hydrochloride salt, C20H28N2O5 HCl, with a molecular weight of 412.

ULTIVA is indicated for IV administration:

  1. As an analgesic agent for use during the induction and maintenance of general anesthesia for inpatient and outpatient procedures.
  2. For continuation as an analgesic into the immediate postoperative period in adult patients under the direct supervision of an anesthesia practitioner in a postoperative anesthesia care unit or intensive care setting.
  3. As an analgesic component of monitored anesthesia care in adult patients.

See all Ultiva indications & dosage >>


Media Articles Related to Ultiva (Remifentanil)

Surgery Patients Might Not Need Sedative Before Anesthesia
Source: MedicineNet lorazepam Specialty [2015.03.04]
Title: Surgery Patients Might Not Need Sedative Before Anesthesia
Category: Health News
Created: 3/3/2015 12:00:00 AM
Last Editorial Review: 3/4/2015 12:00:00 AM

more news >>

Published Studies Related to Ultiva (Remifentanil)

Remifentanil during cardiac surgery is associated with chronic thoracic pain 1 yr after sternotomy. [2012]
patient and perioperative characteristics... CONCLUSIONS: In this follow-up study in cardiac surgery patients, intraoperative

An intraoperative small dose of ketamine prevents remifentanil-induced postanesthetic shivering. [2011.09]
Patients undergoing gynecological laparotomy were randomized to receive either 0.5 mg/kg ketamine at induction of anesthesia followed by an infusion of 0.3 mg/kg/h until the end of surgery (ketamine group, n = 32), or an equivalent volume of normal saline (control group, n = 32)...

A double-blind randomised comparison of intravenous patient-controlled remifentanil with intramuscular pethidine for labour analgesia. [2011.09]
In a prospective, double-blind, randomised controlled trial, we compared the efficacy of patient-controlled analgesia using remifentanil (25-30 mug per bolus) with intramuscular pethidine (50-75 mg) for labour analgesia in 69 parturients. Parturients receiving patient-controlled analgesia reported less pain than those receiving intramuscular pethidine throughout the study period (p < 0.001), with maximal reduction in visual analogue pain score at 2 h after commencement of analgesia (mean (SD) 20 (17) in the patient-controlled analgesia group and 36 (22) in the intramuscular pethidine group...

An exploration of remifentanil-propofol combinations that lead to a loss of response to esophageal instrumentation, a loss of responsiveness, and/or onset of intolerable ventilatory depression. [2011.09]
BACKGROUND: Remifentanil and propofol are increasingly used for short-duration procedures in spontaneously breathing patients. In this setting, it is preferable to block the response to moderate stimuli while avoiding loss of responsiveness (LOR) and intolerable ventilatory depression (IVD). In this study, we explored selected effects of combinations of remifentanil-propofol effect-site concentrations (Ces) that lead to a loss of response to esophageal instrumentation (EI), LOR, and/or onset of IVD. A secondary aim was to use these observations to create response surface models for each effect measure. We hypothesized that (1) in a large percentage of volunteers, selected remifentanil and propofol Ces would allow EI but avoid LOR and IVD, and (2) the drug interaction for these effects would be synergistic... CONCLUSION: Selected remifentanil-propofol concentration pairs, especially higher propofol-lower remifentanil concentration pairs, can block the response to EI while avoiding IVD in spontaneously breathing volunteers. It is, however, difficult to block the response to EI and avoid both LOR and IVD. It may be necessary to accept some discomfort and blunt rather than block the response to EI to consistently avoid LOR and IVD.

Magnesium sulfate prevents remifentanil-induced postoperative hyperalgesia in patients undergoing thyroidectomy. [2011.08]
BACKGROUND: In a randomized, double-blind, prospective study, we investigated whether an intraoperative high versus low dose of remifentanil increased postoperative hyperalgesia and whether magnesium can prevent remifentanil-induced hyperalgesia... CONCLUSIONS: A relatively high dose of intraoperative remifentanil enhances periincisional hyperalgesia. Intraoperative MgSO(4) prevents remifentanil-induced hyperalgesia. However, hyperalgesia did not reach clinical relevance in terms of postoperative pain or analgesic consumption in patients undergoing thyroidectomy.

more studies >>

Clinical Trials Related to Ultiva (Remifentanil)

Co-Administration of Propofol and Remifentanil for Lumbar Puncture in Children [Completed]
The objective of this study is to compare intraoperative and recovery parameters in patients who receive two different dose combinations of propofol and remifentanil in patients undergoing a lumbar puncture.

Safety of Remifentanil Infusion [Recruiting]
The effect of maintenance remifentanil infusion with target controlled infusion during laryngeal mask airway removal on hemodynamic parameters and emergence quality is going to be investigated.

Sevoflurane-Remifentanil Interaction: Multiple Response Surfaces, Validation of Calibration Stimuli, Validation of the Intraoperative Isobole Concept and Investigating Remifentanil Induced Opioid Tolerance [Recruiting]
During this study, the pharmacodynamic interactions between sevoflurane and remifentanil will be studied.

Remifentanil Only vs. Midazolam and Meperidine During Elective Colonoscopy [Recruiting]
The aim of the present study is to compare patients discharge time from the recovery unit between remifentanil only group and combination group (midazolam + meperidine) during elective colonoscopy

Efficacy of Two Bolus Doses of Remifentanil on the Incidence of Coughing During Emergence of Anesthesia [Not yet recruiting]
This study is designed to compare the effects of two bolus doses of intravenous remifentanil given prior to the emergence of anesthesia:

- on the incidence of perioperative coughing

- on the time needed for the emergence of a desflurane-based anesthesia

- on the incidence of sore throat after extubation.

The investigators hypothesis is that the use of a higher remifentanil bolus dose (0. 5 mcg/kg) given prior to emergence of a desflurane-based anesthesia will reduce the incidence of perioperative coughing when compared to a lower dose of remifentanil (0. 25 mcg/kg).

more trials >>

Reports of Suspected Ultiva (Remifentanil) Side Effects

Drug Rash With Eosinophilia and Systemic Symptoms (21)Premature Baby (11)Drug Withdrawal Syndrome Neonatal (8)Transient Tachypnoea of THE Newborn (8)Vomiting (8)Hyperreflexia (8)Irritability (8)Feeding Disorder (8)Anaphylactic Shock (7)OFF Label USE (7)more >>

Page last updated: 2015-03-04

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