SUMMARY
TYZINE
(tetrahydrozoline hydrochloride)
NASAL SOLUTION
Tyzine® Nasal Solution contains tetrahydrozoline hydrochloride, 2-(1,2,3,4-Tetrahydro-1, naphthyl)-2-imidazoline monohydrochloride, as a nasal decongestant.
Tyzine® Nasal Solution is indicated for decongestion of nasal and nasopharyngeal mucosa.
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NEWS HIGHLIGHTS
Published Studies Related to Tyzine Pediatric (Tetrahydrozoline Nasal)
Serum concentrations in three children with unintentional tetrahydrozoline overdose. [2011.06]
CONCLUSION: We report three pediatric cases after ingestion of THZ where plasma concentrations were obtained with a calculated half-life of 4.4 h in one case.
Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. [2008.02]
Tetrahydrozoline is an imidazoline derivative with alpha receptor agonist activity widely available in over-the-counter topical ocular and nasal formulations... We report a case of unintentional tetrahydrozoline ingestion with cardiovascular effects persisting for 36 hours.
Pediatric Visine (tetrahydrozoline) ingestion: case report and review of imidazoline toxicity. [2003.08]
Visine, an over-the-counter, tetrahydrozoline topical ophthalmic decongestant, possesses central and peripheral alpha2-adrenergic properties. We present a case of accidental pediatric oral exposure with resultant neurological and cardiovascular complications... Over-the-counter medications with potent pharmacological properties should be stored in areas out of the reach of children, and manufacturers should package these products in childproof containers.
[The usage of nasal drops Tyzine in otorhinolaryngology] [1997]
In this research the authors presented their experiences in the treatment of non-complicated and complicated acute mucous membranous rhinitis with application of shrinking nasal drops Tyzine as a locally affective remedy assisting the therapy. The aim of this research was the estimation of the efficiency of Tyzine drops with mucous membranous rhinitis, their effect on the efficiency of the ciliary transport and stating the probable side effects occurring after their application...
Clinical Trials Related to Tyzine Pediatric (Tetrahydrozoline Nasal)
Pharmacokinetics, Safety and Tolerability of the Preservative-free Fixed Dose Combination of Tafluprost 0.0015% and Timolol 0.5% Eye Drops [Not yet recruiting]
Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease [Recruiting]
This study will evaluate the safety, efficacy, and acceptability of an eye drop formulation
in subjects with dry eye disease.
Glaucoma Eye Drop Instillation: Impact of Education [Recruiting]
The purpose of this study is to assess whether an educational intervention will have a
positive effect on patients' ability to properly administer eye drops. The investigators
predict that the educational intervention will have a positive impact on the efficacy,
safety, and efficiency with which patients administer their eye drops.
Safety, Tolerability and Pharmacokinetics of 0.5% and 2.5% Cis-UCA Eye Drops in Adult Healthy Volunteers (Phase I) [Recruiting]
The purpose of this two-part study is to evaluate safety, tolerability and pharmacokinetics
of 0. 5% and 2. 5% cis-UCA eye drops in comparison to placebo in adult healthy volunteers.
A Phase II, Dose Ranging Study Of CP-690,550 Eye Drops In Patients With Dry Eye Disease [Recruiting]
The purpose of the study is to evaluate dose-response, efficacy and safety of CP-690,550 eye
drops in patients with dry eye disease.
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