SUMMARY
TYZINE
(tetrahydrozoline hydrochloride)
NASAL SOLUTION
Tyzine® Nasal Solution contains tetrahydrozoline hydrochloride, 2-(1,2,3,4-Tetrahydro-1, naphthyl)-2-imidazoline monohydrochloride, as a nasal decongestant.
Tyzine® Nasal Solution is indicated for decongestion of nasal and nasopharyngeal mucosa.
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NEWS HIGHLIGHTS
Published Studies Related to Tyzine Pediatric (Tetrahydrozoline Nasal)
Serum concentrations in three children with unintentional tetrahydrozoline overdose. [2011.06]
CONCLUSION: We report three pediatric cases after ingestion of THZ where plasma concentrations were obtained with a calculated half-life of 4.4 h in one case.
Prolonged cardiovascular effects after unintentional ingestion of tetrahydrozoline. [2008.02]
Tetrahydrozoline is an imidazoline derivative with alpha receptor agonist activity widely available in over-the-counter topical ocular and nasal formulations... We report a case of unintentional tetrahydrozoline ingestion with cardiovascular effects persisting for 36 hours.
Pediatric Visine (tetrahydrozoline) ingestion: case report and review of imidazoline toxicity. [2003.08]
Visine, an over-the-counter, tetrahydrozoline topical ophthalmic decongestant, possesses central and peripheral alpha2-adrenergic properties. We present a case of accidental pediatric oral exposure with resultant neurological and cardiovascular complications... Over-the-counter medications with potent pharmacological properties should be stored in areas out of the reach of children, and manufacturers should package these products in childproof containers.
[The usage of nasal drops Tyzine in otorhinolaryngology] [1997]
In this research the authors presented their experiences in the treatment of non-complicated and complicated acute mucous membranous rhinitis with application of shrinking nasal drops Tyzine as a locally affective remedy assisting the therapy. The aim of this research was the estimation of the efficiency of Tyzine drops with mucous membranous rhinitis, their effect on the efficiency of the ciliary transport and stating the probable side effects occurring after their application...
Clinical Trials Related to Tyzine Pediatric (Tetrahydrozoline Nasal)
The Effect of "Eye Drop Guide" on the Success Rate of Eye Drops Self-instillation in Glaucoma Patients [Recruiting]
To investigate if the Eye Drop Guide more effective than carefully instructed routine
technique for chronic glaucoma patients to self-instill eye drops.
And what factors are associated with the failure of self-instillation eye drops with the Eye
Drop Guide?
Efficacy and Safety of Three Different Latanoprost 0,005% Eyedrops in Subjects Affected by Primary Open Angle Glaucoma [Recruiting]
BASIC (Boric Acid, Alternate Solution for Intravaginal Colonization) Study [Recruiting]
Bacterial vaginosis (BV), the world's most common vaginal infection, continues to cost
patients time, energy, comfort and money. BV is associated with increased incidence of
sexually transmitted infections (including HIV), spontaneous abortion, pre-term labour,
post-surgical infections, and endometritis. Current treatment for those women symptomatic
for BV includes both oral and intravaginal antibiotics, such as metronidazole, which have
success rates of 70-80 % at 1 month after treatment. These treatments also have high
recurrence rates (49-66 % at one year after treatment) and side effects (10-20 % of women)
that include secondary vaginal infection with candida. Intravaginal boric acid has been used
for >100 years for the treatment of vaginal infections and is quite commonly prescribed
today as a treatment for BV. It is cheap, easily accessible, easy to use, and is an
effective treatment of other vaginal infections, such as candida. To date, there are no
clinical trials studying the effectiveness of boric acid in the treatment of BV.
Objectives: To determine whether boric acid is at least as effective and as safe as
metronidazole for treating women with symptomatic BV, our study will compare intravaginal
boric acid to the current standard intravaginal treatment, metronidazole, and to a placebo.
Our goal is to expand women's options for the treatment of BV. Hypothesis: Boric acid is an
effective treatment of bacterial vaginosis as compared to placebo. Boric acid is at least
as effective and as safe in the treatment of bacterial vaginosis as compared to
metronidazole.
Pharmacokinetics, Safety and Tolerability of the Preservative-free Fixed Dose Combination of Tafluprost 0.0015% and Timolol 0.5% Eye Drops [Not yet recruiting]
Safety, Efficacy, and Acceptability Study of an Eye Drop Formulation in Subjects With Dry Eye Disease [Recruiting]
This study will evaluate the safety, efficacy, and acceptability of an eye drop formulation
in subjects with dry eye disease.
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