NEWS HIGHLIGHTSMedia Articles Related to Tylenol (Acetaminophen)
Tylenol May Weaken Infant Vaccines
Source: MedicineNet acetaminophen Specialty [2009.10.16]
Title: Tylenol May Weaken Infant Vaccines
Category: Health News
Created: 10/16/2009 9:29:00 AM
Last Editorial Review: 10/16/2009 9:29:30 AM
Some Children's, Infants' Tylenol Recalled
Source: MedicineNet Cystic Fibrosis Specialty [2009.09.25]
Title: Some Children's, Infants' Tylenol Recalled
Category: Health News
Created: 9/25/2009 11:11:00 AM
Last Editorial Review: 9/25/2009 11:11:44 AM
Common Pain Relievers May Dilute Power Of Flu Shots
Source: Biology / Biochemistry News From Medical News Today [2009.11.04]
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers -- Advil, Tylenol, aspirin -- at the time of injection may blunt the effect of the shot and have a negative effect on the immune system. Richard P. Phipps, Ph.D.
Ibuprofen Bests Acetaminophen/Codeine for Kids' Broken Arms (CME/CE)
Source: MedPage Today Emergency Medicine [2009.08.19]
Children treated for arm fractures reported that ibuprofen killed the pain as effectively as a combination of codeine and acetaminophen (Tylenol 3), with fewer adverse effects in a randomized trial.
propoxyphene and acetaminophen, Darvocet A500; Darvocet-N (Darvocet, Wygesic)
Source: MedicineNet Tylenol Liver Damage Specialty [2009.09.10]
Title: propoxyphene and acetaminophen, Darvocet A500; Darvocet-N (Darvocet, Wygesic)
Category: Medications
Created: 3/26/1998 2:30:00 PM
Last Editorial Review: 9/10/2009
Published Studies Related to Tylenol (Acetaminophen)
A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. [2009.10]
STUDY OBJECTIVE: We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)... CONCLUSION: Ibuprofen was at least as effective as acetaminophen with codeine for outpatient analgesia for children with arm fractures. There was no significant difference in analgesic failure or pain scores, but children receiving ibuprofen had better functional outcomes. Children receiving ibuprofen had significantly fewer adverse effects, and both children and parents were more satisfied with ibuprofen. Ibuprofen is preferable to acetaminophen with codeine for outpatient treatment of children with uncomplicated arm fractures.
Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. [2009.09]
BACKGROUND & AIMS: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetaminophen-related acute liver failure... CONCLUSIONS: Intravenous NAC improves transplant-free survival in patients with early stage non-acetaminophen-related acute liver failure. Patients with advanced coma grades do not benefit from NAC and typically require emergency liver transplantation.
The prophylactic effect of rectal acetaminophen on postoperative pain and opioid requirements after adenotonsillectomy in children. [2009.06]
BACKGROUND: Postoperative pain in children is common after adenotonsillectomy. Rectal acetaminophen has been used effectively for postoperative pain management in small children. The aim of this randomized double blind study was to evaluate the prophylactic effect of rectal acetaminophen on postoperative pain management and opioid requirements in children undergoing adenotonsillectomy... CONCLUSION: We conclude that prophylactic rectal acetaminophen is effective in reducing pain after adenotonsillectomy and postoperative analgesic requirement.
A randomized, controlled study on the influence of acetaminophen, diclofenac, or naproxen on aspirin-induced inhibition of platelet aggregation. [2009.05.01]
Nonsteroidal anti-inflammatory drugs (NSAID) may interfere with aspirin (acetylsalicylic acid) and increase the risk for cardiovascular events...
The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. [2009.05]
BACKGROUND: High body temperature in the first 12-24 h after stroke onset is associated with poor functional outcome. The Paracetamol (Acetaminophen) In Stroke (PAIS) trial aimed to assess whether early treatment with paracetamol improves functional outcome in patients with acute stroke by reducing body temperature and preventing fever... INTERPRETATION: These results do not support routine use of high-dose paracetamol in patients with acute stroke. Paracetamol might have a beneficial effect on functional outcome in patients admitted with a body temperature 37-39 degrees C, but this post-hoc finding needs further study. FUNDING: Netherlands Heart Foundation.
Clinical Trials Related to Tylenol (Acetaminophen)
Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days [Completed]
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by
processing it in the liver. During the processing, some of the acetaminophen may bind to
proteins in the liver. The protein-acetaminophen product is called an "adduct". After a large
acetaminophen overdose, the liver has to process a lot of acetaminophen, so large amounts of
adducts are formed. However, we have found that lower levels may be formed even when people
take recommended doses. The purpose of this study is to measure the amount of adducts formed
when healthy people who do not drink alcohol take normal doses of acetaminophen for 10 days.
A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery [Completed]
Increasingly in general surgery, the investigators are conducting outpatient day surgery.
Ambulatory surgery currently comprises 60 to 70% of surgeries performed in North America.
These patients all require some form of analgesia which can be taken at home in the first few
days after the surgery. The current standard at the investigators' centre and many others in
the maritime provinces is to provide a prescription for oral acetaminophen plus codeine or
oxycodone (Tylenol #3®, Percocet ®). Some patients may receive more potent opioids such as
oral hydromorphone (Dilaudid®). Unfortunately, the most commonly prescribed medication
(Tylenol #3®) is often poorly tolerated by patients, has several undesirable side effects,
and may not provide effective pain relief. In the investigators' experience, non-steroidal
anti-inflammatory drugs (NSAIDs) are uncommonly a routine addition to the home analgesic
regimen.
Tylenol #3®, in the investigators' experience and opinion, is a poor post surgical pain
medication. They hope to show that a combination of ibuprofen and acetaminophen is better for
pain relief after these procedures. The combination of acetaminophen and ibuprofen would be a
safe, cheap, and readily available regimen. Unfortunately, as the prescribing practices of
surgeons are old habits, it will require a very convincing argument to get them to change
their practices. A randomized controlled trial comparing these two regimens, the
investigators hope, would be a powerful enough argument.
The hypothesis of this study, therefore, is that the pain control provided by a combination
of acetaminophen plus ibuprofen (650 mg/400 mg four times per day) will be superior to
Tylenol #3® (600 mg acetaminophen/60 mg codeine/15 mg caffeine four times per day).
This study will attempt to enroll 150 patients in total. Eligible patients will be identified
by their attending surgeon and contacted by study personnel. Patients who enroll in the study
will undergo their surgery in the usual manner. After the surgery, in the recovery room, once
they are ready to go home, they will be randomized to receive combination A or B and be given
a week's worth of pain medication. They will then go home and take this medication as
directed. They will record their pain intensity and pain relief once per day using a diary
provided in the study package. One week after their surgery, they will return to the hospital
clinic and be seen by the study nurse. They will hand over the diary and any unused
medication. They will also be asked several questions regarding their overall satisfaction,
incidence of side effects, and how long until they were pain free.
The risks of participating in this study are minimal from the risks inherent to the
procedures and medications the patients would receive within the standard of care. Ibuprofen
is a commonly used NSAID which is widely available over the counter and has an established
safety profile. The most common adverse effects of ibuprofen and other NSAIDs are
gastrointestinal bleeding and ulceration. Other less common adverse effects include
nephrotoxicity, hypersensitivity reactions, hepatic dysfunction (longterm use), and cognitive
dysfunction. The investigators' patients will be selected to exclude those most at risk for
these complications (see exclusion criteria). Acetaminophen has few side effects, with no
adverse effects on platelet function and no evidence of gastric irritation.
Comparing Intravenous and Oral Paracetamol for Cholecystectomy [Completed]
To determine the amount of paracetamol in the blood when given in either intravenous or oral
forms prior to cholecystectomy. The clinical effectiveness of each form will also be
evaluated with pain scores and the use of other pain relief drugs.
The Effect of Paracetamol in the Treatment of Non-Severe Malaria in Children in Guinea-Bissau [Active, not recruiting]
The National Malaria Programme in Guinea-Bissau recommends paracetamol for all children
treated for malaria. We, the investigators of the Bandim Health Project, want to evaluate
whether this treatment has any effect on:
- the well-being of the child;
- the parasite clearance time; and
- the rate of a re-appearance of parasites during 35 days of follow-up.
Children presenting at Bandim Health Centre with malaria will be treated with chloroquine
plus paracetamol or chloroquine plus placebo. Blood samples will be obtained daily for the
first 4 days and then once a week until day 35.
A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament [Completed]
The purpose of this study is to explore the pain-relieving effects and safety of two
analgesic treatment regimens as compared to placebo in patients experiencing acute
musculoskeletal pain. Patients who are experiencing at least moderate acute musculoskeletal
pain from an ankle sprain severe enough to require prescription pain relief medication will
be randomized to receive either tramadol HCl/acetaminophen, hydrocodone
bitartrate/acetaminophen or placebo.
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