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Tylenol (Acetaminophen) - Summary

 
 



TYLENOL SUMMARY

Each Regular Strength TYLENOL® Tablet contains acetaminophen 325 mg. Each Extra Strength TYLENOL® Gelcap, Geltab, Caplet, or Tablet contains acetaminophen 500 mg. Extra Strength TYLENOL® Adult Liquid is alcohol-free and each 15 mL (1/2 fl oz or one tablespoonful) contains 500 mg acetaminophen. Each TYLENOL® Arthritis Pain Extended Relief Caplet and each TYLENOL® 8 Hour Extended Release Geltab/caplet contains acetaminophen 650 mg.

Regular Strength TYLENOL® Tablets, Extra Strength TYLENOL® Gelcaps, Geltabs, Caplets, or Tablets: temporarily relieves minor aches and pains due to:

  • headache · muscular aches · backache · arthritis
  • the common cold · toothache · menstrual cramps

  • temporarily reduces fever

Extra Strength TYLENOL® Adult Liquid: temporarily relieves minor aches and pains due to:

  • headache · muscular aches · backache · arthritis
  • the common cold · toothache · menstrual cramps
  • reduces fever

TYLENOL® Arthritis Pain Extended Release Geltabs/Caplets: temporarily relieves minor aches and pains due to:

  • arthritis · the common cold · headache · toothache
  • muscular aches · backache · menstrual cramps

TYLENOL® 8 Hour Extended Release Geltabs/Caplets: temporarily relieves minor aches and pains due to:

  • muscular aches · backache · headache · toothache · the common cold
  • menstrual cramps · minor pain of arthritis
  • temporarily reduces fever


See all Tylenol indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Tylenol (Acetaminophen)

Bionic liver micro-organs explain off-target toxicity of acetaminophen (Tylenol)
Source: Liver Disease / Hepatitis News From Medical News Today [2015.08.18]
Israeli-German partnership aims to replace animal experiments with advanced liver-on-chip devicesThis image shows the Hebrew University liver-on-chip device.

Tylenol Liver Damage
Source: MedicineNet hydrocodone/acetaminophen Specialty [2015.05.07]
Title: Tylenol Liver Damage
Category: Diseases and Conditions
Created: 4/28/2001 12:00:00 AM
Last Editorial Review: 5/7/2015 12:00:00 AM

more news >>

Published Studies Related to Tylenol (Acetaminophen)

Randomized, placebo-controlled trial of acetaminophen for the reduction of oxidative injury in severe sepsis: the Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis trial. [2015]
severe sepsis and detectable plasma cell-free hemoglobin... CONCLUSIONS: In adults with severe sepsis and detectable plasma cell-free

Paracetamol (Acetaminophen) in stroke 2 (PAIS 2): protocol for a randomized, placebo-controlled, double-blind clinical trial to assess the effect of high-dose paracetamol on functional outcome in patients with acute stroke and a body temperature of 36.5 °C or above. [2015]
RATIONALE: In the first hours after stroke onset, subfebrile temperatures and fever have been associated with poor functional outcome. In the first Paracetamol (Acetaminophen) in Stroke trial, a randomized clinical trial of 1400 patients with acute stroke, patients who were treated with high-dose paracetamol showed more improvement on the modified Rankin Scale at three-months than patients treated with placebo, but this difference was not statistically significant...

Comparison of subjective effects of extended-release versus immediate-release oxycodone/acetaminophen tablets in healthy nondependent recreational users of prescription opioids: a randomized trial. [2014]
[APAP]) formulation with those of immediate-release (IR) OC/APAP... CONCLUSIONS: Extended-release OC/APAP produced lower subjective drug effects than

A randomized, double-blind, placebo-controlled study of oral oxycodone plus acetaminophen for the treatment of pain in photodynamic therapy on port wine stains. [2014]
efficacy and safety of an oral analgesic for the treatment of pain in PDT on PWS... CONCLUSIONS: The time of the pain beginning was 8.31 ± 4.58 min in

Randomized clinical trial of hydrocodone/acetaminophen versus codeine/acetaminophen in the treatment of acute extremity pain after emergency department discharge. [2014]
(DEA) Schedule III narcotics... CONCLUSIONS: Both medications decreased NRS pain scores by approximately 50%.

more studies >>

Clinical Trials Related to Tylenol (Acetaminophen)

Equality Study of Ofirmev vs Oral Acetaminophen [Not yet recruiting]
Acetaminophen (Tylenol) is a drug that is used commonly for relief of mild to moderate pain. It is found in many pain medicines that people take after having surgery. Narcotics are other drugs also used for pain (examples of narcotics are morphine and related pain medications). Medical science knows for a fact that acetaminophen works well when taken with narcotics for moderate to severe pain. Recently, acetaminophen has become available in an intravenous (IV) form called Ofirmev®. The IV form means that acetaminophen can be given into a vein. The benefits of getting medicine from an IV include:

- making the medicine work quickly

- less medicine having to pass through the liver to be changed into a form that your body

can process The investigators know that acetaminophen is helpful for pain relief at the time of surgery and after surgery. Acetaminophen is a very popular drug in outpatient surgery for pain control when patients go home. The patient's surgeon uses it to control pain after surgery at home in the form of Lortab or Percocet (Lortab and Percocet also have a narcotic medicine that mixes with acetaminophen). Also, currently at Surgicare, some anesthesiologists give intravenous acetaminophen while the patient is waiting to go to surgery. The investigators currently do not give any patient acetaminophen by mouth BEFORE surgery. However, since the addition of the IV form to the drug market, there has been interest to see if the oral form is just as good or better in reducing pain after surgery. This is why we are asking patients to join our study. The goal of this study is to find out if the oral form (by mouth) or the IV form (given into a vein) of acetaminophen controls pain after surgery better.

Protective Effects of Propylene Glycol in Daily Acetaminophen Dosing [Recruiting]
A purpose of this protocol is to is to compare the metabolites of the toxic bioactivating pathway after acetaminophen alone or acetaminophen followed by Propylene Glycol (PG) and to determine if it prevents the formation of the toxic metabolites of acetaminophen.

Effect on Acetaminophen Metabolism by Liquid Formulations [Completed]
The purpose of this study is to determine whether excipients in the liquid formulation of acetaminophen prevent the formation of the toxic metabolites of acetaminophen.

A Randomized Crossover Study to Determine the Pharmacokinetics of Intranasally Administered Acetaminophen in Healthy Adults [Withdrawn]
This study is being done to determine the systemic absorption of nasally inhaled acetaminophen (Tylenol®) versus orally ingested acetaminophen by comparing the serum drug concentrations of the two groups obtained at various times after study drug administration.

Analgesic Effect of Paracetamol, Paracetamol + Codeine, Ibuprofen and Their Combination [Recruiting]
The purpose of this study is to determine whether the combination of paracetamol (acetaminophen) and other NSAIDs with or without weak opioids can give synergistic analgesic effect.

more trials >>

Reports of Suspected Tylenol (Acetaminophen) Side Effects

Drug Ineffective (27)Anxiety (12)Weight Increased (11)Acute Hepatic Failure (9)Toxic Epidermal Necrolysis (8)Urticaria (7)Headache (7)Overdose (7)Renal Failure Acute (7)Suicide Attempt (7)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 8 ratings/reviews, Tylenol has an overall score of 8.25. The effectiveness score is 9 and the side effect score is 9. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Tylenol review by 36 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   headache
Dosage & duration:   400mg taken 1 for the period of 1 dose
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I believe that there are multiple treatment benefits of Taking Tylenol for my headache. Tylenol is safe, inexpensive, and does not require a physicians prescription. Additionally, it is available almost everywhere and therefor is convenient.
Side effects:   There were no treatment side effects from me taking Tylenol for my headache.
Comments:   There are no deatails to report. My headache was gone within 30 minutes.

 

Tylenol review by 21 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Headache
Dosage & duration:   2 pills taken 2-3 times per month for the period of 4 months
Other conditions:   Allergies
Other drugs taken:   Loratadine
  
Reported Results
Benefits:   Actually symptoms dissapeared almost within 15-20 min after taking medication, making it easy to continue with your normal day activities, even if that includes gym or an outdoor activity.
Side effects:   Sometimes I felt nausea, except that, there was no other significant side effect.
Comments:   Two pills everytime I had headache, avoiding to take more than 4 pills in one day.

 

Tylenol review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   pain
Dosage & duration:   250 mg. taken 2 every 4 hours for the period of 3 doses
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Little if any relief from headache.
Side effects:   Patient experienced severe nausea accompanied by moderate lower right abdominal pain.
Comments:   Patient experienced severe headache accompanied by sensitivity to light. Packing information claimed relief of headache as a suggested usage. Patient purchased in reliance on packaging information. After administration of the prescribed dosage over a period of twelve hours, little or no relief was noticed.

See all Tylenol reviews / ratings >>

Page last updated: 2015-08-18

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