DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Tylenol (Acetaminophen) - Summary

 



TYLENOL SUMMARY

Each Regular Strength TYLENOL® Tablet contains acetaminophen 325 mg. Each Extra Strength TYLENOL® Gelcap, Geltab, Caplet, or Tablet contains acetaminophen 500 mg. Extra Strength TYLENOL® Adult Liquid is alcohol-free and each 15 mL (1/2 fl oz or one tablespoonful) contains 500 mg acetaminophen. Each TYLENOL® Arthritis Pain Extended Relief Caplet and each TYLENOL® 8 Hour Extended Release Geltab/caplet contains acetaminophen 650 mg.

Regular Strength TYLENOL® Tablets, Extra Strength TYLENOL® Gelcaps, Geltabs, Caplets, or Tablets: temporarily relieves minor aches and pains due to:

  • headache · muscular aches · backache · arthritis
  • the common cold · toothache · menstrual cramps

  • temporarily reduces fever

Extra Strength TYLENOL® Adult Liquid: temporarily relieves minor aches and pains due to:

  • headache · muscular aches · backache · arthritis
  • the common cold · toothache · menstrual cramps
  • reduces fever

TYLENOL® Arthritis Pain Extended Release Geltabs/Caplets: temporarily relieves minor aches and pains due to:

  • arthritis · the common cold · headache · toothache
  • muscular aches · backache · menstrual cramps

TYLENOL® 8 Hour Extended Release Geltabs/Caplets: temporarily relieves minor aches and pains due to:

  • muscular aches · backache · headache · toothache · the common cold
  • menstrual cramps · minor pain of arthritis
  • temporarily reduces fever


See all indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Tylenol (Acetaminophen)

Tylenol May Weaken Infant Vaccines
Source: MedicineNet acetaminophen Specialty [2009.10.16]
Title: Tylenol May Weaken Infant Vaccines
Category: Health News
Created: 10/16/2009 9:29:00 AM
Last Editorial Review: 10/16/2009 9:29:30 AM

Some Children's, Infants' Tylenol Recalled
Source: MedicineNet Cystic Fibrosis Specialty [2009.09.25]
Title: Some Children's, Infants' Tylenol Recalled
Category: Health News
Created: 9/25/2009 11:11:00 AM
Last Editorial Review: 9/25/2009 11:11:44 AM

Common Pain Relievers May Dilute Power Of Flu Shots
Source: Biology / Biochemistry News From Medical News Today [2009.11.04]
With flu vaccination season in full swing, research from the University of Rochester Medical Center cautions that use of many common pain killers -- Advil, Tylenol, aspirin -- at the time of injection may blunt the effect of the shot and have a negative effect on the immune system. Richard P. Phipps, Ph.D.

Ibuprofen Bests Acetaminophen/Codeine for Kids' Broken Arms (CME/CE)
Source: MedPage Today Emergency Medicine [2009.08.19]
Children treated for arm fractures reported that ibuprofen killed the pain as effectively as a combination of codeine and acetaminophen (Tylenol 3), with fewer adverse effects in a randomized trial.

propoxyphene and acetaminophen, Darvocet A500; Darvocet-N (Darvocet, Wygesic)
Source: MedicineNet Tylenol Liver Damage Specialty [2009.09.10]
Title: propoxyphene and acetaminophen, Darvocet A500; Darvocet-N (Darvocet, Wygesic)
Category: Medications
Created: 3/26/1998 2:30:00 PM
Last Editorial Review: 9/10/2009

more news >>

Published Studies Related to Tylenol (Acetaminophen)

A randomized clinical trial of ibuprofen versus acetaminophen with codeine for acute pediatric arm fracture pain. [2009.10]
STUDY OBJECTIVE: We compare the treatment of pain in children with arm fractures by ibuprofen 10 mg/kg versus acetaminophen with codeine 1 mg/kg/dose (codeine component)... CONCLUSION: Ibuprofen was at least as effective as acetaminophen with codeine for outpatient analgesia for children with arm fractures. There was no significant difference in analgesic failure or pain scores, but children receiving ibuprofen had better functional outcomes. Children receiving ibuprofen had significantly fewer adverse effects, and both children and parents were more satisfied with ibuprofen. Ibuprofen is preferable to acetaminophen with codeine for outpatient treatment of children with uncomplicated arm fractures.

Intravenous N-acetylcysteine improves transplant-free survival in early stage non-acetaminophen acute liver failure. [2009.09]
BACKGROUND & AIMS: N-acetylcysteine (NAC), an antidote for acetaminophen poisoning, might benefit patients with non-acetaminophen-related acute liver failure... CONCLUSIONS: Intravenous NAC improves transplant-free survival in patients with early stage non-acetaminophen-related acute liver failure. Patients with advanced coma grades do not benefit from NAC and typically require emergency liver transplantation.

The prophylactic effect of rectal acetaminophen on postoperative pain and opioid requirements after adenotonsillectomy in children. [2009.06]
BACKGROUND: Postoperative pain in children is common after adenotonsillectomy. Rectal acetaminophen has been used effectively for postoperative pain management in small children. The aim of this randomized double blind study was to evaluate the prophylactic effect of rectal acetaminophen on postoperative pain management and opioid requirements in children undergoing adenotonsillectomy... CONCLUSION: We conclude that prophylactic rectal acetaminophen is effective in reducing pain after adenotonsillectomy and postoperative analgesic requirement.

A randomized, controlled study on the influence of acetaminophen, diclofenac, or naproxen on aspirin-induced inhibition of platelet aggregation. [2009.05.01]
Nonsteroidal anti-inflammatory drugs (NSAID) may interfere with aspirin (acetylsalicylic acid) and increase the risk for cardiovascular events...

The Paracetamol (Acetaminophen) In Stroke (PAIS) trial: a multicentre, randomised, placebo-controlled, phase III trial. [2009.05]
BACKGROUND: High body temperature in the first 12-24 h after stroke onset is associated with poor functional outcome. The Paracetamol (Acetaminophen) In Stroke (PAIS) trial aimed to assess whether early treatment with paracetamol improves functional outcome in patients with acute stroke by reducing body temperature and preventing fever... INTERPRETATION: These results do not support routine use of high-dose paracetamol in patients with acute stroke. Paracetamol might have a beneficial effect on functional outcome in patients admitted with a body temperature 37-39 degrees C, but this post-hoc finding needs further study. FUNDING: Netherlands Heart Foundation.

more studies >>

Clinical Trials Related to Tylenol (Acetaminophen)

Acetaminophen Adduct Formation in Non-Drinkers Taking Therapeutic Doses of Acetaminophen for Ten Consecutive Days [Completed]
Acetaminophen is commonly used to treat fever or pain. Your body clears acetaminophen by processing it in the liver. During the processing, some of the acetaminophen may bind to proteins in the liver. The protein-acetaminophen product is called an "adduct". After a large acetaminophen overdose, the liver has to process a lot of acetaminophen, so large amounts of adducts are formed. However, we have found that lower levels may be formed even when people take recommended doses. The purpose of this study is to measure the amount of adducts formed when healthy people who do not drink alcohol take normal doses of acetaminophen for 10 days.

A Trial Comparing Combination Therapy of Acetaminophen Plus Ibuprofen Versus Tylenol #3 for the Treatment of Pain After Outpatient Surgery [Completed]
Increasingly in general surgery, the investigators are conducting outpatient day surgery. Ambulatory surgery currently comprises 60 to 70% of surgeries performed in North America. These patients all require some form of analgesia which can be taken at home in the first few days after the surgery. The current standard at the investigators' centre and many others in the maritime provinces is to provide a prescription for oral acetaminophen plus codeine or oxycodone (Tylenol #3®, Percocet ®). Some patients may receive more potent opioids such as oral hydromorphone (Dilaudid®). Unfortunately, the most commonly prescribed medication (Tylenol #3®) is often poorly tolerated by patients, has several undesirable side effects, and may not provide effective pain relief. In the investigators' experience, non-steroidal anti-inflammatory drugs (NSAIDs) are uncommonly a routine addition to the home analgesic regimen.

Tylenol #3®, in the investigators' experience and opinion, is a poor post surgical pain medication. They hope to show that a combination of ibuprofen and acetaminophen is better for pain relief after these procedures. The combination of acetaminophen and ibuprofen would be a safe, cheap, and readily available regimen. Unfortunately, as the prescribing practices of surgeons are old habits, it will require a very convincing argument to get them to change their practices. A randomized controlled trial comparing these two regimens, the investigators hope, would be a powerful enough argument.

The hypothesis of this study, therefore, is that the pain control provided by a combination of acetaminophen plus ibuprofen (650 mg/400 mg four times per day) will be superior to Tylenol #3® (600 mg acetaminophen/60 mg codeine/15 mg caffeine four times per day).

This study will attempt to enroll 150 patients in total. Eligible patients will be identified by their attending surgeon and contacted by study personnel. Patients who enroll in the study will undergo their surgery in the usual manner. After the surgery, in the recovery room, once they are ready to go home, they will be randomized to receive combination A or B and be given a week's worth of pain medication. They will then go home and take this medication as directed. They will record their pain intensity and pain relief once per day using a diary provided in the study package. One week after their surgery, they will return to the hospital clinic and be seen by the study nurse. They will hand over the diary and any unused medication. They will also be asked several questions regarding their overall satisfaction, incidence of side effects, and how long until they were pain free.

The risks of participating in this study are minimal from the risks inherent to the procedures and medications the patients would receive within the standard of care. Ibuprofen is a commonly used NSAID which is widely available over the counter and has an established safety profile. The most common adverse effects of ibuprofen and other NSAIDs are gastrointestinal bleeding and ulceration. Other less common adverse effects include nephrotoxicity, hypersensitivity reactions, hepatic dysfunction (longterm use), and cognitive dysfunction. The investigators' patients will be selected to exclude those most at risk for these complications (see exclusion criteria). Acetaminophen has few side effects, with no adverse effects on platelet function and no evidence of gastric irritation.

Comparing Intravenous and Oral Paracetamol for Cholecystectomy [Completed]
To determine the amount of paracetamol in the blood when given in either intravenous or oral forms prior to cholecystectomy. The clinical effectiveness of each form will also be evaluated with pain scores and the use of other pain relief drugs.

The Effect of Paracetamol in the Treatment of Non-Severe Malaria in Children in Guinea-Bissau [Active, not recruiting]
The National Malaria Programme in Guinea-Bissau recommends paracetamol for all children treated for malaria. We, the investigators of the Bandim Health Project, want to evaluate whether this treatment has any effect on:

- the well-being of the child;

- the parasite clearance time; and

- the rate of a re-appearance of parasites during 35 days of follow-up.

Children presenting at Bandim Health Centre with malaria will be treated with chloroquine plus paracetamol or chloroquine plus placebo. Blood samples will be obtained daily for the first 4 days and then once a week until day 35.

A Study of the Efficacy and Safety of Tramadol HCl/Acetaminophen, Hydrocodone Bitartrate/Acetaminophen and Placebo in Patients With Pain From an Ankle Sprain With a Partial Torn Ligament [Completed]
The purpose of this study is to explore the pain-relieving effects and safety of two analgesic treatment regimens as compared to placebo in patients experiencing acute musculoskeletal pain. Patients who are experiencing at least moderate acute musculoskeletal pain from an ankle sprain severe enough to require prescription pain relief medication will be randomized to receive either tramadol HCl/acetaminophen, hydrocodone bitartrate/acetaminophen or placebo.

more trials >>

PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 7 ratings/reviews, Tylenol has an overall score of 8.14. The effectiveness score is 9.14 and the side effect score is 8.86. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Tylenol review by 36 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   headache
Dosage & duration:   400mg taken 1 for the period of 1 dose
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   I believe that there are multiple treatment benefits of Taking Tylenol for my headache. Tylenol is safe, inexpensive, and does not require a physicians prescription. Additionally, it is available almost everywhere and therefor is convenient.
Side effects:   There were no treatment side effects from me taking Tylenol for my headache.
Comments:   There are no deatails to report. My headache was gone within 30 minutes.

 

Tylenol review by 21 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Headache
Dosage & duration:   2 pills taken 2-3 times per month for the period of 4 months
Other conditions:   Allergies
Other drugs taken:   Loratadine
  
Reported Results
Benefits:   Actually symptoms dissapeared almost within 15-20 min after taking medication, making it easy to continue with your normal day activities, even if that includes gym or an outdoor activity.
Side effects:   Sometimes I felt nausea, except that, there was no other significant side effect.
Comments:   Two pills everytime I had headache, avoiding to take more than 4 pills in one day.

 

Tylenol review by 42 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   pain
Dosage & duration:   250 mg. taken 2 every 4 hours for the period of 3 doses
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Little if any relief from headache.
Side effects:   Patient experienced severe nausea accompanied by moderate lower right abdominal pain.
Comments:   Patient experienced severe headache accompanied by sensitivity to light. Packing information claimed relief of headache as a suggested usage. Patient purchased in reliance on packaging information. After administration of the prescribed dosage over a period of twelve hours, little or no relief was noticed.

See all reviews / ratings >>

Page last updated: 2009-11-04

-- advertisement -- The American Red Cross
We comply with
HONcode standard.
Verify here.
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2009