Drugs with thyroid hormone activity, alone or together with other therapeutic agents, have been used for the treatment of obesity. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.
Triostat (liothyronine sodium injection) (T3) contains liothyronine (L-triiodothyronine or L-T3), a synthetic form of a natural thyroid hormone, as the sodium salt.
Triostat (liothyronine sodium injection) (T3) is indicated in the treatment of myxedema coma/precoma.
Triostat can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.
Published Studies Related to Triostat (Liothyronine)
Metabolic effects of liothyronine therapy in hypothyroidism: a randomized,
double-blind, crossover trial of liothyronine versus levothyroxine. 
CONCLUSIONS: The substitution of L-T(3) for L-T(4) at equivalent doses (relative
The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. [2010.05]
CONTEXT: The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4... CONCLUSIONS: This is the first study addressing the equivalency between L-T3 and L-T4 therapy measured by baseline and TRH-stimulated TSH. The therapeutic substitution of L-T3 for L-T4 was achieved at approximately 1:3 ratio.
The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized,
double blind, cross-over study in thyroidectomized patients. 
Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4... CONCLUSIONS: This is the first study addressing the equivalency between L-T3 and
Efficacy of combined levothyroxine and liothyronine as compared with levothyroxine monotherapy in primary hypothyroidism: a randomized controlled trial. 
OBJECTIVES: To examine the efficacy of combination therapy with levothyroxine and liothyronine in improvement of general health, psychological problems, and metabolic status in primary hypothyroidism... CONCLUSIONS: The data do not support the hypothesis that combined therapy improves the well-being and general health of patients.
Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. [2007.06]
BACKGROUND: Antidepressant treatments that achieve a higher remission rate than those currently available are urgently needed. The thyroid hormone triiodothyronine may potentiate antidepressant effects. OBJECTIVE: To determine the antidepressant efficacy and safety of liothyronine sodium (triiodothyronine) when administered concurrently with the selective serotonin reuptake inhibitor sertraline hydrochloride to patients with major depressive disorder... CONCLUSIONS: These results demonstrate enhancement of the antidepressant effect of sertraline by concurrent treatment with liothyronine without a significant increase in adverse effects. The antidepressant effect of liothyronine may be directly linked to thyroid function.
Clinical Trials Related to Triostat (Liothyronine)
Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) [Completed]
Purpose: The purpose of the study is to examine if treatment with liothyronine increases
left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.
Can Oral T3 Normalize Thyroid Hormone Levels Following Cardiopulmonary Bypass in Children? [Completed]
Low triiodothyronine (T3) syndrome defines as decrease of T3 levels during critically ill.
This decrease of T3 levels was observed after congenital heart surgery using cardiopulmonary
bypass. Previous largest study,Triiodothyronine for Infants and Children Undergoing
Cardiopulmonary bypass (TRICC) study showed T3 supplementation decreased time to extubation
for infants less than 5 months undergoing cardiopulmonary bypass. Intravenous regiment was
known effective in maintaining T3 levels during pediatric cardiac surgery. This drug
preparation however is not commonly used in many countries due to the relatively high costs
and/or the simple lack of availability. The use of oral T3 to treat postoperative low T3
levels in pediatric patients has not been reported so far, although recent adult studies
showed benefit in using oral T3 after cardiac surgery. The purpose of this study was to
determine if oral T3 supplementation could prevent the decline of serum T3 in children less
than 2 years of age undergoing congenital heart surgery using CPB.
Combined Levothyroxine/Liothyronine Supplementation in Hypothyroid Patients With Brain Tumors [Terminated]
1. Assess whether combined treatment with Levothyroxine and Liothyronine improves learning
2. Explore the relationship between T3 treatment and other domains of cognitive function,
quality of life, and mood.
Evaluation of Integration Success and Crestal Bone Preservation Biomet 3i's T3 Implant System [Active, not recruiting]
This study evaluates the T3 implant system for the preservation of alveolar crestal bone and
the establishment of initial integration. The new surface-treated features of the implant
may contribute to improved soft and hard tissue healing. The success rate of the T3 implant
will be no different than that of the control implant, which possess similar geometry but
different surface treatments.
Liothyronine (T3) for Bipolar Depression [Completed]
This study evaluates the efficacy of the thyroid hormone T3 for depression in patients with
bipolar disorder. In this study patients will be randomized to receive T3 or placebo.