Published Studies Related to Triostat (Liothyronine)
Metabolic effects of liothyronine therapy in hypothyroidism: a randomized,
double-blind, crossover trial of liothyronine versus levothyroxine. 
CONCLUSIONS: The substitution of L-T(3) for L-T(4) at equivalent doses (relative
The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized, double blind, cross-over study in thyroidectomized patients. [2010.05]
CONTEXT: The substitution of liothyronine (L-T3) for levothyroxine (L-T4) is commonly employed during thyroid hormone (TH) withdrawal in preparation for diagnostic and therapeutic interventions on thyroid cancer patients. Presently, only limited data are available on the L-T3 for L-T4 therapeutic substitution. Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4... CONCLUSIONS: This is the first study addressing the equivalency between L-T3 and L-T4 therapy measured by baseline and TRH-stimulated TSH. The therapeutic substitution of L-T3 for L-T4 was achieved at approximately 1:3 ratio.
The pharmacodynamic equivalence of levothyroxine and liothyronine: a randomized,
double blind, cross-over study in thyroidectomized patients. 
Objective To characterize the pharmcodynamic equivalence of L-T3 and L-T4... CONCLUSIONS: This is the first study addressing the equivalency between L-T3 and
Efficacy of combined levothyroxine and liothyronine as compared with levothyroxine monotherapy in primary hypothyroidism: a randomized controlled trial. 
OBJECTIVES: To examine the efficacy of combination therapy with levothyroxine and liothyronine in improvement of general health, psychological problems, and metabolic status in primary hypothyroidism... CONCLUSIONS: The data do not support the hypothesis that combined therapy improves the well-being and general health of patients.
Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. [2007.06]
BACKGROUND: Antidepressant treatments that achieve a higher remission rate than those currently available are urgently needed. The thyroid hormone triiodothyronine may potentiate antidepressant effects. OBJECTIVE: To determine the antidepressant efficacy and safety of liothyronine sodium (triiodothyronine) when administered concurrently with the selective serotonin reuptake inhibitor sertraline hydrochloride to patients with major depressive disorder... CONCLUSIONS: These results demonstrate enhancement of the antidepressant effect of sertraline by concurrent treatment with liothyronine without a significant increase in adverse effects. The antidepressant effect of liothyronine may be directly linked to thyroid function.
Clinical Trials Related to Triostat (Liothyronine)
Liothyronine (T3) for Bipolar Depression [Recruiting]
This study evaluates the efficacy of the thyroid hormone T3 for depression in patients with
bipolar disorder. In this study patients will be randomized to receive T3 or placebo.
Liothyronine and Heart Failure. The Long Term Effect of Liothyronine on Left Ventricular Ejection Fraction (LVEF) [Recruiting]
Purpose: The purpose of the study is to examine if treatment with liothyronine increases
left ventricular ejection fraction (LVEF) in patients with stable, chronic heart failure.
Acceleration and Relapse Prevention With Triiodothyronine (T3) as an Adjunct to Electroconvulsive Therapy (ECT) [Recruiting]
The purpose of this study is:
- To evaluate liothyronine (Cytomel) as an accelerating agent (i. e. faster rate to
clinical remission) to electroconvulsive therapy.
- To evaluate whether thyroid supplement acceleration can reduce the neurocognitive side
effect of ECT treatment.
- To evaluate whether thyroid status at the time of remission is associated with
subsequent relapse rate.
- To evaluate genetic polymorphisms in enzymes responsible for thyroid metabolism and the
serotonin transporter promoter gene in depression (5-HTTLRP).
Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response. [Recruiting]
In this project we aim to further refine indications for the use of the thyroid hormone - T3
for patients suffering from depression. We aim to identify a sub-group of patients who are
more likely to respond to T3 and establish the time in the treatment course when T3 should
be added. The results of this project could have significant, direct clinical implications.
Study of Triostat in Infants During Heart Surgery [Recruiting]
This is a study to determine the safety and efficacy of liothyronine sodium/triiodothyronine
(Triostat), a synthetic thyroid hormone, when given to infants with congenital heart disease
during cardiopulmonary bypass surgery.