Triostat (Liothyronine Sodium Injection) - Summary

TRIOSTAT SUMMARY

Triostat (liothyronine sodium injection) (T₃) contains liothyronine (L-triiodothyronine or L-T₃), a synthetic form of a natural thyroid hormone, as the sodium salt.

Triostat (liothyronine sodium injection) (T₃) is indicated in the treatment of myxedema coma/precoma.

Triostat can be used in patients allergic to desiccated thyroid or thyroid extract derived from pork or beef.

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NEWS HIGHLIGHTS

Media Articles Related to Triostat (Liothyronine)

Myxedema Coma
Source: MedicineNet Hypothyroidism Specialty [2009.07.13]
Title: Myxedema Coma
Category: Diseases and Conditions
Created: 2/11/2002 1:54:00 PM
Last Editorial Review: 7/13/2009

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Published Studies Related to Triostat (Liothyronine)

Efficacy of combined levothyroxine and liothyronine as compared with levothyroxine monotherapy in primary hypothyroidism: a randomized controlled trial. [2009]
OBJECTIVES: To examine the efficacy of combination therapy with levothyroxine and liothyronine in improvement of general health, psychological problems, and metabolic status in primary hypothyroidism... CONCLUSIONS: The data do not support the hypothesis that combined therapy improves the well-being and general health of patients.

Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. [2007.06]
BACKGROUND: Antidepressant treatments that achieve a higher remission rate than those currently available are urgently needed. The thyroid hormone triiodothyronine may potentiate antidepressant effects. OBJECTIVE: To determine the antidepressant efficacy and safety of liothyronine sodium (triiodothyronine) when administered concurrently with the selective serotonin reuptake inhibitor sertraline hydrochloride to patients with major depressive disorder... CONCLUSIONS: These results demonstrate enhancement of the antidepressant effect of sertraline by concurrent treatment with liothyronine without a significant increase in adverse effects. The antidepressant effect of liothyronine may be directly linked to thyroid function.

Comparative bioavailability of different formulations of levothyroxine and liothyronine in healthy volunteers. [2006.12]
OBJECTIVE: To evaluate the relative bioavailability of T4 sodium and liothyronine sodium (T3), administered in single doses as oral solution (drops) and tablet forms, according to two separate study protocols... CONCLUSIONS: The bioavailability of the two oral solutions (T4-Ibsa and T3-Ibsa oral solutions) and the corresponding tablet forms (Eutirox 100 and Ti-tre tablets) were confirmed and they can be considered bioequivalent and therapeutically interchangeable.

Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. [2005.07]
OBJECTIVE: To attempt to confirm a previous report of superior effectiveness of using two thyroid hormones rather than one hormone to treat hypothyroidism... CONCLUSION: With regard to the outcomes measured, substitution of LT(3) at a 1:5 ratio for a portion of baseline LT(4) yielded no better results than did treatment with the original dose of LT(4) alone.

Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. [2005.05]
Controversy remains about the value of combined treatment with levothyroxine (LT4) and liothyronine (LT3), compared with LT4 alone in primary hypothyroidism. We compared combined treatment with LT4 and LT3 in a ratio of 5:1 or 10:1 with LT4 monotherapy... Decrease in body weight was associated with satisfaction with study medication.

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Clinical Trials Related to Triostat (Liothyronine)

Triiodothyronine (T3) Supplementation in the Treatment of Bipolar and Unipolar Depression. [Completed]
The purpose of this project is to determine whether concurrent treatment of patients with major depression (unipolar or bipolar) with triiodothyronine (T3) and sertraline, will lead to a stronger and/or more rapid antidepressant effect than treatment with sertraline alone.

Effect of T4-T3 Combination Therapy Versus T4 Monotherapy in Patients With Hypothyroidism [Completed]
To compare the effect of T4-T3 combination therapy versus T4 monotherapy in patients with autoimmune hypothyroidism, on stable T4-substitution therapy

Liothyronine (T3) for Bipolar Depression [Recruiting]
This study evaluates the efficacy of the thyroid hormone T3 for depression in patients with bipolar disorder. In this study patients will be randomized to receive T3 or placebo.

Study of T3 on the Incidence of Atrial Fibrillation in Patients Undergoing Cardiac Surgery [Completed]
The purpose of this project is to see whether treatment with a thyroid hormone, called triiodothyronine or T3, following open heart surgery reduces the risk of developing atrial fibrillation.

Augmentation of the Antidepressant Action of Sertraline With Triiodothyronine (T3)and Reboxetine: Clinical Efficacy, Adverse Effects and Predictors of Response. [Not yet recruiting]

In this project we aim to further refine indications for the use of the thyroid hormone - T3

for patients suffering from depression. We aim to identify a sub-group of patients who are more likely to respond to T3 and establish the time in the treatment course when T3 should be added. The results of this project could have significant, direct clinical implications.

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