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Trimethoprim (Trimethoprim) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

The adverse effects encountered most often with trimethoprim were rash and pruritus.

Dermatologic

Rash, pruritus, and phototoxic skin eruptions. At the recommended dosage regimens of 100 mg b.i.d. or 200 mg q.d. each for 10 days, the incidence of rash is 2.9% to 6.7%. In clinical studies which employed high doses of trimethoprim, an elevated incidence of rash was noted. These rashes were maculopapular, morbilliform, pruritic, and generally mild to moderate, appearing 7 to 14 days after the initiation of therapy.

Hypersensitivity

Rare reports of exfoliative dermatitis, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell Syndrome), and anaphylaxis have been received.

Gastrointestinal

Epigastric distress, nausea, vomiting, and glossitis. Elevation of serum transaminase and bilirubin has been noted, but the significance of this finding is unknown. Cholestatic jaundice has been rarely reported.

Hematologic

Thrombocytopenia, leukopenia, neutropenia, megaloblastic anemia, and methemoglobinemia.

Metabolic

Hyperkalemia, hyponatremia.

Neurologic

Aseptic meningitis has been rarely reported.

Miscellaneous

Fever, and increases in BUN and serum creatinine levels.



REPORTS OF SUSPECTED TRIMETHOPRIM SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Trimethoprim. The information is not vetted and should not be considered as verified clinical evidence.

Possible Trimethoprim side effects / adverse reactions in 24 year old female

Reported by a pharmacist from United Kingdom on 2011-10-03

Patient: 24 year old female weighing 44.5 kg (97.8 pounds)

Reactions: Tremor

Adverse event resulted in: disablity

Suspect drug(s):
Trimethoprim



Possible Trimethoprim side effects / adverse reactions in 34 year old female

Reported by a physician from Japan on 2011-10-03

Patient: 34 year old female

Reactions: Malaise, Cataract, Retinal Detachment, Restlessness

Suspect drug(s):
Solu-Medrol
    Dosage: 1000 mg, unk
    Indication: Vogt-Koyanagi-Harada Syndrome

Depo-Medrol
    Dosage: 20 mg, unk
    Indication: Vogt-Koyanagi-Harada Syndrome

Trimethoprim
    Dosage: 20 mg, unk
    Indication: Vogt-Koyanagi-Harada Syndrome



Possible Trimethoprim side effects / adverse reactions in 34 year old female

Reported by a physician from Japan on 2011-10-10

Patient: 34 year old female

Reactions: Cataract, Retinal Detachment

Suspect drug(s):
Depo-Medrol
    Dosage: 20 mg, unk
    Indication: Vogt-Koyanagi-Harada Syndrome

Trimethoprim
    Dosage: 20 mg, unk
    Indication: Vogt-Koyanagi-Harada Syndrome

Solu-Medrol
    Dosage: 1000 mg, unk
    Indication: Vogt-Koyanagi-Harada Syndrome



See index of all Trimethoprim side effect reports >>

Drug label data at the top of this Page last updated: 2012-05-25

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