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Trimethoprim (Trimethoprim) - Summary



Trimethoprim is a synthetic antibacterial available as 100 mg tablets for oral administration. Trimethoprim is 2,4-Diamino-5-(3,4,5-trimethoxybenzyl) pyrimidine. It is a white to cream colored, odorless, bitter compound.

TRIMETHOPRIM is indicated for the following:

For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichiacoli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species and coagulase-negative Staphylococcus species, including S. saprophyticus.

Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests.

See all Trimethoprim indications & dosage >>


Media Articles Related to Trimethoprim

Finafloxacin for the treatment of urinary tract infections: results of a Phase 2 clinical study
Source: Urology / Nephrology News From Medical News Today [2015.09.21]
Results from a double-blind phase 2 clinical study show that finafloxacin was a more effective and safe option than ciprofloxacin for the treatment of complicated urinary tract infections and acute...

Positive Phase III results demonstrate efficacy of AVYCAZ in complicated urinary tract infections
Source: Urology / Nephrology News From Medical News Today [2015.09.03]
Allergan plc. has announced positive topline results from RECAPTURE 1 and 2, the pivotal Phase III studies evaluating the antibiotic AVYCAZ™ (ceftazidime-avibactam) as a treatment for adult...

Urinary Tract Infections (UTIs)
Source: MedicineNet Bedwetting Specialty [2015.02.09]
Title: Urinary Tract Infections (UTIs)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/9/2015 12:00:00 AM

Urinary Tract Infections in Children
Source: MedicineNet Bedwetting Specialty [2015.02.05]
Title: Urinary Tract Infections in Children
Category: Diseases and Conditions
Created: 2/1/2010 12:00:00 AM
Last Editorial Review: 2/5/2015 12:00:00 AM

Urinary Tract Infection (UTI) Symptoms
Source: MedicineNet Urine Infection Specialty [2014.12.01]
Title: Urinary Tract Infection (UTI) Symptoms
Category: Doctor's Views
Created: 12/2/2008 12:00:00 AM
Last Editorial Review: 12/1/2014 12:00:00 AM

more news >>

Published Studies Related to Trimethoprim

Clindamycin versus trimethoprim-sulfamethoxazole for uncomplicated skin infections. [2015]
community-acquired methicillin-resistant Staphylococcus aureus (MRSA) is unclear... CONCLUSIONS: We found no significant difference between clindamycin and TMP-SMX,

Itraconazole vs. trimethoprim-sulfamethoxazole: A comparative cohort study of 200 patients with paracoccidioidomycosis. [2014]
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Brazil accounts for approximately 80% of cases, where it represents a major public health issue due to its disabling impact and the number of premature deaths it causes... Although the results of this study show that itraconazole was the best treatment option for PCM patients, a double-blind, randomized, controlled trial is necessary to confirm this conclusion.

Short- and long-term cure rates of short-duration trimethoprim-sulfamethoxazole treatment in female dogs with uncomplicated bacterial cystitis. [2014]
BACKGROUND: Long-duration beta-lactam antibiotics are used for empirical treatment in female dogs with uncomplicated bacterial cystitis. However, women with bacterial cystitis are treated with short-duration potentiated sulfonamides because longer courses of beta-lactams result in lower cure and higher recurrence rates...

Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal. [2011.07.08]
BACKGROUND: The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom(R), Odypharm Ltd), which involves treatment over two days, appears to be a good alternative, particularly in malaria-endemic areas. This study intends to compare the efficacy and tolerability of the combination dihydroartemisinin-piperaquine phosphate-trimethoprim (DPT) versus artemether-lumefantrine (AL) in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal... CONCLUSION: The overall efficacy and tolerability of DPT are similar to those of AL. The ease of taking DPT and its short treatment course (two days) may help to improve adherence to treatment. Taken together, these findings make this medicinal product a treatment of choice for the effective management of malaria in Africa.

Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. [2010.09]
STUDY OBJECTIVE: Community-associated methicillin-resistant Staphylococcus aureus is now the leading cause of uncomplicated skin abscesses in the United States, and the role of antibiotics is controversial. We evaluate whether trimethoprim-sulfamethoxazole reduces the rate of treatment failures during the 7 days after incision and drainage and whether it reduces new lesion formation within 30 days... CONCLUSION: After the incision and drainage of uncomplicated abscesses in adults, treatment with trimethoprim-sulfamethoxazole does not reduce treatment failure but may decrease the formation of subsequent lesions. Copyright (c) 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

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Clinical Trials Related to Trimethoprim

Drug-drug Interaction Study of GSK1278863 With Pioglitazone, Rosuvastatin and Trimethoprim in Healthy Adult Volunteers [Completed]
This study will be a two-part with an open-label, single oral dose, two-way crossover study design. Part A and Part B of the study are independent and may be conducted in parallel. The Part A of the study will assess the effect of an oral dose of GSK1278863 on the pharmacokinetics of a CYP2C8 (pioglitazone) and OATP1B1 (rosuvastatin) probe substrate in order to determine the potential for clinically-significant drug interactions with CYP2C8 and OATP1B1 substrates. The Part B of the study will assess the effect of a weak CYP2C8 inhibitor (trimethoprim) on the pharmacokinetics of GSK1278863 and its six predominant metabolites. Part A will be conducted in approximately 30 healthy subjects, having a randomized study design. There will be approximate 7-day washout period between each dosing period. Part B will be conducted in approximately 20 healthy subjects, having single sequence study design. Follow up will be conducted within 7 to 10 days after the last dose in both Part A and B. The total duration of a subject's involvement in the part A of the study will be approximately 8 weeks (Screening to Follow-up) and in part B will be approximately 7 weeks (Screening to Follow-up).

Study of Trimethoprim/Sulfamethoxazole as PCP Prophylaxis in CTD Patients [Recruiting]
Evaluation the efficacy and safety profile of trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia (PCP) prophylaxis in Patients With Connective Tissue Diseases (CTD) treated with high-dose glucocorticoids and immunosuppressive agents. Open-labeled, randomized, prospective single-center clinical trial. Observation period of 12 weeks.

Vancomycin Or Trimethoprim/Sulfamethoxazole for Methicillin-resistant Staphylococcus Aureus (MRSA) Osteomyelitis (VOTSMO) [Active, not recruiting]

The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa [Completed]
The purpose of this study is to assess the efficacy of trimethoprim in promoting wound healing and decreasing blister formation in patients with Epidermolysis Bullosa.

Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations [Completed]
This study will find how weight affects the dosing of a drug called sulfamethoxazole and trimethoprim. Currently, the amount of sulfamethoxazole and trimethoprim a patient receives is the same regardless of the patient's weight. All sulfamethoxazole and trimethoprim (Trade name is Bactrim or Septra) medication that you will receive in this study will be referred to as study medication within this informed consent form. This drug is a combination of two antibiotics, sulfamethoxazole and trimethoprim, which belongs to a class of medication known as "sulfones" and is approved by the US Food and Drug Administration (FDA) for the treatment of a wide variety of bacterial infections such as ear infections, urinary tract infections, bronchitis, traveler's diarrhea, and Pneumocystis carinii pneumonia. Sulfamethoxazole and trimethoprim is given orally.

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Reports of Suspected Trimethoprim Side Effects

Pyrexia (52)Malaise (51)Diabetes Mellitus (47)Cardiac Murmur (47)Urinary Tract Infection (47)Sinus Tachycardia (47)Body Mass Index Decreased (46)Constipation (46)Abdominal Tenderness (46)White Blood Cell Count Increased (46)more >>


Based on a total of 2 ratings/reviews, Trimethoprim has an overall score of 8. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Trimethoprim review by care giver of 5 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   bladder infections
Dosage & duration:   1x5ml spoon morning and evening (dosage frequency: 2x daily) for the period of 1 year
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   The drug was to prevent further infections which were starting to scar the kidneys. After taking the drug my daughter did not have any more infections. it was a low level dose and did not seem to affect her in any way e.g causing digestive problems.
Side effects:   There were none
Comments:   I 5ml spoon was to be taken in the morning and evening


Trimethoprim review by 30 year old female patient

Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   Cystitis
Dosage & duration:   200mg taken once a year for the period of For emergency use
Other conditions:   none
Other drugs taken:   combi pill
Reported Results
Benefits:   To stop the infection of cystitis and other urine infections when it became too painful.It makes the passing of water less painful and reduces the passing of bloody quicker which can become very painful.
Side effects:   none that I'm aware but it didn't always work when I used it. I'd no if it didn't work within 30 mins it wouldn't work at all. You can build up and immunity quite quickly to this drug which lessens the effectiveness of the drug
Comments:   You take 200mg tablets twice a day for 3 days

See all Trimethoprim reviews / ratings >>

Page last updated: 2015-09-21

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