Trimethoprim (Trimethoprim) - Summary

TRIMETHOPRIM SUMMARY

TRIMETHOPRIM
Tablets USP
Revised: April 2000
Rx Only

Trimethoprim is a synthetic antibacterial available in tablet form for oral administration.

Trimethoprim (trimethoprim) is indicated for the following:

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Trimethoprim Tablets USP and other antibacterial drugs, Trimethoprim Tablets USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus.

Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests.

See all Trimethoprim indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Trimethoprim

Can You Skip Antibiotics for Urinary Tract Infection?
Source: MedicineNet Urine Infection Specialty [2013.06.04]
Title: Can You Skip Antibiotics for Urinary Tract Infection?
Category: Health News
Created: 6/4/2013 10:35:00 AM
Last Editorial Review: 6/4/2013 12:00:00 AM

Could Adaptable Bacteria Cause Repeat Urinary Tract Infections?
Source: MedicineNet E. Coli 0157:H7 Specialty [2013.05.09]
Title: Could Adaptable Bacteria Cause Repeat Urinary Tract Infections?
Category: Health News
Created: 5/8/2013 2:36:00 PM
Last Editorial Review: 5/9/2013 12:00:00 AM

Urinary Tract Infections 29 Times More Likely In Schizophrenia Relapse
Source: Schizophrenia News From Medical News Today [2013.04.05]
Schizophrenia patients experiencing relapse are 29 times more likely than healthy individuals to have a urinary tract infection, researchers report. Urinary tract infections, which can cause painful and frequent urination, are common but patients hospitalized for schizophrenia are even more likely to have a UTI than healthy individuals or even others whose illness is under control, said Dr...

Urinary Tract Infection (UTI In Adults)
Source: MedicineNet Bedwetting Specialty [2013.02.01]
Title: Urinary Tract Infection (UTI In Adults)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/1/2013 12:00:00 AM

Can Cranberries Fight Urinary Tract Infections?
Source: MedicineNet Acupuncture Specialty [2012.09.12]
Title: Can Cranberries Fight Urinary Tract Infections?
Category: Health News
Created: 9/12/2012 11:00:00 AM
Last Editorial Review: 9/12/2012 12:00:00 AM

more news >>

Published Studies Related to Trimethoprim

Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal. [2011.07.08]
BACKGROUND: The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom(R), Odypharm Ltd), which involves treatment over two days, appears to be a good alternative, particularly in malaria-endemic areas. This study intends to compare the efficacy and tolerability of the combination dihydroartemisinin-piperaquine phosphate-trimethoprim (DPT) versus artemether-lumefantrine (AL) in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal... CONCLUSION: The overall efficacy and tolerability of DPT are similar to those of AL. The ease of taking DPT and its short treatment course (two days) may help to improve adherence to treatment. Taken together, these findings make this medicinal product a treatment of choice for the effective management of malaria in Africa.

Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. [2010.09]
STUDY OBJECTIVE: Community-associated methicillin-resistant Staphylococcus aureus is now the leading cause of uncomplicated skin abscesses in the United States, and the role of antibiotics is controversial. We evaluate whether trimethoprim-sulfamethoxazole reduces the rate of treatment failures during the 7 days after incision and drainage and whether it reduces new lesion formation within 30 days... CONCLUSION: After the incision and drainage of uncomplicated abscesses in adults, treatment with trimethoprim-sulfamethoxazole does not reduce treatment failure but may decrease the formation of subsequent lesions. Copyright (c) 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

Standard versus newer antibacterial agents in the treatment of severe acute exacerbation of chronic obstructive pulmonary disease: a randomized trial of trimethoprim-sulfamethoxazole versus ciprofloxacin. [2010.07.15]
BACKGROUND. Although the use of antibiotics in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) is largely accepted, controversy remains regarding whether the choice of antibiotic has any impact on outcome.

Trimethoprim as adjuvant treatment in schizophrenia: a double-blind, randomized, placebo-controlled clinical trial. [2010.07]
Various infectious agents, such as Toxoplasma gondii, have been hypothesized to be potentially relevant etiological factors in the onset of some cases of schizophrenia. We conducted a randomized, double-blind, placebo-controlled treatment trial in an attempt to explore the hypothesis that the symptoms of schizophrenia may be related to infection of the central nervous system with toxoplasma gondii...

Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. [2010]
within 30 days... CONCLUSION: After the incision and drainage of uncomplicated abscesses in adults,

more studies >>

Clinical Trials Related to Trimethoprim

A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS [Completed]
To evaluate the effectiveness of two oral treatments for mild to moderate Pneumocystis carinii pneumonia (PCP): dapsone/trimethoprim or clindamycin/primaquine as compared to a standard treatment program of sulfamethoxazole/trimethoprim (SMX/TMP) to assess the tolerance of these two alternative treatments as compared to the standard treatment of SMX/TMP. Per 09/09/92 amendment, to assess the efficacy and tolerance of these two alternative treatments in patients who are intolerant to SMX/TMP.

The type of treatment being studied has the advantages of wide applicability throughout the world (including developing countries) and low cost. An oral treatment is more accessible to patients than drugs given by injection or by inhalation.

The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa [Completed]
The purpose of this study is to assess the efficacy of trimethoprim in promoting wound healing and decreasing blister formation in patients with Epidermolysis Bullosa.

Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations [Recruiting]
This study will find how weight affects the dosing of a drug called sulfamethoxazole and trimethoprim. Currently, the amount of sulfamethoxazole and trimethoprim a patient receives is the same regardless of the patient's weight.

All sulfamethoxazole and trimethoprim (Trade name is Bactrim or Septra) medication that you will receive in this study will be referred to as study medication within this informed consent form. This drug is a combination of two antibiotics, sulfamethoxazole and trimethoprim, which belongs to a class of medication known as "sulfones" and is approved by the US Food and Drug Administration (FDA) for the treatment of a wide variety of bacterial infections such as ear infections, urinary tract infections, bronchitis, traveler's diarrhea, and Pneumocystis carinii pneumonia. Sulfamethoxazole and trimethoprim is given orally.

Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS [Completed]
To compare the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium) with that of conventional therapy (sulfamethoxazole-trimethoprim) in the treatment of moderately severe Pneumocystis carinii pneumonia (PCP) in patients who have AIDS, are HIV positive, or are at high risk for HIV infection. New treatments are needed to reduce the mortality rate from PCP in AIDS patients and to reduce the high relapse rate found after conventional therapy. Trimetrexate (TMTX) was chosen for this trial because it was found to be much more potent than sulfamethoxazole/trimethoprim (SMX/TMP) against the PCP organism in laboratory tests. Also TMTX, in combination with leucovorin (LCV), did not cause severe toxicity in a preliminary trial. It is believed that TMTX will be more effective in treating PCP and in preventing a recurrence of PCP.

Study of Trimethoprim/Sulfamethoxazole as PCP Prophylaxis in CTD Patients [Recruiting]
Evaluation the efficacy and safety profile of trimethoprim/sulfamethoxazole as Pneumocystis carinii pneumonia (PCP) prophylaxis in Patients With Connective Tissue Diseases (CTD) treated with high-dose glucocorticoids and immunosuppressive agents.

Open-labeled, randomized, prospective single-center clinical trial. Observation period of 12 weeks.

more trials >>

Reports of Suspected Trimethoprim Side Effects

Pyrexia (52),  Malaise (51),  Diabetes Mellitus (47),  Cardiac Murmur (47),  Urinary Tract Infection (47),  Sinus Tachycardia (47),  Body Mass Index Decreased (46),  Constipation (46),  Abdominal Tenderness (46),  White Blood Cell Count Increased (46), more >>

PATIENT REVIEWS / RATINGS / COMMENTS

Trimethoprim review by care giver of 5 year old female patient
		Rating
Overall rating:
Effectiveness:		Highly Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		bladder infections
Dosage & duration:		1x5ml spoon morning and evening (dosage frequency: 2x daily) for the period of 1 year
Other conditions:		none
Other drugs taken:		none
		Reported Results
Benefits:		The drug was to prevent further infections which were starting to scar the kidneys. After taking the drug my daughter did not have any more infections. it was a low level dose and did not seem to affect her in any way e.g causing digestive problems.
Side effects:		There were none
Comments:		I 5ml spoon was to be taken in the morning and evening

Trimethoprim review by 30 year old female patient
		Rating
Overall rating:
Effectiveness:		Moderately Effective
Side effects:		No Side Effects
		Treatment Info
Condition / reason:		Cystitis
Dosage & duration:		200mg taken once a year for the period of For emergency use
Other conditions:		none
Other drugs taken:		combi pill
		Reported Results
Benefits:		To stop the infection of cystitis and other urine infections when it became too painful.It makes the passing of water less painful and reduces the passing of bloody quicker which can become very painful.
Side effects:		none that I'm aware but it didn't always work when I used it. I'd no if it didn't work within 30 mins it wouldn't work at all. You can build up and immunity quite quickly to this drug which lessens the effectiveness of the drug
Comments:		You take 200mg tablets twice a day for 3 days