DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Trimethoprim (Trimethoprim) - Summary



Tablets USP
Revised: April 2000
Rx Only

Trimethoprim is a synthetic antibacterial available in tablet form for oral administration.

Trimethoprim (trimethoprim) is indicated for the following:

To reduce the development of drug-resistant bacteria and maintain the effectiveness of Trimethoprim Tablets USP and other antibacterial drugs, Trimethoprim Tablets USP should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the empiric selection of therapy.

For the treatment of initial episodes of uncomplicated urinary tract infections due to susceptible strains of the following organisms: Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Enterobacter species, and coagulase-negative Staphylococcus species, including S. saprophyticus.

Cultures and susceptibility tests should be performed to determine the susceptibility of the bacteria to trimethoprim. Therapy may be initiated prior to obtaining the results of these tests.

See all Trimethoprim indications & dosage >>


Media Articles Related to Trimethoprim

Boosting the body's natural ability to fight urinary tract infections
Source: MRSA / Drug Resistance News From Medical News Today [2015.05.04]
Experimental drug that stabilizes immune defense protein HIF-1alpha protects against major UTI pathogenAbundance of bacteria in the opening of a mouse bladder (center) is significantly reduced...

Urinary Tract Infections (UTIs)
Source: MedicineNet Bedwetting Specialty [2015.02.09]
Title: Urinary Tract Infections (UTIs)
Category: Diseases and Conditions
Created: 12/31/1997 12:00:00 AM
Last Editorial Review: 2/9/2015 12:00:00 AM

Urinary Tract Infections in Children
Source: MedicineNet Bedwetting Specialty [2015.02.05]
Title: Urinary Tract Infections in Children
Category: Diseases and Conditions
Created: 2/1/2010 12:00:00 AM
Last Editorial Review: 2/5/2015 12:00:00 AM

Urinary Tract Infection (UTI) Symptoms
Source: MedicineNet Urine Infection Specialty [2014.12.01]
Title: Urinary Tract Infection (UTI) Symptoms
Category: Doctor's Views
Created: 12/2/2008 12:00:00 AM
Last Editorial Review: 12/1/2014 12:00:00 AM

Urinary Tract Infection (UTI) Symptoms Pictures Slideshow
Source: MedicineNet Urine Infection Specialty [2014.08.19]
Title: Urinary Tract Infection (UTI) Symptoms Pictures Slideshow
Category: Slideshows
Created: 12/4/2008 12:00:00 AM
Last Editorial Review: 8/19/2014 12:00:00 AM

more news >>

Published Studies Related to Trimethoprim

Itraconazole vs. trimethoprim-sulfamethoxazole: A comparative cohort study of 200 patients with paracoccidioidomycosis. [2014]
Paracoccidioidomycosis (PCM) is a systemic mycosis endemic to Latin America. Brazil accounts for approximately 80% of cases, where it represents a major public health issue due to its disabling impact and the number of premature deaths it causes... Although the results of this study show that itraconazole was the best treatment option for PCM patients, a double-blind, randomized, controlled trial is necessary to confirm this conclusion.

Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal. [2011.07.08]
BACKGROUND: The ACT recommended by WHO is very effective and well-tolerated. However, these combinations need to be administered for three days, which may limit adherence to treatment.The combination of dihydroartemisinin-piperaquine phosphate-trimethoprim (Artecom(R), Odypharm Ltd), which involves treatment over two days, appears to be a good alternative, particularly in malaria-endemic areas. This study intends to compare the efficacy and tolerability of the combination dihydroartemisinin-piperaquine phosphate-trimethoprim (DPT) versus artemether-lumefantrine (AL) in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal... CONCLUSION: The overall efficacy and tolerability of DPT are similar to those of AL. The ease of taking DPT and its short treatment course (two days) may help to improve adherence to treatment. Taken together, these findings make this medicinal product a treatment of choice for the effective management of malaria in Africa.

Randomized controlled trial of trimethoprim-sulfamethoxazole for uncomplicated skin abscesses in patients at risk for community-associated methicillin-resistant Staphylococcus aureus infection. [2010.09]
STUDY OBJECTIVE: Community-associated methicillin-resistant Staphylococcus aureus is now the leading cause of uncomplicated skin abscesses in the United States, and the role of antibiotics is controversial. We evaluate whether trimethoprim-sulfamethoxazole reduces the rate of treatment failures during the 7 days after incision and drainage and whether it reduces new lesion formation within 30 days... CONCLUSION: After the incision and drainage of uncomplicated abscesses in adults, treatment with trimethoprim-sulfamethoxazole does not reduce treatment failure but may decrease the formation of subsequent lesions. Copyright (c) 2010 American College of Emergency Physicians. Published by Mosby, Inc. All rights reserved.

Standard versus newer antibacterial agents in the treatment of severe acute exacerbation of chronic obstructive pulmonary disease: a randomized trial of trimethoprim-sulfamethoxazole versus ciprofloxacin. [2010.07.15]
BACKGROUND. Although the use of antibiotics in the treatment of acute exacerbation of chronic obstructive pulmonary disease (COPD) is largely accepted, controversy remains regarding whether the choice of antibiotic has any impact on outcome.

Trimethoprim as adjuvant treatment in schizophrenia: a double-blind, randomized, placebo-controlled clinical trial. [2010.07]
Various infectious agents, such as Toxoplasma gondii, have been hypothesized to be potentially relevant etiological factors in the onset of some cases of schizophrenia. We conducted a randomized, double-blind, placebo-controlled treatment trial in an attempt to explore the hypothesis that the symptoms of schizophrenia may be related to infection of the central nervous system with toxoplasma gondii...

more studies >>

Clinical Trials Related to Trimethoprim

A Phase III Comparative Study of Dapsone / Trimethoprim and Clindamycin / Primaquine Versus Sulfamethoxazole / Trimethoprim in the Treatment of Mild-to-Moderate PCP in Patients With AIDS [Completed]
To evaluate the effectiveness of two oral treatments for mild to moderate Pneumocystis carinii pneumonia (PCP): dapsone/trimethoprim or clindamycin/primaquine as compared to a standard treatment program of sulfamethoxazole/trimethoprim (SMX/TMP) to assess the tolerance of these two alternative treatments as compared to the standard treatment of SMX/TMP. Per 09/09/92 amendment, to assess the efficacy and tolerance of these two alternative treatments in patients who are intolerant to SMX/TMP.

The type of treatment being studied has the advantages of wide applicability throughout the world (including developing countries) and low cost. An oral treatment is more accessible to patients than drugs given by injection or by inhalation.

The Efficacy of Trimethoprim in Wound Healing of Patients With Epidermolysis Bullosa [Completed]
The purpose of this study is to assess the efficacy of trimethoprim in promoting wound healing and decreasing blister formation in patients with Epidermolysis Bullosa.

Effect of Weight and/or Obesity on Sulfamethoxazole and Trimethoprim Concentrations [Recruiting]
This study will find how weight affects the dosing of a drug called sulfamethoxazole and trimethoprim. Currently, the amount of sulfamethoxazole and trimethoprim a patient receives is the same regardless of the patient's weight.

All sulfamethoxazole and trimethoprim (Trade name is Bactrim or Septra) medication that you will receive in this study will be referred to as study medication within this informed consent form. This drug is a combination of two antibiotics, sulfamethoxazole and trimethoprim, which belongs to a class of medication known as "sulfones" and is approved by the US Food and Drug Administration (FDA) for the treatment of a wide variety of bacterial infections such as ear infections, urinary tract infections, bronchitis, traveler's diarrhea, and Pneumocystis carinii pneumonia. Sulfamethoxazole and trimethoprim is given orally.

Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS [Completed]
To compare the safety and effectiveness of an investigational drug therapy (trimetrexate plus leucovorin calcium) with that of conventional therapy (sulfamethoxazole-trimethoprim) in the treatment of moderately severe Pneumocystis carinii pneumonia (PCP) in patients who have AIDS, are HIV positive, or are at high risk for HIV infection. New treatments are needed to reduce the mortality rate from PCP in AIDS patients and to reduce the high relapse rate found after conventional therapy. Trimetrexate (TMTX) was chosen for this trial because it was found to be much more potent than sulfamethoxazole/trimethoprim (SMX/TMP) against the PCP organism in laboratory tests. Also TMTX, in combination with leucovorin (LCV), did not cause severe toxicity in a preliminary trial. It is believed that TMTX will be more effective in treating PCP and in preventing a recurrence of PCP.

A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS [Completed]
Evaluate the effectiveness rate of dapsone plus trimethoprim as a therapy for the first episode of Pneumocystis carinii pneumonia (PCP) in AIDS patients. Compare the rates and

severity of adverse effects using dapsone versus trimethoprim - sulfamethoxazole (TMP /

PurposeX). Establish relative toxicities with regard to suitability for outpatient treatment.

more trials >>

Reports of Suspected Trimethoprim Side Effects

Pyrexia (52)Malaise (51)Diabetes Mellitus (47)Cardiac Murmur (47)Urinary Tract Infection (47)Sinus Tachycardia (47)Body Mass Index Decreased (46)Constipation (46)Abdominal Tenderness (46)White Blood Cell Count Increased (46)more >>


Based on a total of 2 ratings/reviews, Trimethoprim has an overall score of 8. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.

Trimethoprim review by care giver of 5 year old female patient

Overall rating:  
Effectiveness:   Highly Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   bladder infections
Dosage & duration:   1x5ml spoon morning and evening (dosage frequency: 2x daily) for the period of 1 year
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   The drug was to prevent further infections which were starting to scar the kidneys. After taking the drug my daughter did not have any more infections. it was a low level dose and did not seem to affect her in any way e.g causing digestive problems.
Side effects:   There were none
Comments:   I 5ml spoon was to be taken in the morning and evening


Trimethoprim review by 30 year old female patient

Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
Treatment Info
Condition / reason:   Cystitis
Dosage & duration:   200mg taken once a year for the period of For emergency use
Other conditions:   none
Other drugs taken:   combi pill
Reported Results
Benefits:   To stop the infection of cystitis and other urine infections when it became too painful.It makes the passing of water less painful and reduces the passing of bloody quicker which can become very painful.
Side effects:   none that I'm aware but it didn't always work when I used it. I'd no if it didn't work within 30 mins it wouldn't work at all. You can build up and immunity quite quickly to this drug which lessens the effectiveness of the drug
Comments:   You take 200mg tablets twice a day for 3 days

See all Trimethoprim reviews / ratings >>

Page last updated: 2015-05-04

-- advertisement -- The American Red Cross
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2015