Published Studies Related to Trilyte (Polyethylene Glycol 3350)
Reduced cathartic bowel preparation for CT colonography: prospective comparison of 2-L polyethylene glycol and magnesium citrate. [2011.10]
PURPOSE: To prospectively compare adequacy of colonic cleansing, adequacy of solid stool and fluid tagging, and patient acceptance by using reduced-volume, 2-L polyethylene glycol (PEG) versus magnesium citrate bowel preparations for CT colonography... CONCLUSION: Reduced-volume PEG and magnesium citrate bowel preparations demonstrated adequate cleansing effectiveness for CT colonography, with better tagging and shorter interpretation time observed in the PEG group. Adequate polyp detection was maintained but requires further validation because of the small number of clinically important polyps. (c) RSNA, 2011.
Effect of bowel preparation with polyethylene glycol on quality of capsule endoscopy. [2011.06]
BACKGROUND AND AIMS: Capsule endoscopy (CE) has the problem that lumen visualization is impaired by bubbles, bile, and debris. The benefits of bowel preparation are still controversial and the best method remains to be determined. The objective of this study was to evaluate the effect of the method of bowel preparation on the quality of visualization and on transit time... CONCLUSIONS: Bowel preparation with PEG resulted in better image quality than fasting alone. No significant difference was observed between 2 and 4 l. PEG 2 l rather than 4 l may be a useful method of preparation for CE.
Low-volume bowel preparation is inferior to standard 4 1 polyethylene glycol. [2011.03]
BACKGROUND: Four liters or more of orally taken polyethylene glycol solution (PEG) has proved to be an effective large-bowel cleansing method prior to colonoscopy. The problem has been the large volume of fluid and its taste, which is unacceptable to some examinees. We aimed to investigate the effectiveness of 2 l PEG combined with senna compared with 4 l PEG for bowel preparation... CONCLUSIONS: 4 l PEG treatment is better than 36 mg senna and 2 l PEG as routine colonic cleansing before colonoscopy because of fewer failures.
Comparison of the effectiveness of polyethylene glycol 4000 without electrolytes and magnesium hydroxide in the treatment of chronic functional constipation in children. [2011.01]
OBJECTIVE: To compare the effectiveness of two drugs, polyethylene glycol 4000 without electrolytes and magnesium hydroxide, in the treatment of chronic functional constipation in children... CONCLUSION: The two laxatives showed no difference in effectiveness for the treatment of constipation. However, due to its better acceptance, because it is odorless and tasteless, polyethylene glycol proved to be a better option for treating chronic functional constipation.
The effects of polyethylene glycosylated creatine supplementation on muscular strength and power. [2010.12]
The purpose of the present investigation was to examine the effects of 28 days of polyethylene glycosylated creatine (PEG-creatine) supplementation on 1-repetition maximum bench press (1RMBP) and leg extension (1RMLE), mean power (MP), and peak power (PP) from the Wingate Anaerobic test and body weight (BW)...
Clinical Trials Related to Trilyte (Polyethylene Glycol 3350)
Gatorade/Miralax With or Without Bisacodyl Versus NuLytely for Colonoscopy Preparation [Recruiting]
The purpose of this study is to compare Nulytely (or Trilyte) with a Gatorade and Miralax
combination for cleaning out the colon before colonoscopy. A laxative pill called Bisacodyl
may also be used with the Gatorade and Miralax to see if it helps with the clean out
process. We are trying to find out if either of these methods is more acceptable to the
patient and does a better job cleaning out the colon for a colonoscopy.
Safety and Efficacy of OsmoPrep� Tablets Versus HalfLytely� and Bisacodyl Tablet Bowel Prep Kit for Colon Cleansing [Recruiting]
The purpose of this study is to compare the safety and efficacy of OsmoPrep tablets versus
HalfLytely and Bisacodyl Tablet Bowel Prep Kit in subjects who are undergoing colonoscopy.
Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy [Recruiting]
A major limitation to the widespread acceptance of colonoscopy as a procedure to screen for
colorectal cancer is the laxative preparation. Phosphate-based preps (e. g. Fleets
Phosphosoda) are now used on a limited basis because of their known association with renal
injury. Polyethylene glycol (PEG) mixed with a balanced electrolyte solution (e. g. Golytely)
has been used for over two decades for colon cleansing. The mixture is not very palatable
due to the electrolyte additives which include sodium sulfate.
To overcome the limitation of existing preps, gastroenterologists and colorectal surgeons
worldwide have been using PEG powder alone (same quantity as found in Golytely prep) not
mixed with electrolytes (Glycolax or Miralax) and dissolving this into 64 ounces of
Gatorade. Conservatively, we estimate that 25% of colonoscopies in the US are being done
with this prep. Anecdotally there have been reports (case series) that it is far more
palatable and the prep is equally efficacious. The active ingredient, PEG, is not changed
and therefore this is not surprising. The issue at present is that there has never been a
blinded study to confirm these claims.
This study will compare the efficacy of the two preps. There is no funding. The
investigators will charge insurance companies for the prep - this is our current practice.
The procedures will be done on healthy individuals referred for colon cancer screening and
the exam will be billed to their insurance. There will be no patient honorarium. The
investigators will check electrolytes to be sure patients do not develop hypokalemia with
the Gatorade prep.
Efficacy of Lubiprostone in Combination With Standard PEG Preparation [Recruiting]
A large population-based study has shown diabetes to be an independent risk factor for colon
cancer compared to the general population. Thus, the completion of an adequately prepped
colonoscopy is requisite in providing diabetics with adequate colon cancer screening.
Recent data has shown that diabetic patients have poorer response to bowel cleansing
compared to non-diabetics (with a standard PEG prep, only 62% of diabetic patients had their
colonoscopy preps rated as good or better vs. 97% of normal patients, p<0. 001). This may be
due to the fact that a majority of diabetic patients report constipation as a common
We postulate that lubiprostone (Amitiza), in combination with PEG, will have additional
efficacy over standard PEG preparation, and provide optimal safe and effective colonic
cleansing for diabetics.
PillCam� Platform With the PillCam Crohn's Disease Capsule [Recruiting]
This is a prospective, multi-center (up to 6 sites) study which aims to To establish the
effectiveness of the PillCam Platform with the PillCam Crohn's capsule as demonstrated by
visualizing the small bowel and colon in patients with active symptoms associated with
Crohn's disease (CD).