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Trilipix (Choline Fenofibrate) - Drug Interactions, Contraindications, Overdosage, etc



Oral Anticoagulants

Caution should be exercised when oral coumarin anticoagulants are given in conjunction with Trilipix [see WARNINGS AND PRECAUTIONS].

Bile Acid Resins

Since bile acid resins may bind other drugs given concurrently, patients should take Trilipix at least 1 hour before or 4-6 hours after a bile acid resin to avoid impeding its absorption.


Because cyclosporine can produce nephrotoxicity with decreases in creatinine clearance and rises in serum creatinine, and because renal excretion is the primary elimination route of drugs of the fibrate class including Trilipix, there is a risk that an interaction will lead to decline of renal function. The benefits and risks of using Trilipix with immunosuppressants and other potentially nephrotoxic agents should be carefully considered, and the lowest effective dose employed.


There is no specific treatment for overdose with Trilipix. General supportive care of the patient is indicated, including monitoring of vital signs and observation of clinical status, should an overdose occur. If indicated, elimination of unabsorbed drug should be achieved by emesis or gastric lavage; usual precautions should be observed to maintain the airway. Because Trilipix is highly bound to plasma proteins, hemodialysis should not be considered.


Trilipix is contraindicated in:

  • patients with severe renal impairment, including those receiving dialysis.
  • patients with active liver disease, including those with primary biliary cirrhosis and unexplained persistent liver function abnormalities.
  • patients with preexisting gallbladder disease.
  • nursing mothers.
  • patients with hypersensitivity to fenofibric acid, choline fenofibrate or fenofibrate [see WARNINGS and PRECAUTIONS].

When Trilipix is co-administered with a statin, refer to the Contraindications section of the respective statin labeling.

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