NEWS HIGHLIGHTSMedia Articles Related to Trileptal (Oxcarbazepine)
Increased Risk Of Seizures Faced By Current Cigarette Smokers
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2009.11.19]
A recent study determined there is a significant risk of seizure for individuals who currently smoke cigarettes. Boston-based researchers from Brigham and Women's Hospital and Harvard Medical School also found that long-term, moderate intake of caffeine or alcohol does not increase the chance of having a seizure or developing epilepsy.
Improved Understanding Of Why Seizures Occur With Alcohol Withdrawal
Source: Epilepsy News From Medical News Today [2009.10.19]
Epileptic seizures are the most dramatic and prominent aspect of the "alcohol withdrawal syndrome" that occurs when a person abruptly stops a long-term or chronic drinking habit. Researchers have shown that the flow of calcium ions into brain cells via voltage-gated calcium channels plays an important role in the generation of alcohol withdrawal seizures, because blocking this flow suppresses these seizures.
Gene Mutation Linked to Fever-Induced Seizures
Source: MedicineNet Seizure Specialty [2009.09.21]
Title: Gene Mutation Linked to Fever-Induced Seizures
Category: Health News
Created: 9/18/2009 2:10:00 PM
Last Editorial Review: 9/21/2009
Febrile Seizures And Severe Epilepsy In Infants Traced To A Sodium Channel Gene Mutation
Source: Epilepsy News From Medical News Today [2009.09.20]
Mutations in the SCN9A sodium channel gene are a cause of febrile seizures and contribute to a severe form of epilepsy in infants 6 months and younger, report researchers from the University of Utah, University of Antwerp, and University of Washington.
Febrile Seizures
Source: MedicineNet Pediatric Epilepsy Surgery Specialty [2008.05.09]
Title: Febrile Seizures
Category: Diseases and Conditions
Created: 5/9/2008
Last Editorial Review: 5/9/2008
Published Studies Related to Trileptal (Oxcarbazepine)
Comparative efficacy and safety of oxcarbazepine versus divalproex sodium in the treatment of acute mania: a pilot study. [2009.04]
CONCLUSION: Oxcarbazepine demonstrated comparable efficacy to divalproex sodium in the management of acute mania. Also the overall adverse event profile was found to be superior for oxcarbazepine.
Effect of Oxcarbazepine in the Treatment of Agitation and Aggression in Severe Dementia. [2009.02.02]
Background/Aims: To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both. Methods: This is an 8-week, multicenter, randomized, double-blind, placebo-controlled trial carried out independently of the pharmaceutical industry...
Bipolar I and II disorder residual symptoms: Oxcarbazepine and carbamazepine as add-on treatment to lithium in a double-blind, randomized trial. [2009.02.01]
Bipolar affective disorders often require adjunctive therapy to treat persistent symptoms. In order to evaluate bipolar symptoms inadequately responsive to lithium, we have compared the effects of two structurally related compounds carbamazepine (CBZ) and oxcarbazepine (OXC).However, further adequately placebo-controlled trials are needed to expand these findings.
Effect of oxcarbazepine in the treatment of agitation and aggression in severe dementia. [2009]
BACKGROUND/AIMS: To evaluate the efficacy of oxcarbazepine (OXC) in the treatment of agitation and aggression in patients with Alzheimer's disease, vascular dementia or both... CONCLUSION: This study found no significant effect of OXC in treatment of agitation and aggression in patients with dementia. Copyright 2009 S. Karger AG, Basel.
Bioequivalence of oxcarbazepine oral suspension vs. film-coated tablet in healthy Chinese male subjects. [2008.10]
OBJECTIVE: Oxcarbazepine (Trileptal) is an antiepileptic drug used as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and children. The primary objective of this study was to assess the bioequivalence of Trileptal oral suspension formulation vs. the film-coated tablet after single and multiple twice-daily administrations in fasted, healthy Chinese male subjects... CONCLUSIONS: Trileptal oral suspension formulation and film-coated tablets are bioequivalent in healthy Chinese males.
Clinical Trials Related to Trileptal (Oxcarbazepine)
Safety and Efficacy of Oxcarbazepine Monotherapy in Adults With Partial Seizures [Completed]
This study is aimed to evaluate the efficacy, safety and tolerability of oxcarbazepine
monotherapy in adults with partial seizures.
Induction of Drug Metabolism: In Vivo Comparison of Carbamazepine and Oxcarbazepine. [Active, not recruiting]
This is a study of the possible effect of two antiepileptic drug on enzymes in the liver that
metabolizes a number of drugs. It is a well know fact that carbamazepine induces some of
these enzymes and this may reduce the effect of concomitantly administered drugs. Clinical
observations suggest that oxcarbazepine does not induce these enzymes to the same degree.
This study directly compares the ability of these two drugs to induce the cytochrome P450 3A4
enzyme, in healthy volunteers using a well defined biomarker reaction of a specific enzyme
activity.
It is the hypothesis that oxcarbazepine induces CYP3A4 to a lesser degree than
carbamazepine.
Oxcarbazepine as an Adjunct of Antipsychotic Therapy in Acute Schizophrenia [Recruiting]
Over recent years an approach with the adjunctive administration of various anticonvulsant
drugs has been discussed and a limited number of open and controlled studies were performed
for carbamazepine, valproic acid, and lamotrigine. While the latter shows promising effects
in the long run it has some handling difficulties in the acute treatment of acute psychotic
exacerbations. Valproic acid has shown inconsistent effects in schizophrenia with no
significant effects in a recent controlled study. Although still controversially discussed,
carbamazepine was found to offer beneficial effects in the treatment of schizophrenia.
Nonetheless, data on these effects are limited by small sample sizes or poor design of most
of the respective studies. Furthermore, the complex pharmaco-logical interactions of new
atypical neuroleptics with carbamazepine underline the necessity of alternative strategies in
adjuvant treatment of schizophrenia as well as in combined treatment of bipolar disorders
with mood stabilizers and neuroleptics.
Oxcarbazepine (OXC) is a new anticonvulsant drug that acts as a pro-drug for the
10-monohydroxy metabo-lite (MHD), an active metabolite also of carbamazepine that is
suggested to be responsible for most of its therapeutic actions. Therefore, the
pharmacological action of OXC is very well comparable to carbamazepine whilst there are fewer
unwanted side effects of OXC regarding eg. skinrush, and effects on blood compounds or
cardiotropic effects.
The effects of OXC on cytochrome CYP3A4 and CYP3A5 are moderate and UDPGT is only slightly
affected by OXC, which leads to less interaction with other compounds on a pharmacokinetical
level.
In psychiatry, the few studies published until now report positive effects of OXC in bipolar
disorders. With regards to our own clinical observations, OXC has shown potential beneficial
effects as an adjunct in the treatment of schizophrenia as well that require further
evaluation in a controlled study design.
Bioequivalency Study of Oxcarbazepine 600 mg Tablets Under Fed Conditions [Completed]
The objective of this study was to assess bioequivalence of a potential generic 600 mb
oxcarbazepine tablet formulation compared with Novartis Pharmaceutical's 600 mg oxcarbazepine
tablet, Trileptal, following a single 600 mg dose, administered with food.
Bioequivalency Study of 600 mg Oxcarbazepine Tablets Under Fasting Conditions [Completed]
The objective of this study was to assess the bioequivalence of a potential generic 600 mg
oxcarbazepine tablet formulation compared with Novartis Pharmaceutical's 600 mg oxcarbazepine
tablet, Trileptal, following a single 600 mg dose administered under fasting conditions.
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