TRILEPTAL SUMMARY
Trileptal is an antiepileptic drug available as 150 mg, 300 mg and 600 mg film-coated tablets for oral administration. Trileptal is also available as a 300 mg/5 mL (60Â mg/mL) oral suspension.
Trileptal is indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and as monotherapy in the treatment of partial seizures in children aged 4 years and above with epilepsy, and as adjunctive therapy in children aged 2 years and above with partial seizures.Â
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NEWS HIGHLIGHTSMedia Articles Related to Trileptal (Oxcarbazepine)
Epilepsy & Seizures Quiz: What Causes Seizures? Source: MedicineNet Seizure Specialty [2017.09.19] Title: Epilepsy & Seizures Quiz: What Causes Seizures? Category: MedicineNet Quiz Created: 2/17/2011 12:00:00 AM Last Editorial Review: 9/19/2017 5:25:51 PM
Febrile Seizures Source: MedicineNet benazepril and hydrochlorothiazide Specialty [2016.09.13] Title: Febrile Seizures Category: Diseases and Conditions Created: 5/9/2008 12:00:00 AM Last Editorial Review: 9/13/2016 12:00:00 AM
Antidepressants Linked to First-Time Seizures Source: MedicineNet mirtazapine Specialty [2015.04.09] Title: Antidepressants Linked to First-Time Seizures Category: Health News Created: 4/9/2015 12:00:00 AM Last Editorial Review: 4/9/2015 12:00:00 AM
Published Studies Related to Trileptal (Oxcarbazepine)
Oxcarbazepine for neuropathic pain. [2013] CONCLUSIONS: On the basis of moderate quality evidence from one trial in
Pharmacokinetics of the monohydroxy derivative of oxcarbazepine and its enantiomers after a single intravenous dose given as racemate compared with a single oral dose of oxcarbazepine. [2011.06] Oxcarbazepine (OXC) is an antiepileptic drug...
Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers. [2010.08] The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported...
[Efficacy and safety of the monotherapy with trileptal (oxcarbazepine) in children and adolescents.] [2010] A prospective non-randomized non-controlled multicenter trial has been conducted. The trial included 254 children, aged from 11 months to 18 years (mean age 9,3+/-4,5 years), with predominantly focal forms of epilepsy treated with trileptal (oxcarbazepine)... In conclusion, trileptal as the monotherapy is effective and well-tolerated in the treatment of focal epilepsies in the age groups studied.
Comparative efficacy and safety of oxcarbazepine versus divalproex sodium in the treatment of acute mania: a pilot study. [2009.04] CONCLUSION: Oxcarbazepine demonstrated comparable efficacy to divalproex sodium in the management of acute mania. Also the overall adverse event profile was found to be superior for oxcarbazepine.
Clinical Trials Related to Trileptal (Oxcarbazepine)
Oxcarbazepine 600 mg Tablets Under Non-Fasting Conditions [Completed]
Tolerability and Pharmacokinetics of a Single 900 mg Oral Dose of BIA 2-093 and Oxcarbazepine in Healthy Volunteers [Completed]
Oxcarbazepine 600 mg Tablets Under Fasting Conditions [Completed]
The objective of this study is to evaluate the comparative bioavailability between
Oxcarbazepine 600 mg Tablets (test) and Trileptal® 600 mg Tablets (reference) after a
single-dose in healthy subjects under fasting conditions.
Protective Role of Oxcarbazepine in Multiple Sclerosis [Recruiting]
People with multiple sclerosis (MS) have nerve loss even without acute inflammatory
relapses, as obvious in the progressive phase of disease. Drugs that may prevent nerve loss
work better in earlier stages when it is difficult to measure progressive disability. But it
is now possible to measure the nerve loss as neurofilament light (NFL) in the cerebrospinal
fluid (CSF). This is a trial of a neuroprotective drug, oxcarbazepine, which showed benefit
in an animal model of multiple sclerosis. The investigators will use an innovative outcome,
a reduction in the content of NFL in the CSF, as well as the usual clinical disability and
imaging methods, to measure the success of the oxcarbazepine as a neuroprotective agent in
MS. The use of NFL, a surrogate marker of neurodegeneration, allows a blinded and accurate
outcome.
Oxcarbazepine for the Treatment of Chronic Peripheral Neuropathic Pain [Completed]
The purpose of this trial is to determine if the effect of oxcarbazepine on chronic
peripheral nerve pain depends on the supposed mechanism of the pain, ie. if oxcarbazepine
mainly relieve pain in patients with irritable nerves.
Reports of Suspected Trileptal (Oxcarbazepine) Side Effects
Convulsion (88),
Headache (37),
Somnolence (35),
Malaise (33),
Nausea (31),
Dizziness (30),
Feeling Abnormal (27),
Hyponatraemia (26),
Vomiting (22),
Pyrexia (21), more >>
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 2 ratings/reviews, Trileptal has an overall score of 7.50. The effectiveness score is 7 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst.
| Trileptal review by 57 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Considerably Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | epilepsy |
Dosage & duration: | | 300 mg taken 4 times a day for the period of 1 year, so far |
Other conditions: | | none |
Other drugs taken: | | vitamins, tryptanol | | Reported Results |
Benefits: | | Controlled complex partial seizures. |
Side effects: | | Dizziness, fatigue, nausea |
Comments: | | Started at 2 doses of 300 mg a day and worked up to 4 doses per day over a six month period. Only at 1200 mg a day did the drug control the seizures. During each time when I increased the dosage, I founf the side-effects worsened, but after a week or so, the side effects minimized and then disappeared. |
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| Trileptal review by care giver of 50 year old male patient | | Rating |
Overall rating: | | |
Effectiveness: | | Moderately Effective |
Side effects: | | Moderate Side Effects | | Treatment Info |
Condition / reason: | | Tri Geminal Neuralgia |
Dosage & duration: | | 150 mg taken 2 x a day for the period of 2 years |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | Stop pain of nerve spasms, without the drug, the tri geminal neuralgia pain is considered one of the most painful of all medical conditions. With this medicine the patient has been able to avoid the risks of neuro surgury and still control the pain. |
Side effects: | | Headaches occasionally. |
Comments: | | Took 150 mg or 1 tablet 2 times a day |
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Page last updated: 2017-09-19
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