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Trileptal (Oxcarbazepine) - Summary

 
 



TRILEPTAL SUMMARY

Trileptal® (oxcarbazepine) is an antiepileptic drug available as 150 mg, 300 mg and 600 mg film-coated tablets for oral administration. Trileptal is also available as a 300 mg/5 mL (60 mg/mL) oral suspension.

Trileptal® (oxcarbazepine) is indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and children ages 4-16 with epilepsy.


See all Trileptal indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Trileptal (Oxcarbazepine)

Primary data from Phase 3 study evaluating brivaracetam as adjunctive treatment of partial-onset seizures in epilepsy announced
Source: Clinical Trials / Drug Trials News From Medical News Today [2014.12.11]
UCB has announced the primary efficacy and safety data from the latest Phase 3 study evaluating brivaracetam (fixed doses of 100 and 200 mg/day with no up-titration) as adjunctive treatment in...

Investigational medication used to resolve life-threatening seizures in children
Source: Epilepsy News From Medical News Today [2014.11.17]
In its first clinical application in pediatric patients, an investigational medication developed and manufactured at UC Davis has been found to effectively treat children with life-threatening...

Seizures and migraines in the brain linked
Source: Headache / Migraine News From Medical News Today [2014.11.04]
Seizures and migraines have always been considered separate physiological events in the brain, but now a team of engineers and neuroscientists looking at the brain from a physics viewpoint discovered...

New mechanism for febrile seizures in young children discovered
Source: Epilepsy News From Medical News Today [2014.11.03]
Febrile seizures are among the most dreaded complications of infectious diseases in small children.

Low-carb, high-fat diets may reduce epilepsy seizures
Source: Epilepsy News From Medical News Today [2014.10.30]
Scientists find that diets high in fat and low in carbohydrates, such as the ketogenic diet or modified Atkins diet, may reduce seizures in adults with refractory epilepsy.

more news >>

Published Studies Related to Trileptal (Oxcarbazepine)

Oxcarbazepine for neuropathic pain. [2013]
CONCLUSIONS: On the basis of moderate quality evidence from one trial in

Pharmacokinetics of the monohydroxy derivative of oxcarbazepine and its enantiomers after a single intravenous dose given as racemate compared with a single oral dose of oxcarbazepine. [2011.06]
Oxcarbazepine (OXC) is an antiepileptic drug...

Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers. [2010.08]
The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported...

[Efficacy and safety of the monotherapy with trileptal (oxcarbazepine) in children and adolescents.] [2010]
A prospective non-randomized non-controlled multicenter trial has been conducted. The trial included 254 children, aged from 11 months to 18 years (mean age 9,3+/-4,5 years), with predominantly focal forms of epilepsy treated with trileptal (oxcarbazepine)... In conclusion, trileptal as the monotherapy is effective and well-tolerated in the treatment of focal epilepsies in the age groups studied.

Comparative efficacy and safety of oxcarbazepine versus divalproex sodium in the treatment of acute mania: a pilot study. [2009.04]
CONCLUSION: Oxcarbazepine demonstrated comparable efficacy to divalproex sodium in the management of acute mania. Also the overall adverse event profile was found to be superior for oxcarbazepine.

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Clinical Trials Related to Trileptal (Oxcarbazepine)

Oxcarbazepine for the Treatment of Chronic Peripheral Neuropathic Pain [Recruiting]
The purpose of this trial is to determine if the effect of oxcarbazepine on chronic peripheral nerve pain depends on the supposed mechanism of the pain, ie. if oxcarbazepine mainly relieve pain in patients with irritable nerves.

Levetiracetam Versus Oxcarbazepine as Monotherapy to Evaluate Efficacy and Safety in Subject With Partial Epilepsy [Recruiting]
To evaluate the long term effectiveness of Levetiracetam (LEV) monotherapy on Treatment Failure Rate in subjects with newly diagnosed partial onset seizures with or without secondary generalized seizures, compared to Oxcarbazepine (OXC) monotherapy over 50 weeks from the first dose

Safety and Efficacy of Oxcarbazepine Monotherapy in Adults With Partial Seizures [Completed]
This study is aimed to evaluate the efficacy, safety and tolerability of oxcarbazepine monotherapy in adults with partial seizures.

Induction of Drug Metabolism: In Vivo Comparison of Carbamazepine and Oxcarbazepine. [Active, not recruiting]
This is a study of the possible effect of two antiepileptic drug on enzymes in the liver that metabolizes a number of drugs. It is a well know fact that carbamazepine induces some of these enzymes and this may reduce the effect of concomitantly administered drugs. Clinical observations suggest that oxcarbazepine does not induce these enzymes to the same degree.

This study directly compares the ability of these two drugs to induce the cytochrome P450 3A4 enzyme, in healthy volunteers using a well defined biomarker reaction of a specific enzyme activity.

It is the hypothesis that oxcarbazepine induces CYP3A4 to a lesser degree than carbamazepine.

Oxcarbazepine as an Adjunct of Antipsychotic Therapy in Acute Schizophrenia [Recruiting]
Over recent years an approach with the adjunctive administration of various anticonvulsant drugs has been discussed and a limited number of open and controlled studies were performed for carbamazepine, valproic acid, and lamotrigine. While the latter shows promising effects in the long run it has some handling difficulties in the acute treatment of acute psychotic exacerbations. Valproic acid has shown inconsistent effects in schizophrenia with no significant effects in a recent controlled study. Although still controversially discussed, carbamazepine was found to offer beneficial effects in the treatment of schizophrenia. Nonetheless, data on these effects are limited by small sample sizes or poor design of most of the respective studies. Furthermore, the complex pharmaco-logical interactions of new atypical neuroleptics with carbamazepine underline the necessity of alternative strategies in adjuvant treatment of schizophrenia as well as in combined treatment of bipolar disorders with mood stabilizers and neuroleptics.

Oxcarbazepine (OXC) is a new anticonvulsant drug that acts as a pro-drug for the 10-monohydroxy metabo-lite (MHD), an active metabolite also of carbamazepine that is suggested to be responsible for most of its therapeutic actions. Therefore, the pharmacological action of OXC is very well comparable to carbamazepine whilst there are fewer unwanted side effects of OXC regarding eg. skinrush, and effects on blood compounds or cardiotropic effects.

The effects of OXC on cytochrome CYP3A4 and CYP3A5 are moderate and UDPGT is only slightly affected by OXC, which leads to less interaction with other compounds on a pharmacokinetical level.

In psychiatry, the few studies published until now report positive effects of OXC in bipolar disorders. With regards to our own clinical observations, OXC has shown potential beneficial effects as an adjunct in the treatment of schizophrenia as well that require further evaluation in a controlled study design.

more trials >>

Reports of Suspected Trileptal (Oxcarbazepine) Side Effects

Convulsion (88)Headache (37)Somnolence (35)Malaise (33)Nausea (31)Dizziness (30)Feeling Abnormal (27)Hyponatraemia (26)Vomiting (22)Pyrexia (21)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 2 ratings/reviews, Trileptal has an overall score of 7.50. The effectiveness score is 7 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst.
 

Trileptal review by 57 year old male patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   epilepsy
Dosage & duration:   300 mg taken 4 times a day for the period of 1 year, so far
Other conditions:   none
Other drugs taken:   vitamins, tryptanol
  
Reported Results
Benefits:   Controlled complex partial seizures.
Side effects:   Dizziness, fatigue, nausea
Comments:   Started at 2 doses of 300 mg a day and worked up to 4 doses per day over a six month period. Only at 1200 mg a day did the drug control the seizures. During each time when I increased the dosage, I founf the side-effects worsened, but after a week or so, the side effects minimized and then disappeared.

 

Trileptal review by care giver of 50 year old male patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Tri Geminal Neuralgia
Dosage & duration:   150 mg taken 2 x a day for the period of 2 years
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Stop pain of nerve spasms, without the drug, the tri geminal neuralgia pain is considered one of the most painful of all medical conditions. With this medicine the patient has been able to avoid the risks of neuro surgury and still control the pain.
Side effects:   Headaches occasionally.
Comments:   Took 150 mg or 1 tablet 2 times a day

See all Trileptal reviews / ratings >>

Page last updated: 2014-12-11

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