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Trileptal (Oxcarbazepine) - Summary



Trileptal is an antiepileptic drug available as 150 mg, 300 mg and 600 mg film-coated tablets for oral administration. Trileptal is also available as a 300 mg/5 mL (60 mg/mL) oral suspension.

Trileptal is indicated for use as monotherapy or adjunctive therapy in the treatment of partial seizures in adults and as monotherapy in the treatment of partial seizures in children aged 4 years and above with epilepsy, and as adjunctive therapy in children aged 2 years and above with partial seizures. 

See all Trileptal indications & dosage >>


Media Articles Related to Trileptal (Oxcarbazepine)

Brain study sheds light on processes that prompt epilepsy seizures
Source: Epilepsy News From Medical News Today [2015.11.19]
A study of how brain cells communicate with each other when minds are most active could aid research into epilepsy, experts say.

Febrile Seizures
Source: MedicineNet Roseola Specialty [2015.06.08]
Title: Febrile Seizures
Category: Diseases and Conditions
Created: 5/9/2008 12:00:00 AM
Last Editorial Review: 6/8/2015 12:00:00 AM

Antidepressants Linked to First-Time Seizures
Source: MedicineNet mirtazapine Specialty [2015.04.09]
Title: Antidepressants Linked to First-Time Seizures
Category: Health News
Created: 4/9/2015 12:00:00 AM
Last Editorial Review: 4/9/2015 12:00:00 AM

CHMP Recommends EU Approval for Brivaracetam
Source: Medscape NeurologyHeadlines [2015.11.20]
The Committee for Medicinal Products for Human Use recommends marketing approval for brivaracetam (Briviact, UCB Pharma SA) as adjunctive therapy for partial-onset seizures.
International Approvals

Researchers discover an epilepsy switch
Source: Epilepsy News From Medical News Today [2015.10.27]
Scientists at the University of Bonn and the Hebrew University of Jerusalem (Israel) have decoded a central signal cascade associated with epileptic seizures.

more news >>

Published Studies Related to Trileptal (Oxcarbazepine)

Oxcarbazepine for neuropathic pain. [2013]
CONCLUSIONS: On the basis of moderate quality evidence from one trial in

Pharmacokinetics of the monohydroxy derivative of oxcarbazepine and its enantiomers after a single intravenous dose given as racemate compared with a single oral dose of oxcarbazepine. [2011.06]
Oxcarbazepine (OXC) is an antiepileptic drug...

Effect of eslicarbazepine acetate and oxcarbazepine on cognition and psychomotor function in healthy volunteers. [2010.08]
The results of two single-blind studies conducted to evaluate the cognitive and psychomotor effects of eslicarbazepine acetate and oxcarbazepine following single and repeated administration in healthy volunteers are reported...

[Efficacy and safety of the monotherapy with trileptal (oxcarbazepine) in children and adolescents.] [2010]
A prospective non-randomized non-controlled multicenter trial has been conducted. The trial included 254 children, aged from 11 months to 18 years (mean age 9,3+/-4,5 years), with predominantly focal forms of epilepsy treated with trileptal (oxcarbazepine)... In conclusion, trileptal as the monotherapy is effective and well-tolerated in the treatment of focal epilepsies in the age groups studied.

Comparative efficacy and safety of oxcarbazepine versus divalproex sodium in the treatment of acute mania: a pilot study. [2009.04]
CONCLUSION: Oxcarbazepine demonstrated comparable efficacy to divalproex sodium in the management of acute mania. Also the overall adverse event profile was found to be superior for oxcarbazepine.

more studies >>

Clinical Trials Related to Trileptal (Oxcarbazepine)

Oxcarbazepine 600 mg Tablets Under Non-Fasting Conditions [Completed]

Tolerability and Pharmacokinetics of a Single 900 mg Oral Dose of BIA 2-093 and Oxcarbazepine in Healthy Volunteers [Completed]

Oxcarbazepine 600 mg Tablets Under Fasting Conditions [Completed]
The objective of this study is to evaluate the comparative bioavailability between Oxcarbazepine 600 mg Tablets (test) and Trileptal 600 mg Tablets (reference) after a single-dose in healthy subjects under fasting conditions.

Protective Role of Oxcarbazepine in Multiple Sclerosis [Recruiting]
People with multiple sclerosis (MS) have nerve loss even without acute inflammatory relapses, as obvious in the progressive phase of disease. Drugs that may prevent nerve loss work better in earlier stages when it is difficult to measure progressive disability. But it is now possible to measure the nerve loss as neurofilament light (NFL) in the cerebrospinal fluid (CSF). This is a trial of a neuroprotective drug, oxcarbazepine, which showed benefit in an animal model of multiple sclerosis. The investigators will use an innovative outcome, a reduction in the content of NFL in the CSF, as well as the usual clinical disability and imaging methods, to measure the success of the oxcarbazepine as a neuroprotective agent in MS. The use of NFL, a surrogate marker of neurodegeneration, allows a blinded and accurate outcome.

Oxcarbazepine for the Treatment of Chronic Peripheral Neuropathic Pain [Completed]
The purpose of this trial is to determine if the effect of oxcarbazepine on chronic peripheral nerve pain depends on the supposed mechanism of the pain, ie. if oxcarbazepine mainly relieve pain in patients with irritable nerves.

more trials >>

Reports of Suspected Trileptal (Oxcarbazepine) Side Effects

Convulsion (88)Headache (37)Somnolence (35)Malaise (33)Nausea (31)Dizziness (30)Feeling Abnormal (27)Hyponatraemia (26)Vomiting (22)Pyrexia (21)more >>


Based on a total of 2 ratings/reviews, Trileptal has an overall score of 7.50. The effectiveness score is 7 and the side effect score is 7. The scores are on ten point scale: 10 - best, 1 - worst.

Trileptal review by 57 year old male patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   epilepsy
Dosage & duration:   300 mg taken 4 times a day for the period of 1 year, so far
Other conditions:   none
Other drugs taken:   vitamins, tryptanol
Reported Results
Benefits:   Controlled complex partial seizures.
Side effects:   Dizziness, fatigue, nausea
Comments:   Started at 2 doses of 300 mg a day and worked up to 4 doses per day over a six month period. Only at 1200 mg a day did the drug control the seizures. During each time when I increased the dosage, I founf the side-effects worsened, but after a week or so, the side effects minimized and then disappeared.


Trileptal review by care giver of 50 year old male patient

Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   Moderate Side Effects
Treatment Info
Condition / reason:   Tri Geminal Neuralgia
Dosage & duration:   150 mg taken 2 x a day for the period of 2 years
Other conditions:   none
Other drugs taken:   none
Reported Results
Benefits:   Stop pain of nerve spasms, without the drug, the tri geminal neuralgia pain is considered one of the most painful of all medical conditions. With this medicine the patient has been able to avoid the risks of neuro surgury and still control the pain.
Side effects:   Headaches occasionally.
Comments:   Took 150 mg or 1 tablet 2 times a day

See all Trileptal reviews / ratings >>

Page last updated: 2015-11-20

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