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Triazolam (Triazolam) - Summary

 
 



TRIAZOLAM SUMMARY

Triazolam tablets contain triazolam, a triazolobenzodiazepine hypnotic agent. Triazolam is a white crystalline powder, soluble in alcohol and poorly soluble in water. It has a molecular weight of 343.21. The chemical name for triazolam is 8-chloro-6-(o-chlorophenyl)-1-methyl-4 - -triazolo-[4,3-α][1,4]benzodiazepine.

Triazolam Tablets are indicated for the short-term treatment of insomnia (generally 7 to 10 days). Use for more than 2 to 3 weeks requires complete reevaluation of the patient (see). WARNINGS

Prescriptions for triazolam should be written for short-term use (7 to 10 days) and it should not be prescribed in quantities exceeding a 1-month supply.


See all Triazolam indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Triazolam

'Start high and go low' dosing strategy advised for chronic insomnia
Source: Sleep / Sleep Disorders / Insomnia News From Medical News Today [2015.08.06]
A study finds chronic insomnia patients may get better treatment response and lower incidence of side effects if they use smaller and fewer doses of sleep drugs plus placebos.

Chronic insomnia sufferers may find relief with half of standard pill dose
Source: Sleep / Sleep Disorders / Insomnia News From Medical News Today [2015.08.04]
Findings point to use of placebos to help sufferers sleepThe roughly nine million Americans who rely on prescription sleeping pills to treat chronic insomnia may be able to get relief from as...

Cognitive behavioral therapy for insomnia with psychiatric, medical conditions
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2015.07.06]
Cognitive behavioral therapy is a widely used nonpharmacologic treatment for insomnia disorders and an analysis of the medical literature suggests it also can work for patients whose insomnia is...

73% of insomniacs cured after 1-hour therapy session
Source: Complementary Medicine / Alternative Medicine News From Medical News Today [2015.06.02]
A simple one-hour therapy session has helped to cure 73% of people suffering from acute insomnia, according to a new study from Northumbria University.

Insomnia
Source: MedicineNet Creutzfeldt-Jakob Disease Specialty [2014.07.17]
Title: Insomnia
Category: Diseases and Conditions
Created: 6/6/2005 12:00:00 AM
Last Editorial Review: 7/17/2014 12:00:00 AM

more news >>

Published Studies Related to Triazolam

Physiological doses of progesterone potentiate the effects of triazolam in healthy, premenopausal women. [2011.06]
RATIONALE: Gender plays a critical role in the effects of drugs and drug abuse liability. Biological factors, including ovarian hormones, may contribute to gender differences in drug abuse. Preclinical and some clinical research suggests that progesterone and its metabolites have activity at the GABA(A) receptor and may enhance the effect of GABAergic compounds (e.g., benzodiazepines). Because women are exposed to varying levels of progesterone from puberty until menopause, and appear more sensitive to the negative consequences of benzodiazepine use, it is important to understand the impact of progesterone on GABAergic drug effects. OBJECTIVES: The purpose of this experiment was to characterize the behavioral effects of progesterone, alone and in combination with the short-acting benzodiazepine, triazolam, to determine if progesterone potentiates the behavioral effects of triazolam... CONCLUSIONS: Progesterone potentiates the behavioral effects of benzodiazepines and may contribute to benzodiazepine use and abuse among women.

Dose effects of triazolam and scopolamine on metamemory. [2010.02]
The present study compared the acute dose effects of the benzodiazepine triazolam and the anticholinergic scopolamine on metamemory (knowledge and awareness of one's own memory) in a two-phase paradigm designed to assess effects on both monitoring and control components of metamemory in both semantic (general knowledge) and episodic memory (cued-recall) tasks...

Flumazenil reversal of sublingual triazolam: a randomized controlled clinical trial. [2009.05]
BACKGROUND: Incremental sublingual (SL) dosing of triazolam has emerged as a popular sedation technique. Nevertheless, few studies have evaluated the technique's safety or efficacy. Given its popularity, an easily administered rescue strategy is needed... CONCLUSIONS: Deep sedation from incremental SL dosing of triazolam is incompletely reversed by a single intraoral injection of flumazenil. The reversal did not persist. The authors discharged the patients from the dental clinic at 360 minutes. CLINICAL IMPLICATIONS: A single intraoral injection of flumazenil (0.2 mg) cannot immediately reverse oversedation with triazolam. A higher dose might be effective. Reversal for the purpose of discharging the patient early is neither appropriate nor safe.

Modulation of the discriminative stimulus effects of triazolam across the menstrual cycle phase in healthy pre-menopausal women. [2008.04.01]
Pre-clinical studies indicate that changes in progesterone levels across menstrual cycle phases modulate the behavioral effects of sedative drugs acting at GABA(A) receptor sites. In this study, seven healthy women learned to discriminate triazolam (0.25 mg/70 kg) from placebo... These results suggest that the discriminative stimulus effects of the positive GABA(A) modulator, triazolam, are sensitive to menstrual cycle phase in healthy adult women.

Relative abuse liability of GHB in humans: A comparison of psychomotor, subjective, and cognitive effects of supratherapeutic doses of triazolam, pentobarbital, and GHB. [2006.11]
Although preclinical studies suggest that GHB has low likelihood for abuse, case reports indicate that GHB is abused. This study evaluated the relative abuse liability of GHB in 14 volunteers with histories of drug abuse... Although the likelihood for GHB to be abused is intermediate to triazolam and pentobarbital, the possibility of accidental overdose (ie greater sedation than intended) with GHB appears to be greater.

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Reports of Suspected Triazolam Side Effects

Drug Ineffective (23)Blepharospasm (8)Somnolence (6)Overdose (5)Intentional Overdose (4)Headache (4)Stevens-Johnson Syndrome (4)Maternal Exposure During Pregnancy (4)Ventricular Tachycardia (4)Pain (3)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Triazolam has an overall score of 4. The effectiveness score is 8 and the side effect score is 6. The scores are on ten point scale: 10 - best, 1 - worst.
 

Triazolam review by 48 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Moderate Side Effects
  
Treatment Info
Condition / reason:   Sedation Dentistry for dental implants
Dosage & duration:   2-4 250 mg before each session taken varried - 1-3 times a month for 6 months for the period of 6 months
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   Made dental implants possible
Side effects:   The triazolam seemed to stay in my system for days. I experienced a moderate degree of memory loss. There were also a couple instances of loss of cognitive reasoning, which was most frightening.
Comments:   I had total dental implants, which involved removing my existing deteriorating teeth (full set) and then placing first, temporary titanium posts into my upper and lower jaws and then permanent posts. A series of temporary acrylic "teeth" were fashioned to fit onto the temporary and permanent posts until my gums healed. Then permanent porcelain teeth were attached to the implant posts.

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Page last updated: 2015-08-06

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