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Triacin-C (Codeine Phosphate / Triprolidine Hydrochloride / Pseudoephedrine Hydrochloride) - Summary

 
 



WARNING: Death Related to Ultra-Rapid Metabolism of Codeine to Morphine Respiratory depression and death have occurred in children who received codeine following tonsillectomy and/or adenoidectomy and had evidence of being ultra-rapid metabolizers of codeine due to a CYP2D6 polymorphism (see WARNINGS - Codeine Phosphate - Death Related to Ultra-Rapid Metabolism of Codeine to Morphine).

 

TRIACIN-C SUMMARY

Triprolidine and pseudoephedrine hydrochlorides and codeine phosphate syrup produces antitussive, antihistaminic and nasal decongestant effects.

Triprolidine and pseudoephedrine hydrochlorides and codeine phosphate syrup is indicated for temporary relief of coughs and upper respiratory symptoms, including nasal congestion, associated with allergy or the common cold.


See all Triacin-C indications & dosage >>

NEWS HIGHLIGHTS

Clinical Trials Related to Triacin-C (Codeine / Triprolidine / Pseudoephedrine)

The Effect of Fluid Restriction in Congestive Heart Failure Complicated With Hyponatremia [Recruiting]
The purpose of this study is to determine the effect of fluid restriction and the neurohormonal mechanisms in the development of hyponatremia in patients with congestive heart failure and hyponatremia. The hypothesis is that strict fluid restriction leads to a larger increase in plasma sodium than standard treatment in patients with decompensated heart failure associated with hyponatremia. A secondary hypothesis is that the neurohormonal change is greater in patients treated with strict fluid restriction versus standard treatment.

Can a Nasal Decongestant Test Predict Treatment Outcomes in Seasonal Allergic Rhinitis? [Completed]
We hypothesize that those patients with purely seasonal allergic rhinitis will decongest better than those subjects with another cause contributing to their symptoms. These latter patients will not improve as well on an intranasal steroid as those who decongest well, potentially explaining the 60% response rate in prior studies.

TransMEM Gas Exchange -- Project 1, Aim 2 [Recruiting]
This study will determine if exposure to an allergy material (ragweed) or exposure to an allergic-symptom-provoking substance (histamine) and medications typically used to decongest the nose changes the rate of blood-flow in the lining of the middle-ear. Otitis media (the build-up of water-like fluid in the middle-ear airspace) may occur if the blood flow in the lining of the middle-ear is too high and may be prevented if a way could be found to lower the blood flow in persons susceptible to the disease. Middle-ear blood flow is measured indirectly by measuring the change in middle-ear pressure while a person breathes a gas mixture containing nitrous oxide ("laughing gas"). In this study, 4 groups of subjects will be entered and middle-ear pressure in persons breathing a mixture of 50% Oxygen, 50% Nitrous Oxide ("laughing gas")will be measured after exposure to one of four substances (ragweed, histamine,an oral decongestant, a decongestant nasal spray) and a fake medication (placebo) at separate test sessions. All subjects will have one set of 2 x-rays of the middle ears and mastoids. The group exposed to ragweed will require 3 study visits while the other 3 groups will have 2 study visits. From this information middle-ear blood flow will be calculated. This will help determine the relationship between what happens in the nose and what happens in the middle ear.

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Page last updated: 2013-05-23

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