Media Articles Related to Trental (Pentoxifylline)
No Mortality Benefit From Pentoxifylline in Alcoholic Hepatitis (CME/CE)
Source: MedPage Today Gastroenterology [2015.04.22]
(MedPage Today) -- But prednisolone improved short-term survival.
Published Studies Related to Trental (Pentoxifylline)
Pentoxifylline decreases serum level of adhesion molecules in atherosclerosis
with coronary artery disease (CAD)... CONCLUSION: Based on the results of our pilot study, administration of PTX in CAD
Pentoxifylline for intermittent claudication. 
CONCLUSIONS: Given the generally poor quality of the published studies
Pentoxifylline improves nonalcoholic steatohepatitis: a randomized placebo-controlled trial. [2011.11]
CONCLUSION: PTX improved histological features of NASH compared to placebo. PTX was well tolerated in patients with NASH. Copyright (c) 2011 American Association for the Study of Liver Diseases.
Pentoxifylline decreases serum levels of tumor necrosis factor alpha, interleukin 6 and C-reactive protein in hemodialysis patients: results of a randomized double-blind, controlled clinical trial. [2011.10.03]
CONCLUSIONS: Pentoxifylline significantly decreased serum concentrations of TNF-alpha, IL-6 and CRP compared to placebo. Pentoxifylline could be a promising and useful strategy to reduce the systemic inflammation frequently observed in patients on HD.
Pentoxifylline (anti-tumor necrosis factor drug): effective adjuvant therapy in the control of ocular cicatricial pemphigoid. [2011.09]
PURPOSE: The detection of tumor necrosis factor-a (TNF-a) in conjunctiva affected by ocular cicatricial pemphigoid (OCP) may indicate that this cytokine plays an important role in its pathogenesis. The purpose of this randomized, controlled, comparative, blinded study was to evaluate the effectiveness of adding pentoxifylline as an anti-TNF-a drug to the well-documented therapy of steroids and cyclophosphamide in controlling OCP... CONCLUSIONS: The significantly increased level of serum TNF-a in OCP as compared to controls proves that TNF-a has an important role in the pathogenesis of this disease. The study illustrates that the addition of pentoxifylline to pulse steroid cyclophosphamide therapy is an effective, safe, and economical method in controlling OCP through directly reducing TNF-a levels, with long periods of remission as detected in our 18-month follow-up period.
Clinical Trials Related to Trental (Pentoxifylline)
Pentoxifylline/Nonalcoholic Steatohepatitis (NASH) Study: The Effect of Pentoxifylline on NASH [Recruiting]
Prevention of Capsular Contracture Using Trental and Vitamin E [Recruiting]
The main purpose of this research study is to determine if the use of Trental and Vitamin E
compared to Placebo (an inactive substance) will decrease the incidence and severity of
contractures (shrinking and or hardening of tissue surrounding the implant) associated with
breast implant reconstruction following radiation treatment. Another goal is to find out
the impact that Trental and Vitamin E compared to Placebo may have on implant loss or need
for surgical intervention in the setting of chest wall radiation after reconstruction. In
addition, the investigators want to evaluate the patient's sense of well being and quality
Pentoxifylline (Trental) as a Modulator of Tumor Necrosis Factor and of HIV Replication in Patients With AIDS [Completed]
To determine whether pentoxifylline lowers tumor necrosis factor (TNF) levels in AIDS
patients. Pentoxifylline decreases tumor necrosis factor (TNF), and therefore should decrease
such TNF-intensified events as cachexia, enhanced HIV expression, and inhibition of
zidovudine (AZT) activity.
Efficacy of Combined Pentoxifylline and Conventional Immunosuppressive Regimens on Rapidly Progressive Glomerulonephritis [Recruiting]
We have recently demonstrated that pentoxifylline (PTX) has the potential to treat severe
glomerular inflammation in a rat model of accelerated anti-glomerular basement membrane
glomerulonephritis. This study aims to investigate the therapeutic effects of combined
pentoxifylline and conventional immunosuppressive regimens on patients with rapidly
Clinical Trial of Pentoxifylline in Patient With Cirrhosis [Completed]
In patients with cirrhosis and liver failure, pro-inflammatory cytokines (TNF alpha) might be
responsible of severe complications and death. Thus, the prevention of cytokine production
should prevent complications and mortality.
The aim of this study is to study the 2 months survival rate in patients with severe
cirrhosis (Child-Pugh C) with pentoxifylline - an inhibitor of cytokine production. The 6
month mortality, the proportion of transplanted patients, the occurrence of complications
(bacterial infection, renal failure, hepatic encephalopathy and gastrointestinal bleeding),
plasma cytokine levels and fibrotest - a marker of fibrosis - will be also studied. This is a
multicenter double blind randomized trial with a placebo.
All adult patients with severe cirrhosis might be randomized after written consent. Patients
with severe carcinoma, intolerance or contraindication to pentoxifylline will not be
included. Patients receive either pentoxifylline or placebo 3 times a day for 6 months. Three
hundred and forty two patients are necessary to decrease mortality rate by 50% at 2 months in
a beta risk of 10% and an alpha risk of 5%. Patients will be seen every month.
Reports of Suspected Trental (Pentoxifylline) Side Effects
Inappropriate Antidiuretic Hormone Secretion (3),
Headache (2), more >>