Media Articles Related to Trelstar Depot (Triptorelin)
Surgery Trumps Surveillance in Major Prostate Cancer Trial
Source: Medscape General Surgery Headlines [2014.03.06]
Undergoing surgery can improve survival in younger men and those with intermediate-risk early prostate cancer, as opposed to watchful waiting.
Medscape Medical News
Surgery better than watchful waiting for younger prostate cancer patients
Source: Cancer / Oncology News From Medical News Today [2014.03.06]
A new study in the New England Journal of Medicine finds that mortality rates are lower for younger men having surgery for prostate cancer, compared with those who follow watchful waiting.Prostate cancer is common among older men and rare in men under the age of 40.
New diagnostic, treatment approach for aggressive prostate cancer suggested by cholesterol-metabolism study
Source: Cholesterol News From Medical News Today [2014.03.06]
Researchers have discovered a link between prostate cancer aggressiveness and the accumulation of a compound produced when cholesterol is metabolized in cells, findings that could bring new diagnostic and treatment methods.Findings also suggest that a class of drugs previously developed to treat atherosclerosis might be repurposed for treatment of advanced prostate cancer.
Surgery May Benefit Younger Prostate Cancer Patients
Source: MedicineNet Prostate Specific Antigen Specialty [2014.03.06]
Title: Surgery May Benefit Younger Prostate Cancer Patients
Category: Health News
Created: 3/5/2014 5:36:00 PM
Last Editorial Review: 3/6/2014 12:00:00 AM
Reliable pretreatment information assists prostate cancer patients in decision-making
Source: Anxiety / Stress News From Medical News Today [2014.03.05]
Men who have been diagnosed with prostate cancer need to assimilate information rapidly in order to weigh the treatment options and make informed decisions.
Published Studies Related to Trelstar Depot (Triptorelin)
Effect of the gonadotropin-releasing hormone analogue triptorelin on the occurrence of chemotherapy-induced early menopause in premenopausal women with breast cancer: a randomized trial. [2011.07.20]
CONTEXT: Premenopausal patients with breast cancer are at high risk of premature ovarian failure induced by systemic treatments, but no standard strategies for preventing this adverse effect are yet available. OBJECTIVE: To determine the effect of the temporary ovarian suppression obtained by administering the gonadotropin-releasing hormone analogue triptorelin during chemotherapy on the incidence of early menopause in young patients with breast cancer undergoing adjuvant or neoadjuvant chemotherapy... CONCLUSION: The use of triptorelin-induced temporary ovarian suppression during chemotherapy in premenopausal patients with early-stage breast cancer reduced the occurrence of chemotherapy-induced early menopause. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT00311636.
A comparison of the effect of short-term aromatase inhibitor (letrozole) and GnRH agonist (triptorelin) versus case control on pregnancy rate and symptom and sign recurrence after laparoscopic treatment of endometriosis. [2011.07]
PURPOSE: To compare the role of an aromatase inhibitor (letrozole) with a GnRH agonist (triptorelin) versus case control on the pregnancy rate and recurrence of symptoms and signs in patients with endometriosis... CONCLUSION: Pregnancy rate and endometriosis recurrence rate are comparable among the 3 groups.
Synchronization of ovulation and fertility in weaned sows treated with intravaginal triptorelin is influenced by timing of administration and follicle size. [2011.01.15]
A 100 mug dose of triptorelin was tested for synchronizing ovulation in sows. In Experiment 1, conducted in April through June, sows (n = 125) were assigned to Control (untreated), TG-96 (Triptorelin Gel (TG) given intravaginally at 96 h post-weaning), or TG-E (given intravaginally at estrus)... However, ovulation induction and timed AI success may benefit from an approach that ensures sows have adequate follicle development at time of treatment.
A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. [2010.01]
OBJECTIVE: To examine and compare the efficacy and safety of GnRH agonist (GnRHa) vs. aromatase inhibitor in premenopausal women with leiomyomas.
A randomized, controlled clinical trial comparing the effects of aromatase inhibitor (letrozole) and gonadotropin-releasing hormone agonist (triptorelin) on uterine leiomyoma volume and hormonal status. [2009.01.08]
OBJECTIVE: To examine and compare the efficacy and safety of GnRH agonist (GnRHa) vs. aromatase inhibitor in premenopausal women with leiomyomas.Rapid onset of action and avoidance of initial gonadotropin flare with an aromatase inhibitor may be advantageous for short-term management of women with myomas of any size who are to be managed transiently and who wish to avoid surgical intervention, specifically women with unexplained infertility having uterine myoma.
Clinical Trials Related to Trelstar Depot (Triptorelin)
Equivalence of Intramuscular (IM) Versus Subcutaneous (SC) Applications of Long Acting Pamorelin 11.25 mg [Recruiting]
The purpose of this study is to demonstrate the pharmacodynamic equivalence of triptorelin
pamoate (Pamorelin® LA 11. 25 mg), applied either IM or SC, in terms of the area under the
curve [AUC1-85day] for serum testosterone in patients with advanced prostate cancer.
Study to Assess the Non-Inferiority of Pamorelin® 11,25mg SC Injected Versus Pamorelin® 11,25mg IM Injected in Patients Suffering From Advanced Prostate Cancer (PAMOJECT) [Recruiting]
The active ingredient of Pamorelin® 11,25 mg is Triptorelin. Triptorelin is a substitute for
a natural hormone produced in the body called Gonadotrophin-releasing hormone (GnRH). GnRH is
a hormone secreted by hypothalamus (a gland located in brain) and controls the production of
sex hormones (eg testosterone in men) in other organs in the body. The growth of prostate
cancer cells, one of the most common cancers in men, is induced by the hormone testosterone.
Hormono-therapy is one of treatments available to treat this type of disease by controlling
the testosterone serum level. Pamorelin® 11,25 mg is normally injected in the muscle but
this type of injection is not suitable for every patient. Therefore the primary purpose of
this study is to assess the non-inferiority of the 12-week triptorelin formulation PamorelinÂ®
11,25 mg administered via subcutaneous (SC) injection as compared to PamorelinÂ® 11,25 mg
administered via standard intramuscular (IM) injection based on the percentage of patients
presenting a testosterone level â‰¤ 50 ng/dl at week 24.
Efficacy, Safety, and PK of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty [Recruiting]
The study will investigate the efficacy, safety and pharmacokinetics of triptorelin 22. 5 mg
6-month formulation in 44 patients suffering from central precocious puberty. The null
hypothesis of the study is that the proportion of patients achieving LH suppression to
prepubertal levels at Month 6 is 80%.
HOBOE: A Phase 3 Study of Adjuvant Triptorelin and Tamoxifen, Letrozole, or Letrozole and Zoledronic Acid in Premenopausal Patients With Breast Cancer. [Recruiting]
The HOBOE study was amended in November 2009, and, after reaching enrollment of the first
500 patients, the study began recruiting premenopausal patients only. The primary objective
of the extended study is to compare disease free survival in premenopausal patients with
early breast cancer. Patients receive triptorelin and are randomized in a 1: 1:1 fashion to
receive tamoxifen or letrozole, or letrozole + zoledronic acid.
The purpose of the HOBOE study, Version 1, was to compare the adjuvant hormonal therapy
treatments of Tamoxifen, Letrozole and Letrozole + Zoledronate for their effects on bone
loss in breast cancer patients. Postmenopausal and premenopausal patients were eligible, the
latter also receiving monthly triptorelin. Upon reaching the enrollment of the first 500
patients in March 2010, the study began recruiting premenopausal patients only.
Study on Efficacy, Pharmacokinetics, and Safety of Two Subcutaneous Injections of Triptorelin Embonate 6 Month Formulation in Patients With Advanced Prostate Cancer [Recruiting]
The study will investigate the efficacy, pharmacokinetics and safety of triptorelin embonate
22. 5 mg 6-month formulation administered by subcutaneous injections in patients with