TRECATOR SUMMARY
Trecator® (ethionamide tablets, USP) is used in the treatment of tuberculosis.
Trecator-SC (ethionamide) is primarily indicated for the treatment of active tuberculosis in patients with
M. tuberculosis
resistant to isoniazid or rifampin, or when there is intolerance on the part of the patient to other drugs. Its use alone in the treatment of tuberculosis results in the rapid development of resistance. It is essential, therefore, to give a suitable companion drug or drugs, the choice being based on the results of susceptibility tests. If the susceptibility tests indicate that the patient's organism is resistant to one of the first-line antituberculosis drugs (i.e., isoniazid or rifampin) yet susceptible to ethionamide, ethionamide should be accompanied by at least one drug to which the
M. tuberculosis
isolate is known to be susceptible.6 If the tuberculosis is resistant to both isoniazid and rifampin, yet susceptible to ethionamide, ethionamide should be accompanied by at least two other drugs to which the
M. tuberculosis
isolate is known to be susceptible.6
Patient nonadherence to prescribed treatment can result in treatment failure and in the development of drug-resistant tuberculosis, which can be life-threatening and lead to other serious health risks. It is, therefore, essential that patients adhere to the drug regimen for the full duration of treatment. Directly observed therapy is recommended for all patients receiving treatment for tuberculosis. Patients in whom drug-resistant
M. tuberculosis
organisms are isolated should be managed in consultation with an expert in the treatment of drug-resistant tuberculosis.
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TRECATOR NEWS HIGHLIGHTS Media Articles Related to Trecator (Ethionamide)
100,000 Saved From Dying Of Tuberculosis
Source: Aid / Disasters News From Medical News Today [2008.11.15]
Extensively Drug-Resistant Tuberculosis Cases Decline But Do Not Disappear
Source: HIV / AIDS News From Medical News Today [2008.11.15]
Tuberculosis Skin Test (PPD Skin Test)
Source: MedicineNet Tuberculosis Specialty [2008.09.02]
Tuberculosis
Source: MedicineNet Erythema Nodosum Specialty [2008.01.17]
Extensively Drug-Resistant Tuberculosis (XDR TB)
Source: MedicineNet ICU Psychosis Specialty [2007.05.30]
Published Studies Related to Trecator (Ethionamide)
A clinical trial of ethionamide and prothionamide for treatment of lepromatous leprosy. [2006.03]
Pharmacokinetics of ethionamide administered under fasting conditions or with orange juice, food, or antacids. [2001.03]
Pharmacokinetic evaluation of ethionamide suppositories. [1991]
[Case of SIADH caused by ethionamide in a patient with pulmonary tuberculosis] [2006.12]
Gatifloxacin and ethionamide as the foundation for therapy of tuberculosis. [2003.08]
Clinical Trials Related to Trecator (Ethionamide)
A Prospective Study of Multidrug Resistance and a Pilot Study of the Safety of and Clinical and Microbiologic Response to Levofloxacin in Combination With Other Antimycobacterial Drugs for Treatment of Multidrug-Resistant Pulmonary Tuberculosis (MDRTB) in HIV-Infected Patients. [Completed]
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