Travatan Z (Travoprost Ophthalmic) - Indications and Dosage

INDICATIONS AND USAGE

TRAVATAN Z® ophthalmic solution is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension who are intolerant of other intraocular pressure lowering medications or insufficiently responsive (failed to achieve target IOP determined after multiple measurements over time) to another intraocular pressure lowering medication.

DOSAGE AND ADMINISTRATION

The recommended dosage is one drop in the affected eye(s) once-daily in the evening. The dosage of TRAVATAN Z® ophthalmic solution should not exceed once-daily since it has been shown that more frequent administration of travoprost may decrease the intraocular pressure lowering effect.

Reduction of intraocular pressure starts approximately 2 hours after administration of travoprost. The maximum effect is observed 12 hours after administration and is maintained throughout the day.

TRAVATAN Z® may be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure. If more than one topical ophthalmic drug is being used, the drugs should be administered at least five (5) minutes apart.

HOW SUPPLIED

TRAVATAN Z® (travoprost ophthalmic solution) 0.004% is a sterile, isotonic, buffered, preserved, aqueous solution of travoprost (0.04 mg/mL) supplied in Alcon's oval DROP-TAINER® package system.

TRAVATAN Z® is supplied as a 2.5 mL solution in a 4 mL and a 5 mL solution in a 7.5 mL natural polypropylene dispenser bottle with a natural polypropylene dropper tip and a turquoise polypropylene overcap. Tamper evidence is provided with a shrink band around the closure and neck area of the package.

2.5 mL fill in 4 mL bottle NDC 0065-0260-25

5 mL fill in 7.5 mL bottle NDC 0065-0260-05

Storage: Store at 2° - 25°C (36° - 77°F).

Rx Only

U.S. Patent Nos. 5,889,052 and 6,235,781

* TIMOPTIC is the registered trademark of Merck & Co., Inc.

ALCON LABORATORIES, INC.

Fort Worth, Texas 76134 USA

© 2005-2007 Alcon, Inc.

9001483-1207