Media Articles Related to Transderm Scop (Scopolamine Transdermal)
Nausea and Vomiting
Source: MedicineNet Anthrax Specialty [2012.04.24]
Title: Nausea and Vomiting
Category: Diseases and Conditions
Created: 1/31/2005 8:21:00 AM
Last Editorial Review: 4/24/2012 12:00:00 AM
Published Studies Related to Transderm Scop (Scopolamine Transdermal)
Randomized, double-blind comparison of oral aprepitant alone compared with
aprepitant and transdermal scopolamine for prevention of postoperative nausea and
and vomiting (PONV) treated with oral aprepitant with or without scopolamine... CONCLUSIONS: This trial evaluating the effectiveness of aprepitant alone and in
A comparison of cinnarizine and transdermal scopolamine for the prevention of
seasickness in naval crew: a double-blind, randomized, crossover study. 
reactions... CONCLUSIONS: Higher efficacy, a lower rate of adverse reactions, and convenience
Additive effects of a cholinesterase inhibitor and a histamine inverse agonist on scopolamine deficits in humans. [2011.12]
RATIONALE: Enhancement of histaminergic neurotransmission or histaminergic plus cholinergic neurotransmission may represent novel strategies for improving cognition in Alzheimer's disease. OBJECTIVE: To evaluate the effects of a novel histamine H3 receptor inverse agonist (MK-3134), an acetylcholinesterase inhibitor (donepezil), and their combination in attenuating the cognitive impairment associated with scopolamine... CONCLUSIONS: Exploratory analyses provide evidence for cognitive improvement through inverse agonism of the H3 histamine receptor and for cooperation between human cholinergic and histaminergic neurotransmitter systems. (ClinicalTrials.gov trial registration number: NCT01181310).
Central nervous system effects of the interaction between risperidone (single dose) and the 5-HT6 antagonist SB742457 (repeated doses) in healthy men. [2011.06]
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: * Several lines of evidence suggest a possible role of 5-HT(6) receptor antagonists in dementia or cognitive dysfunction of schizophrenia. SB-742457 is a potent 5-HT(6) antagonist and has shown efficacy in different animal models of cognitive impairment. It is currently in development as a cognitive enhancer. Risperidone, commonly used to control agitation and psychotic features in both schizophrenia and Alzheimer's disease, is a D(2)/5-HT(2A ) antagonist with low affinity for 5-HT(6) receptors and limited effects on cognitive parameters. WHAT THIS STUDY ADDS: * As the combination of risperidone and SB-742457 may constitute a reasonable combination in cognitively impaired patients, pharmacodynamic interaction effects were investigated in this study. The only significant drug-drug interaction was a small increase of electroencephalogram (EEG) alpha and beta bands, which might suggest mild arousing activity of SB-742457 on the central nervous system-depressant effects of risperidone. The clinical relevance of these findings in patients remains to be established. Additionally, this study provided an extensive multidimensional pharmacodynamic profile of risperidone in healthy volunteers, showing that this antipsychotic suppresses motor performance (eye-hand coordination, finger tapping and postural stability), alertness, memory and neurophysiological functions (saccadic eye movements and EEG power spectrum). AIM: Several lines of evidence suggest a possible role of 5-HT(6 ) receptor antagonists in cognitive dysfunction of schizophrenia. Atypical antipsychotics, such as risperidone, are currently used in these disorders. Therefore, the pharmacological interactions between the 5-HT(6) antagonist SB-742457 and risperidone were investigated in the light of possible co-medication... CONCLUSION: The pharmacokinetic interactions between SB-742457 and risperidone detected in this study were not clinically relevant. The increase in EEG alpha and beta power is incompatible with enhanced risperidone activity, but could point to mild arousing effects of the combination. Most pharmacodynamic changes of risperidone are consistent with previously reported data. The potential cognitive effects of SB-742457 remain to be established. (c) 2011 Centre for Human Drug Research. British Journal of Clinical Pharmacology (c) 2011 The British Pharmacological Society.
Scopolamine produces larger antidepressant and antianxiety effects in women than in men. [2010.11]
Some antidepressant agents generate differential benefit based on gender.Men and women show a rapid antidepressant response following scopolamine, but the magnitude of response is larger in women than in men.
Clinical Trials Related to Transderm Scop (Scopolamine Transdermal)
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies [Recruiting]
Scopolamine to Treat Depression
This study will examine the antidepressant effects of scopolamine in patients with major
depressive disorder or bipolar disorder. Scopolamine is commonly used to treat motion
sickness and diarrhea, and is sometimes given before anesthesia or during eye examinations.
In preliminary studies, scopolamine has shown strong antidepressant effects when given as an
intravenous (through a vein) infusion. This study will examine its effectiveness when given
through a skin patch and in pill form.
People between 18 and 50 years of age who have major depressive disorder or bipolar disorder
may be eligible for this study. Candidates are screened with a physical exam,
electrocardiogram (EKG), eye exam, blood and urine tests, psychiatric and clinical interviews
and neuropsychological testing.
Participants wear skin patches behind the ear and take pills according to a prescribed
regimen over an 8-week period. Half of the time the medications contain scopolamine and half
of the time they contain an "active" placebo called glycopyrrolate, a drug that produces side
effects similar to those that may be experienced with scopolamine, but that does not go into
Participants come to the NIH Clinical Center every 4 to 5 days while taking the medication
and then for two follow-up visits over the next 2 weeks for a physical exam and evaluations
with clinical rating scales. In addition, participants are asked to undergo two sessions of
cognitive testing and to have two positron emission tomography (PET) studies. Those who have
the PET scans also have a magnetic resonance imaging (MRI) scan. Participants can choose to
participate in the rest of the study without doing the PET scan.
PET is a diagnostic imaging tool that uses a radioactive chemical "tracer" to show cellular
activity in specific tissues of the body. For this procedure, a catheter (thin plastic tube)
is placed into an arm vein for injecting the tracer, and a second catheter is inserted into
an artery in the wrist to obtain arterial blood samples during the scan. The patient lies on
the scanner bed, wearing a special mask that is placed over the head to limit movement during
the scan. MRI uses a magnetic field and radio waves to produce pictures of the brain. For
this test, the subject lies on a table that is moved into the scanner (a metal cylinder),
wearing earplugs to muffle the noise of the machine during the scan.
Reports of Suspected Transderm Scop (Scopolamine Transdermal) Side Effects
OFF Label USE (16),
Vision Blurred (8),
Confusional State (6),
Therapeutic Response Unexpected (6),
Inappropriate Schedule of Drug Administration (6),
Withdrawal Syndrome (6), more >>