Tramadol Related Published Studies
Well-designed clinical trials related to Tramadol
Effects of tramadol on the minimum alveolar concentration of sevoflurane in dogs. [2009.07]
OBJECTIVE: To evaluate the effect of tramadol on sevoflurane minimum alveolar concentration (MAC(SEVO)) in dogs. It was hypothesized that tramadol would dose-dependently decrease MAC(SEVO).CONCLUSION AND CLINICAL RELEVANCE: Tramadol significantly reduced MAC(SEVO) but this was not dose dependent at the doses studied.
Pharmacokinetics of tramadol and its major metabolites following rectal and intravenous administration in dogs. [2009.06]
AIM: To compare the rectal and I/V administration of tramadol in dogs, to assess both its pharmacokinetic properties and absolute bioavailability... CONCLUSIONS: After rectal administration of tramadol suppositories, absorption of the active ingredient was rapid, but its metabolism quickly transformed the parent drug to high levels of M2 and M5. CLINICAL RELEVANCE: In the dog, rectal pharmaceutical formulation of tramadol would have a different pharmacokinetic behaviour than in humans.
Significance of the biopharmaceutical properties of tramadol sustained-release formulations for chrono-pharmacologically optimized treatment of pain from various sources. [2009.06]
Tramadol is currently one of the most frequently used opioid analgesics in the world. OBJECTIVE: The objective of this study was to investigate the rate and extent of tramadol bioavailability following evening versus morning intake of an extended-release pellet system designed for once daily administration. Moreover, the suitability of the preparation for chrono-adjusted pharmacotherapy was to be investigated... CONCLUSIONS: Bioavailability of the extended-release tramadol capsules for once daily administration is not affected by the time-point of administration. Total and maximum exposure of the product was bioequivalent after intake in the morning and at night. Thus, the time-point of administration may be adjusted to the patient's needs without any significant change in the in-vivo performance.
Comparison of analgesic effect of tramadol alone and a combination of tramadol and paracetamol in day-care laparoscopic surgery. [2009.06]
BACKGROUND AND OBJECTIVE: To compare the analgesic efficacy of tramadol alone (1.5 mg kg(-1)) with a tramadol (1 mg kg(-1)) and paracetamol combination in day-care laparoscopic patients... CONCLUSION: We conclude that reducing the dose of tramadol to 1 mg kg(-1) and combining it with paracetamol 1 g orally decreased the incidence of side effects of tramadol without reducing analgesic efficacy.
Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy. [2009.06]
The analgesic efficacy of tramadol and/or vedaprofen was evaluated in cats submitted for elective ovariohysterectomy, using a randomised double blind placebo controlled design. Forty adult female cats (3.0+/-0.32kg; 1.8+/-0.7 years) were distributed into four groups... This work also provides evidence for the benefits of analgesia for up to 3 days following ovariohysterectomy.
N-of-1 double-blind, randomized controlled trial of tramadol to treat chronic cough. [2009.05]
BACKGROUND: Chronic cough caused by interstitial pneumopathy can present a therapeutic dilemma, and the use of tramadol in the treatment of this symptom might be an alternative to improve the quality of life in patients. The present study describes a patient with rheumatoid arthritis and interstitial lung disease lasting 11 years who developed dry cough secondary to interstitial pneumopathy but was nonresponsive to several treatments (codeine 20 mg q6h; clobutinol 240 mg/d; and dextromethorphan 10 mg q4h). OBJECTIVE: The purpose of this study was to investigate, for an individual patient, the effectiveness of tramadol 50 mg compared with placebo, and whether tramadol provided any antitussive benefit... CONCLUSIONS: Tramadol appeared to be effective in controlling cough in this patient. Because no similar report was found in the literature, further studies assessing the efficacy of tramadol as an antitussive agent are warranted.
Comparison of intravenous and peritonsillar infiltration of tramadol for postoperative pain relief in children following adenotonsillectomy. [2009.04]
BACKGROUND AND OBJECTIVE: The aim of this study was to compare the postoperative analgesic efficacy and side-effects of intravenous tramadol with peritonsillar infiltration of tramadol in children undergoing adenotonsillectomy... CONCLUSION: In adenotonsillectomy cases, peritonsillar infiltration of tramadol maintains efficient pain relief with lower incidence of nausea and vomiting.
Wound infiltration with magnesium sulphate and ropivacaine mixture reduces postoperative tramadol requirements after radical prostatectomy. [2009.04]
PURPOSE: This prospective, randomized, double-dummy study was undertaken to compare the effects of magnesium sulphate (MgSO(4)) administered by the intravenous vs. the infiltration route on postoperative pain and analgesic requirements... CONCLUSION: Co-administration of MgSO(4) with ropivacaine for postoperative infiltration analgesia after radical retropubic prostatectomy produces a significant reduction in tramadol requirements.
Ultra low-dose naloxone and tramadol/acetaminophen in elderly patients undergoing joint replacement surgery: a pilot study. [2009.03]
OBJECTIVE: A pilot study was conducted to assess whether both the rationale and feasibility exist for future randomized clinical trials to evaluate the combined use of naloxone infusion and tramadol/acetaminophen as opioid-sparing drugs in elderly patients undergoing lower extremity joint replacement surgery... CONCLUSION: Consequently, a randomized, double-blinded clinical trial comparing standard therapy versus standard therapy plus these two drugs seems warranted. In such a trial, it would require approximately 20 subjects per treatment arm to detect a 80% decrease in morphine use.
Intraperitoneal analgesia for laparoscopic cholecystectomy: bupivacaine versus bupivacaine with tramadol. [2009.03]
The type of pain after laparoscopic surgery differs considerably from that seen after laparotomy... In our study we found no differences between bupivacaine with tramadol and bupivacaine in postoperative VAS score and analgesic requirements.
Efficacy and safety of low-dose transdermal buprenorphine patches (5, 10, and 20 microg/h) versus prolonged-release tramadol tablets (75, 100, 150, and 200 mg) in patients with chronic osteoarthritis pain: a 12-week, randomized, open-label, controlled, parallel-group noninferiority study. [2009.03]
Tramadol in neuropathic pain after spinal cord injury: a randomized, double-blind, placebo-controlled trial. [2009.03]
Subcutaneous tramadol infiltration at the wound site versus intravenous administration after pyelolithotomy. [2009.03]
Tramadol for prevention of postanaesthetic shivering: a randomised double-blind comparison with pethidine. [2009.02]
A comparison of tramadol and pethidine analgesia on the duration of labour: a randomised clinical trial. [2009.02]
Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs. [2009.01]
Tramadol as an adjuvant to lidocaine for axillary brachial plexus block. [2009.01]
[Comparison of the effects of lidocaine, lidocaine plus tramadol and lidocaine plus morphine for intravenous regional anesthesia] [2009.01]
Comparative study on the sedative effects of morphine, methadone, butorphanol or tramadol, in combination with acepromazine, in dogs. [2009.01]
Tramadol added to bupivacaine does not prolong analgesia of continuous psoas compartment block. [2009.01]
Addition of remifentanil to patient-controlled tramadol for postoperative analgesia: a double-blind, controlled, randomized trial after major abdominal surgery. [2008.12]
Analgesic efficacy and tolerability of flupirtine vs. tramadol in patients with subacute low back pain: a double-blind multicentre trial*. [2008.12]
Comparison of caudal bupivacaine and bupivacaine-tramadol for postoperative analgesia in children with hypospadias repair. [2008.10]
Evaluation of intra-operative tramadol for prevention of catheter-related bladder discomfort: a prospective, randomized, double-blind study. [2008.10]
Tramadol as a local anaesthetic in tendon repair surgery of the hand. [2008.09]
Tramadol for pain relief in children undergoing adenotonsillectomy: a comparison with dextromethorphan. [2008.09]
Effect of diclofenac suppository on tramadol consumption in posthysterectomy pain. [2008.09]
Effects of extended-release tramadol on pain-related sleep parameters in patients with osteoarthritis. [2008.08]
Tramadol as an adjuvant to intravenous regional anesthesia with lignocaine. [2008.08]
Pharmacokinetics of intravenous tramadol in dogs. [2008.07]
Intraarticular tramadol-bupivacaine combination prolongs the duration of postoperative analgesia after outpatient arthroscopic knee surgery. [2008.07]
MRI-demonstrated outcome of subchondral stress fractures of the knee after treatment with iloprost or tramadol: observations in 14 patients. [2008.07]
Effect of orally administered tramadol alone or with an intravenously administered opioid on minimum alveolar concentration of sevoflurane in cats. [2008.06.15]
Addition of remifentanil to patient-controlled tramadol for postoperative analgesia: a double-blind, controlled, randomized trial after major abdominal surgery. [2008.06.05]
Intraoperative tramadol reduces shivering but not pain after remifentanil-isoflurane general anaesthesia. A placebo-controlled, double-blind trial. [2008.06]
Supra-additive effects of tramadol and acetaminophen in a human pain model. [2008.06]
Tramadol as a prophylactic analgesic for hysterosalpingography in African women. [2008.06]
A comparison of analgesic efficacy of tramadol and pethidine for management of postoperative pain in children: a randomized, controlled study. [2008.06]
The postoperative analgesic efficacy of intraperitoneal tramadol compared to normal saline or intravenous tramadol in laparoscopic cholecystectomy. [2008.05]
Post-herniorrhapy infiltration of tramadol versus bupivacaine for postoperative pain relief: a randomized study. [2008.05]
Comparison of the analgesic efficacy of preemptive and preventive tramadol after lumpectomy. [2008.05]
[Importance of the formulation for a chronopharmacologically optimised way of pain therapy. Results of a comparative bioavailability study of tramadol extended-release capsules after single-dose evening versus morning administration] [2008.04.10]
Once-daily, controlled-release tramadol and sustained-release diclofenac relieve chronic pain due to osteoarthritis: a randomized controlled trial. [2008.03]
Comparison of caudal epidural bupivacaine with bupivacaine plus tramadol and bupivacaine plus ketamine for postoperative analgesia in children. [2008.03]
Extended-release tramadol (tramadol ER) in the treatment of chronic low back pain. [2008.03]
A randomized, double-blind, crossover comparison of the efficacy and safety of oral controlled-release tramadol and placebo in patients with painful osteoarthritis. [2008.03]
Effect of transcutaneous electrical acupoint stimulation on nausea and vomiting induced by patient controlled intravenous analgesia with tramadol. [2008.03]
Intraoperative tramadol reduces shivering but not pain after remifentanil-isoflurane general anaesthesia. A placebo-controlled, double-blind trial. [2008.02.21]
Pharmacokinetics of tramadol in horses after intravenous, intramuscular and oral administration. [2008.02]
Pharmacokinetics of tramadol, and its metabolite O-desmethyl-tramadol, in cats. [2008.02]
Pharmacokinetics of tramadol and o-desmethyltramadol in goats after intravenous and oral administration. [2008.02]
Effects of intramuscular and peritonsillar injection of tramadol before tonsillectomy: a double blind, randomized, placebo-controlled clinical trial. [2008.02]
Antinociceptive effects of tramadol and acepromazine in cats. [2008.02]
Hydrocodone/acetaminophen and tramadol chlorhydrate combination tablets for the management of chronic cancer pain: a double-blind comparative trial. [2008.01]
A randomized trial of tramadol versus ibuprofen as an adjunct to pain control during vacuum aspiration abortion. [2008.01]
Haemodynamic response of intravenous tramadol and intravenous morphine during laryngoscopy and endotracheal intubation. [2008.01]
A comparative study of the analgesic effect of patient-controlled morphine, pethidine, and tramadol for postoperative pain management after abdominal hysterectomy. [2008.01]
Comparison of lornoxicam versus tramadol analgesia for transrectal prostate biopsy: a randomized prospective study. [2008]
Effects of intramuscular and peritonsillar injection of tramadol before tonsillectomy: A double blind, randomized, placebo-controlled clinical trial. [2007.12.11]
The analgesic efficacy of tramadol in ambulatory gynecological laparoscopic procedures: a randomized controlled trial. [2007.12]
Preoperative diclofenac sodium and tramadol for pain relief after bimaxillary osteotomy. [2007.12]
Improved cancer pain treatment using combined fentanyl-TTS and tramadol. [2007.12]
The effect of single-dose tramadol on oxycodone clearance. [2007.11]
Open-label study of the safety and effectiveness of long-term therapy with extended-release tramadol in the management of chronic nonmalignant pain. [2007.10]
Modest opioid withdrawal suppression efficacy of oral tramadol in humans. [2007.10]
Chronic non-cancer pain: Focus on once-daily tramadol formulations. [2007.10]
[Comparison of tramadol, tramadol-metamizol and tramadol-lornoxicam administered by intravenous PCA in management of postoperative pain] [2007.10]
Comparative Study between Tramadol and Dexamethasone as an admixture to Bupivacaine in Supraclavicular Brachial Plexus Block. [2007.10]
Short-term outcome of painful bone marrow oedema of the knee following oral treatment with iloprost or tramadol: results of an exploratory phase II study of 41 patients. [2007.09]
A comparison of the analgesic efficacy of Tramadol Contramid OAD versus placebo in patients with pain due to osteoarthritis. [2007.09]
Pharmacokinetics and dose proportionality of three Tramadol Contramid OAD tablet strengths. [2007.09]
Regular tramadol use does not affect the propofol dose requirement for induction of anaesthesia. [2007.09]
Efficacy and safety of 12 weeks of osteoarthritic pain therapy with once-daily tramadol (Tramadol Contramid OAD). [2007.09]
Pre-emptive analgesic effect of tramadol after mandibular third molar extraction: a pilot study. [2007.07]
Single-dose intravenous tramadol for acute migraine pain in adults: a single-blind, prospective, randomized, placebo-controlled clinical trial. [2007.07]
A 2-week, multicenter, randomized, double-blind, double-dummy, add-on study of the effects of titration on tolerability of tramadol/acetaminophen combination tablet in Korean adults with knee osteoarthritis pain. [2007.07]
Pain relief and pain-related sleep disturbance with extended-release tramadol in patients with osteoarthritis. [2007.07]
Single- and multiple-dose bioequivalence of two once-daily tramadol formulations using stereospecific analysis of tramadol and its demethylated (M1 and M5) metabolites. [2007.07]
Tramadol does not prolong the effect of ropivacaine 7.5 mg/ml for axillary brachial plexus block. [2007.07]
[Effect of preoperative 900 and 1200 mg single oral dose of gabapentin on postoperative pain relief and tramadol consumption in open cholecystectomy surgery] [2007.07]
Comparison of the analgesic efficacy and respiratory effects of morphine, tramadol and codeine after craniotomy. [2007.06]
Intraarticular tramadol plus pericapsular incisional bupivacaine provides better analgesia than intraarticular plus pericapsular incisional bupivacaine after outpatient arthroscopic partial meniscectomy. [2007.05]
The addition of a small-dose ketamine infusion to tramadol for postoperative analgesia: a double-blinded, placebo-controlled, randomized trial after abdominal surgery. [2007.04]
Tramadol/acetaminophen or hydrocodone/acetaminophen for the treatment of ankle sprain: a randomized, placebo-controlled trial. [2007.04]
[Cost-effectiveness of patient-controlled analgesia compared to continuous elastomeric pump infusion of tramadol and metamizole] [2007.04]
Tramadol improves patients' tolerance of transrectal ultrasound-guided prostate biopsy. [2007.03]
The addition of tramadol to morphine via patient-controlled analgesia does not lead to better post-operative pain relief after total knee arthroplasty. [2007.03]
A comparison of oral midazolam, oral tramadol, and intranasal sufentanil premedication in pediatric patients. [2007.03]
Tramadol versus nalbuphine in total intravenous anaesthesia for dilatation and evacuation. [2007.02]
Combined spinal-epidural analgesia in labor--comparison of sufentanil vs tramadol. [2007.02]
Efficacy of intravenous tramadol treatment for reducing pain during office diagnostic hysteroscopy. [2007.01]
Post hoc analysis of a randomized, double-blind, placebo-controlled efficacy and tolerability study of tramadol extended release for the treatment of osteoarthritis pain in geriatric patients. [2007]
Tramadol 37.5-mg/acetaminophen 325-mg combination tablets added to regular therapy for rheumatoid arthritis pain: a 1-week, randomized, double-blind, placebo-controlled trial. [2006.12]
A comparative study of intravenous patient-controlled analgesia morphine and tramadol in patients undergoing major operation. [2006.12]
Tramadol/Acetaminophen or Hydrocodone/Acetaminophen for the Treatment of Ankle Sprain: A Randomized, Placebo-Controlled Trial. [2006.11.17]
The addition of tramadol to morphine via patient-controlled analgesia does not lead to better post-operative pain relief after total knee arthroplasty. [2006.11.10]
The effects of tramadol added to articaine on anesthesia duration. [2006.11]
Fentanyl or tramadol, with midazolam, for outpatient colonoscopy: analgesia, sedation, and safety. [2006.11]
Comparison between tramadol and pethidine in patient controlled intravenous analgesia. [2006.10]
Does tramadol wound infiltration offer an advantage over bupivacaine for postoperative analgesia in children following herniotomy? [2006.10]
Combination of oral tramadol, acetaminophen and 1% lidocaine induced periprostatic nerve block for pain control during transrectal ultrasound guided biopsy of the prostate: a prospective, randomized, controlled trial. [2006.10]
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