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Tramadol (Tramadol Hydrochloride) - Summary

 
 



TRAMADOL SUMMARY

Tramadol hydrochloride tablet, USP is a centrally acting analgesic.

Tramadol hydrochloride tablets, USP are indicated for the management of moderate to moderately severe pain in adults.


See all Tramadol indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Tramadol

DPP-4 Inhibitors Can Cause Severe Joint Pain, FDA Says
Source: Medscape Diabetes & Endocrinology Headlines [2015.08.28]
However, the pain associated with dipeptidyl peptidase-4 inhibitors for type 2 diabetes goes away once patients stop taking the medicine, according to the agency.
News Alerts

Group Offers Guidelines to Lessen Vaccination Pain
Source: Medscape Pediatrics Headlines [2015.08.28]
Clinicians can shuffle the order of vaccine injections, leverage the calming influence of parents and breast-feeding, and routinely apply topical anesthetic to ease vaccination pain for patients.
Medscape Medical News

DPP-4 Inhibitors Linked to Severe Joint Pain, FDA Warns
Source: MedPageToday.com - medical news plus CME for physicians [2015.08.28]
(MedPage Today) -- The agency has identified 33 cases since 2006

Low Back Pain and GI Symptoms on the Swiss Alps
Source: Medscape Gastroenterology Headlines [2015.08.26]
Dr Paget discusses a recent patient of his who presented with a 5-year history of recurrent severe low back pain and gastrointestinal symptoms.
Medscape Rheumatology

Is There Sex After Low Back Pain?
Source: Medscape Orthopaedics Headlines [2015.08.26]
For many people with low back pain, sex is excruciating. But the recommended position for the past 25 years--'side-lying' (ie, 'spooning')--is contraindicated by two new biomechanical studies.
Medscape Orthopedics

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Published Studies Related to Tramadol

Does the addition of tramadol and ketamine to ropivacaine prolong the axillary brachial plexus block? [2014]
ropivacaine in brachial plexus anesthesia... CONCLUSION: We conclude that when added to brachial plexus analgesia at a dose of

Efficacy of extended-release tramadol for treatment of prescription opioid withdrawal: a two-phase randomized controlled trial. [2013]
whether cessation of ER tramadol produces opioid withdrawal... CONCLUSIONS: ER tramadol 200mg modestly attenuated opioid withdrawal. Mild opioid

Comparison of the analgesic effects of oral tramadol and naproxen sodium on pain relief during IUD insertion. [2012]
on pain during insertion of an intrauterine device (IUD)... CONCLUSION: Prophylactic analgesia using 50 mg tramadol and 550 mg naproxen,

Tramadol versus methadone for treatment of opiate withdrawal: a double-blind, randomized, clinical trial. [2012]
The aim of this study was to compare the efficacy and safety of tramadol versus methadone for treatment of opiate withdrawal. Seventy patients randomly were assigned in two groups to receive either prescribed methadone (60 mg/day) or tramadol (600 mg/day)... Tramadol may be as effective as methadone in the control of withdrawal and could be considered as a potential substitute for methadone to manage opioids withdrawal.

Comparison of peritonsillar infiltration effects of ketamine and tramadol on post tonsillectomy pain: a double-blinded randomized placebo-controlled clinical trial. [2012]
on post tonsillectomy pain and compare the side effects... CONCLUSION: Preoperative peritonsillar infiltration of tramadol can decrease

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Clinical Trials Related to Tramadol

A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Completed]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The postoperative period can be particularly painful. Codeine (usually in mixed formulation with acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data questions its ability to provide optimal pain relief, while avoiding side effects, especially in the postoperative setting. Tramadol may be a better option for children in the postoperative setting due to its well-documented analgesic properties, low potential for side effects, and excellent safety profile. Seventy-two children scheduled to undergo tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers will be asked to record daily information about their child's postoperative pain and other core outcomes and domains as recommended in the recent consensus statement put forth by the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the efficacy and side effects associated with tramadol as compared with codeine/acetaminophen (the current practice standard) in a pediatric population. Hypotheses H1: Children who receive scheduled tramadol following tonsillectomy will report better pain control than children who receive scheduled codeine/acetaminophen. H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side effects than children who receive scheduled codeine/acetaminophen.

Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US, with over 530,000 procedures performed annually in children under 15 years (Baugh et al., 2011). The postoperative period can be particularly painful. A recent clinical consensus acknowledges there is no standard analgesic protocol, and calls for further research comparing postoperative pain medications (Baugh et al., 2011). Tramadol was found to be as effective as codeine with few reported side effects in a recent double-blinded, controlled trial conducted by the investigators at Children's Hospitals and Clinics (CHC), and it is currently being prescribed in the postoperative setting. However, despite its effectiveness for pain control, there were some children that continued to report pain during the 10-day follow-up period. In response, the investigators will conduct a randomized, double-blinded controlled trial to determine whether or not adding scheduled gabapentin to a scheduled tramadol + "as needed" (PRN) ibuprofen regimen provides better pain control than tramadol + ibuprofen PRN alone during the post-tonsillectomy period. Using a 10-day take-home diary, caregivers will be asked to record daily information about their child's postoperative pain and other core outcomes and domains as recommended in the recent consensus statement put forth by the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the efficacy and side effects associated with adding scheduled gabapentin to a postoperative pain management protocol in a pediatric population.

A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers [Completed]
The purpose of this study is to determine the safety and tolerability profile of tramadol hydrochloride (HCl) given as oral doses every 6 hours, within the range of dosages supported by currently available toxicology and clinical data (200 mg to 600 mg per day).

Evaluation of the Role of Tramadol 50mg as an Analgesic During Outpatient Hysteroscopy [Completed]

PK PD of the Enantiomers of Tramadol and O-desmethyltramadol in Elderly and Young Subjects [Completed]
This study evaluates the pharmacokinetics and pharmacodynamics of the enantiomers of tramadol and O-desmethyltramadol (ODM) in generally healthy young and elderly adults. Using a randomised, double-blind, crossover design, participants were administered a single 200mg tramadol extended-release tablet and placebo.

more trials >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 27 ratings/reviews, Tramadol has an overall score of 5.89. The effectiveness score is 7.19 and the side effect score is 6.52. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Tramadol review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Highly Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Nerve Painn
Dosage & duration:   30mg but increased to 50mg taken once in the evenings for the period of 2years
Other conditions:   Required Hip to be resurfaced
Other drugs taken:   Endep, cortisone,
  
Reported Results
Benefits:   The benefits allowed me to physically calm. this allowed me to sleep better, eat less and encourage a better outlook. Without Tramal life was very down.
Side effects:   Immediate sleepness, so needed to be careful when I took the tablet. Had to be careful if I took any other medications or alochol as there would be 'high' episodes.
Comments:   I only was required to take one tablet in the evenings, this was easy and I never forgot.

 

Tramadol review by 37 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   Fibromyalgia Pain
Dosage & duration:   100 mg/day taken daily for the period of 6months
Other conditions:   hypothyroid, depression
Other drugs taken:   Effexor XR, Armour Thyroid
  
Reported Results
Benefits:   In order to get any effects, I had to take 4-5 times the prescribed dosage. The medication is simply VERY WEAK. This drug did prove to me that managing pain on a daily basis, rather than responding to pain, significantly improved my quality of life and activity level.
Side effects:   I did not experience any side effects on a normal or high dose. A VERY HIGH dose (only taken accidentally, because I forgot I had taken my usual dose earlier) on an empty stomach, will produce an unpleasant "high" feeling mentally, including spaciness and shakiness. Therefore you can't just keep taking more and more of the drug.
Comments:   Bottom line, this drug just isn't very effective. It's more effective, and SIGNIFICANTLY SAFER, than the NSAIDS that docs are still prescribing for fibromylagia. But I am looking for better daily pain management.

 

Tramadol review by 53 year old female patient

  Rating
Overall rating:  
Effectiveness:   Marginally Effective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   shoulder pain
Dosage & duration:   50 mg tablet, 1-2 tablets as needed taken every 6 hours for the period of 6 weeks
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   relief of pain
Side effects:   agitation, insomnia
Comments:   This drug was prescribed for pain caused by therapy for frozen shoulder. The pain was making it impossible to sleep at night, so the doctor prescribed tramadol. While the drug did moderate the pain, it also caused agitation, anxiety, insomnia. I stopped taking it after a few days. I also stopped the therapy. The pain went away and my shoulder improved on its own.

See all Tramadol reviews / ratings >>

Page last updated: 2015-08-28

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