TRAMADOL SUMMARY
Tramadol hydrochloride tablet, USP is a centrally acting analgesic.
Tramadol hydrochloride tablets, USP are indicated for the management of moderate to moderately severe pain in adults.
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NEWS HIGHLIGHTSMedia Articles Related to Tramadol
The Opioid Crisis and Need for Compassion in Pain Management Source: Medscape Anesthesiology Headlines [2017.09.28] In this commentary, the author expresses concern that the response to the public health crisis of opioid addiction is creating a growing crisis of inadequate pain management. American Journal of Public Health
CVS to Restrict Opioid Painkiller Prescription Amounts Source: MedicineNet Drug Abuse Specialty [2017.09.25] Title: CVS to Restrict Opioid Painkiller Prescription Amounts Category: Health News Created: 9/22/2017 12:00:00 AM Last Editorial Review: 9/25/2017 12:00:00 AM
Stomach Pain Quiz: Nausea & Other Causes Source: MedicineNet Anal Fissure Specialty [2017.09.19] Title: Stomach Pain Quiz: Nausea & Other Causes Category: MedicineNet Quiz Created: 1/20/2011 12:00:00 AM Last Editorial Review: 9/19/2017 5:59:56 PM
Back Pain Quiz: Test Your Back Pain IQ Source: MedicineNet Ankylosing Spondylitis Specialty [2017.09.19] Title: Back Pain Quiz: Test Your Back Pain IQ Category: MedicineNet Quiz Created: 6/16/2011 3:41:00 PM Last Editorial Review: 9/19/2017 6:39:04 PM
Pain Quiz: Test Your IQ of Pain Source: MedicineNet Constipation Specialty [2017.09.19] Title: Pain Quiz: Test Your IQ of Pain Category: MedicineNet Quiz Created: 7/14/2011 3:53:00 PM Last Editorial Review: 9/19/2017 6:41:41 PM
Published Studies Related to Tramadol
Does the addition of tramadol and ketamine to ropivacaine prolong the axillary
brachial plexus block? [2014] ropivacaine in brachial plexus anesthesia... CONCLUSION: We conclude that when added to brachial plexus analgesia at a dose of
Efficacy of extended-release tramadol for treatment of prescription opioid
withdrawal: a two-phase randomized controlled trial. [2013] whether cessation of ER tramadol produces opioid withdrawal... CONCLUSIONS: ER tramadol 200mg modestly attenuated opioid withdrawal. Mild opioid
Comparison of the analgesic effects of oral tramadol and naproxen sodium on pain
relief during IUD insertion. [2012] on pain during insertion of an intrauterine device (IUD)... CONCLUSION: Prophylactic analgesia using 50 mg tramadol and 550 mg naproxen,
Tramadol versus methadone for treatment of opiate withdrawal: a double-blind,
randomized, clinical trial. [2012] The aim of this study was to compare the efficacy and safety of tramadol versus
methadone for treatment of opiate withdrawal. Seventy patients randomly were
assigned in two groups to receive either prescribed methadone (60 mg/day) or
tramadol (600 mg/day)... Tramadol may be as effective as methadone in the
control of withdrawal and could be considered as a potential substitute for
methadone to manage opioids withdrawal.
Comparison of peritonsillar infiltration effects of ketamine and tramadol on post
tonsillectomy pain: a double-blinded randomized placebo-controlled clinical
trial. [2012] on post tonsillectomy pain and compare the side effects... CONCLUSION: Preoperative peritonsillar infiltration of tramadol can decrease
Clinical Trials Related to Tramadol
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Completed]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The
postoperative period can be particularly painful. Codeine (usually in mixed formulation with
acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data
questions its ability to provide optimal pain relief, while avoiding side effects,
especially in the postoperative setting. Tramadol may be a better option for children in the
postoperative setting due to its well-documented analgesic properties, low potential for
side effects, and excellent safety profile. Seventy-two children scheduled to undergo
tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate
in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects
of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers
will be asked to record daily information about their child's postoperative pain and other
core outcomes and domains as recommended in the recent consensus statement put forth by the
Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials
(IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with tramadol as compared with codeine/acetaminophen
(the current practice standard) in a pediatric population.
Hypotheses
H1: Children who receive scheduled tramadol following tonsillectomy will report better pain
control than children who receive scheduled codeine/acetaminophen.
H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side
effects than children who receive scheduled codeine/acetaminophen.
Postoperative Tramadol/Gabapentin/Ibuprofen Versus Tramadol/Placebo/Ibuprofen [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US, with over
530,000 procedures performed annually in children under 15 years (Baugh et al., 2011). The
postoperative period can be particularly painful. A recent clinical consensus acknowledges
there is no standard analgesic protocol, and calls for further research comparing
postoperative pain medications (Baugh et al., 2011). Tramadol was found to be as effective
as codeine with few reported side effects in a recent double-blinded, controlled trial
conducted by the investigators at Children's Hospitals and Clinics (CHC), and it is
currently being prescribed in the postoperative setting. However, despite its effectiveness
for pain control, there were some children that continued to report pain during the 10-day
follow-up period. In response, the investigators will conduct a randomized, double-blinded
controlled trial to determine whether or not adding scheduled gabapentin to a scheduled
tramadol + "as needed" (PRN) ibuprofen regimen provides better pain control than tramadol +
ibuprofen PRN alone during the post-tonsillectomy period. Using a 10-day take-home diary,
caregivers will be asked to record daily information about their child's postoperative pain
and other core outcomes and domains as recommended in the recent consensus statement put
forth by the Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical
Trials (IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with adding scheduled gabapentin to a postoperative
pain management protocol in a pediatric population.
A Dose Ranging Escalation Study of Tramadol Hydrochloride in Healthy Volunteers [Completed]
The purpose of this study is to determine the safety and tolerability profile of tramadol
hydrochloride (HCl) given as oral doses every 6 hours, within the range of dosages supported
by currently available toxicology and clinical data (200 mg to 600 mg per day).
Evaluation of the Role of Tramadol 50mg as an Analgesic During Outpatient Hysteroscopy [Completed]
PK PD of the Enantiomers of Tramadol and O-desmethyltramadol in Elderly and Young Subjects [Completed]
This study evaluates the pharmacokinetics and pharmacodynamics of the enantiomers of
tramadol and O-desmethyltramadol (ODM) in generally healthy young and elderly adults. Using
a randomised, double-blind, crossover design, participants were administered a single 200mg
tramadol extended-release tablet and placebo.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 27 ratings/reviews, Tramadol has an overall score of 5.89. The effectiveness score is 7.19 and the side effect score is 6.52. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| Tramadol review by 44 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Highly Effective |
Side effects: | | Mild Side Effects | | Treatment Info |
Condition / reason: | | Nerve Painn |
Dosage & duration: | | 30mg but increased to 50mg taken once in the evenings for the period of 2years |
Other conditions: | | Required Hip to be resurfaced |
Other drugs taken: | | Endep, cortisone, | | Reported Results |
Benefits: | | The benefits allowed me to physically calm. this allowed me to sleep better, eat less and encourage a better outlook. Without Tramal life was very down. |
Side effects: | | Immediate sleepness, so needed to be careful when I took the tablet. Had to be careful if I took any other medications or alochol as there would be 'high' episodes. |
Comments: | | I only was required to take one tablet in the evenings, this was easy and I never forgot. |
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| Tramadol review by 37 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Marginally Effective |
Side effects: | | No Side Effects | | Treatment Info |
Condition / reason: | | Fibromyalgia Pain |
Dosage & duration: | | 100 mg/day taken daily for the period of 6months |
Other conditions: | | hypothyroid, depression |
Other drugs taken: | | Effexor XR, Armour Thyroid | | Reported Results |
Benefits: | | In order to get any effects, I had to take 4-5 times the prescribed dosage. The medication is simply VERY WEAK. This drug did prove to me that managing pain on a daily basis, rather than responding to pain, significantly improved my quality of life and activity level. |
Side effects: | | I did not experience any side effects on a normal or high dose. A VERY HIGH dose (only taken accidentally, because I forgot I had taken my usual dose earlier) on an empty stomach, will produce an unpleasant "high" feeling mentally, including spaciness and shakiness. Therefore you can't just keep taking more and more of the drug. |
Comments: | | Bottom line, this drug just isn't very effective. It's more effective, and SIGNIFICANTLY SAFER, than the NSAIDS that docs are still prescribing for fibromylagia. But I am looking for better daily pain management. |
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| Tramadol review by 53 year old female patient | | Rating |
Overall rating: | | |
Effectiveness: | | Marginally Effective |
Side effects: | | Severe Side Effects | | Treatment Info |
Condition / reason: | | shoulder pain |
Dosage & duration: | | 50 mg tablet, 1-2 tablets as needed taken every 6 hours for the period of 6 weeks |
Other conditions: | | none |
Other drugs taken: | | none | | Reported Results |
Benefits: | | relief of pain |
Side effects: | | agitation, insomnia |
Comments: | | This drug was prescribed for pain caused by therapy for frozen shoulder. The pain was making it impossible to sleep at night, so the doctor prescribed tramadol. While the drug did moderate the pain, it also caused agitation, anxiety, insomnia. I stopped taking it after a few days. I also stopped the therapy. The pain went away and my shoulder improved on its own. |
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Page last updated: 2017-09-28
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