NEWS HIGHLIGHTSMedia Articles Related to Tramadol
Addex: ADX71943 Demonstrates Analgesic Effects In Pain Models
Source: Health News from Medical News Today [2010.02.08]
Addex Pharmaceuticals / Addex: ADX71943 Demonstrates Analgesic Effects in Pain Models processed and transmitted by Hugin AS. The issuer is solely responsible for the content of this announcement. Addex Pharmaceuticals (SWISS: ADXN), the allosteric modulation company, announced today that ADX71943 has demonstrated statistically significant analgesic-like effects in three preclinical models of pain...
AAPM: Spine Stimulation Leads to Durable Pain Relief (CME/CE)
Source: MedPage Today Neurology [2010.02.07]
SAN ANTONIO (MedPage Today) -- Spinal cord stimulation provided durable pain relief for patients with complex regional pain syndrome but did not halt progression, a retrospective analysis of a small clinical series showed.
AAPM: Facet Graft Quells Refractory Back Pain (CME/CE)
Source: MedPage Today Neurology [2010.02.07]
SAN ANTONIO (MedPage Today) -- Minimally invasive facet arthrodesis significantly reduced pain and improved physical function for one year in patients with medically refractory facet arthropathy, according to data from a prospective clinical series.
Minimally Invasive Spine Surgery And Spinal Cord Stimulation Show Promise In Alleviating Back Pain
Source: Clinical Trials / Drug Trials News From Medical News Today [2010.02.05]
Results from the first prospective study of minimally invasive facet arthrodesis and long-term data on spinal cord stimulation demonstrate the viability of these options to achieve pain relief in patients with various back pain conditions. The studies were presented at the American Academy of Pain Medicine's 26th Annual Meeting in San Antonio, TX...
New, Targeted Pain Medicine Delivery Systems May Reduce Costs Long Term; Cost To Treat Pain Varies Significantly By Chronic Pain Condition
Source: Clinical Trials / Drug Trials News From Medical News Today [2010.02.05]
Estimates of pain care treatment costs exceed $1 billion annually in the United States. Today at the American Academy of Pain Medicine's 26th Annual Meeting two abstracts looked at the issue. One evaluated intrathecal drug delivery (a targeted medicine delivery system) that could save costs over time. The other analyzed the differences between the costs of treatment for chronic pain treatments...
Published Studies Related to Tramadol
Effects of tramadol on the minimum alveolar concentration of sevoflurane in dogs. [2009.07]
OBJECTIVE: To evaluate the effect of tramadol on sevoflurane minimum alveolar concentration (MAC(SEVO)) in dogs. It was hypothesized that tramadol would dose-dependently decrease MAC(SEVO).CONCLUSION AND CLINICAL RELEVANCE: Tramadol significantly reduced MAC(SEVO) but this was not dose dependent at the doses studied.
Pharmacokinetics of tramadol and its major metabolites following rectal and intravenous administration in dogs. [2009.06]
AIM: To compare the rectal and I/V administration of tramadol in dogs, to assess both its pharmacokinetic properties and absolute bioavailability... CONCLUSIONS: After rectal administration of tramadol suppositories, absorption of the active ingredient was rapid, but its metabolism quickly transformed the parent drug to high levels of M2 and M5. CLINICAL RELEVANCE: In the dog, rectal pharmaceutical formulation of tramadol would have a different pharmacokinetic behaviour than in humans.
Significance of the biopharmaceutical properties of tramadol sustained-release formulations for chrono-pharmacologically optimized treatment of pain from various sources. [2009.06]
Tramadol is currently one of the most frequently used opioid analgesics in the world. OBJECTIVE: The objective of this study was to investigate the rate and extent of tramadol bioavailability following evening versus morning intake of an extended-release pellet system designed for once daily administration. Moreover, the suitability of the preparation for chrono-adjusted pharmacotherapy was to be investigated... CONCLUSIONS: Bioavailability of the extended-release tramadol capsules for once daily administration is not affected by the time-point of administration. Total and maximum exposure of the product was bioequivalent after intake in the morning and at night. Thus, the time-point of administration may be adjusted to the patient's needs without any significant change in the in-vivo performance.
Comparison of analgesic effect of tramadol alone and a combination of tramadol and paracetamol in day-care laparoscopic surgery. [2009.06]
BACKGROUND AND OBJECTIVE: To compare the analgesic efficacy of tramadol alone (1.5 mg kg(-1)) with a tramadol (1 mg kg(-1)) and paracetamol combination in day-care laparoscopic patients... CONCLUSION: We conclude that reducing the dose of tramadol to 1 mg kg(-1) and combining it with paracetamol 1 g orally decreased the incidence of side effects of tramadol without reducing analgesic efficacy.
Analgesic efficacy of perioperative use of vedaprofen, tramadol or their combination in cats undergoing ovariohysterectomy. [2009.06]
The analgesic efficacy of tramadol and/or vedaprofen was evaluated in cats submitted for elective ovariohysterectomy, using a randomised double blind placebo controlled design. Forty adult female cats (3.0+/-0.32kg; 1.8+/-0.7 years) were distributed into four groups... This work also provides evidence for the benefits of analgesia for up to 3 days following ovariohysterectomy.
Clinical Trials Related to Tramadol
A Comparison of the Effectiveness and Safety of ULTRACETŪ (Tramadol Hydrochloride/Acetaminophen) Versus ULTRAMŪ (Tramadol Hydrochloride) Versus Placebo in Patients With Pain After Oral Surgery [Completed]
The purpose of this study is to explore the pain-relieving effects and safety of two
analgesic treatment regimens as compared to placebo in patients experiencing pain after oral
surgery. Tramadol hydrochloride/acetaminophen is approved to treat acute pain. This study
will evaluate the effectiveness and safety of tramadol hydrochloride/acetaminophen compared
with tramadol hydrochloride alone compared with placebo as a pain medication in the treatment
of pain following oral surgery.
Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain. [Completed]
This study investigates if Celebrex is as effective as tramadol hydrochloride (Ultram) for
patients with chronic low back pain, when administered over a 6-week period.
Comparison of Butorphanol and Tramadol Associated PCA After Hysterectomy [Completed]
Intravenous patient-controlled analgesia (PCA) is a popular technique for postoperative pain
management. Although several drugs are recognized as effective therapeutic options, optimal
selection of drugs in hysterectomy patients underwent different anesthesia treatments remains
unknown explicitly. We hypothesized that butorphanol and tramadol can produce different
analgesic effects with intravenous PCA after abdominal hysterectomy.
A One-Year, Open-Label Study to Assess the Safety and Effectiveness of Extended Release Tramadol HCl in the Treatment of Chronic, Non-Malignant Pain. [Completed]
The purpose of this study is to assess the safety of tramadol HCl ER following long-term
treatment. The study hypothesis is that long-term treatment with tramadol HCl ER is safe and
effective for the treatment of chronic, non-malignant pain.
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee [Completed]
The purpose of this study is to compare the analgesic effectiveness and safety of tramadol
HCl ER to placebo in patients with moderate to severe pain due to osteoarthritis (OA). The
study hypothesis is that tramadol HCl ER is effective and safe in the treatment of OA.
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PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 15 ratings/reviews, Tramadol has an overall score of 5.27. The effectiveness score is 6.93 and the side effect score is 6.40. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Tramadol review by 50 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Pain |
| Dosage & duration: | | 50 mg every 6 hours or as needed taken twice daily for the period of 5 days |
| Other conditions: | | N/A |
| Other drugs taken: | | N/A | | |
Reported Results |
| Benefits: | | Pain relief allowing uninterupted sleep. |
| Side effects: | | None |
| Comments: | | Previous adverse effects from hydrocodone made Tramadol the drug of choice for pain relief after a complicated tooth extraction. I was very pleased to have adequate pain relief without the "fuzzy" feeling and slight nausea previously experienced with other prescription pain relievers. |
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| | Tramadol review by 28 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Interstital Cystitis |
| Dosage & duration: | | 50mg taken 1 tablet every 6 hrs for the period of One month |
| Other conditions: | | Constant severe bladder pain |
| Other drugs taken: | | Ambien for a sleep disorder | | |
Reported Results |
| Benefits: | | The first two days I took this drug the pain went away. Then, the effectiveness declined rapidly. I called my doctor and she increased the dosage to 100mg every 6 hours. This helped for about two days, and then it was back to being ineffective.
I think this is a rather weak way to manage daily pain associated with IC. |
| Side effects: | | A little bit of nausea when the pill actually worked. No side effects at all when the pill didn't work. |
| Comments: | | My IC cocktail started to work after about a month and there wasn't much need for pain killers anymore so I just stopped taking Tramadol.
In the future, when my IC would flare up, I requested no Tramadol and instead received Tylenol with Codiene. It worked much better. |
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| | Tramadol review by 26 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | severe abdominal pain yet to be diagnosed |
| Dosage & duration: | | 50mg-100mg taken every 4 to 6 hours for the period of 2 weeks |
| Other conditions: | | insomnia and other GI issues |
| Other drugs taken: | | elavil for GI problems and metaprolol for mitral valve prolapse | | |
Reported Results |
| Benefits: | | The benefits were almost non-existent. I had taken this med before after a terrible car accident and therefore felt secure enough to take it again this time. However after only one day medicine stopped being effective. |
| Side effects: | | Some drowsiness at night after taken it throughout the day and some constipation. However after taking it for only two weeks I had a seizure that sent me to hospital and was told by doc there that elavil and tramadol combined can cause seizures! NO ONE told me this. Not my primary care doc, my GI doc or the pharmacist. This seems to me to be a pretty severe "side effect" for a medicine that barely works! The two meds were prescribed to me by the same physician and I understand oversights can happen. However if I had known from beginning that seizures might be a possibility I would asked for something else. Also after only two weeks I had some weird effects after stopping usage including diarrhea, cold sweats, hot flashes, restless leg syndrome and anxiety. I never experienced anything like this with any other meds. This medicine is NOT worth it! |
| Comments: | | 1 to 2 50mg tablets every 4 to 6 hours. |
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