TRAMADOL HYDROCHLORIDE TABLET
Tramadol hydrochloride tablet is a centrally acting analgesic.
Tramadol hydrochloride is indicated for the management of moderate to moderately severe pain in adults.
Media Articles Related to Tramadol
Low Back Pain Pictures Slideshow: Symptoms, Causes, Treatment and Relief
Source: MedicineNet Alternative Medicine Specialty [2015.06.26]
Title: Low Back Pain Pictures Slideshow: Symptoms, Causes, Treatment and Relief
Created: 2/16/2012 12:00:00 AM
Last Editorial Review: 6/26/2015 12:00:00 AM
Low Back Pain Pictures Slideshow: Good and Bad Exercises for Low Back Pain
Source: MedicineNet Low Back Pain Specialty [2015.06.26]
Title: Low Back Pain Pictures Slideshow: Good and Bad Exercises for Low Back Pain
Created: 9/29/2014 12:00:00 AM
Last Editorial Review: 6/26/2015 12:00:00 AM
Make the Diagnosis: Painful red eye
Source: MedPage Today Dermatology [2015.06.25]
(MedPage Today) -- Case Study: A 29 year old contact lens wearer presents to urgent care with a red eye, pain, and visual loss that has been increasing over the past twelve hours. Examination shows injected conjunctiva with ciliary flush, and a cornea with white infiltrate in the stroma.
What is your Diagnosis?
Chronic Pain Pictures Slideshow: Causes, Solutions and Management
Source: MedicineNet Chronic Pain Specialty [2015.06.25]
Title: Chronic Pain Pictures Slideshow: Causes, Solutions and Management
Created: 4/26/2012 12:00:00 AM
Last Editorial Review: 6/25/2015 12:00:00 AM
Payment Reform: Will Gain Follow Pain?
Source: Medscape Hematology-Oncology Headlines [2015.06.24]
No doubt payment reform is painful, but is there an emerging payment model that provides a gain for oncologists? A panel of experts sorts out the options as part of a special session at ASCO 2015.
Published Studies Related to Tramadol
Efficacy of extended-release tramadol for treatment of prescription opioid
withdrawal: a two-phase randomized controlled trial. 
whether cessation of ER tramadol produces opioid withdrawal... CONCLUSIONS: ER tramadol 200mg modestly attenuated opioid withdrawal. Mild opioid
Comparison of the analgesic effects of oral tramadol and naproxen sodium on pain
relief during IUD insertion. 
on pain during insertion of an intrauterine device (IUD)... CONCLUSION: Prophylactic analgesia using 50 mg tramadol and 550 mg naproxen,
Tramadol versus methadone for treatment of opiate withdrawal: a double-blind,
randomized, clinical trial. 
The aim of this study was to compare the efficacy and safety of tramadol versus
methadone for treatment of opiate withdrawal. Seventy patients randomly were
assigned in two groups to receive either prescribed methadone (60 mg/day) or
tramadol (600 mg/day)... Tramadol may be as effective as methadone in the
control of withdrawal and could be considered as a potential substitute for
methadone to manage opioids withdrawal.
Comparison of peritonsillar infiltration effects of ketamine and tramadol on post
tonsillectomy pain: a double-blinded randomized placebo-controlled clinical
on post tonsillectomy pain and compare the side effects... CONCLUSION: Preoperative peritonsillar infiltration of tramadol can decrease
Evaluation of analgesic efficacy of intra-articular bupivacaine, bupivacaine plus fentanyl, and bupivacaine plus tramadol after arthroscopic knee surgery. [2011.12]
PURPOSE: To compare the efficacy of intra-articular (IA) bupivacaine, bupivacaine-fentanyl, and bupivacaine-tramadol for relief of postoperative pain after arthroscopic knee surgery... CONCLUSIONS: On the primary outcome measure (VAS pain score), both bupivacaine with fentanyl and bupivacaine with tramadol were better than IA bupivacaine, and bupivacaine with fentanyl was better than that with tramadol. However, both the combinations were comparable to each other with regard to the secondary outcome measure (supplementary analgesic requirement). Thus IA bupivacaine-fentanyl appears to be the best combination for relief of postoperative pain in patients undergoing arthroscopic knee surgery, followed by IA bupivacaine-tramadol. LEVEL OF EVIDENCE: Level I, randomized controlled trial. Copyright (c) 2011 Arthroscopy Association of North America. Published by Elsevier Inc. All rights reserved.
Clinical Trials Related to Tramadol
A Comparison of the Effectiveness and Safety of ULTRACET® (Tramadol Hydrochloride/Acetaminophen) Versus ULTRAM® (Tramadol Hydrochloride) Versus Placebo in Patients With Pain After Oral Surgery [Completed]
The purpose of this study is to explore the pain-relieving effects and safety of two
analgesic treatment regimens as compared to placebo in patients experiencing pain after oral
surgery. Tramadol hydrochloride/acetaminophen is approved to treat acute pain. This study
will evaluate the effectiveness and safety of tramadol hydrochloride/acetaminophen compared
with tramadol hydrochloride alone compared with placebo as a pain medication in the treatment
of pain following oral surgery.
CYTRAM (Cytochrome P450, Tramadol) [Recruiting]
Many methods to detect CYP2D6 poor metabolizers have been validated. Some of them are based
on phenotyping (metabolism of dextromethorphan or debrisoquine) and some others on
genotyping. Up to now, CYP2D6 pharmacogenetics has been restricted to the field of research,
in spite of poor metabolizer profile concerns 5 to 10 % of caucasian population.
Nevertheless, the polymorphism of CYP2D6 is responsible for the metabolism of many drugs,
particularly of two opioids involved in pain management: codeine and tramadol, their
metabolites representing the most effective part of the drug effect. So prescribing codeine
or tramadol in a patient poor metabolizer for the CYP2D6 is likely to be ineffective in pain
O-demethyl-tramadol, the metabolite of tramadol via CYP2D6, is important to consider because
its analgesic effect is 2 to 4 times more potent than tramadol.
The investigators propose to phenotype CYP2D6 in post-operative patients treated by tramadol
by monitoring seric concentrations of O-demethyl tramadol and tramadol to make a ratio in
comparison with genotype, and to find a threshold to determine poor metabolizers. As already
described, genotyping CYP2D6 will use a rapid detection method of the alleles implicated in
poor metabolizer status (CYP2D6*3, *4, *5 et *6) in a Caucasian population. Sampling will be
executed at two times (H24 and H48 after surgery) and only with blood (three EDTA tubes)
during the post-operative monitoring of the patients. This study is likely to include 320
post-operative patients treated with intravenous tramadol during one year in three
university hospitals centers (CHU of Caen, CrÃ©teil and Rouen).
The first aim of this study is the validation of monitoring seric concentrations of
O-demethyl-tramadol and tramadol to make the ratio in order to detect CYP2D6 poor
metabolizers in therapeutic situation, comparing the result with genotyping. The finding of
a poor metabolizer status in a patient will make the choice of analgesic drugs easier,
avoiding tramadol and codeine. The final objective of this research is to be able to
determine the CYP2D6 phenotype in a patient treated by tramadol without a good analgesia. By
a single take of blood and a rapid response, this method should be liked to improve pain
management. Furthermore, CYP2D6 phenotyping is interesting for the patient because many
other drugs depend on this way of metabolism.
A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy [Recruiting]
Tonsillectomy is the most common pediatric surgical procedure performed in the US. The
postoperative period can be particularly painful. Codeine (usually in mixed formulation with
acetaminophen) is the most commonly prescribed opioid in the US. However, evolving data
questions its ability to provide optimal pain relief, while avoiding side effects,
especially in the postoperative setting. Tramadol may be a better option for children in the
postoperative setting due to its well-documented analgesic properties, low potential for
side effects, and excellent safety profile. Seventy-two children scheduled to undergo
tonsillectomy (with or without adenoidectomy) at Children's will be invited to participate
in a randomized, prospective, double-blinded study to evaluate the efficacy and side effects
of codeine with acetaminophen versus tramadol. Using a 10-day take-home diary, caregivers
will be asked to record daily information about their child's postoperative pain and other
core outcomes and domains as recommended in the recent consensus statement put forth by the
Pediatric Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials
(IMMPACT) (McGrath et al., 2008). This study will offer new information regarding the
efficacy and side effects associated with tramadol as compared with codeine/acetaminophen
(the current practice standard) in a pediatric population.
H1: Children who receive scheduled tramadol following tonsillectomy will report better pain
control than children who receive scheduled codeine/acetaminophen.
H2: Children who receive scheduled tramadol following tonsillectomy will report fewer side
effects than children who receive scheduled codeine/acetaminophen.
Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin [Recruiting]
Tramadol is an opioid analgesic, which is widely used in the treatment of acute and
neuropathic pain. Treatment of neuropathic pain often requires a combination of pain
medications due to the complex nature of neuropathic pain and frequent inadequate response
to drug treatment. Common drugs used concomitantly with tramadol are SNRI antidepressant
duloxetine and anticonvulsants such as pregabalin. Both tramadol and duloxetine have
serotonergic effects and duloxetine has also a potential to inhibit metabolism of tramadol.
The objective of the study is to investigate the pharmacokinetics and pharmacodynamic
interaction of oral tramadol with duloxetine and pregabalin in patients with chronic
neuropathic pain due to postherpetic neuralgia or diabetic polyneuropathy. All subjects will
receive tramadol and duloxetine or tramadol and pregabalin in a randomized double-blind
order. Primary end point is O-desmethyltramadol concentration.
Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain. [Completed]
This study investigates if Celebrex is as effective as tramadol hydrochloride (Ultram) for
patients with chronic low back pain, when administered over a 6-week period.
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 27 ratings/reviews, Tramadol has an overall score of 5.89. The effectiveness score is 7.19 and the side effect score is 6.52. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
Tramadol review by 44 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || Nerve Painn|
|Dosage & duration:|| || 30mg but increased to 50mg taken once in the evenings for the period of 2years|
|Other conditions:|| || Required Hip to be resurfaced|
|Other drugs taken:|| || Endep, cortisone, |
|Benefits:|| || The benefits allowed me to physically calm. this allowed me to sleep better, eat less and encourage a better outlook. Without Tramal life was very down.|
|Side effects:|| || Immediate sleepness, so needed to be careful when I took the tablet. Had to be careful if I took any other medications or alochol as there would be 'high' episodes.|
|Comments:|| || I only was required to take one tablet in the evenings, this was easy and I never forgot.|
Tramadol review by 37 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Marginally Effective|
|Side effects:|| || No Side Effects|
|Condition / reason:|| || Fibromyalgia Pain|
|Dosage & duration:|| || 100 mg/day taken daily for the period of 6months|
|Other conditions:|| || hypothyroid, depression|
|Other drugs taken:|| || Effexor XR, Armour Thyroid|
|Benefits:|| || In order to get any effects, I had to take 4-5 times the prescribed dosage. The medication is simply VERY WEAK. This drug did prove to me that managing pain on a daily basis, rather than responding to pain, significantly improved my quality of life and activity level.|
|Side effects:|| || I did not experience any side effects on a normal or high dose. A VERY HIGH dose (only taken accidentally, because I forgot I had taken my usual dose earlier) on an empty stomach, will produce an unpleasant "high" feeling mentally, including spaciness and shakiness. Therefore you can't just keep taking more and more of the drug. |
|Comments:|| || Bottom line, this drug just isn't very effective. It's more effective, and SIGNIFICANTLY SAFER, than the NSAIDS that docs are still prescribing for fibromylagia. But I am looking for better daily pain management. |
Tramadol review by 53 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Marginally Effective|
|Side effects:|| || Severe Side Effects|
|Condition / reason:|| || shoulder pain|
|Dosage & duration:|| || 50 mg tablet, 1-2 tablets as needed taken every 6 hours for the period of 6 weeks|
|Other conditions:|| || none|
|Other drugs taken:|| || none|
|Benefits:|| || relief of pain|
|Side effects:|| || agitation, insomnia|
|Comments:|| || This drug was prescribed for pain caused by therapy for frozen shoulder. The pain was making it impossible to sleep at night, so the doctor prescribed tramadol. While the drug did moderate the pain, it also caused agitation, anxiety, insomnia. I stopped taking it after a few days. I also stopped the therapy. The pain went away and my shoulder improved on its own.|
Page last updated: 2015-06-26