TRAMADOL SUMMARY
TRAMADOL HYDROCHLORIDE TABLETS
Tramadol hydrochloride tablet is a centrally acting analgesic.
Tramadol hydrochloride is indicated for the management of moderate to moderately severe pain in adults.
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TRAMADOL NEWS HIGHLIGHTS Media Articles Related to Tramadol
New Treatment For Receding Gums: No Pain, Lots Of Gain
Source: Cosmetic Medicine / Plastic Surgery News From Medical News Today [2009.07.02]
Tufts dental researchers conducted a three-year follow-up study that examined the stability of a treatment option for receding gums and found that complete root coverage the goal of the surgery had been maintained. This specific tissue regeneration application, developed at Tufts, reduces the considerable pain and recovery time of gum grafting surgery. The case study of six patients is published in the July 2009 issue of the Journal of Periodontology.
Increasing Age Of Mothers In Spain Leads To Rise In Mortality Rates
Source: Seniors / Aging News From Medical News Today [2009.07.02]
A new study examining the evolution of maternal mortality rates in Spain since 1996 shows a 17% increase in deaths. This trend is linked to the widespread increase in maternal age. The highest death rates are among foreign women and those who live in the province of Malaga. Medicine has taken giant strides during the 20th Century. However, European studies show a clear and constant increase in maternal mortality rates over recent years.
Health Tip: What's Causing My Neck Pain?
Source: MedicineNet Arthritis Specialty [2009.07.02]
Title: Health Tip: What's Causing My Neck Pain?
Category: Health News
Created: 7/2/2009 7:00:00 AM
Last Editorial Review: 7/2/2009
Laughter - The Best Medicine? Spain Hosts The Most Renowned International Symposium On Sense Of Humor And Its Applications
Source: Conferences News From Medical News Today [2009.07.01]
Spain hosts this week, for the first time in history, this event, the most renowned international symposium on humour and laughter, where scientists and experts from four continents will discuss the latest advances and research of this field of study.
Lower Empathic Responses To Outsiders' Pain Shown By Imaging Study
Source: Neurology / Neuroscience News From Medical News Today [2009.07.01]
An observer feels more empathy for someone in pain when that person is in the same social group, according to new research in the July 1 issue of The Journal of Neuroscience. The study shows that perceiving others in pain activates a part of the brain associated with empathy and emotion more if the observer and the observed are the same race. The findings may show that unconscious prejudices against outside groups exist at a basic level.
Published Studies Related to Tramadol
Tramadol for prevention of postanaesthetic shivering: a randomised double-blind comparison with pethidine. [2009.02]
The present study was conducted with the aims of comparing intravenous tramadol 1, 2 and 3 mg.kg(-1) with pethidine 0.5 mg.kg(-1) for prophylaxis of postanaesthetic shivering and to find a dose of tramadol that could provide the dual advantage of antishivering and analgesic effect in the postoperative period... Tramadol 2 mg.kg(-1) had the best combination of antishivering and analgesic efficacy without excessive sedation and thus appeared to be a good choice to be administered at the time of wound closure to provide antishivering effect and analgesia without significant side effects in the postoperative period.
Glomerular filtration rate after tramadol, parecoxib and pindolol following anaesthesia and analgesia in comparison with morphine in dogs. [2009.01]
OBJECTIVE: To compare the effects of morphine, parecoxib, tramadol and a combination of parecoxib, tramadol and pindolol on nociceptive thresholds in awake animals and their effect on glomerular filtration rate (GFR) in dogs subjected to 30 minutes of anesthesia. ANIMALS: Eight adult mixed breed experimental dogs. STUDY DESIGN: Randomized, controlled trial... CONCLUSION: Tramadol and parecoxib (either alone or in combination) can increase nociceptive thresholds in awake dogs and have minimal effects on renal perfusion in normotensive dogs subjected to anaesthesia.
Tramadol as an adjuvant to lidocaine for axillary brachial plexus block. [2009.01]
BACKGROUND: In this prospective randomized study, we evaluated the effect of tramadol as an adjuvant to axillary block... CONCLUSIONS: The benefit of block prolongation associated with the addition of 200 mg tramadol to lidocaine during axillary block is limited by the slow onset of the block.
Addition of remifentanil to patient-controlled tramadol for postoperative analgesia: a double-blind, controlled, randomized trial after major abdominal surgery. [2008.12]
BACKGROUND AND OBJECTIVE: We have investigated whether, after major abdominal surgery, the addition of remifentanil to tramadol for intravenous patient-controlled analgesia improved analgesia and lowered pain scores, compared to a patient-controlled analgesia containing only tramadol... CONCLUSIONS: After major abdominal surgery, adding remifentanil (0.2 microg kg(-1)) to tramadol (0.2 mg kg(-1)), with 10-min lockout times, for patient-controlled analgesia offered better postoperative pain relief and patient comfort, without causing any sedation or respiratory depression.
Comparison of caudal bupivacaine and bupivacaine-tramadol for postoperative analgesia in children with hypospadias repair. [2008.10]
Objective: To compare the effects after caudal bupivacaine alone and bupivacaine-tramadol in young children with hypospadias repair... The risk of toxicity from bupivacaine decreased when combined with tramadol in low doses.
Clinical Trials Related to Tramadol
A Comparison of the Effectiveness and Safety of ULTRACETŪ (Tramadol Hydrochloride/Acetaminophen) Versus ULTRAMŪ (Tramadol Hydrochloride) Versus Placebo in Patients With Pain After Oral Surgery [Completed]
The purpose of this study is to explore the pain-relieving effects and safety of two
analgesic treatment regimens as compared to placebo in patients experiencing pain after oral
surgery. Tramadol hydrochloride/acetaminophen is approved to treat acute pain. This study
will evaluate the effectiveness and safety of tramadol hydrochloride/acetaminophen compared
with tramadol hydrochloride alone compared with placebo as a pain medication in the treatment
of pain following oral surgery.
Celebrex vs Tramadol in the Treatment of Chronic Lower Back Pain. [Completed]
This study investigates if Celebrex is as effective as tramadol hydrochloride (Ultram) for
patients with chronic low back pain, when administered over a 6-week period.
Comparison of Butorphanol and Tramadol Associated PCA After Hysterectomy [Completed]
Intravenous patient-controlled analgesia (PCA) is a popular technique for postoperative pain
management. Although several drugs are recognized as effective therapeutic options, optimal
selection of drugs in hysterectomy patients underwent different anesthesia treatments remains
unknown explicitly. We hypothesized that butorphanol and tramadol can produce different
analgesic effects with intravenous PCA after abdominal hysterectomy.
A One-Year, Open-Label Study to Assess the Safety and Effectiveness of Extended Release Tramadol HCl in the Treatment of Chronic, Non-Malignant Pain. [Completed]
The purpose of this study is to assess the safety of tramadol HCl ER following long-term
treatment. The study hypothesis is that long-term treatment with tramadol HCl ER is safe and
effective for the treatment of chronic, non-malignant pain.
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee [Completed]
The purpose of this study is to compare the analgesic effectiveness and safety of tramadol
HCl ER to placebo in patients with moderate to severe pain due to osteoarthritis (OA). The
study hypothesis is that tramadol HCl ER is effective and safe in the treatment of OA.
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TRAMADOL PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 9 ratings/reviews, Tramadol has an overall score of 5.33. The effectiveness score is 6.89 and the side effect score is 6.67. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Tramadol review by 50 year old female patient | | | Rating |
| Overall rating: | |   |
| Effectiveness: | | Considerably Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Pain |
| Dosage & duration: | | 50 mg every 6 hours or as needed taken twice daily for the period of 5 days |
| Other conditions: | | N/A |
| Other drugs taken: | | N/A | | |
Reported Results |
| Benefits: | | Pain relief allowing uninterupted sleep. |
| Side effects: | | None |
| Comments: | | Previous adverse effects from hydrocodone made Tramadol the drug of choice for pain relief after a complicated tooth extraction. I was very pleased to have adequate pain relief without the "fuzzy" feeling and slight nausea previously experienced with other prescription pain relievers. |
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| | Tramadol review by 37 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Marginally Effective |
| Side effects: | | No Side Effects | | |
Treatment Info |
| Condition / reason: | | Fibromyalgia Pain |
| Dosage & duration: | | 100 mg/day taken daily for the period of 6months |
| Other conditions: | | hypothyroid, depression |
| Other drugs taken: | | Effexor XR, Armour Thyroid | | |
Reported Results |
| Benefits: | | In order to get any effects, I had to take 4-5 times the prescribed dosage. The medication is simply VERY WEAK. This drug did prove to me that managing pain on a daily basis, rather than responding to pain, significantly improved my quality of life and activity level. |
| Side effects: | | I did not experience any side effects on a normal or high dose. A VERY HIGH dose (only taken accidentally, because I forgot I had taken my usual dose earlier) on an empty stomach, will produce an unpleasant "high" feeling mentally, including spaciness and shakiness. Therefore you can't just keep taking more and more of the drug. |
| Comments: | | Bottom line, this drug just isn't very effective. It's more effective, and SIGNIFICANTLY SAFER, than the NSAIDS that docs are still prescribing for fibromylagia. But I am looking for better daily pain management. |
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| | Tramadol review by 56 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Moderately Effective |
| Side effects: | | Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | Severe pain |
| Dosage & duration: | | 300 mg slow release taken once a day for the period of 12 weeks |
| Other conditions: | | Severe pain from herniated cervical disk |
| Other drugs taken: | | Mobic | | |
Reported Results |
| Benefits: | | Some reduction of pain |
| Side effects: | | Became dependant on it as suffered severe movement disorder/restless legs coming off it, leading to depression and permant movement disorder long after other problems have settled. This is now managed with other drugs, but a neurotherapist has indicated that the Tramadol caused a permanent dopamine imbalance in my brain. |
| Comments: | | Was taking Tramadol for assistance with pain caused by the herniated disk. Was also having physiotherapy and anti-inflamatories Mobic. |
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Page last updated: 2009-07-02
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