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Toprol-XL (Metoprolol Succinate) - Summary

 


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BOX WARNING

Ischemic Heart Disease:

Following abrupt cessation of therapy with certain beta-blocking agents, exacerbations of angina pectoris and, in some cases, myocardial infarction have occurred. When discontinuing chronically administered TOPROL-XL, particularly in patients with ischemic heart disease, the dosage should be gradually reduced over a period of 1−2 weeks and the patient should be carefully monitored. If angina markedly worsens or acute coronary insufficiency develops, TOPROL-XL administration should be reinstated promptly, at least temporarily, and other measures appropriate for the management of unstable angina should be taken. Patients should be warned against interruption or discontinuation of therapy without the physician’s advice. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue TOPROL-XL therapy abruptly even in patients treated only for hypertension.

 

TOPROL-XL SUMMARY

TOPROL-XL®
(metoprolol succinate)
EXTENDED-RELEASE TABLETS
TABLETS: 25 MG, 50 MG, 100 MG, AND 200 MG

TOPROL-XL, metoprolol succinate, is a beta1-selective (cardioselective) adrenoceptor blocking agent, for oral administration, available as extended release tablets. TOPROL-XL has been formulated to provide a controlled and predictable release of metoprolol for once-daily administration. The tablets comprise a multiple unit system containing metoprolol succinate in a multitude of controlled release pellets. Each pellet acts as a separate drug delivery unit and is designed to deliver metoprolol continuously over the dosage interval. The tablets contain 23.75, 47.5, 95 and 190 mg of metoprolol succinate equivalent to 25, 50, 100 and 200 mg of metoprolol tartrate, USP, respectively. Its chemical name is (±)1-(isopropylamino)-3-[p-(2-methoxyethyl) phenoxy]-2-propanol succinate (2:1) (salt).

Hypertension

TOPROL-XL is indicated for the treatment of hypertension. It may be used alone or in combination with other antihypertensive agents.

Angina Pectoris

TOPROL-XL is indicated in the long-term treatment of angina pectoris.

Heart Failure

TOPROL-XL is indicated for the treatment of stable, symptomatic (NYHA Class II or III) heart failure of ischemic, hypertensive, or cardiomyopathic origin. It was studied in patients already receiving ACE inhibitors, diuretics, and, in the majority of cases, digitalis. In this population, TOPROL-XL decreased the rate of mortality plus hospitalization, largely through a reduction in cardiovascular mortality and hospitalizations for heart failure.


See all Toprol-XL indications & dosage >>

TOPROL-XL NEWS HIGHLIGHTS

Published Studies Related to Toprol-XL (Metoprolol)

A randomized, double-blind study of valsartan versus metoprolol on arterial distensibility and endothelial function in essential hypertension. [2008.07]

Randomized comparison of metoprolol versus conventional treatment in preventing recurrence of vasovagal syncope in children and adolescents. [2008.04]

Comparison of the effects of carvedilol and metoprolol on exercise ventilatory efficiency in patients with congestive heart failure. [2008.03]

Renal and cardiac effects of antihypertensive treatment with ramipril vs metoprolol in autosomal dominant polycystic kidney disease. [2008.02]

Nebivolol and metoprolol for treating migraine: an advance on beta-blocker treatment? [2008.01]

more >>

Clinical Trials Related to Toprol-XL (Metoprolol)

Carvedilol Versus Metoprolol for the Prevention of Atrial Fibrillation After Off-Pump Coronary Bypass Surgery [Completed]

Metoprolol and Formoterol in Chronic Obstructive Pulmonary Disease (COPD) [Recruiting]

Efficacy and Safety of Adding Clopidogrel to Aspirin or Use of Metoprolol in Myocardial Infarction [Completed]

A Comparison of the Effect of Carvedilol and Metoprolol on Airways Tone in Patients With Heart Failure [Terminated]

Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-Release (ER) for Hypertension [Completed]

more >>

TOPROL-XL PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Toprol-XL has an overall score of 7. The effectiveness score is 6 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
 

Toprol-XL review by 45 year old female patient

  Rating
Overall rating:  
Effectiveness:   Moderately Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   high blood pressure and
Dosage & duration:   25mg taken once daily for the period of one year to date
Other conditions:   none
Other drugs taken:   tylenol and advil; ketorolac: frova
  
Reported Results
Benefits:   It seems to keep my blood pressure and headaches in check, especially during hormonal changes right before my period begins. I am also sleeping better at night (falling asleep and staying asleep; able to get back to sleep during the night), whereas before I was getting only a couple of hours of sleep a night.
Side effects:   none so far
Comments:   I had been dealing with more frequent "migraine" headaches (headaches unresponsive to OTC pain relievers)and began to notice a pattern that was related to my menstrual cycle. During treatment for the headaches with frova and ketorolac I had an episode where I had sudden and severe pain in my head and felt like my head was going to explode, which sent me to the emergency room. The cause was never really determined but in the process it was noticed that my blood pressure was elevated and remained elevated during following doctor visits. Since being on toprol, the headaches and blood pressure have remained managable throughout monthly hormonal changes.

See all Toprol-XL reviews / ratings >>

Page last updated: 2008-11-03

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