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Topicort (Desoximetasone Topical) - Summary

 
 



TOPICORT SUMMARY

Topicort (desoximetasone) Ointment 0.25% contains the active synthetic corticosteroid desoximetasone. The topical corticosteroids constitute a class of primarily synthetic steroids used as anti-inflammatory and antipruritic agents.

Topicort (desoximetasone) Ointment 0.25% is indicated for the relief of the inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.


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NEWS HIGHLIGHTS

Published Studies Related to Topicort (Desoximetasone Topical)

Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis. [2006.11]
Long-term in vitro compatibility of desoximetasone and tacrolimus ointments prompted the current trial in humans. We aimed to evaluate the efficacy of twice-daily simultaneous application of desoximetasone and tacrolimus in the treatment of atopic dermatitis versus tacrolimus monotherapy.Combination treatment with desoximetasone and tacrolimus offered increased efficacy and tolerability over tacrolimus alone in patients with atopic dermatitis.

Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay. [2008]
INTRODUCTION: We report on a double-blind, vehicle-controlled, single-center confirmatory study with random assignment. The purpose of the study was to investigate the topical bioavailability of different topical corticosteroid formulations in healthy human beings focussing on desoximetasone (DM)... CONCLUSION: DM-o 0.25%, DM-fo 0.25% and BM 0.05% showed similar vasoconstrictive potential, i.e., clear blanching. In fact, both DM preparations were proven to be noninferior to BM 0.05%, while CP 0.05% was found a little less active. HC 1.0% and the DM vehicles showed no clear-cut vasoconstrictive effect. No adverse events related to the study medications were observed. Good topical bioavailability of both DM formulations was detected by chromametric measurement and clinical assessment. (c) 2008 S. Karger AG, Basel.

Cross-reactions to desoximetasone and mometasone furoate in a patient with multiple topical corticosteroid allergies. [2006.09]
A 60-year-old man developed a bullous contact dermatitis after topical corticosteroid treatment of dermatitis on his lower leg. Subsequent patch testing showed cross-reactions to numerous group B and group D corticosteroids as well as cross-reactions to group C desoximetasone and group D1 mometasone furoate.

Compatibility of desoximetasone and tacrolimus. [2003.12]
The physical and chemical compatibility of desoximetasone ointment 0.25% and tacrolimus ointment 0.1%, both widely used to treat atopic dermatitis, were determined. A 1:1 (w/w) mixture of desoximetasone ointment 0.25% (Topicort, Taro Pharmaceuticals USA, Inc.) and tacrolimus ointment 0.1% (Protopic, Fujisawa Healthcare, Inc.) were prepared and stored under three different temperature/relative humidity conditions: 25 degrees C/60% RH; 30 degrees C/60% RH; and 40 degrees C/75% RH...

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Clinical Trials Related to Topicort (Desoximetasone Topical)

Effects of Desoximetasone Spray 0.25% in Patients With Moderate to Severe Plaque Psoriasis [Recruiting]
The objective of this study is to demonstrate that desoximetasone 0. 25% topical spray is effective for the treatment of patients with moderate to severe plaque psoriasis.

Effects of Desoximetasone Spray 0.25% on Moderate to Severe Plaque Psoriasis [Recruiting]
The objective of this study is to demonstrate that desoximetasone 0. 25% topical spray is effective for the treatment of patients with moderate to severe plaque psoriasis.

Desoximetasone Spray 0.25%, Hypothalamic Pituitary Adrenal (HPA) Axis Study [Recruiting]
The objective of this study is to evaluate the potential of desoximetasone 0. 25% topical spray to suppress HPA axis function. The potential for adrenal suppression will be assessed following multiple dosing with Desoximetasone 0. 25% Topical Spray in patients with moderate to severe plaque psoriasis. The secondary objectives are to evaluate the efficacy parameters and to evaluate the adverse event (AE) profile.

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PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 1 ratings/reviews, Topicort has an overall score of 6. The effectiveness score is 8 and the side effect score is 10. The scores are on ten point scale: 10 - best, 1 - worst.
 

Topicort review by 40 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   No Side Effects
  
Treatment Info
Condition / reason:   itchy and irritated skin
Dosage & duration:   a small coat of cream (dosage frequency: twice a day) for the period of 10 days and then when needed
Other conditions:   none
Other drugs taken:   none
  
Reported Results
Benefits:   After applying the medicament, the itching sensation reduced after 20 minutes and irritation slowly dissapeared after 10 days, The irritation occasionally re-occurred. I have applied the medicament occasionally (about twice a month) when the irritation re-occured for about oone years. Now the irritation never reappears
Side effects:   none
Comments:   I had a irritation on both my feet. I applied the medicament twice a day and when the itchy sensation occurs.

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Page last updated: 2008-06-22

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