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Topamax (Topiramate) - Summary

 
 



TOPAMAX SUMMARY

TOPAMAX®(topiramate)
Tablets
TOPAMAX®(topiramate capsules)
Sprinkle Capsules

Topiramate is a sulfamate-substituted monosaccharide that is intended for use as an antiepileptic drug. TOPAMAX® (topiramate) Tablets are available as 25 mg, 50 mg, 100 mg, and 200 mg round tablets for oral administration. TOPAMAX® (topiramate capsules) Sprinkle Capsules are available as 15 mg and 25 mg sprinkle capsules for oral administration as whole capsules or opened and sprinkled onto soft food.

TOPAMAX® (topiramate) Tablets and TOPAMAX® (topiramate capsules) Sprinkle Capsules are indicated as adjunctive therapy for adults and pediatric patients ages 2 - 16 years with partial onset seizures, or primary generalized tonic-clonic seizures, and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome.


See all Topamax indications & dosage >>

NEWS HIGHLIGHTS

Published Studies Related to Topamax (Topiramate)

[Topiramate in substance-related and addictive disorders]. [Article in French] [2014]
CONCLUSION: Topiramate showed interest mainly in alcoholism, binge eating

Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: a randomized double blind placebo controlled clinical trial. [2014]
treatment... CONCLUSIONS: The combination of lithium+olanzapine+clonazepam decreased the

Oral morphine for cancer pain. [2013]
CONCLUSIONS: The effectiveness of oral morphine has stood the test of

A double-blind, placebo-controlled trial of topiramate for the treatment of comorbid cocaine and alcohol dependence. [2013]
BACKGROUND: Topiramate increases GABAergic activity and antagonizes the AMPA/kainate subtype of glutamate receptors. Through these mechanisms of action, topiramate may reduce alcohol and cocaine reward and may reduce alcohol and cocaine craving... DISCUSSION: Topiramate plus cognitive behavioral therapy may reduce cocaine use for some patients with comorbid cocaine and alcohol dependence.

A comparative study of the effects of low-dose topiramate versus sodium valproate in migraine prophylaxis. [2012]
The present study was performed to evaluate the efficacy of low-dose topiramate and compare it with sodium valproate that is prevalently prescribed as a migraine prophylaxis. This was a randomized, double-blind, parallel-group clinical trial on 56 patients who completed the course of study... Topiramate dose of 50 mg/day with fewer side effects in comparison with its higher doses may be an appropriate substitution for first-line migraine prophylaxis such as valproate.

more studies >>

Clinical Trials Related to Topamax (Topiramate)

Topiramate Treatment of Alcohol Use Disorders in Veterans With PTSD: A Pilot Controlled Trial of Augmentation Therapy [Not yet recruiting]
The proposed project aims to:

1. Obtain a preliminary assessment of the efficacy of topiramate treatment in reducing alcohol use in veterans with PTSD and alcohol dependence;

2. Obtain preliminary assessments of safety/tolerability of topiramate in these patients;

3. Assess the feasibility of recruitment and retention for topiramate treatment in this comorbid population; and 4) to inform the design of a planned subsequent larger controlled trial of topiramate.

PRIMARY HYPOTHESIS: Topiramate treatment combined with Medical Management alcohol counseling will be associated with a significant increase in percent days abstinent from baseline to end of treatment.

SECONDARY HYPOTHESIS: There will be a significantly greater percent of days abstinent from alcohol use in the topiramate treatment group compared to the placebo group.

Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine [Recruiting]
Subjects enrolled at 2 investigative sites will complete 3 visits. Following Visit 1, during a 1-month Baseline Period, subjects will treat with their usual medication and document any warning signs (Prodrome pre-headache) that a migraine will occur. Following randomization (like a flip of the coin) at Visit 2, subjects will treat daily with topiramate or during Prodrome with frovatriptan. Subjects complete a 2-month Treatment Period before exit at Visit 3. This study will compare the effectiveness of daily treatment vs. treatment during the pre-headache phase for prevention of migraine.

Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD) [Completed]

Fed Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's topiramate sprinkle 25 mg capsules to Ortho-McNeil's Topamax® Sprinkle 25 mg capsules following a single, oral 25 mg (1 x 25 mg) dose administered under fed conditions.

Fasting Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's topiramate sprinkle 25 mg capsule to Ortho-McNeil's Topamax® Sprinkle 25 mg capsule following a single, oral 25 mg (1 x 25 mg) dose administered under fasting conditions.

more trials >>

Reports of Suspected Topamax (Topiramate) Side Effects

Depression (94)Cleft Palate (85)Maternal Exposure During Pregnancy (78)Anxiety (78)Convulsion (63)Self Injurious Behaviour (60)Weight Decreased (55)Cleft LIP and Palate (47)Developmental Delay (43)Cleft LIP (43)more >>


PATIENT REVIEWS / RATINGS / COMMENTS

Based on a total of 35 ratings/reviews, Topamax has an overall score of 6.83. The effectiveness score is 7.71 and the side effect score is 6.34. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
 

Topamax review by 43 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   Migraine prevention
Dosage & duration:   Five 25 mg tablets Twice a Day taken daily for the period of 3 Years
Other conditions:   Allergies
Other drugs taken:   Benadryl, Aleve. birth control pills
  
Reported Results
Benefits:   Topamax helped decrease the frequency and intensity of my migraines.
Side effects:   Treatment side effects include paresthesia of my hands and mild drowsiness.
Comments:   Topamax was taken in order to prevent migraines. I also monitored my diet to avoid migraine triggers such as caffeine, aged cheeses, preserved meats, bananas, avocados, beans, dairy products, beer, wine, etc. In addition, I took birth control pills to control hormonal fluctuations. This helped prevent menstrual migraines.

 

Topamax review by 44 year old female patient

  Rating
Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
  
Treatment Info
Condition / reason:   migraine
Dosage & duration:   25mg taken 2 x daily for the period of 1 year and current
Other conditions:   none
Other drugs taken:   hormone replacement therapy (natural cream)
  
Reported Results
Benefits:   My conclusions of the medication are that it has definately lessened the amount of migraine headaches that I was encountering. I have not had to have an emergency hospital visit in almost a year. This went from a visit occuring almost every other month with horrible painful headaches in between this time. I still get headaches which are tollerable, and if I have a migraine have not had to go to the hospital for pain relief. It has been tolerable. I have now gotten my dose down to 15mg at night time only and am still having the same benefit. My only side effect were some memory difficulty in the beginning. I drove to my doctors office and became disoriented. Rather than panic I laughed it off and pulled over and had to think about where I was going. It has definately had a positive influence on the migraines. It seems to have some sort of effect on eating though. I did loose a bit more weight which I did not need to loose, but now have been able to be back at my normal weight.
Side effects:   Some forgetfulness,, tiredness at onset. Nothing unbearable.
Comments:   25mg morning and night. 9 months, then went to 15mg capsules morning and night for a few months. Now down to 15mg at night time only.

 

Topamax review by 50 year old female patient

  Rating
Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
  
Treatment Info
Condition / reason:   Migraines
Dosage & duration:   50 mg taken once daily for the period of 6 months
Other conditions:   None
Other drugs taken:   None
  
Reported Results
Benefits:   I did not experience any treatment benefits from Topamax for my severe and incapacitating migraines. I did not get relief for my migraine headaches. My migraine headaches did not stop. My migraine headaches did not decrease in duration(3 days per migraine) or intensity (severe). I had one - 3 day a week migraine for over seven years.
Side effects:   The Topamax treatment side effects were extreme when I was taking it. I experienced extreme weight loss, I went from one hundred thirty pounds down to ninety eight pounds. I experienced mental confusion and had a hard time focusing on anything including family, relationships and work. I experienced a deep depression and had suicidal ideations that I had never before had. I also experienced loss of my word finding skills.
Comments:   The treatment details for Topamax which is used to treat seizure disorders was also supposed to treat migraines are as follows. As the patient I was to take fifty milligrams per day and was told I would lose perhaps two percent of my body weight but that after a thirty day period my migraines would decrease in intensity and decrease in duration.

See all Topamax reviews / ratings >>

Page last updated: 2014-11-30

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