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Topamax (Topiramate) - Summary



TOPAMAX® (topiramate) is an anticonvulsant.

Monotherapy Epilepsy

TOPAMAX® (topiramate) Tablets and TOPAMAX® (topiramate capsules) Sprinkle Capsules are indicated as initial monotherapy in patients 2 years of age and older with partial onset or primary generalized tonic-clonic seizures. Safety and effectiveness in patients who were converted to monotherapy from a previous regimen of other anticonvulsant drugs have not been established in controlled trials [see Clinical Studies].

Adjunctive Therapy Epilepsy

TOPAMAX® Tablets and TOPAMAX® Sprinkle Capsules are indicated as adjunctive therapy for adults and pediatric patients ages 2 to 16 years with partial onset seizures or primary generalized tonic-clonic seizures, and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome [see Clinical Studies].


TOPAMAX® Tablets and TOPAMAX® Sprinkle Capsules are indicated for adults for the prophylaxis of migraine headache [see Clinical Studies]. The usefulness of TOPAMAX® in the acute treatment of migraine headache has not been studied.

See all Topamax indications & dosage >>


Published Studies Related to Topamax (Topiramate)

[Topiramate in substance-related and addictive disorders]. [Article in French] [2014]
CONCLUSION: Topiramate showed interest mainly in alcoholism, binge eating

Topiramate as an adjuvant treatment for obsessive compulsive symptoms in patients with bipolar disorder: a randomized double blind placebo controlled clinical trial. [2014]
treatment... CONCLUSIONS: The combination of lithium+olanzapine+clonazepam decreased the

Topiramate treatment of alcohol use disorder in veterans with posttraumatic stress disorder: a randomized controlled pilot trial. [2014]
veterans with both disorders... CONCLUSIONS: These preliminary results indicate that in veterans with

Topiramate for cocaine dependence during methadone maintenance treatment: a randomized controlled trial. [2014]
CONCLUSION: Topiramate is not efficacious for increasing cocaine abstinence in

Randomized clinical trial of topiramate for levodopa-induced dyskinesia in Parkinson's disease. [2014]
disease and levodopa-induced dyskinesia... CONCLUSIONS: Topiramate tended to worsen dyskinesia in patients with Parkinson's

more studies >>

Clinical Trials Related to Topamax (Topiramate)

Aripiprazole and Topiramate on Free-Choice Alcohol Use [Recruiting]
The current study investigates the effects of two potential alcohol treatment medications on drinking in a laboratory setting. Aripiprazole (APZ), effects dopamine and serotonin receptors with fewer limiting side effects seen with other atypical antipsychotics. Topiramate (TPMT), an antiepileptic, affects glutamate and GABA-A receptors and shows promise in reducing heavy drinking. Few studies have used two medications with such a diverse combination of actions to examine a potential synergistic effect on reducing alcohol consumption. The primary aims are to: 1. determine if APZ and TPMT are each more effective than placebo, and the combination of APZ and TPMT is more effective than either drug alone or placebo, in reducing alcohol use in non-treatment seeking alcohol dependent subjects in a laboratory based alcohol self-administration experiment (ASAE) 2. examine a hypothesized dose-response for three doses of APZ (0, 7. 5 mg/d and 15 mg/d) along with three doses of TPMT (0, 100mg/d and 200mg/d) 3. examine the putative mechanisms of action of APZ, TPMT alone and together on craving, subjective stimulation, candidate gene influences and other behavioral effects associated with alcohol consumption 4. establish the safety of giving APZ and TPMT together. Non-treatment seeking, alcohol dependent Participants (N=216) will be recruited from the community and randomly assigned to one of the 9 cells. Subjects drinking and safety is monitored over a 5-week titration to their target dose, leading to an in-laboratory alcohol self administration session, during which clinical and behavioral effects are assessed during access to alcohol. A 1 month follow-up assesses adverse events and drinking.

Pilot Study to Compare Frovatriptan vs. Topiramate for Prevention of Migraine [Completed]
Subjects enrolled at 2 investigative sites will complete 3 visits. Following Visit 1, during a 1-month Baseline Period, subjects will treat with their usual medication and document any warning signs (Prodrome pre-headache) that a migraine will occur. Following randomization (like a flip of the coin) at Visit 2, subjects will treat daily with topiramate or during Prodrome with frovatriptan. Subjects complete a 2-month Treatment Period before exit at Visit 3. This study will compare the effectiveness of daily treatment vs. treatment during the pre-headache phase for prevention of migraine.

Topiramate-Phentermine Combinations for Cocaine Dependence [Recruiting]
This study will determine the influence of topiramate (Topamax) and phentermine (Adipex), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine.

Topiramate for Alcohol Use in Posttraumatic Stress Disorder [Recruiting]
Alcohol abuse and dependence (alcohol use disorders, AUDs) and posttraumatic stress disorder (PTSD) are both prevalent in Veterans. Treating AUDs in Veterans with PTSD may be more difficult than treating AUDs in the general population. The FDA-approved medication topiramate has been shown to improve drinking outcomes in people with AUDs. Topiramate has also improved symptoms in people with PTSD. This study is designed to investigate whether topiramate will improve drinking outcomes in Veterans with PTSD.

Efficacy and Safety of Topiramate in the Treatment of Sleep-Related Eating Disorder [Recruiting]

more trials >>

Reports of Suspected Topamax (Topiramate) Side Effects

Depression (94)Cleft Palate (85)Maternal Exposure During Pregnancy (78)Anxiety (78)Convulsion (63)Self Injurious Behaviour (60)Weight Decreased (55)Cleft LIP and Palate (47)Developmental Delay (43)Cleft LIP (43)more >>


Based on a total of 35 ratings/reviews, Topamax has an overall score of 6.83. The effectiveness score is 7.71 and the side effect score is 6.34. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.

Topamax review by 43 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   Migraine prevention
Dosage & duration:   Five 25 mg tablets Twice a Day taken daily for the period of 3 Years
Other conditions:   Allergies
Other drugs taken:   Benadryl, Aleve. birth control pills
Reported Results
Benefits:   Topamax helped decrease the frequency and intensity of my migraines.
Side effects:   Treatment side effects include paresthesia of my hands and mild drowsiness.
Comments:   Topamax was taken in order to prevent migraines. I also monitored my diet to avoid migraine triggers such as caffeine, aged cheeses, preserved meats, bananas, avocados, beans, dairy products, beer, wine, etc. In addition, I took birth control pills to control hormonal fluctuations. This helped prevent menstrual migraines.


Topamax review by 44 year old female patient

Overall rating:  
Effectiveness:   Considerably Effective
Side effects:   Mild Side Effects
Treatment Info
Condition / reason:   migraine
Dosage & duration:   25mg taken 2 x daily for the period of 1 year and current
Other conditions:   none
Other drugs taken:   hormone replacement therapy (natural cream)
Reported Results
Benefits:   My conclusions of the medication are that it has definately lessened the amount of migraine headaches that I was encountering. I have not had to have an emergency hospital visit in almost a year. This went from a visit occuring almost every other month with horrible painful headaches in between this time. I still get headaches which are tollerable, and if I have a migraine have not had to go to the hospital for pain relief. It has been tolerable. I have now gotten my dose down to 15mg at night time only and am still having the same benefit. My only side effect were some memory difficulty in the beginning. I drove to my doctors office and became disoriented. Rather than panic I laughed it off and pulled over and had to think about where I was going. It has definately had a positive influence on the migraines. It seems to have some sort of effect on eating though. I did loose a bit more weight which I did not need to loose, but now have been able to be back at my normal weight.
Side effects:   Some forgetfulness,, tiredness at onset. Nothing unbearable.
Comments:   25mg morning and night. 9 months, then went to 15mg capsules morning and night for a few months. Now down to 15mg at night time only.


Topamax review by 50 year old female patient

Overall rating:  
Effectiveness:   Ineffective
Side effects:   Severe Side Effects
Treatment Info
Condition / reason:   Migraines
Dosage & duration:   50 mg taken once daily for the period of 6 months
Other conditions:   None
Other drugs taken:   None
Reported Results
Benefits:   I did not experience any treatment benefits from Topamax for my severe and incapacitating migraines. I did not get relief for my migraine headaches. My migraine headaches did not stop. My migraine headaches did not decrease in duration(3 days per migraine) or intensity (severe). I had one - 3 day a week migraine for over seven years.
Side effects:   The Topamax treatment side effects were extreme when I was taking it. I experienced extreme weight loss, I went from one hundred thirty pounds down to ninety eight pounds. I experienced mental confusion and had a hard time focusing on anything including family, relationships and work. I experienced a deep depression and had suicidal ideations that I had never before had. I also experienced loss of my word finding skills.
Comments:   The treatment details for Topamax which is used to treat seizure disorders was also supposed to treat migraines are as follows. As the patient I was to take fifty milligrams per day and was told I would lose perhaps two percent of my body weight but that after a thirty day period my migraines would decrease in intensity and decrease in duration.

See all Topamax reviews / ratings >>

Page last updated: 2015-08-10

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