TOPAMAX SUMMARY
TOPAMAX®(topiramate)
Tablets
TOPAMAX®(topiramate capsules)
Sprinkle Capsules
Topiramate is a sulfamate-substituted monosaccharide that is intended for use as an antiepileptic drug. TOPAMAX® (topiramate) Tablets are available as 25 mg, 50 mg, 100 mg, and 200 mg round tablets for oral administration. TOPAMAX® (topiramate capsules) Sprinkle Capsules are available as 15 mg and 25 mg sprinkle capsules for oral administration as whole capsules or opened and sprinkled onto soft food.
TOPAMAX® (topiramate) Tablets and TOPAMAX® (topiramate capsules) Sprinkle Capsules are indicated as adjunctive therapy for adults and pediatric patients ages 2 - 16 years with partial onset seizures, or primary generalized tonic-clonic seizures, and in patients 2 years of age and older with seizures associated with Lennox-Gastaut syndrome.
|
TOPAMAX NEWS HIGHLIGHTS Media Articles Related to Topamax (Topiramate)
Topamax May Raise Risk of Birth Defects
Source: MedicineNet topiramate Specialty [2008.07.22]
Title: Topamax May Raise Risk of Birth Defects
Category: Health News
Created: 7/22/2008
Last Editorial Review: 7/22/2008
Published Studies Related to Topamax (Topiramate)
A double-blind randomized controlled trial of topiramate and amitriptyline either alone or in combination for the prevention of migraine. [2008.12]
OBJECTIVE: Effectiveness of antidepressants and antiepileptic drugs has already been demonstrated for migraine prophylaxis as monotherapy. In the present study, the efficacy and tolerability of amitriptyline and topiramate [generic for Topamax] combination is examined in the prevention of migraine attacks, in comparison to the monotherapy of each drug... CONCLUSION: Amitriptyline and topiramate combination may be beneficial for patients with migraine and comorbid depression, particularly in terms of side effects and associated displeasure due to monotherapy.
A double-blind, randomized trial of low-dose topiramate vs propranolol in migraine prophylaxis. [2008.11]
OBJECTIVE: To assess the efficacy and safety of low-dose topiramate [generic for Topamax] in migraine prophylaxis vs propranolol... CONCLUSION: This study demonstrated that both low-dose topiramate and propranolol could significantly reduce migraine headache frequency, intensity, and duration. However, compared with propranolol, low-dose topiramate showed better results.
Effects of topiramate and levetiracetam vs placebo on habituation of contingent negative variation in migraine patients. [2008.09.12]
Migraine is characterized by reduced habituation of multimodal evoked potentials, which in turn reflects an abnormal pattern of cortical excitability. We assessed the effects of a 2-month treatment with topiramate [generic for Topamax] or levetiracetam vs placebo on contingent negative variation (CNV) habituation and amplitude in a cohort of migraine without aura (MO) patients...
A double-blind randomized controlled trial of topiramate and amitriptyline either alone or in combination for the prevention of migraine. [2008.07.10]
OBJECTIVE: Effectiveness of antidepressants and antiepileptic drugs has already been demonstrated for migraine prophylaxis as monotherapy. In the present study, the efficacy and tolerability of amitriptyline and topiramate [generic for Topamax] combination is examined in the prevention of migraine attacks, in comparison to the monotherapy of each drug... CONCLUSION: Amitriptyline and topiramate combination may be beneficial for patients with migraine and comorbid depression, particularly in terms of side effects and associated displeasure due to monotherapy.
Topiramate in older patients with partial-onset seizures: a pilot double-blind, dose-comparison study. [2008.07]
PURPOSE: Pharmacokinetics of antiepileptic drugs (AEDs) can be altered by age-related changes in physiology, thereby altering clinical effects, especially tolerability, in older adults. We compared two dosages of topiramate [generic for Topamax] (TPM) in a pilot study of patients >or=60 years of age with partial-onset seizures... CONCLUSIONS: This pilot study supports the practice of using low-to-moderate dosages of AEDs in older adults.
Clinical Trials Related to Topamax (Topiramate)
Topiramate in the Treatment of Post Traumatic Stress Disorder (PTSD) [Completed]
Fed Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's topiramate
sprinkle 25 mg capsules to Ortho-McNeil's Topamax® Sprinkle 25 mg capsules following a
single, oral 25 mg (1 x 25 mg) dose administered under fed conditions.
Fasting Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's topiramate
sprinkle 25 mg capsule to Ortho-McNeil's Topamax® Sprinkle 25 mg capsule following a single,
oral 25 mg (1 x 25 mg) dose administered under fasting conditions.
Applesauce Study of Topiramate Sprinkle Capsules 25 mg and Topamax® Sprinkle Capsules 25 mg [Completed]
The objective of this study was to investigate the bioequivalence of Mylan's topiramate
sprinkle 25 mg capsule to Ortho-McNeil's Topamax® Sprinkle 25 mg capsule following a single,
oral 25 mg (1 x 25 mg) dose sprinkled on one teaspoon of applesauce under fasting
conditions.
Safety and Efficacy of Topamax Versus Carbamazepine in Benign Rolandic Epilepsy [Completed]
|
TOPAMAX PATIENT REVIEWS / RATINGS / COMMENTSBased on a total of 16 ratings/reviews, Topamax has an overall score of 6.88. The effectiveness score is 7.75 and the side effect score is 6.88. The scores are on ten point scale: 10 - best, 1 - worst. Below are selected reviews: the highest, the median and the lowest rated.
| | Topamax review by 39 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Highly Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | Migraine |
| Dosage & duration: | | 200 MG taken 2x per day for the period of 4 years |
| Other conditions: | | bi-polar disorder |
| Other drugs taken: | | klonopin, prozac | | |
Reported Results |
| Benefits: | | Greatly reduced severe migraines that were occurring almost daily. This drug was added as a preventative medication when migraines became so dibilitating that I could not function in everyday life, i.e., go to work, take care of self and family, etc. Migraines were reduced after approximately 6-8 weeks on the medication to about 1 per month and then continually reduced to 1 every 3 to 6 months as I stayed on the medication. I also use the medication to manage my mood disorder (bi-polar disorder) and was able to not have to take a mood stabalizer, because this drug also manages to keep me from getting "manic", so it is an extra "bonus" on top of the migraine management!! |
| Side effects: | | The only side effect I noticed was some weight loss in the beginning. My doctor was very careful to start me out on 50 MG and move me up VERY slowly to the 200 MG 2x per day, which I understand is a very high dosage and took all of 4 years to get to that dosage. I was monitored every 30 days to ensure that I was not losing too much weight, having any type of eye problems, or numbness in my hands or feet--the eye problems, and numbness I never experienced; but was always told that if I did experience even a hint of these things, that I would have to stop the medication immediately--so my doctor does constantly ask me about those things. I have also read that Topamax has been used to treat alcoholics, and have noticed that since taking it, I have no desire to drink alcohol at all--but I am not an alcoholic--just a unique observation. It really just seems like a great drug!! |
| Comments: | | I am still taking it to manage both my migraines and my mood disorder--200 MG 2x per day. I take 2 in the AM and 2 in the PM. It is prescribed by my Neurologist and managed by him mostly; and my psychatrist also works with him, because if I ever go off of the drug, I would be required to go onto a mood stabalizer due to the bi-polar disorder. I would be very unhappy to have to go back onto something like Depakote, because that made me very slow and sluggish and Topamax does not have that side effect. |
|
| | Topamax review by 44 year old female patient | | | Rating |
| Overall rating: | |  |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Mild Side Effects | | |
Treatment Info |
| Condition / reason: | | migraines |
| Dosage & duration: | | 100mg taken once a day for the period of 2 years |
| Other conditions: | | None |
| Other drugs taken: | | Synthroid, Ortho cyclen | | |
Reported Results |
| Benefits: | | Significantly reduced migraines frequency and severity |
| Side effects: | | mild tingling sensation in fingers and toes for several weeks after starting, occaissional problems remembering names, lethargy after taking but this was addressed by adjusting time of dosage to bedtime. |
| Comments: | | I sought treatment for frequent severe migrains. I started getting migraines at age 30 and in recent months had been having 2-3 migrains a week. I was taking Imitrex at the initial sign of a migrain (eye aura) but this was had limited effectiveness. My doctor recommended trying Topamax. In the first 2 months I had 2 migrains and have only had 4 in the last 18 months. I take 100mg at bed because it makes very relaxed and sleep very deeply. I very occasionally find myself forgetting nouns and proper names but that has been the only cognitive effect. I still have been able to be effective and focused at my job. |
|
| | Topamax review by 50 year old female patient | | | Rating |
| Overall rating: | | |
| Effectiveness: | | Considerably Effective |
| Side effects: | | Extremely Severe Side Effects | | |
Treatment Info |
| Condition / reason: | | severe headaches |
| Dosage & duration: | | 25mg taken 4 times per day for the period of 1 month |
| Other conditions: | | anxiety and depression |
| Other drugs taken: | | propranalol and citalopram | | |
Reported Results |
| Benefits: | | they helped to reduce headaches that I had been sufferein over a period of over 2 years |
| Side effects: | | I noticed, after only a couple of weeks that my anxiety and depression had to an almost unbearable level, I looked at the tablets side effects and realised that they must be the contributing factor as my condition had remained stable for a few years, before i started taking them. the side effects still remain, months after stopping the medication. |
| Comments: | | I took 1 x 25mg per day which built up to 4 x 25mg per day over 4 weeks |
|
|
|
Page last updated: 2009-02-08
|
