TOLMETIN SODIUM CAPSULES USP
DESCRIPTION
Each capsule, for oral administration, contains 492 mg of tolmetin sodium (as the dihydrate), equivalent to 400 mg of tolmetin. Each capsule contains 36 mg (1.56 mEq) of sodium. Each capsule contains the following inactive ingredients: colloidal silicon dioxide, FD&C Red #40, gelatin, magnesium stearate, pregelatinized starch, and titanium dioxide.
The pKa of tolmetin is 3.5 and tolmetin sodium is freely soluble in water.
Tolmetin sodium is a nonselective non-steroidal anti-inflammatory agent. Chemically it is sodium 1-methyl-5- P -toluoylpyrrole-2-acetate dihydrate. It has the following structural formula:
C15H14NNaO3•2H2O M.W. 315.30
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