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Tolbutamide (Tolbutamide) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Hypoglycemia

See PRECAUTIONS and OVERDOSAGE.

Gastrointestinal Reactions

Cholestatic jaundice may occur rarely; tolbutamide should be discontinued if this occurs. Gastrointestinal disturbances, e.g., nausea, epigastric fullness, and heartburn, are the most common reactions and occur in 1.4% of patients treated during clinical trial. They tend to be dose related and may disappear when dosage is reduced.

Dermatologic Reactions

Allergic skin reactions, e.g., pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, occur in 1.1% of patients treated during clinical trials. These may be transient and may disappear despite continued use of tolbutamide; if skin reactions persist, the drug should be discontinued.

Porphyria cutanea tarda and photosensitivity reactions have been reported with sulfonylureas.

Hematologic Reactions

Leukopenia, agranulocytosis, thrombocytopenia, hemolytic anemia, aplastic anemia, and pancytopenia have been reported with sulfonylureas.

Metabolic Reactions

Hepatic porphyria and disulfiram-like reactions have been reported with sulfonylureas.

Endocrine Reactions

Cases of hyponatremia and the syndrome of inappropriate antidiuretic hormone (SIADH) secretion have been reported with this and other sulfonylureas.

Miscellaneous Reactions

Headache and taste alterations have occasionally been reported with tolbutamide administration.



REPORTS OF SUSPECTED TOLBUTAMIDE SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Tolbutamide. The information is not vetted and should not be considered as verified clinical evidence.

Possible Tolbutamide side effects / adverse reactions in 52 year old female

Reported by a health professional (non-physician/pharmacist) from Australia on 2012-01-05

Patient: 52 year old female

Reactions: Liver Injury

Suspect drug(s):
Fluvastatin

Carbamazepine

Metformin HCL
    Indication: Type 2 Diabetes Mellitus

Enalapril Maleate
    Indication: Hypertension

Fluoxetine HCL

Tolbutamide



See index of all Tolbutamide side effect reports >>

Drug label data at the top of this Page last updated: 2009-02-01

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