DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Tofranil (Imipramine Hydrochloride) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Note – Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug, the pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when Tofranil is administered.

Cardiovascular: Orthostatic hypotension, hypertension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, ECG changes, precipitation of congestive heart failure, stroke.

Psychiatric: Confusional states (especially in the elderly) with hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia and nightmares; hypomania; exacerbation of psychosis.

Neurological: Numbness, tingling, paresthesias of extremities; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures, alterations in EEG patterns; tinnitus.

Anticholinergic: Dry mouth, and, rarely, associated sublingual adenitis; blurred vision, disturbances of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.

Allergic: Skin rash, petechiae, urticaria, itching, photosensitization; edema (general or of face and tongue); drug fever; cross-sensitivity with desipramine.

Hematologic: Bone marrow depression including agranulocytosis; eosinophilia; purpura; thrombocytopenia.

Gastrointestinal: Nausea and vomiting, anorexia, epigastric distress, diarrhea; peculiar taste, stomatitis, abdominal cramps, black tongue.

Endocrine: Gynecomastia in the male; breast enlargement and galactorrhea in the female; increased or decreased libido, impotence; testicular swelling; elevation or depression of blood sugar levels; inappropriate antidiuretic hormone (ADH) secretion syndrome.

Other: Jaundice (simulating obstructive); altered liver function; weight gain or loss; perspiration; flushing; urinary frequency; drowsiness, dizziness, weakness and fatigue; headache; parotid swelling; alopecia; proneness to falling.

Withdrawal Symptoms: Though not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache, and malaise.

Note – In enuretic children treated with Tofranil the most common adverse reactions have been nervousness, sleep disorders, tiredness, and mild gastrointestinal disturbances. These usually disappear during continued drug administration or when dosage is decreased. Other reactions which have been reported include constipation, convulsions, anxiety, emotional instability, syncope, and collapse. All of the adverse effects reported with adult use should be considered.



REPORTS OF SUSPECTED TOFRANIL SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Tofranil. The information is not vetted and should not be considered as verified clinical evidence.

Possible Tofranil side effects / adverse reactions in 4 year old male

Reported by a consumer/non-health professional from Brazil on 2011-12-13

Patient: 4 year old male

Reactions: Accident, Confusional State, Hypersensitivity, Psychological Trauma, Aggression

Suspect drug(s):
Carbolitium
    Dosage: unk ukn, unk

Ritalin
    Dosage: 3 tabs, daily
    Administration route: Oral
    Indication: Psychomotor Hyperactivity

Ritalin
    Dosage: 2 tabs, daily
    Administration route: Oral

Tofranil
    Dosage: 1 tab, at night

Other drugs received by patient: Neozine; Risperidone



Possible Tofranil side effects / adverse reactions in 41 year old female

Reported by a pharmacist from United States on 2012-07-27

Patient: 41 year old female weighing 75.2 kg (165.4 pounds)

Reactions: Dysarthria, Somnolence, Accidental Overdose

Adverse event resulted in: hospitalization

Suspect drug(s):
Diazepam
    Dosage: chronic
    Indication: Back Pain

Dilaudid
    Dosage: chronic
    Indication: Back Pain

Fentanyl
    Dosage: chronic
    Indication: Back Pain

Klonopin
    Dosage: chronic
    Indication: Back Pain

Lorazepam
    Dosage: chronic
    Indication: Back Pain

Morphine
    Dosage: chronic
    Indication: Back Pain

Tofranil
    Dosage: chronic
    Indication: Back Pain

Tramadol HCL
    Dosage: chronic
    Indication: Back Pain

Other drugs received by patient: Synthroid; Lotemax; Prednisone TAB; Reglan; Depakote; Restasis; Seasonale; Zofran; Colace



Possible Tofranil side effects / adverse reactions in 60 year old female

Reported by a physician from United States on 2012-08-08

Patient: 60 year old female

Reactions: NO Adverse Event

Suspect drug(s):
Butazolidin Alka
    Dosage: unk

Codeine Sulfate
    Dosage: unk

Limbitrol
    Dosage: unk

Morphine Sulfate
    Dosage: unk

Pseudoephedrine HCL
    Dosage: unk

Stadol
    Dosage: unk

Tofranil
    Dosage: unk



See index of all Tofranil side effect reports >>

Drug label data at the top of this Page last updated: 2014-05-30

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017