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Tofranil-PM (Imipramine Pamoate) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Note: Although the listing which follows includes a few adverse reactions which have not been reported with this specific drug, the pharmacological similarities among the tricyclic antidepressant drugs require that each of the reactions be considered when imipramine is administered.

Cardiovascular: Orthostatic hypotension, hypertension, tachycardia, palpitation, myocardial infarction, arrhythmias, heart block, ECG changes, precipitation of congestive heart failure, stroke.

Psychiatric: Confusional states (especially in the elderly) with hallucinations, disorientation, delusions; anxiety, restlessness, agitation; insomnia and nightmares; hypomania; exacerbation of psychosis.

Neurological: Numbness, tingling, paresthesias of extremities; incoordination, ataxia, tremors; peripheral neuropathy; extrapyramidal symptoms; seizures, alterations in EEG patterns; tinnitus.

Anticholinergic: Dry mouth, and, rarely, associated sublingual adenitis; blurred vision, disturbances of accommodation, mydriasis; constipation, paralytic ileus; urinary retention, delayed micturition, dilation of the urinary tract.

Allergic: Skin rash, petechiae, urticaria, itching, photosensitization; edema (general or of face and tongue); drug fever; cross-sensitivity with desipramine.

Hematologic: Bone marrow depression including agranulocytosis; eosinophilia; purpura; thrombocytopenia.

Gastrointestinal: Nausea and vomiting, anorexia, epigastric distress, diarrhea; peculiar taste, stomatitis, abdominal cramps, black tongue.

Endocrine: Gynecomastia in the male; breast enlargement and galactorrhea in the female; increased or decreased libido, impotence; testicular swelling; elevation or depression of blood sugar levels; inappropriate antidiuretic hormone (ADH) secretion syndrome.

Other: Jaundice (simulating obstructive); altered liver function; weight gain or loss; perspiration; flushing; urinary frequency; drowsiness, dizziness, weakness and fatigue; headache; parotid swelling; alopecia; proneness to falling.

Withdrawal Symptoms: Though not indicative of addiction, abrupt cessation of treatment after prolonged therapy may produce nausea, headache and malaise.



REPORTS OF SUSPECTED TOFRANIL-PM SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Tofranil-PM. The information is not vetted and should not be considered as verified clinical evidence.

Possible Tofranil-PM side effects / adverse reactions in 60 year old male

Reported by a physician from Singapore on 2012-08-20

Patient: 60 year old male

Reactions: Cataract, Pupillary Light Reflex Tests Abnormal, Floppy Iris Syndrome, Visual Acuity Reduced

Suspect drug(s):
Tofranil-PM



Possible Tofranil-PM side effects / adverse reactions in 65 year old male

Reported by a physician from Singapore on 2012-08-21

Patient: 65 year old male

Reactions: Cataract, Visual Acuity Reduced, Diabetic Retinopathy, Floppy Iris Syndrome

Suspect drug(s):
Tofranil-PM

Other drugs received by patient: Insulin



See index of all Tofranil-PM side effect reports >>

Drug label data at the top of this Page last updated: 2008-05-22

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