Suicidality and Antidepressant Drugs
Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Anyone considering the use of imipramine pamoate or any other antidepressant in a child, adolescent, or young adult must balance this risk with the clinical need. Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Depression and certain other psychiatric disorders are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Imipramine pamoate is not approved for use in pediatric patients ( see WARNINGS: Clinical Worsening and Suicide Risk, PRECAUTIONS: Information for Patients, and PRECAUTIONS: Pediatric Use ).
Tofranil-PM® (imipramine pamoate capsules), is a tricyclic antidepressant, available as capsules for oral administration. The 75-, 100-, 125-, and 150-mg capsules contain imipramine pamoate equivalent to 75, 100, 125, and 150 mg of imipramine hydrochloride.
Tofranil-PM (imipramine) is indicated for the following:
For the relief of symptoms of depression. Endogenous depression is more likely to be alleviated than other depressive states. One to three weeks of treatment may be needed before optimal therapeutic effects are evident.
Media Articles Related to Tofranil-PM (Imipramine)
Severe depression linked with inflammation in the brain
Source: Depression News From Medical News Today [2015.01.29]
A new study claims to be the first to find 'definitive evidence' of an association between brain inflammation and major depression.
Binge-Watching TV May Be Sign of Depression, Loneliness
Source: MedicineNet Depression Specialty [2015.01.29]
Title: Binge-Watching TV May Be Sign of Depression, Loneliness
Category: Health News
Created: 1/29/2015 12:00:00 AM
Last Editorial Review: 1/29/2015 12:00:00 AM
Certain Allergy, Depression Meds Tied to Higher Odds for Dementia
Source: MedicineNet Allergy Specialty [2015.01.27]
Title: Certain Allergy, Depression Meds Tied to Higher Odds for Dementia
Category: Health News
Created: 1/26/2015 12:00:00 AM
Last Editorial Review: 1/27/2015 12:00:00 AM
Hearing-aid intervention could help stave off depression, improve quality of life
Source: Depression News From Medical News Today [2015.01.23]
When individuals wear their hearing aids for the first time, they are flooded with sounds they have not heard in months or years; yet, previous research has shown that not all new sounds are welcomed.
Regular group walking linked to reduced risk of heart disease, stroke and depression
Source: Sports Medicine / Fitness News From Medical News Today [2015.01.20]
Regular group walking was found to reduce blood pressure, cholesterol levels, BMI, body fat, resting heart rate and depression in a new study of more than 1,800 adults.
Published Studies Related to Tofranil-PM (Imipramine)
Comparison between imipramine and imipramine combined with pseudoephedrine in 5-12-year-old children with uncomplicated enuresis: a double-blind clinical trial. [2011.02]
OBJECTIVE: Monosymptomatic nocturnal enuresis is a common entity, with a prevalence of 10% at the age of 7 years. For its primary treatment, we compared the effect of combination medical therapy (imipramine with pseudoephedrine) with imipramine alone... CONCLUSION: The additive pharmacologic effects of imipramine with pseudoephedrine for the treatment of monosymptomatic nocturnal enuresis in children were well tolerated, and gave significantly faster results than single drug therapy using imipramine. The moderate-to-high recurrence rate following discontinuation of medical treatment indicates the need for a longer term study involving more cases. Crown Copyright (c) 2010. Published by Elsevier Ltd. All rights reserved.
Comparison between imipramine and imipramine combined with pseudoephedrine in
5-12-year-old children with uncomplicated enuresis: a double-blind clinical
imipramine alone... CONCLUSION: The additive pharmacologic effects of imipramine with pseudoephedrine
Serum zinc level in depressed patients during zinc supplementation of imipramine treatment. [2010.11]
BACKGROUND: Recurrent major depression is associated with decreased blood zinc concentrations that may be increased by effective antidepressant therapy. Some clinical investigations point to alterations of the zinc level in blood as a potential marker of depression... CONCLUSIONS: Serum zinc is a state marker of depression. Copyright (c) 2010 Elsevier B.V. All rights reserved.
Low-dose gabapentin as useful adjuvant to opioids for neuropathic cancer pain when combined with low-dose imipramine. [2010.06]
PURPOSE: Painful neuropathic conditions of cancer pain often show little response to nonopioid and opioid analgesics but may be eased by antidepressants and anticonvulsants. Although gabapentin is effective in the treatment of neuropathic pain in patients with cancer, some patients experience intolerable side effects sufficient to warrant discontinuation. The aim of this study was to see whether low-dose gabapentin is effective in treating cancer-related neuropathic pain when combined with low-dose imipramine... CONCLUSION: Low-dose gabapentin-antidepressant combination with opioids was effective in managing neuropathic cancer pain without severe adverse effects.
Treatment of unipolar psychotic depression: a randomized, double-blind study comparing imipramine, venlafaxine, and venlafaxine plus quetiapine. [2010.03]
CONCLUSION: That unipolar psychotic depression should be treated with a combination of an antidepressant and an antipsychotic and not with an antidepressant alone, can be considered evidence based with regard to venlafaxine-quetiapine vs. venlafaxine monotherapy. Whether this is also the case for imipramine monotherapy is likely, but cannot be concluded from the data.
Clinical Trials Related to Tofranil-PM (Imipramine)
The Efficacy of Imipramine in Treatment of Functional Dyspepsia [Recruiting]
The aim of this study is evaluate the efficacy of Imipramine, a tricyclic antidepressant, in
treatment of functional dyspepsia. This is a double blind randomised placebo controlled
trial in which consecutive patients with diagnosis of functional dyspepsia will be studied.
After exclusion of organic cause of dyspepsia by endoscopy, these patients will be randomly
assigned to either imipramine or placebo. All the patients will enter an additional 4 weeks
of drug withdrawal phase after the initial 12 weeks of study drug treatment. They will be
evaluated for treatment response, which is defined as satisfactory relief of dyspeptic
symptoms at the end of 12-week treatment.
Efficacy of Imipramine for Treatment of Patients With Esophageal Hypersensitivity/ Functional Heartburn [Recruiting]
Esophageal hypersensitivity/Functional heartburn are common among non-erosive reflux disease
(NERD) patients who do not response to proton pump inhibitors. Whether tricyclic
antidepressant improves NERD patient's symptoms remains unknown
Aim of this randomized controlled trial study is to determine the efficacy of imipramine,
which could increase esophageal pain thresholds in healthy volunteers, in comparison with
placebo for treatment patients with esophageal hypersensitivity or functional heartburn
evaluated by improvement of specific-symptom score and quality of life
Imipramine and Pregabalin Combination in Painful Polyneuropathy [Not yet recruiting]
Polyneuropathy of different etiologies is often associated with pain and the standard
treatment for this type of pain is gabapentinoids or antidepressants. The hypothesis of this
study is that the combination of the gabapentinoid pregabalin and the antidepressant
imipramine will provide better pain relief than the single compounds alone.
This is a randomized, placebo-controlled, double-blind, 4-way, cross-over trial of
pregabalin 300 mg/day, imipramine 75 mg/day and their combination versus placebo. The study
will include 60 patients and the treatment outcome will be pain intensity as measured by
numeric rating scales.
Imipramine Treatment for Patients With Multi-organ Bodily Distress Syndrome [Recruiting]
The aim of this study is to test the effect of the tricyclic antidepressant Imipramine in
patients with longlasting health problems with no known medical explanation, defined as
multi-organ Bodily distress syndrome (BDS). Pharmacological treatment of patients with BDS
have never been tested, and Imipramine i low dosage (10-75 mg) has the potential of reducing
both pain and other symptoms of bodily distress for patients with BDS. Control conditions
are pill placebo. Study duration is 19 weeks for each of the 140 patients.
Medication Effects on Periurethral Sensation,Urethral Sphincter Activity and Pressure Flow Parameters [Recruiting]
Lower urinary tract symptoms such as urinary leakage and overactive bladder affect millions
of American women. Women may develop these problems because the nerves that control the
muscles of the bladder and urethra are injured. Most research on treating these problems has
focused on the abnormalities of the bladder muscle, but newer studies have shown
abnormalities in the nerve and muscle function of the urethra.
Women with these symptoms may benefit from treatment with medications to improve their
urethral function. However, to truly understand what types of medications will benefit women
with these symptoms, the investigators wish to study how these medications affect the nerves
and muscle function in healthy women who don't leak urine.
PATIENT REVIEWS / RATINGS / COMMENTS
Based on a total of 1 ratings/reviews, Tofranil-PM has an overall score of 9. The effectiveness score is 10 and the side effect score is 8. The scores are on ten point scale: 10 - best, 1 - worst.
Tofranil-PM review by 31 year old female patient
|Overall rating:|| || |
|Effectiveness:|| || Highly Effective|
|Side effects:|| || Mild Side Effects|
|Condition / reason:|| || panic attacks|
|Dosage & duration:|| || 25mg taken 1 daily for the period of 3 years|
|Other conditions:|| || tachycardia|
|Other drugs taken:|| || propranolol|
|Benefits:|| || After 2-3 weeks complete abatement of panic attack symptoms. After one year tried to stop taking them but within 3 weeks symptoms were back. continued for two more years and stopped taking them. Have not had any symptoms for @10 years now|
|Side effects:|| || hyperactivity for up to 8 hrs after taking.|
|Comments:|| || started at 5 mg then increased every 5-7 days up to 25 mg. Hyperactivity decreased with longer treatment|
Page last updated: 2015-01-29