Tobramycin (Tobramycin Sulfate) - Side Effects and Adverse Reactions

ADVERSE REACTIONS

Neurotoxicity — Adverse effects on both the vestibular and auditory branches of the eighth nerve have been noted, especially in patients receiving high doses or prolonged therapy, in those given previous courses of therapy with an ototoxin, and in cases of dehydration. Symptoms include dizziness, vertigo, tinnitus, roaring in the ears, and hearing loss. Hearing loss is usually irreversible and is manifested initially by diminution of high-tone acuity. Tobramycin and gentamicin closely parallel each other in regard to ototoxic potential.

Nephrotoxicity — Renal function changes, as shown by rising BUN, NPN, and serum creatinine and by oliguria, cylindruria, and increased proteinuria, have been reported, especially in patients with a history of renal impairment who are treated for longer periods or with higher doses than those recommended. Adverse renal effects can occur in patients with initially normal renal function.

Clinical studies and studies in experimental animals have been conducted to compare the nephrotoxic potential of tobramycin and gentamicin. In some of the clinical studies and in the animal studies, tobramycin caused nephrotoxicity significantly less frequently than gentamicin. In some other clinical studies, no significant difference in the incidence of nephrotoxicity between tobramycin and gentamicin was found.

Other reported adverse reactions possibly related to tobramycin include anemia, granulocytopenia, and thrombocytopenia; and fever, rash, itching, urticaria, nausea, vomiting, diarrhea, headache, lethargy, pain at the injection site, mental confusion, and disorientation. Laboratory abnormalities possibly related to tobramycin include increased serum transaminases (AST, ALT); increased serum LDH and bilirubin; decreased serum calcium, magnesium, sodium, and potassium; and leukopenia, leukocytosis, and eosinophilia.

REPORTS OF SIDE EFFECTS / ADVERSE REACTIONS RELATED TO TOBRAMYCIN

Possible Tobramycin side effects / adverse reactions in 82 year old female

Reported by a physician from United States on 2007-02-09

Patient: 82 year old female

Reactions: Cellulitis, Urine Output Decreased, Haemoglobin Decreased, Haematocrit Decreased, Staphylococcal Infection, Arthralgia, Arthritis Infective, Septic Shock, Renal Failure Acute, Incision Site Erythema, Influenza Like Illness

Adverse event resulted in: life threatening event

Suspect drug(s):
Tobramycin
    Dosage: once, implant 049
    Indication: HIP Arthroplasty

Tobramycin
    Dosage: once, implant 049
    Indication: Infection

Other drugs received by patient: Intranasal Calcitonin; Weekly Alendronate; Famotidine

Possible Tobramycin side effects / adverse reactions in 79 year old male

Reported by a physician from United States on 2007-02-09

Patient: 79 year old male

Reactions: Surgical Procedure Repeated, Vomiting, Arthritis Infective, Nausea, Dehydration, Constipation, Renal Failure Acute

Adverse event resulted in: life threatening event

Suspect drug(s):
Tobramycin
    Dosage: 14.4g, once, implant
    Indication: Device Related Infection

Tobramycin
    Dosage: 14.4g, once, implant
    Indication: Joint Arthroplasty

Other drugs received by patient: Travoprost EYE Drops; Tamsulosin HCL; Warfarin Sodium; Furosemide; Verapamil; Potassium Chloride; Polyethylene Glycol IN Water; Magnesium Hydroxide TAB; Cyclobenzaprine HCL; Fluticasone Nasal Spray; Albuterol/ipratropium and Flunisolide Inhalers

Possible Tobramycin side effects / adverse reactions in 16 month old male

Reported by a physician from United States on 2007-03-19

Patient: 16 month old male

Reactions: Dyspnoea, Drug Hypersensitivity, Forced Expiratory Volume Decreased, Wheezing, Bronchial Obstruction, Chest X-RAY Abnormal, Eosinophilia, Bronchospasm, Lung Infiltration, Pathogen Resistance, Blood Immunoglobulin E Increased

Adverse event resulted in: hospitalization

Suspect drug(s):
Tobramycin
    Indication: Pseudomonas Infection

Tobramycin

Other drugs received by patient: Ceftazidime; Amoxicillin; Clavulanate Potassium; Ciprofloxacin; Azithromycin; Prednisone; Antibiotics