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Tobramycin (Tobramycin Sulfate) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

Neurotoxicity

Adverse effects on both the vestibular and auditory branches of the eighth nerve have been noted, especially in patients receiving high doses or prolonged therapy, in those given previous courses of therapy with an ototoxin, and in cases of dehydration.  Symptoms include dizziness, vertigo, tinnitus, roaring in the ears, and hearing loss.  Hearing loss is usually irreversible and is manifested initially by diminution of high-tone acuity.  Tobramycin and gentamicin sulfates closely parallel each other in regard to ototoxic potential.

Nephrotoxicity

Renal function changes, as shown by rising BUN, NPN, and serum creatinine and by oliguria, cylindruria, and increased proteinuria, have been reported, especially in patients with a history of renal impairment who are treated for longer periods or with higher doses than those recommended.  Adverse renal effects can occur in patients with initially normal renal function.

Clinical studies and studies in experimental animals have been conducted to compare the nephrotoxic potential of tobramycin and gentamicin.  In some of the clinical studies and in the animal studies, tobramycin caused nephrotoxicity significantly less frequently than gentamicin.  In some other clinical studies, no significant difference in the incidence of nephrotoxicity between tobramycin and gentamicin was found.

Other reported adverse reactions possibly related to tobramycin include anemia, granulocytopenia, and thrombocytopenia; and fever, rash, exfoliative dermatitis, itching, urticaria, nausea, vomiting, diarrhea, headache, lethargy, pain at the injection site, mental confusion, and disorientation.  Laboratory abnormalities possibly related to tobramycin include increased serum transaminases (AST, ALT); increased serum LDH and bilirubin; decreased serum calcium, magnesium, sodium, and potassium; and leukopenia, leukocytosis, and eosinophilia.



REPORTS OF SUSPECTED TOBRAMYCIN SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Tobramycin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Tobramycin side effects / adverse reactions in 25 year old female

Reported by a health professional (non-physician/pharmacist) from Greece on 2011-10-03

Patient: 25 year old female

Reactions: Corneal Infiltrates, Visual Acuity Reduced

Suspect drug(s):
Diclofenac Sodium
    Dosage: top
    Administration route: Topical
    Indication: Product Used FOR Unknown Indication

Dextran INJ
    Dosage: every 3 minutes;io
    Indication: Keratoconus

Riboflavin CAP
    Dosage: 0.1 pct;every 3 minutes; io
    Indication: Keratoconus

Tobramycin
    Indication: Product Used FOR Unknown Indication

Dexamethasone
    Indication: Product Used FOR Unknown Indication



Possible Tobramycin side effects / adverse reactions in 16 year old female

Reported by a physician from United States on 2011-10-06

Patient: 16 year old female

Reactions: Abdominal Pain, Electrocardiogram QT Prolonged, Unresponsive TO Stimuli, Headache, Hypokalaemia, Malaise, Hypomagnesaemia, Blood Creatinine Increased, Chest Discomfort, Nausea, Urine Output Decreased, Chromaturia, Anxiety, Torsade DE Pointes, Renal Impairment, Ventricular Tachycardia, Feeling Jittery, Pulse Absent, Renal Tubular Necrosis, Ventricular Fibrillation, Cardiac Arrest

Adverse event resulted in: life threatening event, hospitalization

Suspect drug(s):
Ondansetron HCL
    Administration route: Oral

Tobramycin
    Indication: Ecthyma

Furosemide
    Indication: Blood Creatinine Increased

Mercaptopurine

Vancomycin
    Indication: Ecthyma

Clarithromycin

Vincristine

Ondansetron HCL

Asparaginase

Cytarabine

Other drugs received by patient: Cefepime; Pantoprazole; Amoxicillin; Diphenhydramine HCL; Cefepime; Cefepime; Amoxicillin; Cefepime; Pantoprazole; Metronidazole; Lorazepam; Sulfamethoxazole and Trimethoprim; Hydroxyzine



Possible Tobramycin side effects / adverse reactions in 21 year old female

Reported by a health professional (non-physician/pharmacist) from United States on 2011-10-10

Patient: 21 year old female

Reactions: Productive Cough, Aphagia, Vomiting, Haemoptysis, Tachycardia, Toxic Epidermal Necrolysis, Pyrexia, Rash, Arthralgia, Coombs Positive Haemolytic Anaemia, Conjunctival Hyperaemia, Vaginal Erosion, Tachypnoea, Decreased Appetite

Adverse event resulted in: hospitalization

Suspect drug(s):
Allopurinol
    Dosage: unk ukn, unk
    Indication: Urinary Tract Infection

Amoxicillin
    Dosage: unk ukn, unk
    Indication: Pruritus

Clavulanate Potassium
    Dosage: unk ukn, unk
    Indication: Pruritus

Ciprofloxacin
    Dosage: unk ukn, unk
    Indication: Urinary Tract Infection

Diphenhydramine HCL
    Dosage: unk ukn, unk
    Indication: Pruritus

Meloxicam
    Dosage: unk ukn, unk
    Indication: Vulvovaginal Mycotic Infection

Miconazole
    Dosage: unk ukn, unk
    Indication: Vulvovaginal Mycotic Infection

Tobramycin
    Dosage: unk ukn, unk
    Indication: Vulvovaginal Mycotic Infection



See index of all Tobramycin side effect reports >>

Drug label data at the top of this Page last updated: 2012-09-05

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