DOSAGE AND ADMINISTRATION
The recommended dosage for both adults and pediatric patients 6 years of age and older is 1 single-use ampule (300 mg) administered BID for 28 days. Dosage is not adjusted by weight. All patients should be administered 300 mg BID. The doses should be taken as close to 12 hours apart as possible; they should not be taken less than 6 hours apart.
TOBI® is inhaled while the patient is sitting or standing upright and breathing normally through the mouthpiece of the nebulizer. Nose clips may help the patient breathe through the mouth.
TOBI® is administered BID in alternating periods of 28 days. After 28 days of therapy, patients should stop TOBI® therapy for the next 28 days, and then resume therapy for the next 28 day on/28 day off cycle.
TOBI® is supplied as a single-use ampule and is administered by inhalation, using a hand-held PARI LC PLUS™ Reusable Nebulizer with a DeVilbiss® Pulmo-Aide® compressor. TOBI® is not for subcutaneous, intravenous or intrathecal administration.
TOBI® is administered by inhalation over an approximately 15-minute period, using a hand-held PARI LC PLUS™ Reusable Nebulizer with a DeVilbiss® Pulmo-Aide® compressor. TOBI® should not be diluted or mixed with dornase alfa (PULMOZYME®, Genentech) in the nebulizer.
During clinical studies, patients on multiple therapies were instructed to take them first, followed by TOBI®.