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Timentin (Ticarcillin Disodium / Clavulanate Potassium) - Side Effects and Adverse Reactions



As with other penicillins, the following adverse reactions may occur:

Hypersensitivity Reactions

Skin rash, pruritus, urticaria, arthralgia, myalgia, drug fever, chills, chest discomfort, erythema multiforme, toxic epidermal necrolysis, Stevens-Johnson syndrome, and anaphylactic reactions.

Central Nervous System

Headache, giddiness, neuromuscular hyperirritability, or convulsive seizures.

Gastrointestinal Disturbances

Disturbances of taste and smell, stomatitis, flatulence, nausea, vomiting and diarrhea, epigastric pain, and pseudomembranous colitis have been reported. Onset of pseudomembranous colitis symptoms may occur during or after antibiotic treatment. (See WARNINGS.)

Hemic and Lymphatic Systems

Thrombocytopenia, leukopenia, neutropenia, eosinophilia, reduction of hemoglobin or hematocrit, and prolongation of prothrombin time and bleeding time.

Abnormalities of Hepatic Function Tests

Elevation of serum aspartate aminotransferase (SGOT), serum alanine aminotransferase (SGPT), serum alkaline phosphatase, serum LDH, serum bilirubin. There have been reports of transient hepatitis and cholestatic jaundice—as with some other penicillins and some cephalosporins.

Renal and Urinary Effects

Elevation of serum creatinine and/or BUN, hypernatremia, reduction in serum potassium and uric acid. Rare reports of hemorrhagic cystitis.

Local Reactions

Pain, burning, swelling, and induration at the injection site and thrombophlebitis with intravenous administration.

Available safety data for pediatric patients treated with TIMENTIN demonstrate a similar adverse event profile to that observed in adult patients.


Below is a sample of reports where side effects / adverse reactions may be related to Timentin. The information is not vetted and should not be considered as verified clinical evidence.

Possible Timentin side effects / adverse reactions in 90 year old female

Reported by a physician from Greece on 2011-11-02

Patient: 90 year old female

Reactions: Dyspnoea, Cardiac Murmur, Angioedema, Rales, Otitis Externa, Atrial Fibrillation, Erythema, Viith Nerve Paralysis, Hypoacusis, C-Reactive Protein Increased, Conjunctival Hyperaemia, Oedema Peripheral, Blood Immunoglobulin E Increased, Renal Failure Acute, Herpes Virus Infection

Adverse event resulted in: hospitalization

Suspect drug(s):
Netilmicin Sulfate


Possible Timentin side effects / adverse reactions in 50 year old male

Reported by a physician from United States on 2012-04-16

Patient: 50 year old male

Reactions: Toxic Epidermal Necrolysis, Septic Shock

Adverse event resulted in: death

Suspect drug(s):
    Indication: Cellulitis

Vancomycin Hydrochloride
    Indication: Cellulitis

Possible Timentin side effects / adverse reactions in 85 year old female

Reported by a physician from Greece on 2012-05-25

Patient: 85 year old female

Reactions: Depressed Level of Consciousness, Hypokalaemia

Suspect drug(s):

See index of all Timentin side effect reports >>

Drug label data at the top of this Page last updated: 2008-09-24

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