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Tilade (Nedocromil Sodium Inhalation) - Summary



Tilade® Inhaler

Tilade (nedocromil sodium) is an inhaled anti-inflammatory agent for the preventive management of asthma.

Tilade Inhaler is indicated for maintenance therapy in the management of adult and pediatric patients 6 years and older with mild to moderate asthma.

Tilade is not indicated for the reversal of acute bronchospasm.

See all Tilade indications & dosage >>


Media Articles Related to Tilade (Nedocromil Inhalation)

High Physical Activity Tied to Poor Asthma Control in Females
Source: Medscape Allergy & Clinical Immunology Headlines [2015.11.20]
The link was not found in boys and young men. Findings suggested a need for extra attention in asthma treatment for highly active girls and young women.
Medscape Medical News

High levels of physical activity may worsen asthma control in young females
Source: Respiratory / Asthma News From Medical News Today [2015.11.19]
Among 526 adolescents and young adults who were asked about their exercise habits, those with asthma tended to report more physical activity than those without asthma.

Asthma: No Clear Winners in Combination Treatment in Blacks
Source: Medscape Allergy & Clinical Immunology Headlines [2015.11.18]
A randomized trial showed no benefit to long-acting beta-agonists over tiotropium in combination with inhaled corticosteroid for improving outcomes in black adults with asthma.
Medscape Medical News

Emergency Visit for Asthma Predicts Future Acute Care
Source: Medscape Allergy & Clinical Immunology Headlines [2015.11.17]
Children who have made at least one acute-care visit to the emergency department for asthma are at risk for future visits, and might benefit from specialist care, a new study suggests.
Medscape Medical News

Asthma in Children
Source: MedicineNet Allergy Specialty [2015.11.17]
Title: Asthma in Children
Category: Diseases and Conditions
Created: 1/31/2005 12:00:00 AM
Last Editorial Review: 11/17/2015 12:00:00 AM

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Published Studies Related to Tilade (Nedocromil Inhalation)

Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. [2009.05]
OBJECTIVES: To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued... CONCLUSIONS: Clinically meaningful improvements in the control of asthma and in airway responsiveness achieved during continuous treatment with inhaled corticosteroids do not persist after continuous treatment is discontinued.

AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. [2006.12]
BACKGROUND: Allergen challenge results in an immediate reduction in exhaled nitric oxide (FE(NO)) followed by a long-term increase. To study mast cell activation in relation to nitric oxide (NO), the study investigated the effect of inhaled adenosine monophosphate (AMP) as a mast cell activator and mast cell stabilizer - nedocromil sodium - on FE(NO). The NO synthase (NOS) iso-enzyme involved was studied by the NOS inhibitor aminoguanidine... CONCLUSIONS: The AMP challenge caused a reduction in FE(NO) as a result of prior treatment with nedocromil. Aminoguanidine abolished the nedocromil-induced protection on the late reduction in FE(NO), but not on AMP PC(20). Inducible NOS was implicated in the late FE(NO) decrease after the AMP challenge.

Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis. [2006.05]
BACKGROUND: The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis. OBJECTIVE: To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR). PATIENTS: Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years... CONCLUSIONS: Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.

Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. [2005.09]
CONCLUSIONS: Nedocromil strongly attenuates mannitol-induced bronchoconstriction but has a negligible effect on mannitol-provoked cough. Therefore, these responses seem to have different pathways in asthma. Recording of both provoked coughs and induced bronchoconstriction during mannitol challenge may provide supplementary information about a patient's disease.

Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study. [2004.08]
Asthma severity can be judged by measurements of symptoms, lung function, and medication requirements. The objective was to compare the effect of a 4-wk monotherapy with low-dose triamcinolone, montelukast and nedocromil on asthma control, lung function, eosinophil blood count, and bronchial hyper-reactivity in children with mild to moderate asthma allergic to dust mite...

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Clinical Trials Related to Tilade (Nedocromil Inhalation)

Childhood Asthma Management Program (CAMP) Phases I (Trial), II (CAMPCS), III (CAMPCS/2), and IV (CAMPCS/3) [Completed]
The purpose of this study is to evaluate the long term effects of anti-inflammatory therapy compared to bronchodilator therapy on the course of asthma, particularly on lung function and bronchial hyperresponsiveness, and on physical and psychosocial growth and development.

Immune Dysregulation in Children and Adults With Asthma [Completed]
To immunize both normal and asthmatic subjects with a neoantigen, keyhole limpet hemocyanin (KLH) and observe the type of antibody and T cell response that develops.

Comparing Modified Meek and Mesh Techniques [Completed]
This is a clinical trial study that compare two plastic surgery techniques in patients with third degree of burning and both techniques are used in all patients but in different areas of burning sites of the patients.

Extended Safety Study of Montelukast in Infants and Young Children With Chronic Asthma (0476-232) [Completed]
Patients were treated with either montelukast 4 mg oral granules or usual care. Patients who completed Protocol MK0476-176-01 (NCT00943683) had the option to enroll in this study. Additionally, patients with asthma who were 6 to 11 months of age and who had not participated in Protocol MK0476-176-01, could also enroll.

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Page last updated: 2015-11-20

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