Media Articles Related to Tilade (Nedocromil Inhalation)
Scientists discover asthma's potential root cause and a novel treatment
Source: Allergy News From Medical News Today [2015.04.24]
Published in Science Translational Medicine journal, Cardiff University researchers, working in collaboration with scientists at King's College London and the Mayo Clinic (USA), describe the...
Scientists 'incredibly excited' by asthma treatment breakthrough
Source: Respiratory / Asthma News From Medical News Today [2015.04.24]
Using mouse models and human cells, scientists have for the first time uncovered a potential root cause of asthma and shown that an existing drug could reverse all symptoms.
Genetic variance explains poor response to common asthma medications
Source: Respiratory / Asthma News From Medical News Today [2015.04.21]
Researchers have identified a biological basis for asthmatic children who do not respond well to corticosteroid treatment - currently the most effective treatment for chronic asthma and acute...
How Twitter can help predict asthma-related emergency room visits
Source: Respiratory / Asthma News From Medical News Today [2015.04.18]
Researchers created a model that was able to predict with 75 percent accuracy how many asthma-related emergency room visits a hospital could expect on a given dayTwitter users who post information...
Asthma rates among black youth are similarly high in urban, rural communities
Source: Respiratory / Asthma News From Medical News Today [2015.04.10]
Asthma rates among black youth living in urban Detroit and rural Georgia are essentially the same, researchers report, a finding that conflicts with the widely held theory that city life is a risk...
Published Studies Related to Tilade (Nedocromil Inhalation)
Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. [2009.05]
OBJECTIVES: To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued... CONCLUSIONS: Clinically meaningful improvements in the control of asthma and in airway responsiveness achieved during continuous treatment with inhaled corticosteroids do not persist after continuous treatment is discontinued.
AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. [2006.12]
BACKGROUND: Allergen challenge results in an immediate reduction in exhaled nitric oxide (FE(NO)) followed by a long-term increase. To study mast cell activation in relation to nitric oxide (NO), the study investigated the effect of inhaled adenosine monophosphate (AMP) as a mast cell activator and mast cell stabilizer - nedocromil sodium - on FE(NO). The NO synthase (NOS) iso-enzyme involved was studied by the NOS inhibitor aminoguanidine... CONCLUSIONS: The AMP challenge caused a reduction in FE(NO) as a result of prior treatment with nedocromil. Aminoguanidine abolished the nedocromil-induced protection on the late reduction in FE(NO), but not on AMP PC(20). Inducible NOS was implicated in the late FE(NO) decrease after the AMP challenge.
Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis. [2006.05]
BACKGROUND: The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis. OBJECTIVE: To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR). PATIENTS: Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years... CONCLUSIONS: Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.
Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. [2005.09]
CONCLUSIONS: Nedocromil strongly attenuates mannitol-induced bronchoconstriction but has a negligible effect on mannitol-provoked cough. Therefore, these responses seem to have different pathways in asthma. Recording of both provoked coughs and induced bronchoconstriction during mannitol challenge may provide supplementary information about a patient's disease.
Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study. [2004.08]
Asthma severity can be judged by measurements of symptoms, lung function, and medication requirements. The objective was to compare the effect of a 4-wk monotherapy with low-dose triamcinolone, montelukast and nedocromil on asthma control, lung function, eosinophil blood count, and bronchial hyper-reactivity in children with mild to moderate asthma allergic to dust mite...
Clinical Trials Related to Tilade (Nedocromil Inhalation)
Early Airway Response to Allergen in Asthmatics (0000-176) [Recruiting]
This study will assess the Early Airway Response (EAR) associated change in forced
expiratory volume in one second (FEV1) and plasma 9a-11ß-PGF2 ('9P') after single dose
pretreatment of nedocromil, montelukast, and mometasone.