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Tilade (Nedocromil Sodium Inhalation) - Summary



Tilade® Inhaler

Tilade (nedocromil sodium) is an inhaled anti-inflammatory agent for the preventive management of asthma.

Tilade Inhaler is indicated for maintenance therapy in the management of adult and pediatric patients 6 years and older with mild to moderate asthma.

Tilade is not indicated for the reversal of acute bronchospasm.

See all Tilade indications & dosage >>


Media Articles Related to Tilade (Nedocromil Inhalation)

Medical News Today: Alcohol and Asthma: What's the Connection?
Source: Featured Health News from Medical News Today [2016.10.13]
Asthma is a condition that causes breathing difficulties. Learn how alcohol use can affect asthma and how to lower the chances of an attack.

Alcohol and Asthma: What's the Connection?
Source: Alcohol / Addiction / Illegal Drugs News From Medical News Today [2016.10.13]
Asthma is a condition that causes breathing difficulties. Learn how alcohol use can affect asthma and how to lower the chances of an attack.

Alternative treatment approaches may be needed for some children with asthma
Source: Respiratory / Asthma News From Medical News Today [2016.10.07]
A new study by Henry Ford Health System in collaboration with eight other health systems in large U.S.

CINQAIR Improves Asthma Control in Eosinophil-Phenotype Patients (CME/CE)
Source: MedPage Today Allergy & Immunology [2016.10.07]
(MedPage Today) -- Optimal cut-off point for eosinophil counts, though, remains unclear

New drug target for asthma, autoimmune disorders identified
Source: Respiratory / Asthma News From Medical News Today [2016.10.04]
Researchers discover the cell surface protein PD-1, an existing drug target for some cancers, could also be a target for autoimmune disorders like asthma.

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Published Studies Related to Tilade (Nedocromil Inhalation)

Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. [2009.05]
OBJECTIVES: To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued... CONCLUSIONS: Clinically meaningful improvements in the control of asthma and in airway responsiveness achieved during continuous treatment with inhaled corticosteroids do not persist after continuous treatment is discontinued.

AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. [2006.12]
BACKGROUND: Allergen challenge results in an immediate reduction in exhaled nitric oxide (FE(NO)) followed by a long-term increase. To study mast cell activation in relation to nitric oxide (NO), the study investigated the effect of inhaled adenosine monophosphate (AMP) as a mast cell activator and mast cell stabilizer - nedocromil sodium - on FE(NO). The NO synthase (NOS) iso-enzyme involved was studied by the NOS inhibitor aminoguanidine... CONCLUSIONS: The AMP challenge caused a reduction in FE(NO) as a result of prior treatment with nedocromil. Aminoguanidine abolished the nedocromil-induced protection on the late reduction in FE(NO), but not on AMP PC(20). Inducible NOS was implicated in the late FE(NO) decrease after the AMP challenge.

Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis. [2006.05]
BACKGROUND: The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis. OBJECTIVE: To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR). PATIENTS: Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years... CONCLUSIONS: Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.

Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. [2005.09]
CONCLUSIONS: Nedocromil strongly attenuates mannitol-induced bronchoconstriction but has a negligible effect on mannitol-provoked cough. Therefore, these responses seem to have different pathways in asthma. Recording of both provoked coughs and induced bronchoconstriction during mannitol challenge may provide supplementary information about a patient's disease.

Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study. [2004.08]
Asthma severity can be judged by measurements of symptoms, lung function, and medication requirements. The objective was to compare the effect of a 4-wk monotherapy with low-dose triamcinolone, montelukast and nedocromil on asthma control, lung function, eosinophil blood count, and bronchial hyper-reactivity in children with mild to moderate asthma allergic to dust mite...

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Clinical Trials Related to Tilade (Nedocromil Inhalation)

Childhood Asthma Management Program (CAMP) Phases I (Trial), II (CAMPCS), III (CAMPCS/2), and IV (CAMPCS/3) [Completed]
The purpose of this study is to evaluate the long term effects of anti-inflammatory therapy compared to bronchodilator therapy on the course of asthma, particularly on lung function and bronchial hyperresponsiveness, and on physical and psychosocial growth and development.

Immune Dysregulation in Children and Adults With Asthma [Completed]
To immunize both normal and asthmatic subjects with a neoantigen, keyhole limpet hemocyanin (KLH) and observe the type of antibody and T cell response that develops.

Comparing Modified Meek and Mesh Techniques [Completed]
This is a clinical trial study that compare two plastic surgery techniques in patients with third degree of burning and both techniques are used in all patients but in different areas of burning sites of the patients.

Extended Safety Study of Montelukast in Infants and Young Children With Chronic Asthma (0476-232) [Completed]
Patients were treated with either montelukast 4 mg oral granules or usual care. Patients who completed Protocol MK0476-176-01 (NCT00943683) had the option to enroll in this study. Additionally, patients with asthma who were 6 to 11 months of age and who had not participated in Protocol MK0476-176-01, could also enroll.

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Page last updated: 2016-10-13

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