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Tilade (Nedocromil Sodium Inhalation) - Summary

 
 



TILADE SUMMARY

Tilade® Inhaler
(NEDOCROMIL SODIUM INHALATION AEROSOL)

Tilade (nedocromil sodium) is an inhaled anti-inflammatory agent for the preventive management of asthma.

Tilade Inhaler is indicated for maintenance therapy in the management of adult and pediatric patients 6 years and older with mild to moderate asthma.

Tilade is not indicated for the reversal of acute bronchospasm.


See all Tilade indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Tilade (Nedocromil Inhalation)

Study Confirms Higher CVD Risk in Late-Onset Asthma
Source: Medscape Allergy & Clinical Immunology Headlines [2016.08.27]
Although early- and late-onset asthma are often lumped together, the risk for CVD events follows distinctly different paths in these patients, the authors caution.
Heartwire from Medscape

PTSD in 9/11 Workers Linked to Higher Asthma Risk (CME/CE)
Source: MedPageToday.com - medical news plus CME for physicians [2016.08.27]
(MedPage Today) -- Causal mechanism related to stress appears likely, investigators say

Biologic Therapy in the Management of Asthma
Source: Medscape Allergy & Clinical Immunology Headlines [2016.08.25]
What benefit does biologic therapy offer patients with asthma? A new review examines the current role of these agents in managing this disease.
Current Opinion in Allergy and Clinical Immunology

Blood Eosinophil Markers to Predict Severity of Asthma
Source: Medscape Allergy & Clinical Immunology Headlines [2016.08.25]
Are measuring blood eosinophil levels an effective way to determine disease severity in asthma?
BMC Pulmonary Medicine

Late-onset asthma linked to increased heart disease, stroke risk
Source: Respiratory / Asthma News From Medical News Today [2016.08.25]
People who develop asthma as adults (late onset asthma) may also be at greater risk of developing heart disease and having a stroke, according to new research in Journal of the American Heart...

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Published Studies Related to Tilade (Nedocromil Inhalation)

Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. [2009.05]
OBJECTIVES: To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued... CONCLUSIONS: Clinically meaningful improvements in the control of asthma and in airway responsiveness achieved during continuous treatment with inhaled corticosteroids do not persist after continuous treatment is discontinued.

AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. [2006.12]
BACKGROUND: Allergen challenge results in an immediate reduction in exhaled nitric oxide (FE(NO)) followed by a long-term increase. To study mast cell activation in relation to nitric oxide (NO), the study investigated the effect of inhaled adenosine monophosphate (AMP) as a mast cell activator and mast cell stabilizer - nedocromil sodium - on FE(NO). The NO synthase (NOS) iso-enzyme involved was studied by the NOS inhibitor aminoguanidine... CONCLUSIONS: The AMP challenge caused a reduction in FE(NO) as a result of prior treatment with nedocromil. Aminoguanidine abolished the nedocromil-induced protection on the late reduction in FE(NO), but not on AMP PC(20). Inducible NOS was implicated in the late FE(NO) decrease after the AMP challenge.

Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis. [2006.05]
BACKGROUND: The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis. OBJECTIVE: To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR). PATIENTS: Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years... CONCLUSIONS: Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.

Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. [2005.09]
CONCLUSIONS: Nedocromil strongly attenuates mannitol-induced bronchoconstriction but has a negligible effect on mannitol-provoked cough. Therefore, these responses seem to have different pathways in asthma. Recording of both provoked coughs and induced bronchoconstriction during mannitol challenge may provide supplementary information about a patient's disease.

Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study. [2004.08]
Asthma severity can be judged by measurements of symptoms, lung function, and medication requirements. The objective was to compare the effect of a 4-wk monotherapy with low-dose triamcinolone, montelukast and nedocromil on asthma control, lung function, eosinophil blood count, and bronchial hyper-reactivity in children with mild to moderate asthma allergic to dust mite...

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Clinical Trials Related to Tilade (Nedocromil Inhalation)

Childhood Asthma Management Program (CAMP) Phases I (Trial), II (CAMPCS), III (CAMPCS/2), and IV (CAMPCS/3) [Completed]
The purpose of this study is to evaluate the long term effects of anti-inflammatory therapy compared to bronchodilator therapy on the course of asthma, particularly on lung function and bronchial hyperresponsiveness, and on physical and psychosocial growth and development.

Immune Dysregulation in Children and Adults With Asthma [Completed]
To immunize both normal and asthmatic subjects with a neoantigen, keyhole limpet hemocyanin (KLH) and observe the type of antibody and T cell response that develops.

Comparing Modified Meek and Mesh Techniques [Completed]
This is a clinical trial study that compare two plastic surgery techniques in patients with third degree of burning and both techniques are used in all patients but in different areas of burning sites of the patients.

Extended Safety Study of Montelukast in Infants and Young Children With Chronic Asthma (0476-232) [Completed]
Patients were treated with either montelukast 4 mg oral granules or usual care. Patients who completed Protocol MK0476-176-01 (NCT00943683) had the option to enroll in this study. Additionally, patients with asthma who were 6 to 11 months of age and who had not participated in Protocol MK0476-176-01, could also enroll.

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Page last updated: 2016-08-27

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