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Tilade (Nedocromil Sodium Inhalation) - Summary

 
 



TILADE SUMMARY

Tilade® Inhaler
(NEDOCROMIL SODIUM INHALATION AEROSOL)

Tilade (nedocromil sodium) is an inhaled anti-inflammatory agent for the preventive management of asthma.

Tilade Inhaler is indicated for maintenance therapy in the management of adult and pediatric patients 6 years and older with mild to moderate asthma.

Tilade is not indicated for the reversal of acute bronchospasm.


See all Tilade indications & dosage >>

NEWS HIGHLIGHTS

Media Articles Related to Tilade (Nedocromil Inhalation)

Study ties breathing problems, asthma to bone loss
Source: Yahoo Health News [2014.04.11]
By Ronnie Cohen NEW YORK (Reuters Health) - People with asthma-related breathing problems may be at increased risk for bone loss, according to a new study. The study examined the records of more than 7,000 adults in Seoul, Korea, and found those...

Hospital readmission for asthma increased by air pollution from traffic
Source: Respiratory / Asthma News From Medical News Today [2014.03.30]
Higher exposure to traffic-related air pollution (TRAP) dramatically increases the odds of readmission to the hospital for asthma - but only for white children, according to a new Cincinnati...

Decline in preterm births and asthma linked with smoking bans
Source: Respiratory / Asthma News From Medical News Today [2014.03.28]
The first analysis to assess the impact of smoking bans on children's health reveals that introduction of smoke-free laws is linked with decreased rates of preterm births.

Severe Asthma, Rethinking Epi: The FOAMed Report
Source: MedPage Today Allergy & Immunology [2014.03.22]
(MedPage Today) -- A regular update of emergency department must-reads from Free Open Access Meducation (FOAMed). Here's seven from this week.

Drug That's Not Inhaled Passes Tests in Severe Asthma
Source: MedPage Today Allergy & Immunology [2014.03.12]
(MedPage Today) -- In two phase III studies in patients wtih eosinophilic asthma, mepolizumab cut the number of exacerbations and decreased daily oral corticosteroid use, GlaxoSmithKline announced today.

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Published Studies Related to Tilade (Nedocromil Inhalation)

Long-term budesonide or nedocromil treatment, once discontinued, does not alter the course of mild to moderate asthma in children and adolescents. [2009.05]
OBJECTIVES: To determine whether long-term, continuous use of inhaled anti-inflammatory medications affects asthma outcomes in children with mild to moderate asthma after use is discontinued... CONCLUSIONS: Clinically meaningful improvements in the control of asthma and in airway responsiveness achieved during continuous treatment with inhaled corticosteroids do not persist after continuous treatment is discontinued.

AMP challenge induces a decrease in FE(NO) in asthmatic subjects modulated by nedocromil. [2006.12]
BACKGROUND: Allergen challenge results in an immediate reduction in exhaled nitric oxide (FE(NO)) followed by a long-term increase. To study mast cell activation in relation to nitric oxide (NO), the study investigated the effect of inhaled adenosine monophosphate (AMP) as a mast cell activator and mast cell stabilizer - nedocromil sodium - on FE(NO). The NO synthase (NOS) iso-enzyme involved was studied by the NOS inhibitor aminoguanidine... CONCLUSIONS: The AMP challenge caused a reduction in FE(NO) as a result of prior treatment with nedocromil. Aminoguanidine abolished the nedocromil-induced protection on the late reduction in FE(NO), but not on AMP PC(20). Inducible NOS was implicated in the late FE(NO) decrease after the AMP challenge.

Efficacy and safety of mometasone furoate vs nedocromil sodium as prophylactic treatment for moderate/severe seasonal allergic rhinitis. [2006.05]
BACKGROUND: The preventive use of medications has been proposed to be effective in the treatment of seasonal rhinitis. OBJECTIVE: To evaluate the efficacy and safety of mometasone furoate and nedocromil sodium nasal sprays as prophylactic treatment for moderate to severe seasonal allergic rhinitis (SAR). PATIENTS: Sixty-one patients were recruited from 3 referral allergy centers. Inclusion criteria were history of SAR for 2 years or longer, sensitization to relevant local pollen (grasses, Parietaria, and olive), and age older than 12 years... CONCLUSIONS: Prophylactic administration of mometasone furoate before the pollen season is safe and may lead to improved control of SAR compared with the use of nedocromil sodium.

Dissociation in the effect of nedocromil on mannitol-induced cough or bronchoconstriction in asthmatic subjects. [2005.09]
CONCLUSIONS: Nedocromil strongly attenuates mannitol-induced bronchoconstriction but has a negligible effect on mannitol-provoked cough. Therefore, these responses seem to have different pathways in asthma. Recording of both provoked coughs and induced bronchoconstriction during mannitol challenge may provide supplementary information about a patient's disease.

Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study. [2004.08]
Asthma severity can be judged by measurements of symptoms, lung function, and medication requirements. The objective was to compare the effect of a 4-wk monotherapy with low-dose triamcinolone, montelukast and nedocromil on asthma control, lung function, eosinophil blood count, and bronchial hyper-reactivity in children with mild to moderate asthma allergic to dust mite...

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Clinical Trials Related to Tilade (Nedocromil Inhalation)

Early Airway Response to Allergen in Asthmatics (0000-176) [Recruiting]
This study will assess the Early Airway Response (EAR) associated change in forced expiratory volume in one second (FEV1) and plasma 9a-11-PGF2 ('9P') after single dose pretreatment of nedocromil, montelukast, and mometasone.

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Page last updated: 2014-04-11

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