sterile ticarcillin disodium
for Intramuscular or Intravenous Administration
Ticar is a semisynthetic injectable penicillin derived from the penicillin nucleus, 6-aminopenicillanic acid.
Ticar is indicated for the treatment of the following infections:
Skin and soft-tissue infections‡
Acute and chronic respiratory tract infections‡§
‡ Caused by susceptible strains of Pseudomonas aeruginosa, Proteus species (both indole-positive and indole-negative) and Escherichia coli.
§ Though clinical improvement has been shown, bacteriological cures cannot be expected in patients with chronic respiratory disease or cystic fibrosis.
Genitourinary tract infections (complicated and uncomplicated) due to susceptible strains of Pseudomonas aeruginosa, Proteus species (both indole-positive and indole-negative), Escherichia coli, Enterobacter and Streptococcus faecalis (enterococcus).
Ticarcillin is also indicated in the treatment of the following infections due to susceptible anaerobic bacteria:
- Bacterial septicemia.
- Lower respiratory tract infections such as empyema, anaerobic pneumonitis and lung abscess.
- Intra-abdominal infections such as peritonitis and intra-abdominal abscess (typically resulting from anaerobic organisms resident in the normal gastrointestinal tract).
- Infections of the female pelvis and genital tract, such as endometritis, pelvic inflammatory disease, pelvic abscess and salpingitis.
- Skin and soft-tissue infections.
Although ticarcillin is primarily indicated in gram-negative infections, its in vitro activity against gram-positive organisms should be considered in treating infections caused by both gram-negative and gram-positive organisms (see Microbiology).
Based on the in vitro synergism between ticarcillin and gentamicin sulfate, tobramycin sulfate or amikacin sulfate against certain strains of Pseudomonas aeruginosa, combined therapy has been successful, using full therapeutic dosages. (For additional prescribing information, see the gentamicin sulfate, tobramycin sulfate and amikacin sulfate package inserts.)
NOTE: Culturing and susceptibility testing should be performed initially and during treatment to monitor the effectiveness of therapy and the susceptibility of the bacteria.
Media Articles Related to Ticar (Ticarcillin)
FDA approves Xolair® (omalizumab) for people with Chronic Idiopathic Urticaria (CIU), a form of chronic hives
Source: Allergy News From Medical News Today [2014.03.25]
Novartis has announced that the US Food and Drug Administration (FDA) approved Xolair® (omalizumab) for the treatment of chronic idiopathic urticaria (CIU), a form of chronic hives.
New indication for Xolair approved by the European Commission for treatment in chronic spontaneous urticaria patients
Source: Allergy News From Medical News Today [2014.03.10]
Novartis has announced that the European Commission (EC) has approved the use of Xolair® as an add-on therapy for the treatment of chronic spontaneous urticaria (CSU) in adult and adolescent (12...
Picture of Urticaria
Source: MedicineNet desloratadine Specialty [2010.01.05]
Title: Picture of Urticaria
Created: 1/5/2010 4:22:00 PM
Last Editorial Review: 1/5/2010 4:22:11 PM
FDA Approves Xolair for Chronic Hives
Source: MedPage Today Allergy & Immunology [2014.03.21]
(MedPage Today) -- The FDA has approved omalizumab (Xolair) for treatment of chronic idiopathic urticaria, drugmaker Genentech announced.
Published Studies Related to Ticar (Ticarcillin)
Ertapenem or ticarcillin/clavulanate for the treatment of intra-abdominal infections or acute pelvic infections in pediatric patients. [2007.09]
BACKGROUND: Ertapenem, a group I carbapenem antibiotic, has been shown to be safe and effective in treating adults with complicated intra-abdominal (cIAI) or acute pelvic infection (API). This study evaluated ertapenem for treating these infections in children... CONCLUSIONS: This study suggests that ertapenem is generally safe and efficacious for treating cIAI or API in pediatric patients.
A prospective study of cefepime versus ticarcilline/clavulanate as empirical
treatment of febrile neutropenia in lymphoma patients. 
tolerability profile of both drugs... CONCLUSION: CEFEPIME regimen was more effective than TC regimen, with a
High dose intermittent ticarcillin-clavulanate administration in pediatric cystic fibrosis patients. [2010.07]
BACKGROUND: The Intermountain Cystic Fibrosis Pediatric Center utilizes ticarcillin-clavulanate 400mg/kg/day divided every 6h, (maximum 24 g/day). This dosing strategy is higher than the Cystic Fibrosis Foundation (CFF) recommendations and the Food and Drug Administration (FDA) approved package labeling. The purpose is to determine the safety of this dosing regimen... CONCLUSIONS: Higher than FDA approved doses of ticarcillin-clavulanate may be safely used in the treatment of exacerbations in pediatric cystic fibrosis patients. Copyright 2010 European Cystic Fibrosis Society. Published by Elsevier B.V. All rights reserved.
Continuous infusion of ticarcillin-clavulanate for home treatment of serious infections: clinical efficacy, safety, pharmacokinetics and pharmacodynamics. [2005.06]
Continuous infusion (CI) ticarcillin-clavulanate is a potential therapeutic improvement over conventional intermittent dosing because the major pharmacodynamic (PD) predictor of efficacy of beta-lactams is the time that free drug levels exceed the MIC... Home CI of ticarcillin-clavulanate is a safe, effective, convenient and practical therapy and is a therapeutic advance over traditional intermittent dosing when used in the home setting.
Pharmacokinetics of ticarcillin in the loggerhead sea turtle (Caretta caretta) after single intravenous and intramuscular injections. [2005.03]
Three captive loggerhead sea turtles, Caretta caretta, were used in four trials, one i.v...
Clinical Trials Related to Ticar (Ticarcillin)
Pharmacokinetics and Safety of Ticarcillin-clavulanate in Infants [Not yet recruiting]
This study will evaluate the safety, tolerability and PK of ticarcillin-clavulanate in
infants <91 days of age with suspected systemic infection.
PK of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio) [Not yet recruiting]
A Study of the Safety and Effectiveness of Levofloxacin Compared to Ticarcillin/Clavulanate Alone or Followed by Amoxicillin/Clavulanate in the Treatment of Complicated Skin Infections [Completed]
The purpose of this study is to compare the safety and effectiveness of levofloxacin (an
antibiotic) with ticarcillin/clavulanate alone or followed by amoxicillin/clavulanate in the
treatment of complicated skin infections.
An Investigational Agent for the Treatment of Complicated Intra-Abdominal Infections or Acute Pelvic Infections [Completed]
Standard vs. Biofilm Susceptibility Testing in Cystic Fibrosis (CF) [Completed]
This was a randomized multi-center clinical trial to compare the microbiological efficacy,
clinical efficacy, and safety of using standard versus biofilm susceptibility testing of P.
aeruginosa sputum isolates to guide antibiotic selection for treatment of airway infection in
clinically stable patients with CF.
Page last updated: 2014-03-25