Thyrolar (Liothyronine Sodium / Levothyroxine Sodium) - Summary

THYROLAR SUMMARY

Thyrolar® Tablets (Liotrix Tablets, USP)

Thyrolar Tablets (Liotrix Tablets, USP) contain triiodothyronine (T3 liothyronine) sodium and tetraiodothyronine (T4 levothyroxine) sodium in the amounts listed in the “How Supplied” section. (T3 liothyronine sodium is approximately four times as potent as T4 thyroxine on a microgram for microgram basis.

Thyrolar Tablets are indicated:

1. As replacement or supplemental therapy in patients with hypothyroidism of any etiology, except transient hypothyroidism during the recovery phase of subacute thyroiditis. This category includes cretinism, myxedema, and ordinary hypothyroidism in patients of any age (children, adults, the elderly), or state (including pregnancy); primary hypothyroidism resulting from functional deficiency, primary atrophy, partial or total absence of thyroid gland, or the effects of surgery, radiation, or drugs, with or without the presence of goiter; and secondary (pituitary), or tertiary (hypothalamic) hypothyroidism (See WARNINGS).
2. As pituitary TSH suppressants, in the treatment or prevention of various types of euthyroid goiters, including thyroid nodules, sub-acute or chronic Iymphocytic thyroiditis (Hashimoto's), multinodular goiter, and in the management of thyroid cancer.
3. As diagnostic agents in suppression tests to differentiate suspected mild hyperthyroidism or thyroid gland autonomy.

THYROLAR NEWS HIGHLIGHTS

Published Studies Related to Thyrolar (Liothyronine / Levothyroxine)

Combined treatment with sertraline and liothyronine in major depression: a randomized, double-blind, placebo-controlled trial. [2007.06]

Comparative bioavailability of different formulations of levothyroxine and liothyronine in healthy volunteers. [2006.12]

Substitution of liothyronine at a 1:5 ratio for a portion of levothyroxine: effect on fatigue, symptoms of depression, and working memory versus treatment with levothyroxine alone. [2005.07]

Combined therapy with levothyroxine and liothyronine in two ratios, compared with levothyroxine monotherapy in primary hypothyroidism: a double-blind, randomized, controlled clinical trial. [2005.05]

Thyroid hormone replacement therapy in primary hypothyroidism: a randomized trial comparing L-thyroxine plus liothyronine with L-thyroxine alone. [2005.03.15]

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