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Thrombin-JMI (Thrombin Topical) - Summary

 


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THROMBIN-JMI SUMMARY

The thrombin in Thrombin, Topical (Bovine Origin) THROMBIN-JMI® is a protein substance produced through a conversion reaction in which prothrombin of bovine origin is activated by tissue thromboplastin of bovine origin in the presence of calcium chloride. It is supplied as a sterile powder that has been freeze-dried in the final container. Also contained in the preparation are mannitol and sodium chloride. Mannitol is included to make the dried product friable and more readily soluble. The material contains no preservative.

THROMBIN-JMI® is indicated as an aid to hemostasis whenever oozing blood and minor bleeding from capillaries and small venules is accessible.

In various types of surgery, solutions of THROMBIN-JMI® may be used in conjunction with an Absorbable Gelatin Sponge, USP for hemostasis, or any medical device approved by FDA for an indicated use with a specified, approved dosage of Thrombin, Topical (Bovine Origin).


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THROMBIN-JMI NEWS HIGHLIGHTS

Published Studies Related to Thrombin-JMI (Thrombin Topical)

Efficacy and safety of topical application of human fibrinogen/thrombin-coated collagen patch (TachoComb) for treatment of air leakage after standard lobectomy. [2004.02]

Gelatin-thrombin-based hemostatic sealant for intraoperative bleeding in vascular surgery. [2002.05]

Effect of topical and subcutaneous epinephrine in combination with topical thrombin in blood loss during immediate near-total burn wound excision in pediatric burned patients. [1999.09]

Wound hematoma: prophylaxis with topical thrombin. [1989.05]

Topical bovine thrombin and adverse events: a review of the literature. [2008.07]

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Clinical Trials Related to Thrombin-JMI (Thrombin Topical)

Study of Recombinant Human Thrombin for Bleeding During Surgery [Completed]

A Study to Compare Human Thrombin Against Bovine Thrombin in Its Ability to Stop Bleeding After Surgery [Completed]

Observational Study Assessing the Impact of Exposure to THROMBIN-JMIŽ on Coagulation Parameters. [Not yet recruiting]

Evaluating the Role of Thrombin in Saphenous Vein Graft Failure After Heart Bypass Surgery [Recruiting]

Evaluation of an Absorbable Surgical Hemostatic Agent: Thrombi-GelŽ Versus Gelfoam-Thrombin [Recruiting]

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Page last updated: 2008-08-11

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