DrugLib.com — Drug Information Portal

Rx drug information, pharmaceutical research, clinical trials, news, and more

Thiotepa (Thiotepa Intracavitary) - Side Effects and Adverse Reactions

 
 



ADVERSE REACTIONS

In addition to its effect on the blood-forming elements (see WARNINGS and PRECAUTIONS sections), thiotepa may cause other adverse reactions.

General

Fatigue, weakness. Febrile reaction and discharge from a subcutaneous lesion may occur as the result of breakdown of tumor tissue.

Hypersensitivity Reactions

Allergic reactions - rash, urticaria, laryngeal edema, asthma, anaphylactic shock, wheezing.

Local Reactions

Contact dermatitis, pain at the injection site.

Gastrointestinal

Nausea, vomiting, abdominal pain, anorexia.

Renal

Dysuria, urinary retention. There have been rare reports of chemical cystitis or hemorrhagic cystitis following intravesical, but not parenteral administration of thiotepa.

Respiratory

Prolonged apnea has been reported when succinylcholine was administered prior to surgery, following combined use of thiotepa and other anticancer agents. It was theorized that this was caused by decrease of pseudocholinesterase activity caused by the anticancer drugs.

Neurologic

Dizziness, headache, blurred vision.

Skin

Dermatitis, alopecia. Skin depigmentation has been reported following topical use.

Special Senses

Conjunctivitis.

Reproductive

Amenorrhea, interference with spermatogenesis.



REPORTS OF SUSPECTED THIOTEPA SIDE EFFECTS / ADVERSE REACTIONS

Below is a sample of reports where side effects / adverse reactions may be related to Thiotepa. The information is not vetted and should not be considered as verified clinical evidence.

Possible Thiotepa side effects / adverse reactions in 21 year old female

Reported by a physician from United States on 2011-10-12

Patient: 21 year old female

Reactions: Fibrocystic Breast Disease, Breast Cancer in Situ

Suspect drug(s):
Cosmegen
    Indication: Nephroblastoma

Carboplatin
    Indication: Nephroblastoma

Vincristine
    Indication: Nephroblastoma

Doxorubicin HCL
    Indication: Nephroblastoma

Cyclophosphamide
    Indication: Nephroblastoma

Etoposide
    Indication: Nephroblastoma

Thiotepa
    Indication: Nephroblastoma



Possible Thiotepa side effects / adverse reactions in 21 year old female

Reported by a physician from United States on 2011-10-13

Patient: 21 year old female

Reactions: Bone Marrow Transplant, Recurrent Cancer, Nephroblastoma, Breast Cancer in Situ

Suspect drug(s):
Doxorubicin HCL
    Indication: Nephroblastoma

Thiotepa
    Indication: Nephroblastoma

Cosmegen
    Indication: Nephroblastoma

Vincristine
    Indication: Nephroblastoma

Etoposide
    Indication: Nephroblastoma

Cyclophosphamide
    Indication: Nephroblastoma

Carboplatin
    Indication: Nephroblastoma



Possible Thiotepa side effects / adverse reactions in 15 month old male

Reported by a health professional (non-physician/pharmacist) from Canada on 2011-11-07

Patient: 15 month old male

Reactions: Dysphagia, Aspiration, Leukoencephalopathy

Suspect drug(s):
Etoposide
    Dosage: 2.5 mg/kg
    Indication: Brain Neoplasm Malignant

Carboplatin
    Dosage: 17 mg/kg/day
    Indication: Brain Neoplasm Malignant

Methotrexate
    Dosage: 8 gm/m^2
    Indication: Brain Neoplasm Malignant

Cyclophosphamide
    Dosage: 60 mg/kg
    Indication: Brain Neoplasm Malignant

(Therapeutic Radiopharmaceuticals)
    Indication: Brain Neoplasm Malignant

Dexamethasone Sodium Phosphate
    Dosage: 0.05 mg/kg
    Indication: Brain Neoplasm Malignant

Cisplatin
    Dosage: 3.5 mg/kg
    Indication: Brain Neoplasm Malignant

Thiotepa
    Dosage: 10 mg/kg/day
    Indication: Brain Neoplasm Malignant



See index of all Thiotepa side effect reports >>

Drug label data at the top of this Page last updated: 2006-10-17

-- advertisement -- The American Red Cross
 
Home | About Us | Contact Us | Site usage policy | Privacy policy

All Rights reserved - Copyright DrugLib.com, 2006-2017